100 Works

Data from: Opposing effects of allogrooming on disease transmission in ant societies

Fabian J. Theis, Line V. Ugelvig, Carsten Marr & Sylvia Cremer
To prevent epidemics, insect societies have evolved collective disease defences that are highly effective at curing exposed individuals and limiting disease transmission to healthy group members. Grooming is an important sanitary behaviour—either performed towards oneself (self-grooming) or towards others (allogrooming)—to remove infectious agents from the body surface of exposed individuals, but at the risk of disease contraction by the groomer. We use garden ants (Lasius neglectus) and the fungal pathogen Metarhizium as a model system...

Quality Assurance in Individual Monitoring for External Radiation – Results of EURADOS Survey 2012

P. J. Gilvin, J. G. Alves, C. Chesteres, J. W. E. van Dijk, M. Lehtinen, F. Rossi, B. Vekic & M. A. Chevallier
Abstract: EURADOS Working Group 2 (WG2) on Harmonization of Individual Monitoring is a network of institutions and individual monitoring services (IMSs), built up over the last 20 years, that aims to promote quality, technical excellence and good practice in Europe. In pursuit of these aims, in 2012 WG2 carried out a survey of IMSs in Europe. The survey was sent to about 170 IMS and included questions on: the use of formal quality assurance (QA)...

InterComparison on Internal DOSE Assessment – ICIDOSE 2017 Analysing the intercomparison results

Carlo Maria Castellani, Andor Andrasi, Augusto Giussani, Tamas Pázmándi, Gareth Roberts & George Etherington
Abstract: Internal dose assessment often requires complex processes and judgements. “Technical Recommendations for Monitoring Individuals for Occupational Intakes of Radionuclides” (TECHREC) was developed during 2014 to 2016 as a tool for internal dosimetrists. The TECHREC recommendations have been publishedin the Radiation Protection document series of the European Commission as document RP188 (EC 2018). They aim to encourage harmonisation, to present a complete account of the principles of individual monitoring and internal dosimetry, and to provide...

Challenges in Micro-and Nanodosimetry for Ion Beam Cancer Therapy (MIND-IBCT) - Report on an International Workshop co-organized by EURADOS

Thorsten Schneider, Heidi Nettelbeck & Hans Rabus
Abstract: Ion beam therapy offers the possibility of excellent dose localization for treatment of malignant tumours, minimizing radiation damage in normal tissue, while maximizing cell-killing within the tumour. However, the full potential of such therapy can only be realised by better understanding of the physical, chemical and biological mechanisms. The workshop MiND-IBCT (Micro- and Nano-Dosimetry for Ion Beam Cancer Therapy) was focussed on challenges encountered in the application of micro- and nanodosimetry for ion beam...

Uncertainties in internal dose assessment: Lifetime dose assessment for three example workers occupationally exposed to uranium - Analysing the intercomparison results

Estelle Davesne, Richard Bull, Jeri Anderson, Derek Bingham, Alan Birchall, Carlo Maria Castellani, Cécile Challeton-de Vathaire, M. L. Fernandez, Martina Froning, A. Giomi, Anne Laure Lebacq, Jakub Ośko, Inés Gomez Parada, Anna Pántya, A. G. Rojas, Ana Rojo, Masa Takahashi, Kotaro Tani & Eric Blanchardon
Abstract: Recently, several epidemiological studies were interested in identifying potential health effects of incorporated radionuclides. To achieve this work, exposure of individuals was quantified in order to be compared with health status. In order to quantify the exposure of workers, the measurement of retained or excreted activity also called bioassay, must be interpreted in terms of dose. The data available for dose reconstruction are mostly bioassay analyses (mostly urine) carried out to verify the absence...

Additional file 2 of Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition

Marie Breeur, Pietro Ferrari, Laure Dossus, Mazda Jenab, Mattias Johansson, Sabina Rinaldi, Ruth C. Travis, Mathilde His, Tim J. Key, Julie A. Schmidt, Kim Overvad, Anne Tjønneland, Cecilie Kyrø, Joseph A. Rothwell, Nasser Laouali, Gianluca Severi, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Fabian Eichelmann, Domenico Palli, Sara Grioni, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote … & Vivian Viallon
Additional file 2: Supplementary tables and figures. Figure S1. Pearson correlation between the 117 original metabolites. Figure S2. Sensitivity analyses of mutually adjusted ORs for the overall associations and cancer type-specific deviations. Figure S3. Sensitivity analysis of mutually adjusted ORs for the overall associations and cancer type-specific deviations with or without excluding hormone users. Figure S4. p-values of tests for departure from linearity and effect modification by BMI. Figure S5. ORs for the overall associations...

Function outperforms morphology in the assessment of muscular contribution to insulin sensitivity in premenopausal women

Lorena Wanger, Christina Gar, Michaela Rippl, Stefanie Kern-Matschilles, Anne Potzel, Stefanie Haschka, Jochen Seissler, Nina Hesse & Andreas Lechner
IntroductionSkeletal muscle contributes significantly to insulin sensitivity in humans. However, which non-invasive measurement best reflects this contribution remains unknown. Consequently, this paper compares morphologic and functional measurements.Research methods and designWe conducted a cross-sectional analysis of 144 premenopausal women enrolled in the “Prediction, Prevention, and Sub-classification of Type 2 Diabetes” (PPSDiab) cohort study. For the analysis, we quantified insulin sensitivity by oral glucose tolerance testing and, in a subgroup of 30 women, euglycemic clamp. To assess...

Additional file 4 of H3K18 lactylation marks tissue-specific active enhancers

Eva Galle, Chee-Wai Wong, Adhideb Ghosh, Thibaut Desgeorges, Kate Melrose, Laura C. Hinte, Daniel Castellano-Castillo, Magdalena Engl, Joao Agostinho de Sousa, Francisco Javier Ruiz-Ojeda, Katrien De Bock, Jonatan R. Ruiz & Ferdinand von Meyenn
Additional file 4: Table S2: Genes whose promoters lie in state 8 from the mouse H3K18la ChromHMM. Data used in Fig. 2E.

Additional file 1 of Network reconstruction for trans acting genetic loci using multi-omics data and prior information

Johann S. Hawe, Ashis Saha, Melanie Waldenberger, Sonja Kunze, Simone Wahl, Martina Müller-Nurasyid, Holger Prokisch, Harald Grallert, Christian Herder, Annette Peters, Konstantin Strauch, Fabian J. Theis, Christian Gieger, John Chambers, Alexis Battle & Matthias Heinig
Additional file 1 Supplementary material, supporting figures and tables.

Acute radiation syndrome-related gene expression in irradiated peripheral blood cell populations

Patrick Ostheim, Alan Don Mallawaratchy, Thomas Müller, Simone Schüle, Cornelius Hermann, Tanja Popp, Stefan Eder, Stephanie E. Combs, Matthias Port & Michael Abend
In a nuclear or radiological event, an early diagnostic tool is needed to distinguish the worried well from those individuals who may later develop life-threatenFing hematologic acute radiation syndrome. We examined the contribution of the peripheral blood's cell populations on radiation-induced gene expression (GE) changes. EDTA-whole-blood from six healthy donors was X-irradiated with 0 and 4Gy and T-lymphocytes, B-lymphocytes, NK-cells and granulocytes were separated using immunomagnetic methods. GE were examined in cell populations and whole...

Economic evaluation of implementation science outcomes in low- and middle-income countries: a scoping review

Akash Malhotra, Ryan R. Thompson, Faith Kagoya, Felix Masiye, Peter Mbewe, Mosepele Mosepele, Jane Phiri, Jairos Sambo, Abigail Barker, Drew B. Cameron, Victor G. Davila-Roman, William Effah, Brian Hutchinson, Michael Laxy, Brad Newsome, David Watkins, Hojoon Sohn & David W. Dowdy
Abstract Background Historically, the focus of cost-effectiveness analyses has been on the costs to operate and deliver interventions after their initial design and launch. The costs related to design and implementation of interventions have often been omitted. Ignoring these costs leads to an underestimation of the true price of interventions and biases economic analyses toward favoring new interventions. This is especially true in low- and middle-income countries (LMICs), where implementation may require substantial up-front investment....

Additional file 1 of Economic evaluation of implementation science outcomes in low- and middle-income countries: a scoping review

Akash Malhotra, Ryan R. Thompson, Faith Kagoya, Felix Masiye, Peter Mbewe, Mosepele Mosepele, Jane Phiri, Jairos Sambo, Abigail Barker, Drew B. Cameron, Victor G. Davila-Roman, William Effah, Brian Hutchinson, Michael Laxy, Brad Newsome, David Watkins, Hojoon Sohn & David W. Dowdy
Additional file 1. Protocol for scoping review.

Additional file 2 of Economic evaluation of implementation science outcomes in low- and middle-income countries: a scoping review

Akash Malhotra, Ryan R. Thompson, Faith Kagoya, Felix Masiye, Peter Mbewe, Mosepele Mosepele, Jane Phiri, Jairos Sambo, Abigail Barker, Drew B. Cameron, Victor G. Davila-Roman, William Effah, Brian Hutchinson, Michael Laxy, Brad Newsome, David Watkins, Hojoon Sohn & David W. Dowdy
Additional file 2. Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) Checklist.

Additional file 2 of Economic evaluation of implementation science outcomes in low- and middle-income countries: a scoping review

Akash Malhotra, Ryan R. Thompson, Faith Kagoya, Felix Masiye, Peter Mbewe, Mosepele Mosepele, Jane Phiri, Jairos Sambo, Abigail Barker, Drew B. Cameron, Victor G. Davila-Roman, William Effah, Brian Hutchinson, Michael Laxy, Brad Newsome, David Watkins, Hojoon Sohn & David W. Dowdy
Additional file 2. Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) Checklist.

Development of an adverse outcome pathway for radiation-induced microcephaly via expert consultation and machine learning

Thomas Jaylet, Roel Quintens, Mohamed Abderrafi Benotmane, Jukka Luukkonen, Ignacia Braga Tanaka, Chrystelle Ibanez, Christelle Durand, Magdalini Sachana, Omid Azimzadeh, Christelle Adam-Guillermin, Knut Erik Tollefsen, Olivier Laurent, Karine Audouze & Olivier Armant
Brain development during embryogenesis and in early postnatal life is particularly complex and involves the interplay of many cellular processes and molecular mechanisms, making it extremely vulnerable to exogenous insults, including ionizing radiation (IR). Microcephaly is one of the most frequent neurodevelopmental abnormalities that is characterized by small brain size, and is often associated with intellectual deficiency. Decades of research span from epidemiological data on in utero exposure of the A-bomb survivors, to studies on...

Data from: Platelet GPIIb supports initial pulmonary retention but inhibits subsequent proliferation of melanoma cells during hematogenic metastasis

Christian Schulz, Katrin Echtler, Ildiko Konrad, Michael Lorenz, Simon Schneider, Sebastian Hofmaier, Florian Plenagl, Konstantin Stark, Thomas Czermak, Anca Tirniceriu, Martin Eichhorn, Axel Walch, Georg Enders & Steffen Massberg
Platelets modulate the process of cancer metastasis. However, current knowledge on the direct interaction of platelets and tumor cells is mostly based on findings obtained in vitro. We addressed the role of the platelet fibrinogen receptor glycoprotein IIb (integrin αIIb) for experimental melanoma metastasis in vivo. Highly metastatic B16-D5 melanoma cells were injected intravenously into GPIIb-deficient (GPIIb-/-) or wildtype (WT) mice. Acute accumulation of tumor cells in the pulmonary vasculature was assessed in real-time by...

Data from: Association of in utero persistent organic pollutant exposure with placental thyroid hormones

Zhong-Min Li, David Hernandez-Moreno, Katharina Maria Main, Niels Erik Skakkebæk, Hannu Kiviranta, Jorma Toppari, Ulla Feldt-Rasmussen, Heqing Shen, Karl-Werner Schramm & Meri De Angelis
In utero exposure to persistent organic pollutants (POPs) can result in thyroid function disorder, leading to concerns about their impact on fetal and neonatal development. The present study was performed to investigate the associations between placental levels of various POPs and thyroid hormones (THs). In a prospective Danish study initially established for assessing congenital cryptorchidism, 58 placenta samples were collected from mothers of boys born with (28) and without (30) cryptorchidism. The concentrations of polybrominated...

Data from: Effect of plant chemical variation and mutualistic ants on the local population genetic structure of an aphid herbivore

Sharon E. Zytynska, Yasemin Guenay, Sarah Sturm, Mary V. Clancy, Matthias Senft, Joerg-Peter Schnitzler, Saurabh Dilip Pophaly, Christine Wurmser & Wolfgang W. Weisser
1.Plants exhibit impressive genetic and chemical diversity, not just between species but also within species, and the importance of plant intraspecific variation for structuring ecological communities is well known. When there is variation at the local population level, this can create a spatially‐heterogeneous habitat for specialized herbivores potentially leading to non‐random distribution of individuals across host‐plants. 2.Plant variation can affect herbivores directly and indirectly via a third species, resulting in variable herbivore growth rates across...

Carbohydrate depletion in roots impedes phosphorus nutrition of forest trees

Simon Clausing, Rodica Pena, Bin Song, Karolin Müller, Paula Mayer-Gruner, Sven Marhan, Martin Grafe, Stefanie Schulz, Jaane Krüger, Friederike Lang, Michael Schloter, Ellen Kandeler & Andrea Polle
The aim of the study was to determine the effect of belowground plant-derived carbohydrates on P uptake, P concentrations and enzymes activities related to P mobilization in roots, ectomycorrhizas and soil and on the abundances of P-related genes in soil bacteria. We report data from a girdling experiment in two temperate beech forest with contrasting soil phosphorus concentrations. We used soil cores and the fractions of the organic layer and mineral topsoil separately one and...

The impact of subsoil management on the delivery of ecosystem services

Sophie Ittner, Holger Gerdes, Miriam Athmann, Sara Luise Bauke, Martina Gocke, Julien Guigue, Sanjay Jaiswal, Timo Kautz, Oliver Schmittmann, Stefanie Schulz & Sabine Seidel
In recent years, the interest in subsoil has increased, since it can hold immense reservoirs of nutrients, organic matter and water. The subsoil can therefore provide important ecosystem services for the agricultural production system and beyond. This paper assesses the sustainability of two subsoil management measures with regard to the delivery of soil-related ecosystem services: a) the cultivation of deep-rooted pre-crops (biological approach) and b) stripwise mechanical subsoil loosening in combination with the incorporation of...

Data from: Responses of native and invasive woody seedlings to combined competition and drought are species-specific

Judy Simon, Andrea Bueno & Karin Pritsch
A greenhouse experiment was conducted to evaluate the effects of drought on the interactions between native and invasive tree species. Organic and inorganic net N uptake capacity and total soluble protein as well as total soluable amino acid contents were quantified in leaves and fine roots of the native species Fagus sylvatica L., Quercus robur L. and Pinus sylvestris L.) and the invasive species Prunus serotina Ehrh. and Robinia pseudoacacia L.. We used a fully...

Patient maximum skin dose in interventional procedures in radiology and cardiology: summary of WG 12 activities

Olivera Ciraj Bjelac, Jérémie Dabin, Jad Farah, Hannu Järvinen, Francoise Malchair, Teemu Siiskonen & Željka Knežević
Abstract: Fluoroscopically guided interventional procedures in radiology (IR) and cardiology (IC) are techniques that have had wide diffusion in the last decades. Scarcely invasive, they reduce most of the risks to patients and the expenses of operating theatres. Nevertheless, prolonged exposures due, for instance, to complicated interventional procedures or inappropriate equipment may result in high doses to both patients and staff members, in particular, with potentially high radiation doses to the skinof a patient. Working...

A model validation scheme for Monte Carlo simulationsof a medical linear accelerator: geometrical description and dosimetric dataused in the “Linac Action”

Barbara Caccia, Valentin Blidéanu, Maïwenn Le Roy, Hans Rabus & Rick Tanner
Abstract: Radiation therapy has become more complex over the past few years with the use of new techniques like IMRT (Intensity Modulated Radiation Therapy) and stereotactic treatments. Moreover, optimisation of the radiotherapeutic treatment has become a critical point in the overall planning and delivery process due to the trend in dose-escalation with these new techniques and the associated risk for damage to healthy tissue. Typically, in techniques such as IMRT the dose distribution includes steep...

Visions for Radiation Dosimetry over the Next Two Decades -Strategic Research Agenda of the European Radiation Dosimetry Group: Version 2020

Jean-François Bottolier-Depois, Isabelle Clairand, Elena Fantuzzi, Paola Fattibene, Roger Harrison, Oliver Hupe, Pawel Olko, Veronika Olšovcová, Werner Rühm, Marco Silari, Rick Tanner & Filip Vanhavere
Introduction: The European Radiation Dosimetry Group (EURADOS) comprises a self-sustainable network of more than 70 European institutions and about 600 scientists active in the field of radiation dosimetry. It was founded in 1981, and was registered in Germany as an “e.V.” (registered society) in 2008. The aim of the network is to promote research and development and European cooperation in the field of dosimetry of ionising radiation. For this, EURADOS has established Working Groups (WGs)...

EURADOS Stakeholder Workshop on June 30th, 2016

Rühm Werner, Željka Knežević, Elena Fantuzzi, Roger Harrison, Helmut Schuhmacher, Filip Vanhavere, Joao Alves, Jean-Francois Bottolier-Depois, Paola Fattibene, Phil Gilvin, María Antonia Lopez, Sabine Mayer, Saveta Miljanić, Pawel Olko, Hannes Stadtmann, Rick Tanner, Arturo Vargas & Clemens Woda
Introduction: On June 30th, 2016, the “First EURADOS Stakeholder Workshop” was held at the Helmholtz Center Munich (HMGU) in Neuherberg, Germany. The workshop was jointly organized by the HMGU and the EURADOS Office in conjunction with the 57thEURADOS Council meeting, which took place on June 29thand July 1st, also at the HMGU. In the frame of the “European Joint Programme for the Integration of Radiation Protection Research”, the CONCERT project funded by the European Commission...

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