Data from: Pharmacokinetics of morphine in encephalopathic neonates treated with therapeutic hypothermia

Laurent M. A. Favié, Floris Groenendaal, Marcel P. H. Van Den Broek, Carin M. A. Rademaker, Timo R. De Haan, Henrica L. M. Van Straaten, Peter H. Dijk, Arno Van Heijst, Jeroen Dudink, Koen P. Dijkman, Monique Rijken, Inge A. Zonnenberg, Filip Cools, Alexandra Zecic, Johanna H. Van Der Lee, Debbie H. G. M. Nuytemans, Frank Van Bel, Toine C. G. Egberts & Alwin J. R. Huitema
Objective: Morphine is a commonly used drug in encephalopathic neonates treated with therapeutic hypothermia after perinatal asphyxia. Pharmacokinetics and optimal dosing of morphine in this population are largely unknown. The objective of this study was to describe pharmacokinetics of morphine and its metabolites morphine-3-glucuronide and morphine-6-glucuronide in encephalopathic neonates treated with therapeutic hypothermia and to develop pharmacokinetics based dosing guidelines for this population. Study design: Term and near-term encephalopathic neonates treated with therapeutic hypothermia and...

Registration Year

  • 2019
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Resource Types

  • Dataset
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Affiliations

  • Vrije Universiteit Brussel
    1
  • Emma Kinderziekenhuis
    1
  • VU University Medical Center
    1
  • Leiden University
    1
  • Máxima Medisch Centrum
    1
  • University Medical Center Groningen
    1
  • Sophia Children's Hospital
    1
  • University Medical Center Utrecht
    1
  • Wilhelmina Children's Hospital
    1