23 Works

Data from: Broad geographic sampling reveals predictable, pervasive, and strong seasonal adaptation in Drosophila

Heather E. Machado, Alan O. Bergland, Ryan Taylor, Susanne Tilk, Emily Behrman, Kelly Dyer, Daniel K. Fabian, Thomas Flatt, Josefa González, Talia L. Karasov, Iryna Kozeretska, Brian P. Lazzaro, Thomas JS Merritt, John E. Pool, Katherine O’Brien, Subhash Rajpurohit, Paula R. Roy, Stephen W. Schaeffer, Svitlana Serga, Paul Schmidt, Dmitri Petrov & Bernard Kim
To advance our understanding of adaptation to temporally varying selection pressures, we identified signatures of seasonal adaptation occurring in parallel among Drosophila melanogaster populations. Specifically, we estimated allele frequencies genome-wide from flies sampled early and late in the growing season from 20 widely dispersed populations. We identified parallel seasonal allele frequency shifts across North America and Europe, demonstrating that seasonal adaptation is a general phenomenon of temperate fly populations. Seasonally fluctuating polymorphisms are enriched at...

Effects of the macroalga Asparagopsis taxiformis and oregano leaves on methane emission, rumen fermentation, and lactational performance of dairy cows

H.A. Stefenoni, S.E. Räisänen, S.F. Cueva, D.E. Wasson, C.F.A. Lage, A. Melgar, M.E. Fetter, P. Smith, M. Hennessy, B. Vecchiarelli, J. Bender, D. Pitta, C.L. Cantrell, C. Yarish & A.N. Hristov
Asparagopsis taxiformis (AT) is a source of multiple halogenated compounds and, in a limited number of studies, has been shown to decrease enteric CH4 production in vitro and in vivo. Similarly, oregano has also been suggested as a potential CH4 mitigating agent. This study consisted of 2 in vitro and 2 in vivo experiments. Experiment 1 (Exp. 1) was aimed at establishing the effect of AT on total gas production and CH4 emission in vitro....

Early Warning of Financial Stress Events: A Credit-Regime-Switching Approach

Fuchun Li & Hongyu Xiao
We propose an early warning model for predicting the likelihood of a financial stress event for a given future time, and examine whether credit plays an important role in the model as a non-linear propagator of shocks. This propagation takes the form of a threshold regression in which a regime change occurs if credit conditions cross a critical threshold. The in-sample and out-of-sample forecasting performances are encouraging. In particular, the out-of-sample forecasting results suggest that...

Did shell-crushing predators drive the evolution of ammonoid septal shape?

Erynn Johnson, Briana DiMarco, David Peterman, Aja Carter & Warren Allmon
For centuries, paleontologists have sought functional explanations for the uniquely complex internal walls (septa) of ammonoids, extinct shelled cephalopods. Ammonoid septa developed increasingly complex fractal margins, unlike any modern shell morphologies, throughout more than 300 million years of evolution. Some have suggested these morphologies provided increased resistance to shell-crushing predators. We perform the first physical compression experiments on model ammonoid septa using controlled, theoretical morphologies generated by computer-aided design and 3D printing. These biomechanical experiments...

Price Negotiation in Differentiated Products Markets: Evidence from the Canadian Mortgage Market

Jason Allen, Robert Clark & Jean-François Houde
This paper measures market power in a decentralized market where contracts are determined through a search and negotiation process. The mortgage industry has many institutional features which suggest competitiveness: homogeneous contracts, negotiable rates, and, for a given consumer, common lending costs across lenders. As a result, even with a small number of lenders, informed borrowers can gather multiple quotes. However, there is important heterogeneity in the ability of consumers to understand the subtleties of financial...

Cellular dataset for: The anterior Hox gene ceh-13 and elt-1/GATA activate the posterior Hox genes nob-1 and php-3 to specify posterior lineages in the C. elegans embryo

Amanda Zacharias, John Isaac Murray, Elicia Preston, Jeremy Crawford, Jonathan Rumley, Prativa Amom, Breana Anderson, Priya Sivaramakrishnan, Shaili Patel, Barrington Bennett, Teddy Lavon & Felicia Peng
Hox transcription factors play a conserved role in specifying positional identity during animal development, with posterior Hox genes typically repressing the expression of more anterior Hox genes. Here, we dissect the regulation of the posterior Hox genes nob-1 and php-3 in the nematode C. elegans. We show that nob-1 and php-3 are co-expressed in gastrulation-stage embryos in cells that previously expressed the anterior Hox gene ceh-13. This expression is controlled by several partially redundant transcriptional...

Apparent Communicative Efficiency in the Lexicon is Emergent

Spencer Caplan, Jordan Kodner & Charles Yang

Introduction

Rebecca Seifried & Deborah Stewart

Data From: Fear conditioning potentiates the Hippocampal CA1 commissural pathway In vivo and increases awake phase sleep

Manivannan Subramaniyan, Sumithrra Manivannan, Vikas Chelur, Theodoros Tsetsenis, Evan Jiang & John Dani
The hippocampus is essential for spatial learning and memory. To assess learning we used contextual fear conditioning (cFC), where animals learn to associate a place with aversive events like foot-shocks. Candidate memory mechanisms for cFC are long-term potentiation and long-term depression, but there is little direct evidence of them operating in the hippocampus in vivo following cFC. Also, little is known about the behavioral state changes induced by cFC. To address these issues, we recorded...

Phenotypic data for clinal populations, foxo genotypes

Paul Schmidt
The insulin/insulin-like growth factor signaling pathway has been hypothesized as a major determinant of life-history profiles that vary adaptively in natural populations. In Drosophila melanogaster, multiple components of this pathway vary predictably with latitude; this includes foxo, a conserved gene that regulates insulin signaling and has pleiotropic effects on a variety of fitness-associated traits. We hypothesized that allelic variation at foxo contributes to genetic variance for size-related traits that vary adaptively with latitude. We first...

Islamophobia & the Oval Office

Mathangi Subramanian

Data from: Competitive history shapes rapid evolution in a seasonal climate

Tess Grainger, Seth Rudman, Paul Schmidt & Jonathan Levine
Eco-evolutionary dynamics will play a critical role in determining species’ fates as climatic conditions change. Unfortunately, we have little understanding of how rapid evolutionary responses to climate play out when species are embedded in the competitive communities that they inhabit in nature. We tested the effects of rapid evolution in response to interspecific competition on subsequent ecological and evolutionary trajectories in a seasonally changing climate using a field-based evolution experiment with Drosophila melanogaster. Populations of...

Ex Vivo MRI in Frontotemporal Lobar Degeneration

Dylan Tisdall
Ex vivo MRI of 7 human hemispheres, acquired at 7 T using multi-echo gradient recalled echo imaging. Details of these samples are presented in the associated manuscript.

Data from: Prevalence of disability associated with head injury with loss of consciousness: a population-based study

Andrea Lauren Christman Schneider
Objective: To provide nationally representative prevalence estimates of disability associated with prior head injury with loss of consciousness in the U.S. and to examine associations between prior head injury and disability. Methods: Cross-sectional analysis of 7,390 participants aged ³40 years in the 2011-2014 National Health and Nutrition Examination Surveys (NHANES). Head injury with loss of consciousness was assessed by self-report. Domains of disability were assessed using a standardized structured questionnaire and measured grip strength. Logistic...

Load-Bearing Entanglements in Polymer Glasses

Cynthia Bukowski, Tianren Zheng, Robert Riggleman & Alfred Crosby

Collective detection based on visual information in animal groups

Jacob D. Davidson, Matthew M. G. Sosna, Colin R. Twomey, Vivek H. Sridhar, Simon P. Leblanc & Iain D. Couzin
We investigate key principles underlying individual, and collective, visual detection of stimuli, and how this relates to the internal structure of groups. While the individual and collective detection principles are generally applicable, we employ a model experimental system of schooling golden shiner fish ( Notemigonus crysoleucas ) to relate theory directly to empirical data, using computational reconstruction of the visual fields of all individuals. This reveals how the external visual information available to each group...

Pinpointing the neural signatures of single-exposure visual recognition memory

Vahid Mehrpour, Travis Meyer, Eero P. Simoncelli & Nicole C. Rust
Memories of the images that we have seen are thought to be reflected in the reduction of neural responses in high-level visual areas such as inferotemporal (IT) cortex, a phenomenon known as repetition suppression (RS). We challenged this hypothesis with a task that required rhesus monkeys to report whether images were novel or repeated while ignoring variations in contrast, a stimulus attribute that is also known to modulate the overall IT response. The monkeys’ behavior...

Learning Morphological Productivity as Meaning-Form Mappings

Sarah R. Payne, Jordan Kodner & Charles Yang

Web-CDI: A system for online administration of the MacArthur-Bates Communicative Development Inventories

Benjamin Edward deMayo, Danielle Kellier, Mika Braginsky, Christina Bergmann, Cielke Hendriks, Caroline Rowland, Michael Frank & Virginia Marchman

Clinical Trial Transparency and Data-Sharing Among Bio-Pharmaceutical Companies and the Role of Company Size, Location, and Product Type: A Cross-Sectional Descriptive Analysis

Sydney Axson, Michelle Mello, Deborah Lincow, Catherine Yang, Cary Gross, Joseph Ross & Jennifer Miller
Objective: To examine company characteristics associated with better transparency and to apply a tool used to measure and improve clinical trial transparency among large companies and drugs, to smaller companies and biologics. Design: Cross-sectional descriptive analysis. Setting and participants. Novel drugs and biologics FDA approved in 2016 and 2017, and their company sponsors. Using established Good Pharma Scorecard (GPS) measures, companies and products were evaluated on their clinical trial registration, results dissemination, and FDA Amendments...

Retinotopic organization of visual cortex in human infants

Cameron Ellis, Tristan Yates, Lena Skalaban, Vikranth Bejjanki, Michael Arcaro & Nicholas Turk-Browne
Vision develops rapidly during infancy, yet how visual cortex is organized during this period is unclear. In particular, it is unknown whether functional maps that organize the mature adult visual cortex are present in the infant striate and extrastriate cortex. Here we test the functional maturity of infant visual cortex by performing retinotopic mapping with fMRI. Infants aged 5–23 months had retinotopic maps, with alternating preferences for vertical and horizontal meridians indicative of area boundaries...

Muslim Women and Representation (2018)

Noreen Naseem Rodriguez

The Origins of US Interventions in Afghanistan (2001)

Madina Wahab

Registration Year

  • 2021
    23

Resource Types

  • Dataset
    13
  • Text
    7
  • Other
    3

Affiliations

  • University of Pennsylvania
    23
  • Stanford University
    3
  • Princeton University
    3
  • University of Massachusetts Amherst
    2
  • Yale University
    2
  • Pennsylvania State University
    2
  • Cornell University
    2
  • Bank of Canada
    2
  • University of Kansas
    1
  • Max Planck Institute for Psycholinguistics
    1