165 Works

Data from: Skin autofluorescence and subclinical atherosclerosis in mild to moderate chronic kidney disease: a case-control study

Enric Sánchez, Ángels Betriu, David Arroyo, Carolina López, Marta Hernández, Ferran Rius, Elvira Fernández & Albert Lecube
Advanced glycation end-products (AGEs) are increased and predict mortality in patients with chronic kidney disease (CKD) who are undergoing hemodialysis, irrespective of the presence of type 2 diabetes. However, little information exits about the relationship between AGEs and subclinical atherosclerosis at the early stages of CKD. A case-control study was performed including 87 patients with mild-to-moderate stages of CKD (glomerular filtration rate from 89 to 30 ml/min/per 1.73m2) and 87 non-diabetic non-CKD subjects matched by...

Endocannabinoid signalling in stem cells and cerebral organoids drives differentiation to deep layer projection neurons via CB1 receptors

Juan Paraiso-Luna, Jose Aguareles, Ricardo Martin, Ane C. Ayo-Martin, Daniel Garcia-Rincon, Samuel Simon-Sanchez, Adan De Salas-Quiroga, Javier Diaz-Alonso, Elena Garcia-Taboada, Isabel Liste, Jose Sanchez-Prieto, Silvia Cappello, Manuel Guzman, Ismael Galve-Roperh & Carlos Costas-Insua
The endocannabinoid (eCB) system, via cannabinoid CB1 receptor, regulates neurodevelopment by controlling neural progenitor proliferation and neurogenesis. CB1 receptor signalling in vivo drives corticofugal deep layer projection neuron development through the regulation of BCL11B and Satb2 transcription factors. Here, we investigated the role of eCB signalling in mouse pluripotent embryonic stem cell-derived neuronal differentiation. Characterization of the eCB system revealed increased expression of eCB-metabolizing enzymes, eCB ligands and CB1 receptors along neuronal differentiation. CB1 receptor...

Additional file 3 of The association between macrovascular complications and intensive care admission, invasive mechanical ventilation, and mortality in people with diabetes hospitalized for coronavirus disease-2019 (COVID-19)

Gemma Llauradó, Bogdan Vlacho, Matthieu Wargny, Yue Ruan, Josep Franch-Nadal, Pere Domingo, Pierre Gourdy, Pierre-Jean Saulnier, Samy Hadjadj, Sarah H. Wild, Rustam Rea, Bertrand Cariou, Kamlesh Khunti & Dídac Mauricio
Additional file 3: Figure S3. Odds ratio for the association between mortality (1A–C), intensive care unit admission (2A–C) and peripheral artery disease in each of the four cohorts and overall. I2 indicates heterogeneity in the estimates. Odds ratio estimates adjusted for: model 1: age and sex (B); model 2: model 1 + type of diabetes, arterial hypertension, and the presence of microvascular disease (C).

Nut consumption is associated with a shift of the NMR lipoprotein subfraction profile to a less atherogenic pattern among older individuals at high CVD risk

Jesús F. García-Gavilán, Margery A. Connelly, Nancy Babio, Christos S. Mantzoros, Emilio Ros & Jordi Salas-Salvadó
Abstract Background Scientific evidence has accumulated on the beneficial effects of nut consumption on cardiovascular risk and cholesterol reduction, but few studies have examined the effects of nuts on advanced measures of lipoprotein atherogenicity determined by nuclear magnetic resonance (NMR) spectroscopy. We analyzed associations between the amount and type of of nuts consumed and advanced measures of lipoprotein atherogenity and insulin resistance in older individuals at high cardiovascular risk. Methods The present observational study was...

Influence of COPD systemic environment on the myogenic function of muscle precursor cells in vitro

Carme Casadevall, Antonio Sancho-Muñoz, Ignacio Vicente, Sergi Pascual-Guardia, Mireia Admetlló & Joaquim Gea
Abstract Background: Loss of muscle mass and function are well-recognized systemic manifestations of chronic obstructive pulmonary disease (COPD). Acute exacerbations, in turn, significantly contribute to upgrade these systemic comorbidities. Involvement of myogenic precursors in muscle mass maintenance and recovery is poorly understood. The aim of the present study was to investigate the effects of the vascular systemic environment from stable and exacerbated COPD patients on the myogenic behavior of human muscle precursor cells (MPC) in...

Additional file 1 of Diagnostic accuracy of multiplex respiratory pathogen panels for influenza or respiratory syncytial virus infections: systematic review and meta-analysis

Sophie Jullien, Felicity Fitzgerald, Suzanne Keddie, Oliver Baerenbold, Quique Bassat, John Bradley, Jane Falconer, Colin Fink, Ruth Keogh, Heidi Hopkins & Marie Voice
Additional file 1: Annex S1. Search methodology. Annex S2. Databases. Annex S3. Statistical model. Annex S4. Literature search results. Additional tables and figures.

Deletion patterns, genetic variability and protein structure of pfhrp2 and pfhrp3: implications for malaria rapid diagnostic test in Amhara region, Ethiopia

Irene Molina - de la Fuente, Mulat Yimar, Luz García, Vicenta González, Arancha Amor, Melaku Anegagrie, Agustín Benito, Javier Martínez, Marta Moreno & Pedro Berzosa
Abstract Background Although rapid diagnostic tests (RDTs) play a key role in malaria-control strategies, their efficacy has been threatened by deletion and genetic variability of the genes pfhrp2/3. This study aims to characterize the deletion, genetic patterns and diversity of these genes and their implication for malaria RDT effectiveness, as well as their genetic evolution in the Amhara region of Ethiopia. Methods The study included 354 isolates from symptomatic patients from the Amhara region of...

Additional file 1 of Association of α-klotho with subclinical carotid atherosclerosis in subjects with type 1 diabetes mellitus

Esmeralda Castelblanco, Marta Hernández, Nuria Alonso, Aina Ribes-Betriu, Jordi Real, Minerva Granado-Casas, Joana Rossell, Marina Idalia Rojo-López, Adriana Silvia Dusso, Josep Julve & Didac Mauricio
Supplementary Material 1

Additional file 1 of Prevalence of sexual harassment among young Spaniards before, during, and after the COVID-19 lockdown period in Spain

Laura Vall-Llosera Casanovas, Laura Serra, Carme Saurina Canals, Belén Sanz-Barbero, Carmen Vives-Cases, Maria José López, Laura Otero-García, Gloria Pérez & Gemma Renart-Vicens
Additional file 1: Table S1. Prevalence of SH according to the study covariates of the “Sexual Violence among Young People” survey administered to the Spanish population aged 18–35 years.

Additional file 1 of Clinical and economic burden of respiratory syncytial virus in Spanish children: the BARI study

F. Martinón-Torres, M. Carmo, L. Platero, G. Drago, J. L. López-Belmonte, M. Bangert, J. Díez-Domingo & M. Garcés-Sánchez
Additional file 1: Table S1. List of analyzed risk factors andICD9/10 codes used. Table S2. Unit costs considered for each healthcare visit.

Clinical and economic burden of respiratory syncytial virus in Spanish children: the BARI study

F. Martinón-Torres, M. Carmo, L. Platero, G. Drago, J. L. López-Belmonte, M. Bangert, J. Díez-Domingo & M. Garcés-Sánchez
Abstract Respiratory syncytial virus (RSV) infection is a major cause of morbidity in children. However, its disease burden remains poorly understood, particularly outside of the hospital setting. Our study aimed to estimate the burden of medically attended acute lower respiratory infection (ALRI) cases potentially related to RSV in Spanish children. Longitudinal data from September 2017 to June 2018 of 51,292 children aged < 5 years old from the National Healthcare System (NHS) of two Spanish...

Additional file 1 of Resilience of people with chronic medical conditions during the COVID-19 pandemic: a 1-year longitudinal prospective survey

Lorenzo Tarsitani, Irene Pinucci, Federico Tedeschi, Martina Patanè, Davide Papola, Christina Palantza, Ceren Acarturk, Emma Björkenstam, Richard Bryant, Sebastian Burchert, Camille Davisse-Paturet, Amanda Díaz-García, Rachel Farrel, Daniela C. Fuhr, Brian J. Hall, Anja C. Huizink, Agnes Iok Fong Lam, Gülşah Kurt, Ingmar Leijen, Ellenor Mittendorfer-Rutz, Naser Morina, Catherine Panter-Brick, Fredrick Dermawan Purba, Soledad Quero, Soraya Seedat … & Corrado Barbui
Additional file 1: Procedures for model identification. Fig. S1. Flowchart of sample identification. Table S1. Descriptive statistics of resilience indicators across the survey waves (N = 1052)*. Table S2. Frequency of each chronic medical condition in the whole sample. Table S3. Comparison between participants with and without chronic medical conditions at baseline*. Table S4. Descriptive statistics at the first wave of socio-demographic and clinical characteristics of participants with a chronic condition included vs excluded (because...

Additional file 1 of Resilience of people with chronic medical conditions during the COVID-19 pandemic: a 1-year longitudinal prospective survey

Lorenzo Tarsitani, Irene Pinucci, Federico Tedeschi, Martina Patanè, Davide Papola, Christina Palantza, Ceren Acarturk, Emma Björkenstam, Richard Bryant, Sebastian Burchert, Camille Davisse-Paturet, Amanda Díaz-García, Rachel Farrel, Daniela C. Fuhr, Brian J. Hall, Anja C. Huizink, Agnes Iok Fong Lam, Gülşah Kurt, Ingmar Leijen, Ellenor Mittendorfer-Rutz, Naser Morina, Catherine Panter-Brick, Fredrick Dermawan Purba, Soledad Quero, Soraya Seedat … & Corrado Barbui
Additional file 1: Procedures for model identification. Fig. S1. Flowchart of sample identification. Table S1. Descriptive statistics of resilience indicators across the survey waves (N = 1052)*. Table S2. Frequency of each chronic medical condition in the whole sample. Table S3. Comparison between participants with and without chronic medical conditions at baseline*. Table S4. Descriptive statistics at the first wave of socio-demographic and clinical characteristics of participants with a chronic condition included vs excluded (because...

Additional file 1 of Metabolomics analysis of type 2 diabetes remission identifies 12 metabolites with predictive capacity: a CORDIOPREV clinical trial study

Marina Mora-Ortiz, Juan F. Alcala-Diaz, Oriol Alberto Rangel-Zuñiga, Antonio Pablo Arenas-de Larriva, Fernando Abollo-Jimenez, Diego Luque-Cordoba, Feliciano Priego-Capote, Maria M. Malagon, Javier Delgado-Lista, Jose M. Ordovas, Pablo Perez-Martinez, Antonio Camargo & Jose Lopez-Miranda
Additional file 1: Table S1. Baseline characteristics of the study population.

Additional file 2 of Neighborhood environmental factors linked to hospitalizations of older people for viral lower respiratory tract infections in Spain: a case-crossover study

Alejandro Álvaro-Meca, Daniel Sepúlveda-Crespo, Rosa Resino, Pablo Ryan, Isidoro Martínez & Salvador Resino
Additional file 2: Supplementary Table 2. Summary of adjusted associations between ambient air pollutants and hospital admissions for lower respiratory tract viral infections in Spain (2013–2015).

Additional file 1 of Distinctive alterations in the functional anatomy of the cerebral cortex in pain-sensitized osteoarthritis and fibromyalgia patients

Jesus Pujol, Laura Blanco-Hinojo, Andrea Doreste, Fabiola Ojeda, Gerard Martínez-Vilavella, Víctor Pérez-Sola, Joan Deus & Jordi Monfort
Additional file 1: Supplementary Material. Description of data: Supplementary Methods. Supplementary Figures. Supplementary Tables.

Additional file 1 of Blood-based lipidomic signature of severe obstructive sleep apnoea in Alzheimer’s disease

Farida Dakterzada, Iván D. Benítez, Adriano Targa, Anna Carnes, Montse Pujol, Mariona Jové, Olga Mínguez, Rafi Vaca, Manuel Sánchez-de-la-Torre, Ferran Barbé, Reinald Pamplona & Gerard Piñol-Ripoll
Additional file 1: Table S1. Lipid features of the differentially expressed unknown lipids between non-OSA and OSA patients. Figure S1. Boxplot with lipids with differential expression between non-OSA and OSA patients.

A genome-wide association study of survival in patients with sepsis

Tamara Hernandez-Beeftink, Beatriz Guillen-Guio, Jose M. Lorenzo-Salazar, Almudena Corrales, Eva Suarez-Pajes, Rui Feng, Luis A. Rubio-Rodríguez, Megan L. Paynton, Raquel Cruz, M. Isabel García-Laorden, Miryam Prieto-González, Aurelio Rodríguez-Pérez, Demetrio Carriedo, Jesús Blanco, Alfonso Ambrós, Elena González-Higueras, Elena Espinosa, Arturo Muriel, Eduardo Tamayo, María M. Martin, Leonardo Lorente, David Domínguez, Abelardo García de Lorenzo, Heather M. Giannini, John P. Reilly … & Carlos Flores
Abstract Background Sepsis is a severe systemic inflammatory response to infections that is accompanied by organ dysfunction and has a high mortality rate in adult intensive care units. Most genetic studies have identified gene variants associated with development and outcomes of sepsis focusing on biological candidates. We conducted the first genome-wide association study (GWAS) of 28-day survival in adult patients with sepsis. Methods This study was conducted in two stages. The first stage was performed...

Additional file 1 of A genome-wide association study of survival in patients with sepsis

Tamara Hernandez-Beeftink, Beatriz Guillen-Guio, Jose M. Lorenzo-Salazar, Almudena Corrales, Eva Suarez-Pajes, Rui Feng, Luis A. Rubio-Rodríguez, Megan L. Paynton, Raquel Cruz, M. Isabel García-Laorden, Miryam Prieto-González, Aurelio Rodríguez-Pérez, Demetrio Carriedo, Jesús Blanco, Alfonso Ambrós, Elena González-Higueras, Elena Espinosa, Arturo Muriel, Eduardo Tamayo, María M. Martin, Leonardo Lorente, David Domínguez, Abelardo García de Lorenzo, Heather M. Giannini, John P. Reilly … & Carlos Flores
Additional file 1. Supplementary methods, figures, and tables.The supplementary methods include a description of the GEN-SEP and MESSI study populations, genotyping and quality control, more details of the genome-wide association study of 28-day sepsis survival and the index event bias assessment, tools for the annotation of the functional effects of the sentinel variants and the gene expression of related genes, the association of polygenic risks of sepsis with the 28-day sepsis survival, the replication of...

Additional file 1 of Genetically predicted telomere length and Alzheimer’s disease endophenotypes: a Mendelian randomization study

Blanca Rodríguez-Fernández, Natalia Vilor-Tejedor, Eider M. Arenaza-Urquijo, Gonzalo Sánchez-Benavides, Marc Suárez-Calvet, Grégory Operto, Carolina Minguillón, Karine Fauria, Gwendlyn Kollmorgen, Ivonne Suridjan, Manuel Castro de Moura, David Piñeyro, Manel Esteller, Kaj Blennow, Henrik Zetterberg, Immaculata De Vivo, José Luis Molinuevo, Arcadi Navarro, Juan Domingo Gispert, Aleix Sala-Vila & Marta Crous-Bou
Additional file 1: Supplementary Table 1. Characteristics of Single Nucleotide Polymorphisms (SNPs) associated with longer telomere length. The effect allele refers to the allele that is associated with longer telomere length. Chromosomal position of the SNPs (genome assembly GRCh37 (hg19)) according to the public archive for genetic variation within and across different species developed and hosted by the National Center for Biotechnology Information (NCBI) in collaboration with the National Human Genome Research Institute (NHGRI) (dbSNP).

Additional file 2 of Genetically predicted telomere length and Alzheimer’s disease endophenotypes: a Mendelian randomization study

Blanca Rodríguez-Fernández, Natalia Vilor-Tejedor, Eider M. Arenaza-Urquijo, Gonzalo Sánchez-Benavides, Marc Suárez-Calvet, Grégory Operto, Carolina Minguillón, Karine Fauria, Gwendlyn Kollmorgen, Ivonne Suridjan, Manuel Castro de Moura, David Piñeyro, Manel Esteller, Kaj Blennow, Henrik Zetterberg, Immaculata De Vivo, José Luis Molinuevo, Arcadi Navarro, Juan Domingo Gispert, Aleix Sala-Vila & Marta Crous-Bou
Additional file 2: Supplementary Table 1. Linear regression estimates for cognition outcomes in the entire sample. All models are adjusted for covariates: age, sex, education, and APOE status. Supplementary Table 2. Linear regression estimates for neuroimaging outcomes (i.e., Alzheimer’s disease and aging signatures) outcome in the entire sample. All models are adjusted for covariates: age, sex, education, and APOE status. Supplementary Table 3. Linear regression estimates for CSF biomarkers outcomes in the entire sample. All...

Additional file 2 of Genetically predicted telomere length and Alzheimer’s disease endophenotypes: a Mendelian randomization study

Blanca Rodríguez-Fernández, Natalia Vilor-Tejedor, Eider M. Arenaza-Urquijo, Gonzalo Sánchez-Benavides, Marc Suárez-Calvet, Grégory Operto, Carolina Minguillón, Karine Fauria, Gwendlyn Kollmorgen, Ivonne Suridjan, Manuel Castro de Moura, David Piñeyro, Manel Esteller, Kaj Blennow, Henrik Zetterberg, Immaculata De Vivo, José Luis Molinuevo, Arcadi Navarro, Juan Domingo Gispert, Aleix Sala-Vila & Marta Crous-Bou
Additional file 2: Supplementary Table 1. Linear regression estimates for cognition outcomes in the entire sample. All models are adjusted for covariates: age, sex, education, and APOE status. Supplementary Table 2. Linear regression estimates for neuroimaging outcomes (i.e., Alzheimer’s disease and aging signatures) outcome in the entire sample. All models are adjusted for covariates: age, sex, education, and APOE status. Supplementary Table 3. Linear regression estimates for CSF biomarkers outcomes in the entire sample. All...

Additional file 4 of Genetically predicted telomere length and Alzheimer’s disease endophenotypes: a Mendelian randomization study

Blanca Rodríguez-Fernández, Natalia Vilor-Tejedor, Eider M. Arenaza-Urquijo, Gonzalo Sánchez-Benavides, Marc Suárez-Calvet, Grégory Operto, Carolina Minguillón, Karine Fauria, Gwendlyn Kollmorgen, Ivonne Suridjan, Manuel Castro de Moura, David Piñeyro, Manel Esteller, Kaj Blennow, Henrik Zetterberg, Immaculata De Vivo, José Luis Molinuevo, Arcadi Navarro, Juan Domingo Gispert, Aleix Sala-Vila & Marta Crous-Bou
Additional file 4: Supplementary Table 1. Results of the effect of genetically predicted longer telomere length on AD endophenotypes in the entire sample. Supplementary Table 2. Results of the effect of genetically predicted longer telomere length on AD endophenotypes among APOE-ɛ4 carriers. Supplementary Table 3. Results of the effect of genetically predicted longer telomere length on AD endophenotypes among APOE-ɛ4 non-carriers. Supplementary Table 4. Results of the effect of genetically predicted longer telomere length on...

Diagnostic delay in rare diseases: data from the Spanish rare diseases patient registry

Juan Benito-Lozano, Blanca López-Villalba, Greta Arias-Merino, Manuel Posada de la Paz & Verónica Alonso-Ferreira
Abstract Background According to the International Rare Diseases Research Consortium (IRDiRC), a known rare disease (RD) should be diagnosable within a year. This study sought: firstly, to ascertain how long it takes to obtain the diagnosis of a RD in Spain, along with its associated time trend; and secondly, to identify and measure diagnostic delay (defined by the IRDiRC as any period exceeding a year) by reference to the characteristics of RDs and the persons...

Additional file 1 of IL-11 system participates in pulmonary artery remodeling and hypertension in pulmonary fibrosis

Javier Milara, Inés Roger, Paula Montero, Enrique Artigues, Juan Escrivá & Julio Cortijo
Additional file 1: Figure S1. mrIL-11 induces endothelial to mesenchymal transition (EnMT) in vivo, promoting parenchymal myofibroblast-like cells of endothelial origin. A total of 100µg/Kg/day of rmIL-11 (n=11) or saline (n=11) was subcutaneously administered during 21 days. At day 21 parenchymal lug fibroblast were isolated and cultured at passage 1. (A) The expression of extracellular matrix proteins, αSMA and IL-11Rα was measured by quantitative PCR (qPCR) as 2−ΔCt. (B) Isolated lung fibroblasts from sham control...

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Affiliations

  • Instituto de Salud Carlos III
    165
  • University of Barcelona
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  • London School of Hygiene & Tropical Medicine
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  • Hospital Clínic de Barcelona
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  • Institució Catalana de Recerca i Estudis Avançats
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  • Hospital Clínico Universitario de Valencia
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