53 Works

Phenotypic data for clinal populations, foxo genotypes

Paul Schmidt
The insulin/insulin-like growth factor signaling pathway has been hypothesized as a major determinant of life-history profiles that vary adaptively in natural populations. In Drosophila melanogaster, multiple components of this pathway vary predictably with latitude; this includes foxo, a conserved gene that regulates insulin signaling and has pleiotropic effects on a variety of fitness-associated traits. We hypothesized that allelic variation at foxo contributes to genetic variance for size-related traits that vary adaptively with latitude. We first...

Data From: Fear conditioning potentiates the Hippocampal CA1 commissural pathway In vivo and increases awake phase sleep

Manivannan Subramaniyan, Sumithrra Manivannan, Vikas Chelur, Theodoros Tsetsenis, Evan Jiang & John Dani
The hippocampus is essential for spatial learning and memory. To assess learning we used contextual fear conditioning (cFC), where animals learn to associate a place with aversive events like foot-shocks. Candidate memory mechanisms for cFC are long-term potentiation and long-term depression, but there is little direct evidence of them operating in the hippocampus in vivo following cFC. Also, little is known about the behavioral state changes induced by cFC. To address these issues, we recorded...

Islamophobia & the Oval Office

Mathangi Subramanian

Primary language and the electronic health record patient portal: Barriers to use among Spanish-speaking adults with asthma

Anna M. Localio, Heather Klusaritz, Knashawn H. Morales, Dominique G. Ruggieri, Xiaoyan Han & Andrea J. Apter
To assess electronic health record patient portal use among Spanish-speaking patients with asthma compared to English-speaking patients and identify barriers to use. Using data collected for a PCORI-funded randomized controlled trial to increase patient portal use in low-income adults with uncontrolled asthma, we estimated the association between portal use, measured using surveys and actual user login data, and primary language. Open-ended survey responses were grouped into common themes. Among 301 adults with asthma: age 18-87,...

Effects of a high-phosphorus diet on the gut microbiota in CKD rats

Guoxin Ye, Wei Yang, Zhaori Bi, Liya Huang & Fang Liu
To investigate whether high-phosphorus diets alter gut microbiota in healthy rats and chronic kidney disease (CKD) rats. In this 4-week randomized controlled trial, healthy rats and CKD rats were fed a regular-phosphorus (Pi: 0.8%) and high-phosphorus (Pi: 1.2%) diet. The subjects were divided into four groups: sham-group rats with regular-phosphorus diet intervention (CTL group), sham-group rats with high-phosphorus diet intervention (CTLP group), CKD model rats with regular-phosphorus diet intervention (CKD group), and CKD model rats...

Effects of a high-phosphorus diet on the gut microbiota in CKD rats

Guoxin Ye, Wei Yang, Zhaori Bi, Liya Huang & Fang Liu
To investigate whether high-phosphorus diets alter gut microbiota in healthy rats and chronic kidney disease (CKD) rats. In this 4-week randomized controlled trial, healthy rats and CKD rats were fed a regular-phosphorus (Pi: 0.8%) and high-phosphorus (Pi: 1.2%) diet. The subjects were divided into four groups: sham-group rats with regular-phosphorus diet intervention (CTL group), sham-group rats with high-phosphorus diet intervention (CTLP group), CKD model rats with regular-phosphorus diet intervention (CKD group), and CKD model rats...

Network pharmacology-based analysis in determining the mechanisms of Huoxin pill in protecting against myocardial infarction

Jia He, Da Wo, En Ma, Qing Wang, Jinxiao Chen, Jun Peng, Weidong Zhu & Dan-ni Ren
Huoxin pill (HXP) is a commonly used TCM prescription for treatment of cardiovascular diseases. However, its mechanism in protecting against myocardial infarction (MI) remains unknown. We performed a network pharmacology analysis to explore the bioactive ingredients, therapeutic effects, and mechanisms of HXP in protecting against MI. HPLC was used to identify major bioactive compounds, and overlap with MI target genes were visualised. 10-Week old C57BL/6 mice were randomly assigned as: Sham-operated control, MI + Phosphate...

Network pharmacology-based analysis in determining the mechanisms of Huoxin pill in protecting against myocardial infarction

Jia He, Da Wo, En Ma, Qing Wang, Jinxiao Chen, Jun Peng, Weidong Zhu & Dan-ni Ren
Huoxin pill (HXP) is a commonly used TCM prescription for treatment of cardiovascular diseases. However, its mechanism in protecting against myocardial infarction (MI) remains unknown. We performed a network pharmacology analysis to explore the bioactive ingredients, therapeutic effects, and mechanisms of HXP in protecting against MI. HPLC was used to identify major bioactive compounds, and overlap with MI target genes were visualised. 10-Week old C57BL/6 mice were randomly assigned as: Sham-operated control, MI + Phosphate...

Inefficient integration during multiple facial processing in pre-morbid and early phases of psychosis

TianHong Zhang, YingYu Yang, LiHua Xu, XiaoChen Tang, YeGang Hu, Xin Xiong, YanYan Wei, HuiRu Cui, YingYing Tang, HaiChun Liu, Tao Chen, Zhi Liu, Li Hui, ChunBo Li, XiaoLi Guo & JiJun Wang
We used eye-tracking to evaluate multiple facial context processing and event-related potential (ERP) to evaluate multiple facial recognition in individuals at clinical high risk (CHR) for psychosis. In total, 173 subjects (83 CHRs and 90 healthy controls [HCs]) were included and their emotion perception performances were accessed. A total of 40 CHRs and 40 well-matched HCs completed an eye-tracking task where they viewed pictures depicting a person in the foreground, presented as context-free, context-compatible, and...

The effects of emotional trait factors on simulated flight performance under an acute psychological stress situation

Jing Dai, Hang Wang, Lin Yang, Xinsheng Cao, Chunchen Wang, Zhijun Gao, Wendong Hu & Zhihong Wen
Objective. Pilots are commonly exposed to some sources of emotional and cognitive stressors, especially for flight cadets, which have an important influence on flight safety. The present study aimed to study the relationship between emotional trait factors, emotional state, mental workload and simulated flight performance (SFP) under an acute psychological stress situation. Methods. Fifty-five undergraduates were included in the study. The Wong and Law emotional intelligence scale (WLEIS), state-trait anxiety inventory (STAI), stress rating questionnaire...

Did shell-crushing predators drive the evolution of ammonoid septal shape?

Erynn Johnson, Briana DiMarco, David Peterman, Aja Carter & Warren Allmon
For centuries, paleontologists have sought functional explanations for the uniquely complex internal walls (septa) of ammonoids, extinct shelled cephalopods. Ammonoid septa developed increasingly complex fractal margins, unlike any modern shell morphologies, throughout more than 300 million years of evolution. Some have suggested these morphologies provided increased resistance to shell-crushing predators. We perform the first physical compression experiments on model ammonoid septa using controlled, theoretical morphologies generated by computer-aided design and 3D printing. These biomechanical experiments...

Apparent Communicative Efficiency in the Lexicon is Emergent

Spencer Caplan, Jordan Kodner & Charles Yang

Price Negotiation in Differentiated Products Markets: Evidence from the Canadian Mortgage Market

Jason Allen, Robert Clark & Jean-François Houde
This paper measures market power in a decentralized market where contracts are determined through a search and negotiation process. The mortgage industry has many institutional features which suggest competitiveness: homogeneous contracts, negotiable rates, and, for a given consumer, common lending costs across lenders. As a result, even with a small number of lenders, informed borrowers can gather multiple quotes. However, there is important heterogeneity in the ability of consumers to understand the subtleties of financial...

Cellular dataset for: The anterior Hox gene ceh-13 and elt-1/GATA activate the posterior Hox genes nob-1 and php-3 to specify posterior lineages in the C. elegans embryo

Amanda Zacharias, John Isaac Murray, Elicia Preston, Jeremy Crawford, Jonathan Rumley, Prativa Amom, Breana Anderson, Priya Sivaramakrishnan, Shaili Patel, Barrington Bennett, Teddy Lavon & Felicia Peng
Hox transcription factors play a conserved role in specifying positional identity during animal development, with posterior Hox genes typically repressing the expression of more anterior Hox genes. Here, we dissect the regulation of the posterior Hox genes nob-1 and php-3 in the nematode C. elegans. We show that nob-1 and php-3 are co-expressed in gastrulation-stage embryos in cells that previously expressed the anterior Hox gene ceh-13. This expression is controlled by several partially redundant transcriptional...

Introduction

Rebecca Seifried & Deborah Stewart

The synergistic antitumor activity of 3-(2-nitrophenyl) propionic acid-paclitaxel nanoparticles (NPPA-PTX NPs) and anti-PD-L1 antibody inducing immunogenic cell death

Xiao-Chuan Duan, Li-Yuan Peng, Xin Yao, Mei-Qi Xu, Hui Li, Shuai-Qiang Zhang, Zhuo-Yue Li, Jing-Ru Wang, Zhen-Han Feng, Guang-Xue Wang, Ai Liao, Ying Chen & Xuan Zhang
Cancer immunotherapy is a strategy that is moving to the frontier of cancer treatment in the current decade. In this study, we show evidence that 3-(2-nitrophenyl) propionic acid-paclitaxel nanoparticles (NPPA-PTX NPs), act as immunogenic cell death (ICD) inducers, stimulating an antitumor response which results in synergistic antitumor activity by combining anti-PD-L1 antibody (aPD-L1) in vivo. To investigate the antitumor immunity induced by NPPA-PTX NPs, the expression of both ICD marker calreticulin (CRT) and high mobility...

Additional file 1 of Epigenetic interplay between methylation and miRNA in bladder cancer: focus on isoform expression

Manu Shivakumar, Seonggyun Han, Younghee Lee & Dokyoon Kim
Additional file 1 Fig. S1. Plots for combination SGCD_ENST00000435422, cg19748027 and hsa-miR-409-3p. Fig. S2. Plots for combination PLS1_ENST00000457734, cg05652551 and hsa-miR-142-5p. Fig. S3. Plots for combination CAV1_ENST00000341049, cg04474049 and hsa-miR-194-5p. Fig. S4. Plots for combination PLS1_ENST00000457734, cg05652551 and hsa-miR-155-5p. Fig. S5. Plots for combination HID1_ENST00000425042, cg07430967 and hsa-miR-125a-5p. Fig. S6. Plots for combination TGFBR3_ENST00000212355, cg08648138 and hsa-let-7c-5p. Fig. S7. Plots for combination PMEPA1_ENST00000341744, cg01515444 and hsa-miR-200a-5p. Fig. S8. Plots for combination H2AFY_ENST00000304332, cg01874869 and hsa-miR-100-5p....

Additional file 1 of Epigenetic interplay between methylation and miRNA in bladder cancer: focus on isoform expression

Manu Shivakumar, Seonggyun Han, Younghee Lee & Dokyoon Kim
Additional file 1 Fig. S1. Plots for combination SGCD_ENST00000435422, cg19748027 and hsa-miR-409-3p. Fig. S2. Plots for combination PLS1_ENST00000457734, cg05652551 and hsa-miR-142-5p. Fig. S3. Plots for combination CAV1_ENST00000341049, cg04474049 and hsa-miR-194-5p. Fig. S4. Plots for combination PLS1_ENST00000457734, cg05652551 and hsa-miR-155-5p. Fig. S5. Plots for combination HID1_ENST00000425042, cg07430967 and hsa-miR-125a-5p. Fig. S6. Plots for combination TGFBR3_ENST00000212355, cg08648138 and hsa-let-7c-5p. Fig. S7. Plots for combination PMEPA1_ENST00000341744, cg01515444 and hsa-miR-200a-5p. Fig. S8. Plots for combination H2AFY_ENST00000304332, cg01874869 and hsa-miR-100-5p....

Astragalus polysacharin inhibits hepatocellular carcinoma-like phenotypes in a murine HCC model through repression of M2 polarization of tumour-associated macrophages

Chun Li, Xin-You Pan, Mingyun Ma, Jun Zhao, Fengda Zhao & Ya-Ping Lv
Astragalus polysaccharin (APS), an extract of Astragalus propinquus Schischk, exerts antitumor effects in hepatocellular carcinoma (HCC). This study investigated the mechanism of action of APS in HCC. Tumour-associated macrophages (TAMs) were treated with APS (0, 8, 16 mg/mL) for 24 h. APS (16 mg/mL)-treated TAMs were co-cultured with MHCC97H/Huh7 cells for 24 h. Finally, BALB/c nude mice were divided into PBS, APS (50 mg/kg), APS (100 mg/kg), APS (200 mg/kg) groups: mice were inoculated with...

Impact of surfactant when utilized during pediatric cardiac surgery admissions: analysis of a nationwide database

Saul Flores, Enrique G. Villarreal, Brian Lee, Raysa Morales-Demori, Juan S. Farias, Mubbasheer Ahmed, Rohit S. Loomba & Fabio Savorgnan
Surfactant has been routinely used in the neonatal population, particularly in the setting of prematurity and neonatal respiratory distress syndrome. Current evidence, however, does not delineate the effect of surfactant use in neonates and older children during cardiac surgery admissions. This study aimed to characterize the impact of surfactant on pediatric cardiac surgery admissions. Admissions of those under 18 years of age with cardiac surgery were identified from the Pediatric Health Information System (PHIS) database...

Risk of Non-infectious Uveitis with Metformin Therapy in a Large Healthcare Claims Database

Lucia Sobrin, Yinxi Yu, Samuel Han, Gayatri Susarla, John H. Kempen, Rebecca A. Hubbard & Brian L. VanderBeek
To determine if metformin is associated with noninfectious uveitis (NIU). Patients in an insurance claims database who initiated metformin (n = 359,139) or other oral anti-diabetic medications (n = 162,847) were followed for NIU development. Both cohort and case-control analyses were performed to assess differing exposure lengths using Cox and conditional logistic regression, respectively. The hazard ratio (HR) for incident NIU was not significantly different between the metformin and non-metformin cohorts [HR = 1.19, 95%...

Optogenetics experiment checklist

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Optogenetics, calcium imaging, and modern microscopy provide a powerful approach to uncover new biological phenomena and explore cellular and molecular mechanisms in ways that are both visual and quantitative. Paired properly, optogenetic approaches combined with calcium imaging can determine functional relationships within biological circuits. For example, stimulating or inhibiting neural populations, and subsequently recording neural activity, allows one to examine the presence of epistatic neural relationships. While technological advancement makes these methods more accessible, it...

Effects of the macroalga Asparagopsis taxiformis and oregano leaves on methane emission, rumen fermentation, and lactational performance of dairy cows

H.A. Stefenoni, S.E. Räisänen, S.F. Cueva, D.E. Wasson, C.F.A. Lage, A. Melgar, M.E. Fetter, P. Smith, M. Hennessy, B. Vecchiarelli, J. Bender, D. Pitta, C.L. Cantrell, C. Yarish & A.N. Hristov
Asparagopsis taxiformis (AT) is a source of multiple halogenated compounds and, in a limited number of studies, has been shown to decrease enteric CH4 production in vitro and in vivo. Similarly, oregano has also been suggested as a potential CH4 mitigating agent. This study consisted of 2 in vitro and 2 in vivo experiments. Experiment 1 (Exp. 1) was aimed at establishing the effect of AT on total gas production and CH4 emission in vitro....

Early Warning of Financial Stress Events: A Credit-Regime-Switching Approach

Fuchun Li & Hongyu Xiao
We propose an early warning model for predicting the likelihood of a financial stress event for a given future time, and examine whether credit plays an important role in the model as a non-linear propagator of shocks. This propagation takes the form of a threshold regression in which a regime change occurs if credit conditions cross a critical threshold. The in-sample and out-of-sample forecasting performances are encouraging. In particular, the out-of-sample forecasting results suggest that...

Data from: Broad geographic sampling reveals predictable, pervasive, and strong seasonal adaptation in Drosophila

Heather E. Machado, Alan O. Bergland, Ryan Taylor, Susanne Tilk, Emily Behrman, Kelly Dyer, Daniel K. Fabian, Thomas Flatt, Josefa González, Talia L. Karasov, Iryna Kozeretska, Brian P. Lazzaro, Thomas JS Merritt, John E. Pool, Katherine O’Brien, Subhash Rajpurohit, Paula R. Roy, Stephen W. Schaeffer, Svitlana Serga, Paul Schmidt, Dmitri Petrov & Bernard Kim
To advance our understanding of adaptation to temporally varying selection pressures, we identified signatures of seasonal adaptation occurring in parallel among Drosophila melanogaster populations. Specifically, we estimated allele frequencies genome-wide from flies sampled early and late in the growing season from 20 widely dispersed populations. We identified parallel seasonal allele frequency shifts across North America and Europe, demonstrating that seasonal adaptation is a general phenomenon of temperate fly populations. Seasonally fluctuating polymorphisms are enriched at...

Registration Year

  • 2021
    53

Resource Types

  • Dataset
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  • Text
    21
  • Other
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  • Collection
    2
  • Image
    2

Affiliations

  • University of Pennsylvania
    53
  • Shanghai Jiao Tong University
    10
  • Tongji University
    9
  • Fudan University
    8
  • Huazhong University of Science and Technology
    6
  • Capital Medical University
    5
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    5
  • University of Utah
    5
  • Zhejiang University
    4
  • Central South University
    4