Objective It is uncertain if patients with cardioembolic stroke and absence of a guidance-based indication for statin therapy should be administered a statin for prevention of subsequent vascular events. This study was performed to determine whether the statin therapy is beneficial to prevent major vascular events in this population. Methods Using a prospective multicenter stroke registry database, we identified acute cardioembolic stroke patients who were hospitalized between 2008 and 2015. Patients who had other established...
Data from: Pearls & Oy-sters: challenging diagnosis of Gerstmann-Sträussler-Scheinker disease: clinical and imaging findingsMin Ju Kang, Jeewon Suh, Seong Soo An, SangYun Kim & Young Ho Park
PEARLS >Gerstmann-Straussler-Scheinker disease (GSS) is a rare prion disease characterized by cerebellar ataxia with progressive cognitive decline. >GSS is caused by a mutation within the prion protein gene (PRNP), which commonly exhibits autosomal dominant inheritance pattern. However, a significant portion of previously reported cases showed no family history of the disease, and GSS may also occur through de novo mutation of PRNP. OY-STERS >GSS is clinically heterogeneous and has no characteristic features on imaging. GSS...
Data from: Long-term safety and effectiveness of growth hormone therapy in Korean children with growth disorders: 5-year results of LG Growth StudyYoung-Jun Rhie, Jae-Ho Yoo, Jin-Ho Choi, Hyun-Wook Chae, Jae Hyun Kim, Sochung Chung, , Choong Ho Shin, Eun Young Kim & Ho-Seong Kim
Purpose The aim of this registry study was to analyze the long-term safety and effectiveness of recombinant human growth hormone (rhGH) in South Korean pediatric patients (≥2 years of age) with growth hormone deficiency GHD) of idiopathic or organic etiology, idiopathic short stature, Turner syndrome, small for gestational age and chronic renal failure. Methods The study patients were followed-up till two years after the epiphyseal closure, with visits scheduled every six months. The outcome measures...
Objective: To improve epidemiological knowledge of neurological deterioration (ND) in patients with acute ischemic stroke (AIS). Methods: In this prospective observational study, we captured ND prospectively in 29,446 AIS patients admitted to 15 hospitals in Korea within 7 days of stroke onset. ND was defined as an increase in National Institutes of Health Stroke Scale (NIHSS) score ≥2 (total), or ≥1 (motor or consciousness), or any new neurological symptoms. Change of incidence rate after stroke...
Supplemental table: Etiologies of sudden sensorineural hearing loss with or without vertigo
Data from: Profile of and risk factors for post-stroke cognitive impairment in diverse ethno-regional groupsJessica W Lo, John D Crawford, David W Desmond, Olivier Godefroy, Hanna Jokinen, Simin Mahinrad, Hee-Joon Bae, Sebastian Köhler, Elles Douven, Julie Staals, Christopher Chen, Xin Xu, Eddie J Chong, Rufus O Akinyemi, Rajesh N Kalaria, Adesola Ogunniyi, Mélanie Barbay, Martine Roussel, Byung-Chul Lee, Velandai K Srikanth, Christopher Moran, Nagaendran Kandiah, Russell J Chander, Behnam Sabayan, J. Wouter Jukema … & Perminder S Sachdev
OBJECTIVE: To address the variability in prevalence estimates and inconsistencies in potential risk factors for post-stroke cognitive impairment (PSCI) using a standardised approach and individual participant data (IPD) from international cohorts in the STROKOG consortium. METHODS: We harmonised data from thirteen studies based in eight countries. Neuropsychological test scores 2 to 6 months after stroke or TIA and appropriate normative data were used to calculate standardised cognitive domain scores. Domain-specific impairment was based on percentile...
Data from: Three-month modified Rankin Scale as a determinant of five-year cumulative costs after ischemic stroke: an analysis of 11,136 patients in KoreaSeong-Eun Kim, Heeyoung Lee, Jun Yup Kim, Keon-Joo Lee, Jihoon Kang, Beom Joon Kim, Moon-Ku Han, Kang-Ho Choi, Joon-Tae Kim, Dong-Ick Shin, Min-Ju Yeo, Jae-Kwan Cha, Dae-Hyun Kim, Hyun-Wook Nah, Dong-Eog Kim, Wi-Sun Ryu, Jong-Moo Park, Kyusik Kang, Jae Guk Kim, Soo Joo Lee, Mi-Sun Oh, Kyung-Ho Yu, Byung-Chul Lee, Hong-Kyun Park, Keun-Sik Hong … & Hee-Joon Bae
Objective: Stroke is a devastating and costly disease; however, there is a paucity of information on long-term costs and on how they differ according to 3-month modified Rankin scale (mRS), which is a primary outcome variable in acute stroke intervention trials. Methods: We analyzed a prospective multicenter stroke registry (Clinical Research Collaboration for Stroke in Korea) database through linkage with claims data from the National Health Insurance Service with follow up to December 2016. Healthcare...
Data from: Sublingual immunotherapy (SLIT) for house dust mites does not prevent new allergen sensitization and bronchial hyper-responsiveness in allergic rhinitis childrenJae Hyun Lim, Jin Youp Kim, Doo Hee Han, Chul Hee Lee, Seung-No Hong, Jee Hye Wee, Sue K. Park & Chae-Seo Rhee
Introduction: The aim of this study is to identify the effects of sublingual immunotherapy (SLIT) on immunologic parameters and bronchial-hyper-responsiveness in children with allergic rhinitis to house-dust mite (HDM), through long-term follow-up cohort. Methods: Among the Allergic Rhinitis Cohort Study for Kids, pediatric patients who visited the hospital for rhinitis symptoms and proven allergy to HDM through skin prick test were studied. In this cohort, 37 patients received SLIT more than 3-years (SLIT group), and...
Data from: Lipid profiles and obesity as potential risk factors of sudden sensorineural hearing lossJoong Seob Lee, Dong Hyun Kim, Hyo Jeong Lee, Hyung Jong Kim, Ja Won Koo, Hyo Geun Choi, Bumjung Park & Sung Kwang Hong
Objectives: The objective of our study was to establish whether increased lipid profiles and obesity affect the prevalence and prognosis of sudden sensorineural hearing loss (SSNHL). Methods: This was a case-controlled study with a longitudinal design. According to our criteria, 324 patients with SSNHL were included in this study. To manage potential covariates, 972 subjects with normal hearing from the Korean National Health and Nutrition Examination Survey were matched as control group according to their...
Data from: Automatic segmentation of multiple cardiovascular structures from cardiac computed tomography angiography images using deep learningLohendran Baskaran, Subhi J. Al’Aref, Gabriel Maliakal, Benjamin C. Lee, Zhuoran Xu, Jeong W. Choi, Sang-Eun Lee, Ji Min Sung, Fay Y. Lin, Simon Dunham, Bobak Mosadegh, Yong-Jin Kim, Ilan Gottlieb, Byoung Kwon Lee, Eun Ju Chun, Filippo Cademartiri, Erica Maffei, Hugo Marques, Sanghoon Shin, Jung Hyun Choi, Kavitha Chinnaiyan, Martin Hadamitzky, Edoardo Conte, Daniele Andreini, Gianluca Pontone … & Leslee J. Shaw
Objectives: To develop, demonstrate and evaluate an automated deep learning method for multiple cardiovascular structure segmentation. Background: Segmentation of cardiovascular images is resource-intensive. We design an automated deep learning method for the segmentation of multiple structures from Coronary Computed Tomography Angiography (CCTA) images. Methods: Images from a multicenter registry of patients that underwent clinically-indicated CCTA were used. The proximal ascending and descending aorta (PAA, DA), superior and inferior vena cavae (SVC, IVC), pulmonary artery (PA),...
Pearls - Idiopathic normal pressure hydrocephalus (iNPH) is characterized by the classic triad of gait disturbance, urinary incontinence, and cognitive impairment in the presence of ventriculomegaly without known risk factors for communicating hydrocephalus. Shunt surgery is indicated for iNPH patients who respond to the removal of CSF. Oy-sters - The striatal dopaminergic deficit on dopamine transporter (DAT) scan is not uncommon in patients with iNPH, which might be related to an unfavorable long-term outcome of...
Data from: Diagnostic performance of alpha-fetoprotein, protein induced by vitamin K absence, osteopontin, Dickkopf-1 and its combinations for hepatocellular carcinomaJang Eun Sun, Jeong Sook-Hyang, Kim Jin-Wook, Choi Yun Suk, Leissner Philippe, Brechot Christian, Eun Sun Jang, Sook-Hyang Jeong, Jin-Wook Kim & Yun Suk Choi
Background & Aims: Alpha-fetoprotein (AFP) is the most widely used serum biomarker for hepatocellular carcinoma (HCC), despite its limitations. As complementary biomarkers, protein induced by vitamin K absence (PIVKA-II), osteopontin (OPN), and Dickkopf-1 (DKK-1) have been proposed. This study aimed to perform a head-to-head comparison of the diagnostic performance of AFP, PIVKA-II, OPN and DKK-1 as single or in combination to seek the best biomarker or panel, and to investigate the clinical factors affecting their...
In this paper, we present a novel cascaded classification framework for automatic detection of individual and clusters of microcalcifications (μC). Our framework comprises three classification stages: i) a random forest (RF) classifier for simple features capturing the second order local structure of individual μCs, where non-μC pixels in the target mammogram are efficiently eliminated; ii) a more complex discriminative restricted Boltzmann machine (DRBM) classifier for μC candidates determined in the RF stage, which automatically learns...
Supplemental table: Etiologies of sudden sensorineural hearing loss with or without vertigo
Seoul National University Bundang Hospital14
Seoul National University5
Hallym University Sacred Heart Hospital5
Seoul Medical Center3
Chonnam National University Hospital3
Dongguk University Ilsan Hospital3
Inje University Ilsan Paik Hospital3
Keimyung University Dongsan Medical Center3