Additional file 2. Custom code used in Python for analysis of aminoacidic repetition types.

Additional file 4: Table S3. Haplotypes frequency of not—unique samples in pfhrp2 and pfhrp3 by sampling located in Ahmara region. Figure S1. Haplotype networks of pfhpr2 (a) and pfhrp3 (b). Colour represents different sample The size of the circles are proportional to the number of sequences include in each haplotype.

Additional file 5: Table S4. Occurrence and number of variations of Baker’s amino acid repeats types in pfhrp2 and pfhrp3 sequences. *Amino acid repeats types described by Nderu et al. [61]. ^New amino acid repeats types

Additional file 4: Table S3. Haplotypes frequency of not—unique samples in pfhrp2 and pfhrp3 by sampling located in Ahmara region. Figure S1. Haplotype networks of pfhpr2 (a) and pfhrp3 (b). Colour represents different sample The size of the circles are proportional to the number of sequences include in each haplotype.

Additional file 5: Table S4. Occurrence and number of variations of Baker’s amino acid repeats types in pfhrp2 and pfhrp3 sequences. *Amino acid repeats types described by Nderu et al. [61]. ^New amino acid repeats types

Additional file 1: Figure S1. Odds ratio for the association between mortality (1A–C), intensive care unit admission (2A–C) and use of invasive mechanical ventilation during the hospitalization (3A–C) and ischemic heart disease in each of the four cohorts and overall. I2 indicates heterogeneity in the estimates. Odds ratio estimates adjusted for: model 1: age and sex (B); model 2: model 1 + type of diabetes, arterial hypertension, and the presence of microvascular disease (C).

Additional file 2: Figure S2. Odds ratio for the association between mortality (1A–C), intensive care unit admission (2A–C) and and stroke in each of the four cohorts and overall. I2 indicates heterogeneity in the estimates. Odds ratio estimates adjusted for: model 1: age and sex (B); model 2: model 1 + type of diabetes, arterial hypertension, and the presence of microvascular disease (C).

Abstract Background It is not clear whether pre-existing macrovascular complications (ischemic heart disease, stroke or peripheral artery disease) are associated with health outcomes in people with diabetes mellitus hospitalized for COVID-19. Methods We conducted cohort studies of adults with pre-existing diabetes hospitalized for COVID-19 infection in the UK, France, and Spain during the early phase of the pandemic (between March 2020—October 2020). Logistic regression models adjusted for demographic factors and other comorbidities were used to...

Supplementary Material 1

Additional file 1: Table S1. Prevalence of SH according to the study covariates of the “Sexual Violence among Young People” survey administered to the Spanish population aged 18–35 years.

Supplemental Material for Physiotherapy for patients on extracorporeal membrane oxygenation support: How, When, and Who. An international EuroELSO survey by Massimiliano Polastri, Allaina Eden, Antonio Loforte, Andrea Dell’Amore, Marta Velia Antonini, Jordi Riera, Nicholas A Barrett and Justyna Swol

Additional file 1: Supplementary Table 1. Summary of ICD-9-CM coding used for baseline comorbidities investigated in this study.

Abstract Background Tuberculous meningitis (TBM) is the most lethal and disabling form of tuberculosis (TB), particularly in sub-Saharan Africa. Current anti-TB treatment is poorly effective since TBM mortality reaches 40% in HIV-negative patients and up to 70% in HIV-co-infected patients. To reduce TBM-induced morbidity and mortality, the INTENSE-TBM trial evaluates two interventions in both HIV-infected and uninfected patients: an anti-TB treatment intensification using oral high-dose rifampicin (35 mg/kg daily) and linezolid (1200 mg daily and...

Additional file 1: Supplementary Material. Description of data: Supplementary Methods. Supplementary Figures. Supplementary Tables.

Abstract Background Pain-sensitized osteoarthritis and fibromyalgia patients characteristically show nociceptive system augmented responsiveness as a common feature. However, sensitization can be originally related to the peripheral injury in osteoarthritis patients, whereas pain and bodily discomfort spontaneously occur in fibromyalgia with no apparent origin. We investigated the distinct functional repercussion of pain sensitization in the cerebral cortex in both conditions. Methods Thirty-one pain-sensitized knee osteoarthritis patients and 38 fibromyalgia patients were compared with matched control groups....

Additional file 1. Table S1. Complete list of included RD and their ORPHAcodes (version 2021).

Abstract Background According to the International Rare Diseases Research Consortium (IRDiRC), a known rare disease (RD) should be diagnosable within a year. This study sought: firstly, to ascertain how long it takes to obtain the diagnosis of a RD in Spain, along with its associated time trend; and secondly, to identify and measure diagnostic delay (defined by the IRDiRC as any period exceeding a year) by reference to the characteristics of RDs and the persons...

Additional file 5: Figure S5. P21 and P16 senescence markers are increased in isolated pulmonary arteries of patients with idiopathic pulmonary fibrosis (IPF) and pulmonary hypertension (PH) associated to IPF. mRNA expression of P21 and P16 (A, B) in isolated pulmonary arteries (70-500µm of internal diameter) from control (n=20), IPF (n=20) and IPF + PH (n=20) patients. (C, D) Correlation between P21 and P16 mRNA expression with IL-11 protein expression in pulmonary arteries from IPF...

Additional file 6: Figure S6. P21 co-localize in IL-11 positive cells in pulmonary arteries from mice treated with rmIL-11 and bleomycin. (A) A total of 100µg/Kg/day of rmIL-11 or saline (control) was subcutaneously administered during 21 days in tie2-GFP mice. At day 21 lungs were fixed. (B) Wild-type (WT) siRNA(-) tie2-GFP mice and IL-11-KO siRNA-IL-11 tie2-GFP mice received a single intratracheal dose of bleomycin (1.5 U/kg) on day 1 during 14 days. At day 14...

Additional file 7. Figure legends.

Additional file 7. Figure legends.

Additional file 8: Table S1. Clinical data of control subjects. Table S2. Clinical data of IPF patients. Table S3. Clinical data of IPF+PH patients. Table S4. Clinical differences between IPF and IPF+PH patients.

Additional file 9. Supplementary figures.

Additional file 2: Figure S2. mrIL-11 induces lung tissue remodeling increasing profibrotic markers and reducing endothelial cell markers. A total of 100µg/Kg/day of rmIL-11 (n=11) or saline (n=11) was subcutaneously administered during 21 days. At day 21 lung homogenates were processed to (A) measure profibrotic and endothelial cell markers presented by heat map representation of mRNA transcripts of different genes and measured by quantitative PCR (qPCR) as 2−ΔCt. *P < 0.05 vs sham controls (B)...

Additional file 1: Table S1. Lipid features of the differentially expressed unknown lipids between non-OSA and OSA patients. Figure S1. Boxplot with lipids with differential expression between non-OSA and OSA patients.