40 Works

Data from: The Moorfields AMD database report 2 - fellow eye involvement with neovascular age-related macular degeneration

Katrin Fasler, Dun Jack Fu, Gabriella Moraes, Siegfried K Wagner, Eesha Gokhale, Karsten U Kortuem, Reena Chopra, Livia Faes, Gabriella Preston, Nikolas Pontikos, Praveen J Patel, Adnan Tufail, Aaron Y Lee, Konstantinos Balaskas & Pearse A Keane
Background/Aims: Neovascular age-related macular degeneration (nAMD) is frequently bilateral, and previous reports on ‘fellow eyes’’ have assumed sequential treatment after a period of treatment of the first eye only. The aim of our study was to analyse baseline characteristics and visual acuity (VA) outcomes of fellow eye involvement with nAMD, specifically differentiating between sequential and non-sequential (due to macular scarring in the first eye) anti-vascular endothelial growth factor treatment and timelines for fellow eye involvement....

Data from: Chloroplast primers for clade-wide phylogenetic studies of Thalictrum (Ranunculaceae)

Diego Fernando Morales-Briones, Tatiana Arias, Verónica Di Stilio & David C. Tank
Premise Chloroplast primers were developed for phylogenetic and comparative studies in Thalictrum (Ranunculaceae). Methods and Results We assembled and annotated the complete plastome sequence of T. thalictroides by combining multiple whole genome sequencing libraries. Using transcriptome‐sequencing libraries, we also assembled a partial plastome of the related species T. hernandezii. From the newly assembled plastomes and one previously sequenced plastome, we designed and validated 28 primer pairs to target variable portions of the chloroplast genome in...

Computational and experimental insights into the chemosensory navigation of Aedes aegypti mosquito larvae

Eleanor Lutz, Tjinder Grewal & Jeffrey Riffell
Mosquitoes are prolific disease vectors that affect public health around the world. Although many studies have investigated search strategies used by host-seeking adult mosquitoes, little is known about larval search behavior. Larval behavior affects adult body size and fecundity, and thus the capacity of individual mosquitoes to find hosts and transmit disease. Understanding vector survival at all life stages is crucial for improving disease control. In this study we use experimental and computational methods to...

Data from: A comparative analysis of common methods to identify waterbird hotspots

Allison L. Sussman, Beth Gardner, Evan M. Adams, Leo Salas, Kevin P. Kenow, David R. Luukkonen, Michael J. Monfils, William P. Mueller, Kathryn A. Williams, Michele Leduc-Lapierre & Elise F. Zipkin
1. Hotspot analysis is a commonly used method in ecology and conservation to identify areas of high biodiversity or conservation concern. However, delineating and mapping hotspots is subjective and various approaches can lead to different conclusions with regard to the classification of particular areas as hotspots, complicating long-term conservation planning. 2. We present a comparative analysis of recent approaches for identifying waterbird hotspots, with the goal of developing insights about the appropriate use of these...

Data from: Modeling multilocus selection in an individual-based, spatially-explicit landscape genetics framework

Erin Landguth, Brenna R. Forester, Andrew J. Eckert, Andrew J. Shirk, Mitra Menon, Amy Whipple, Casey C. Day & Samuel A. Cushman
We implemented multilocus selection in a spatially-explicit, individual-based framework that enables multivariate environmental gradients to drive selection in many loci as a new module for the landscape genetics programs, CDPOP and CDMetaPOP. Our module simulates multilocus selection using a linear additive model, providing a flexible platform to evaluate a wide range of genotype-environment associations. Importantly, the module allows simulation of selection in any number of loci under the influence of any number of environmental variables....

Do different rates of gene flow underlie variation in phenotypic and phenological clines in a montane grasshopper community?

Sean Schoville, Rachel Slatyer, César Nufio & Lauren Buckley
Species responses to environmental change are likely to depend on existing genetic and phenotypic variation, as well as evolutionary potential. A key challenge is to determine whether gene flow might facilitate or impede genomic divergence among populations responding to environmental change, and if emergent phenotypic variation is limited by gene flow rates. A general expectation is that patterns of genetic differentiation in a set of co-distributed species reflect differences in dispersal ability. In less-dispersive species,...

Public sharing of medical advice using social media: an analysis of Twitter

Gondy Leroy, Philip Harber & Debra Revere

Data from: Parallel signatures of selection at genomic islands of divergence and the major histocompatibility complex in ecotypes of sockeye salmon across Alaska

Wesley A. Larson, Tyler H. Dann, Morten T. Limborg, Garrett J. McKinney, Jim E. Seeb & Lisa W. Seeb
Understanding the genetic mechanisms that facilitate adaptive radiation is an important component of evolutionary biology. Here, we genotyped 82 neutral SNPs, seven SNPs in islands of divergence identified in a previous study (island SNPs), and a region of the major histocompatibility complex (MHC) in 32 populations of sockeye salmon to investigate whether conserved genes and genomic regions are involved in adaptive radiation. Populations representing three ecotypes were sampled from seven drainages with differing habitats and...

Data from: Past tree influence and prescribed fire exert strong controls on reassembly of mountain grasslands after tree removal

Charles B. Halpern, Joseph A. Antos, Shan Kothari & Annette M. Olson
Woody-plant encroachment represents a global threat to grasslands. Although the causes and consequences of this regime shift have received substantial attention, the processes that constrain reassembly of the grassland state remain poorly understood. We experimentally tested two potentially important controls on reassembly—the past influence of trees and the effects of fire—in conifer-invaded grasslands (mountain meadows) of western Oregon. Previously, we had reconstructed the history of tree invasion at fine spatial and temporal resolution. Using small...

Data from: HIV infection is an independent risk factor for decreased 6-minute walk test distance

Tom E. Robertson, Mehdi Nouraie, Shulin Qin, Kristina A. Crothers, Cathy J. Kessinger, Deborah McMahon, Divay Chandra, Lawrence A. Kingsley, Ruth M. Greenblatt, Laurence Huang, Meghan F. Fitzpatrick & Alison Morris
Background: Ambulatory function predicts morbidity and mortality and may be influenced by cardiopulmonary dysfunction. Persons living with HIV (PLWH) suffer from a high prevalence of cardiac and pulmonary comorbidities that may contribute to higher risk of ambulatory dysfunction as measured by 6-minute walk test distance (6-MWD). We investigated the effect of HIV on 6-MWD. Methods: PLWH and HIV-uninfected individuals were enrolled from 2 clinical centers and completed a 6-MWD, spirometry, diffusing capacity for carbon monoxide...

Data from: Environmental gradients determine the potential for ecosystem engineering effects

Joshua B. Grinath, Loralee Larios, Laura R. Prugh, Justin S. Brashares & Katharine N. Suding
Understanding processes that determine biodiversity is a fundamental challenge in ecology. At the landscape scale, physical alteration of ecosystems by organisms, called ecosystem engineering, enhances biodiversity worldwide by increasing heterogeneity in resource conditions and enhancing species coexistence across engineered and non-engineered habitats. Engineering-diversity relationships can vary along environmental gradients due to changes in the amount of physical structuring created by ecosystem engineering, but it is unclear how this variation is influenced by the responsiveness of...

Data from: Climate impacts on the ocean are making the Sustainable Development Goals a moving target traveling away from us

Gerald G. Singh, Nathalie Hilmi, Joey R. Bernhardt, Andres M. Cisneros Montemayor, Madeline Cashion, Yoshitaka Ota, Sevil Acar, Jason M. Brown, Richard Cottrell, Salpie Djoundourian, Pedro C. Gonzalez-Espinosa, Vicky Lam, Nadine Marshall, Barbara Neumann, Nicolas Pascal, Gabriel Reygondeau, Joacim Rocklov, Alain Safa, Laura R. Virto & William Cheung
1. Climate change is impacting marine ecosystems and their goods and services in diverse ways, which can directly hinder our ability to achieve the Sustainable Development Goals, set out under the 2030 Agenda for Sustainable Development. 2. Through expert elicitation and a literature review, we find that most climate change effects have a wide variety of negative consequences across marine ecosystem services, though most studies have highlighted impacts from warming and consequences to marine species....

Initial application of the noise-sorted scanning clustering algorithm to the analysis of composition-dependent organic aerosol thermal desorption measurements

Christopher Cappa, Ziyue Li, Emma D'Ambro, Siegfried Schobesberger, John Shilling, Felipe Lopez-Hilfiker, Jiumeng Liu, Cassandra Gaston & Joel Thornton
The FIGAERO-CIMS (Filter Inlet for Gases and AEROsols + chemical ionization mass spectrometer) measures thermal desorption profiles for individual ions evolved from evaporation of organic aerosol components. Often, hundreds of individual thermograms are obtained, reflecting the compositional complexity of organic aerosol. We have developed a novel clustering algorithm, Noise-Sorted Scanning Clustering (NSSC), that provides a robust, reproducible analysis of the FIGAERO temperature-dependent mass spectral data. The NSSC allows for determination of thermal profiles for compositionally...

Data from: Assexon: assembling exon using gene capture data

Hao Yuan, Calder Atta, Luke Tornabene & Chenhong Li
Exon capture across species has been one of the most broadly applied approaches to acquire multi-locus data in phylogenomic studies of non-model organisms. Methods for assembling loci from short-read sequences (eg, Illumina platforms) that rely on mapping reads to a reference genome may not be suitable for studies comprising species across a wide phylogenetic spectrum; thus, de novo assembling methods are more generally applied. Current approaches for assembling targeted exons from short reads are not...

Extinct plants of North America north of Mexico

Wesley Knapp, Anne Frances, Reed Noss, Robert Naczi, Alan Weakley, George Gann, Bruce Baldwin, James Miller, Patrick McIntyre, Brent Mishler, Gerry Moore, Richard Olmstead, Anna Strong, Daniel Gluesenkamp & Kathryn Kennedy
The recent study by Humphreys et al., reporting extinction of almost 600 plant species globally, represents a groundbreaking effort at compiling direct data on seed plants. We applaud Humphreys et al. for quantifying plant extinctions because they formulate an important and testable hypothesis. However, their study missed many extinctions and rediscoveries of seed plants in the United States and Canada. Our team of experts has been compiling a list of extinct plants of North America...

Registration Year

  • 2019

Resource Types

  • Dataset
  • Text
  • Software


  • University of Washington
  • University of Colorado Boulder
  • University of Montana
  • Stanford University
  • Oregon State University
  • Moorfields Eye Hospital NHS Foundation Trust
  • University of Adelaide
  • University of Eastern Finland
  • Biodiversity Research Institute
  • Utah State University