Teamwork training and evaluation are essential to enhance safety and quality of care. The lack of the psychometric testing of the TeamSTEPPS® Teamwork Attitudes Questionnaire (T-TAQ) and Teamwork Perceptions Questionnaire (T-TPQ) across different language and cultural settings has questioned their widespread use because such attitudes and perceptions are highly subjective and context-bound. The present study aims to translate the T-TAQ and T-TPQ into the French language and validate the psychometric properties of the two questionnaires...

In this interview, anthropologists Maddalena Canna and Rebecca Seligman explain their recent research agenda investigating how culture shapes the relationship between the body and mind. After having studied trance, they shift their focus to Functional Neurological Disorder (FND), an illness in which sensory or motor symptoms do not match any identified physiological causes. Their approach relies on a mix of anthropological and psychophysiological methods to unravel the mechanisms by which cultural expectations influence the perception...

Abstract Background This study examines predictors of nursing home admission (NHA) in Belgium in order to contribute to a better planning of the future demand for nursing home (NH) services and health care resources. Methods Data derived from the Belgian 2013 health interview survey were linked at individual level with health insurance data (2012 tot 2018). Only community dwelling participants, aged ≥65 years at the time of the survey were included in this study (n...

Climatic niche evolution during the diversification of tropical plants has received little attention in Africa. To address this, we characterized the climatic niche of >4000 tropical African woody species, distinguishing two broad bioclimatic groups (forest vs. savanna) and six subgroups. We quantified niche conservatism versus lability at the genus level and for higher clades, using a molecular phylogeny of >800 genera. Although niche stasis at speciation is prevalent, numerous clades individually cover vast climatic spaces...

The ecological theory of adaptive radiation has profoundly shaped our conceptualization of the rules that govern diversification. However, while many radiations follow classic early burst patterns of diversification as they fill ecological space, the longer-term fates of these radiations depend on many factors, such as climatic stability. In systems with periodic disturbances, species-rich clades can contain nested adaptive radiations of subclades with their own distinct diversification histories, and how adaptive radiation theory applies in these...

Termites feed on vegetal matter at various stages of decomposition. Lineages of wood- and soil-feeding termites are distributed across terrestrial ecosystems located between 45°N and 45°S of latitude, a distribution they acquired through many transoceanic dispersal events. While wood-feeding termites often live in the wood on which they feed and are efficient at dispersing across oceans by rafting, soil-feeders are believed to be poor dispersers. Therefore, their distribution across multiple continents requires an explanation. Here,...

Additional file 1. Supplementary Figures S1–S15 and Supplementary Tables S1–S17.

Additional file 1: Table S1. Modern Nuclear Genome sample information. Table S2. Ancient Mitogenome Sample Information. Table S3. Modern Mitogenome Sample Information. Table S4. Divergence times for each node in the phylogenetic tree estimated using BEAST. Table S5. The priors used to specify tip-date information for each ancient sample in the phylogenetic analysis. Table S6. Demographic Modelling using Approximate Bayesian Computation. Table S7. Marginal Likelihood Estimation for demographic models: constant size, skyline, skyride. Table S8....

Additional file 2: Supplementary materials and methods. Information regarding supplemental methods. Figure S1. PSMC plot for Dicrostonyx torquatus using three different mutation rates estimated for mouse (Mus musculus).

Additional file 10: Fig. S2. Effect of ALKs ratio in the influence of inflammation and TGFβ signaling on chondrocyte hypertrophy. Percentage of perturbations remaining in the healthy state (right) or transitioning towards the hypertrophic one (left) during inflammatory pathway activation with TGF-B treatment while changing the ratio between ALK1 and ALK5. The inflammatory and TGF-B profiles that were imposed are the same as in Fig. 4A except that the value imposed for ALK1 and ALK5...

Additional file 13: Fig. S4. Decision tree summarizing the variable updating scheme employed in algorithm to simulate the in silico chondrocyte. Each biological component is represented by the gene expression level (slow variable) and the protein activity potential (fast variable). Variables are updated based on the rules stored in the model’s equations. First, fast variables are updated in random order, when a pseudo-stable state is reached and that all fast variables have been updated, the...

Additional file 15: Fig. S6. Sensitivity analysis: impact of the number of initialization on the canalization results during the Monte Carlo. The percentage of random initialization reaching each attractor is displayed with the Sox9 positive state (healthy) in orange, the Runx2 positive state in blue and the None in grey. Data labels indicate the absolute amount of state reaching the attractors. None of initializations reached an alternative attractor, even for higher amount of random initializations...

A total of 96 individuals were sampled from four populations of Vietnamese local chickens (28 Ho, 32 Dong Tao, 18 Mong, and 18 Mia) distributed in four provinces (Bac Ninh, Hung Yen, Ha Nam, and Hanoi, respectively) in the North of Vietnam. All individuals were from the same conservation program in Vietnam, originating from either private farms or public institutions involved in this program. Neither pedigree nor phenotypic information was available. We used stratified sampling...

The narrow-headed vole, collared lemming and common vole were the most abundant small mammal species across the Eurasian Late Pleistocene steppe-tundra environment. Previous ancient DNA studies of the collared lemming and common vole have revealed dynamic population histories shaped by climatic fluctuations. To investigate the extent to which species with similar adaptations share common evolutionary histories, we generated a dataset comprised the mitochondrial genomes of 139 ancient and 6 modern narrow-headed voles from several sites...

Additional file 9: Data S4. In silico screening predictions of combinatorial treatments. (Microsoft Excel Worksheet). This file reports the results of a screening of combinatorial perturbations. More particularly, it reports all conditions that lead to a transition towards a healthy chondrocyte (SOX9+) when starting from a hypertrophic-like chondrocyte (Runx2+). The first sheet reports conditions leading to such transition 100% of the time, between 99 and 90% of the time for the next sheet and so...

Abstract Background Without the availability of disease-modifying drugs, there is an unmet therapeutic need for osteoarthritic patients. During osteoarthritis, the homeostasis of articular chondrocytes is dysregulated and a phenotypical transition called hypertrophy occurs, leading to cartilage degeneration. Targeting this phenotypic transition has emerged as a potential therapeutic strategy. Chondrocyte phenotype maintenance and switch are controlled by an intricate network of intracellular factors, each influenced by a myriad of feedback mechanisms, making it challenging to intuitively...

Additional file 16: Fig. S7. Pseudo-time evolution of variables during simulations. The sequence of variable updating over each time steps after introducing a perturbation from the healthy state was saved as a timeseries and plotted. It shows the discrete behavior of the simulation and that a steady state is reached way before the duration of the perturbation (1000 time steps) is reached in such a way that maintain the perturbation longer would not change the...

Additional file 1: Table S1. Definitions. Definitions of technical terms pertaining to biological signaling network modeling with a semi-quantitative additive formalism.

Additional file 4: Data S1. Subset of genes for gene expression profiles and description of GEO datasets with manual binary annotations.

Additional file 5: Fig. S1. Individual dataset clustering and heatmap. The microarray sub-datasets, used in the merged dataset, were also investigated individually. They were pre-processed (i.e. processing steps before merging and correcting for batch effect) in the same way as the merged dataset but the unsupervised clustering analysis was done on each sub-dataset separately in order to compare the biological or OA related information content before and after the data merging. The heatmaps show the...

Additional file 8: Data S3. Attractors complete protein and gene expression profiles. (Microsoft Excel Worksheet). The predicted profiles of the 3 attractors are reported for all variables. The dataset contains the values of the fast sub-variables (i.e. protein subnetwork), slow sub-variables (i.e. gene subnetwork) and the global functional activity.

Prokaryotic genomes are often considered to be mosaics of genes that do not necessarily share the same evolutionary history due to widespread Horizontal Gene Transfers (HGTs). Consequently, representing evolutionary relationships of prokaryotes as bifurcating trees has long been controversial. However, studies reporting conflicts among gene trees derived from phylogenomic datasets have shown that these conflicts can be the result of artifacts or evolutionary processes other than HGT, such as incomplete lineage sorting, low phylogenetic signal,...