100 Works

The role of terrestrial productivity in regulating aquatic dissolved organic carbon concentrations in boreal catchments

Xudan Zhu, Liang Chen, Jukka Pumpanen, Anne Ojala, John Zobitz, Xuan Zhou, Hjalmar Laudon, Marjo Palviainen, Kimmo Neitola & Frank Berninger
The past decades have witnessed an increase in dissolved organic carbon (DOC) concentrations in the catchments of the Northern Hemisphere. Increases in terrestrial productivity may be a reason for the increases in DOC concentration. The aim of this study is to investigate the impacts of increased terrestrial productivity and changed hydrology following climate change on DOC concentrations. We tested and quantified the effects of gross primary production (GPP), ecosystem respiration (RE) and discharge on DOC...

Additional file 1 of Evaluation of baseline pediatric readiness of emergency departments in Manitoba, Canada

Alex Aregbesola, Oana Florescu, Clara Tam, Amanda Coyle, Lisa Knisley, Kaitlin Hogue, Darcy Beer, Scott Sawyer & Terry P. Klassen
Additional file 1: Supplementary material 1. Pediatric Readiness Initiative for Emergency Departments Survey.

Validity of the Finnish Care Register for Social Welfare in a nationwide cohort of people with Alzheimer’s disease

Virva Hyttinen, Kirsikka Selander, Anna-Maija Tolppanen, Riikka Väyrynen, Lasse Mielikäinen, Ismo Linnosmaa & Sirpa Hartikainen
Aims:To assess the validity and completeness of the Care Register for Social Welfare among community-dwelling people with Alzheimer’s disease in Finland.Methods:The study was carried out in the Medication Use and Alzheimer’s disease (MEDALZ) study population, which includes 70,719 people who received a clinically verified diagnosis of Alzheimer’s disease between 2005 and 2011 and the people matched with them for comparison (n=282,862). The data were linked to the Care Register for Social Welfare, which contains data...

Additional file 3 of The effect of shunt surgery on corticospinal excitability in idiopathic normal pressure hydrocephalus: a transcranial magnetic stimulation study

Jani Sirkka, Laura Säisänen, Petro Julkunen, Mervi Könönen, Elisa Kallioniemi, Ville Leinonen & Nils Danner
Additional file 3. Data of good responders and limited responders at baseline, TAP and follow-up.

The effect of shunt surgery on corticospinal excitability in idiopathic normal pressure hydrocephalus: a transcranial magnetic stimulation study

Jani Sirkka, Laura Säisänen, Petro Julkunen, Mervi Könönen, Elisa Kallioniemi, Ville Leinonen & Nils Danner
Abstract Background Idiopathic normal pressure hydrocephalus (iNPH) is a multifactorial disease presenting with a classical symptom triad of cognitive decline, gait disturbance and urinary incontinence. The symptoms can be alleviated with shunt surgery but the etiology of the symptoms remains unclear. Navigated transcranial magnetic stimulation (nTMS) was applied to characterize corticospinal excitability and cortical motor function before and after shunt surgery in order to elucidate the pathophysiology of iNPH. We also aimed to determine, whether...

Mode of treatments and achievement of treatment targets among type 2 diabetes patients with different comorbidities – a register-based retrospective cohort study in Finland

Nazma Akter Nazu, Katja Wikström, Marja-Leena Lamidi, Jaana Lindström, Hilkka Tirkkonen, Päivi Rautiainen & Tiina Laatikainen
Abstract Aims Type 2 diabetes (T2D) is a progressive disease often associated with comorbidities that complicate the management of T2D and affect the achievement of treatment targets. However, adherence to guidelines and individualized treatments can potentially improve treatment outcomes. This study assessed the association between different glucose lowering and lipid lowering medication lines and the achievement of treatment targets with different comorbidities among a T2D cohort in North Karelia, Finland (2011-12 to 2015-16). Methods The...

Economic evaluation of infliximab, synthetic triple therapy and methotrexate in the treatment of newly diagnosed juvenile idiopathic arthritis

Maarit Tarkiainen, Pirjo Tynjälä, Paula Vähäsalo, Kristiina Aalto, Liisa Kröger, Katariina Rebane, Pekka Lahdenne & Janne Martikainen
Abstract Background Evaluation of costs and short-term cost-effectiveness of infliximab plus methotrexate (IFX + MTX); triple therapy of hydroxychloquine, sulphasalazine, and methotrexate (TRIPLE); or methotrexate monotherapy (MTX) in patients with new-onset polyarticular juvenile idiopathic arthritis (JIA). Methods In a prospective multicenter study (ACUTE-JIA), costs and health outcomes of 60 randomized patients with new-onset disease-modifying anti-rheumatic drug (DMARD)-naïve polyarticular JIA were analyzed during the first year. A mapping algorithm was used to obtain utility values from...

Airborne cues accelerate flowering and promote photosynthesis in Brassica rapa

Agnes Brosset, Hao Yu & James Blande
1. Volatile cues can induce and/or prime plant defences, but it is less well known if plants also respond by altering growth and reproduction-related parameters. 2. Here we evaluated whether plant volatile cues can elicit changes in growth, flower production, net photosynthesis rate and defences in receiver plants and whether those responses are similar to those elicited in response to direct herbivore-feeding. 3. Our results demonstrate that exposure to volatiles emitted from damaged neighbours accelerated...

Imprints of latitude, host taxon and decay stage on fungus-associated arthropod communities

Janne Koskinen, Nerea Abrego, Eero Vesterinen, Torsti Schulz, Tomas Roslin & Tommi Nyman
Interactions among fungi and insects involve hundreds of thousands of species. While insect communities on plants have formed some of the classic model systems in ecology, fungus-based communities and the forces structuring them remain poorly studied by comparison. We characterize the arthropod communities associated with fruiting bodies of eight mycorrhizal basidiomycete fungus species from three different orders along a 1200-km latitudinal gradient in northern Europe. We hypothesized that—matching the pattern seen for most insect taxa...

Supplementary Figure S5 from Mu-opioid receptor system modulates responses to vocal bonding and distress signals in humans

Lihua Sun, Lasse Lukkarinen, Vesa Putkinen, Henry Karlsson, Jussi Hirvonen, Jari Tiihonen, Hannu Lauerma, Sophie Scott & Lauri Nummenmaa
Figure S5. Correlation matrix for ROI-level MOR levels and ROI-level BOLD response to crying. ACC = anterior cingulate cortex, M1 = primary motor cortex, M2 = secondary motor cortex, OFC = orbitofrontal cortex, PCC = posterior cingulate cortex, S1 = primary somatosensory cortex, S2 = secondary somatosensory cortex.

Circum-Arctic distribution of chemical anti-herbivore compounds arctic shrubs

Elin Lindén, Mariska Te Beest, Ilka Abreu, Thomas Moritz, Maja Sundqvist, Isabel C Barrio, Julia Boike, John Bryant, Kari Anne Bråthen, Agata Buchwal, Guillermo Bueno, Alain Cuerrier, Dagmar Egelkraut, Bruce Forbes, Martin Hallinger, Monique Heijmans, Luise Hermanutz, David S Hik, Annika Hofgaard, Milena Holmgren, Diane C Huebner, Toke Hoye, Ingibjörg Jónsdóttir, Elina Kaarlejärvi, Emilie Kissler … & Johan Olofsson
Spatial variation in plant chemical defence towards herbivores can help us understand variation in herbivore top-down control of shrubs in the Arctic and possibly also shrub responses to global warming. Less defended, non-resinous shrubs could be more influenced by herbivores than more defended, resinous shrubs. However, sparse field measurements limit our current understanding of how much of the circum-Arctic variation in defence compounds is explained by taxa or defence functional groups (resinous/non-resinous). We measured circum-Arctic...

Evaluation of baseline pediatric readiness of emergency departments in Manitoba, Canada

Alex Aregbesola, Oana Florescu, Clara Tam, Amanda Coyle, Lisa Knisley, Kaitlin Hogue, Darcy Beer, Scott Sawyer & Terry P. Klassen
Abstract Background Data on the readiness of the general emergency departments (EDs) in Canada to care for children requiring emergency care are limited. Recent evidence suggests an inverse association between pediatric readiness of the general ED and mortality. Objectives To assess the baseline pediatric readiness of the general EDs in the province of Manitoba, Canada, to care for acutely ill and injured children. Methods This was a cross-sectional survey study conducted between 2019 and 2020....

5-(Sulfamoyl)thien-2-yl 1,3-oxazole inhibitors of carbonic anhydrase II with hydrophilic periphery

Stanislav Kalinin, Alexander Kovalenko, Annika Valtari, Alessio Nocentini, Maxim Gureev, Arto Urtti, Mikhail Korsakov, Claudiu T. Supuran & Mikhail Krasavin
Hydrophilic derivatives of an earlier described series of carbonic anhydrase inhibitors have been designed, prepared and profiled against a panel of carbonic anhydrase isoforms, including the glaucoma-related hCA II. For all hydrophilic derivatives, computational prediction of intraocular permeability routes showed the predominance of conjunctival rather than corneal absorption. The potentially reactive primary or secondary amine periphery of these compounds makes them suitable candidates for bioconjugation to polymeric drug carriers. As was shown previously, the most...

Dataset from: A curated DNA barcode reference library for parasitoids of northern European cyclically outbreaking geometrid moths

Tommi Nyman, Saskia Wutke, Elina Koivisto, Tero Klemola, Mark Shaw, Tommi Andersson, Håkon Haraldseide, Snorre Hagen, Ryosuke Nakadai & Kai Ruohomäki
Large areas of forests are annually damaged or destroyed by outbreaking insect pests. Understanding the factors that trigger and terminate such population eruptions has become crucially important, as plants, plant-feeding insects, and their natural enemies may respond differentially to the ongoing changes in the global climate. In northernmost Europe, climate-driven range expansions of the geometrid moths Epirrita autumnata and Operophtera brumata have resulted in overlapping and increasingly severe outbreaks. Delayed density-dependent responses of parasitoids are...

The values for the proxy variable estimated for poultry trade flows among 318 prefecture-level cities in mainland China

Lingcai Kong, Xuan Zhou, Mengwei Duan, Xinyi Yang, Caifeng Zhou & Yilan Liao
The dataset presents values for a proxy variable for poultry trade flows among 318 prefecture-level mainland China cities, estimated with modified radiation model.

A dataset of proxy variables for poultry trade flows in China

Lingcai Kong, Xuan Zhou, Mengwei Duan, Xinyi Yang, Caifeng Zhou & Yilan Liao
The poultry production output and consumption data for each prefecture-level city in mainland China 2015 were stored in the file Suplement_V1_Poultry_Data.csv. The values for the proxy variable estimated with modified radiation model for poultry trade flows among prefecture-level cities in mainland China 2015 were stored in the file Suplement_V2_Poultry_Trade_Flows.csv.

Cross-cultural adaptation and validation of the Kerlan-Jobe Orthopaedic Clinic shoulder and elbow score in Finnish-speaking overhead athletes

Maria Sukanen, Jesse Pajari, Sami Äyrämö, Juha Paloneva, Benjamin Waller, Arja Häkkinen & Juhani Multanen
Abstract Background The Kerlan-Jobe Orthopaedic Clinic Shoulder and Elbow score (KJOC) is developed to evaluate the shoulder and elbow function in overhead athletes. To date, the score has not been adapted into Finnish language. The aim of this study was to perform a cross-cultural adaptation of the Kerlan-Jobe Orthopaedic Clinic Shoulder and Elbow score (KJOC) into Finnish language and evaluate its validity, reliability, and responsiveness in overhead athletes. Methods Forward–backward translation method was followed in...

Additional file 1 of Cross-cultural adaptation and validation of the Kerlan-Jobe Orthopaedic Clinic shoulder and elbow score in Finnish-speaking overhead athletes

Maria Sukanen, Jesse Pajari, Sami Äyrämö, Juha Paloneva, Benjamin Waller, Arja Häkkinen & Juhani Multanen
Additional file 1. Back-translation of the Finnish KJOC score.

sj-docx-2-sjp-10.1177_14034948221130150 – Supplemental material for Validity of the Finnish Care Register for Social Welfare in a nationwide cohort of people with Alzheimer’s disease

Virva Hyttinen, Kirsikka Selander, Anna-Maija Tolppanen, Riikka Väyrynen, Lasse Mielikäinen, Ismo Linnosmaa & Sirpa Hartikainen
Supplemental material, sj-docx-2-sjp-10.1177_14034948221130150 for Validity of the Finnish Care Register for Social Welfare in a nationwide cohort of people with Alzheimer’s disease by Virva Hyttinen, Kirsikka Selander, Anna-Maija Tolppanen, Riikka Väyrynen, Lasse Mielikäinen, Ismo Linnosmaa and Sirpa Hartikainen in Scandinavian Journal of Public Health

Additional file 1 of Mode of treatments and achievement of treatment targets among type 2 diabetes patients with different comorbidities – a register-based retrospective cohort study in Finland

Nazma Akter Nazu, Katja Wikström, Marja-Leena Lamidi, Jaana Lindström, Hilkka Tirkkonen, Päivi Rautiainen & Tiina Laatikainen
Supplementary Material 1

Pregnancy and delivery after traumatic brain injury: a nationwide population-based cohort study in Finland

Matias Vaajala, Ilari Kuitunen, Lauri Nyrhi, Ville Ponkilainen, Maiju Kekki, Teemu Luoto & Ville M. Mattila
Few studies have assessed pregnancies and deliveries after traumatic brain injury (TBI). We report the incidence of TBIs and TBI-related surgeries in fertile-aged females and investigate subsequent pregnancy outcomes. All fertile-aged (15–49) women with TBI diagnosis during our study period (1998–2018) were retrieved from the Care Register for Health Care and combined with data from the National Medical Birth Register. TBIs were categorized into three subgroups based on the length of the hospitalization period and...

Use of antibiotics and risk of type 2 diabetes, overweight and obesity: the Cardiovascular Risk in Young Finns Study and the national FINRISK study

Joel Nuotio, Teemu Niiranen, Tomi T. Laitinen, Jessica Miller, Matthew A. Sabin, Aki S. Havulinna, Jorma S. A. Viikari, Tapani Rönnemaa, Nina Hutri-Kähönen, Tomi P. Laitinen, Päivi Tossavainen, Veikko Salomaa, Olli T. Raitakari, David P. Burgner & Markus Juonala
Abstract Purpose To investigate whether exposure to systemic antibiotics influences the risk of developing type 2 diabetes and overweight/obesity. Methods The study sample comprised 2209 (110 with incident diabetes) participants from the population-based Cardiovascular Risk in Young Finns Study (YFS) aged 24–39 years in 2001. The exposure was national linked register data on purchased antibiotic courses between 1993 and 2001. Clinical examinations including BMI were conducted in 2001, 2007 and 2011. Participants with prevalent diabetes...

Additional file 1 of Use of antibiotics and risk of type 2 diabetes, overweight and obesity: the Cardiovascular Risk in Young Finns Study and the national FINRISK study

Joel Nuotio, Teemu Niiranen, Tomi T. Laitinen, Jessica Miller, Matthew A. Sabin, Aki S. Havulinna, Jorma S. A. Viikari, Tapani Rönnemaa, Nina Hutri-Kähönen, Tomi P. Laitinen, Päivi Tossavainen, Veikko Salomaa, Olli T. Raitakari, David P. Burgner & Markus Juonala
Additional file 1.

Additional file 1 of The integration of large-scale public data and network analysis uncovers molecular characteristics of psoriasis

Antonio Federico, Alisa Pavel, Lena Möbus, David McKean, Giusy del Giudice, Vittorio Fortino, Hanna Niehues, Joe Rastrick, Kilian Eyerich, Stefanie Eyerich, Ellen van den Bogaard, Catherine Smith, Stephan Weidinger, Emanuele de Rinaldis & Dario Greco
Additional file 1. Additional material including supplemetary figures and tables.

Supplemental Material - The Association of Metformin, Other Antidiabetic Medications, and Statins With the Prognosis of Colon Cancer in Patients With Type 2 Diabetes: A Retrospective Cohort Study

Sami Erkinantti, Ari Hautakoski, Reijo Sund, Martti Arffman, Elina Urpilainen, Ulla Puistola, Arja Jukkola, Karihtala Peeter & Esa Läärä
Supplemental Material for The Association of Metformin, Other Antidiabetic Medications, and Statins With the Prognosis of Colon Cancer in Patients With Type 2 Diabetes: A Retrospective Cohort Study by Sami Erkinantti, Ari Hautakoski, Reijo Sund, Martti Arffman, Elina Urpilainen, Ulla Puistola, Arja Jukkola, Peeter Karihtala, and Esa Läärä in Cancer Control

Registration Year

  • 2022
    100

Resource Types

  • Text
    36
  • Dataset
    31
  • Collection
    24
  • Image
    7
  • Book
    1
  • Other
    1

Affiliations

  • University of Eastern Finland
    100
  • University of Helsinki
    31
  • University of Turku
    23
  • Finnish Institute for Health and Welfare
    20
  • University of Oulu
    20
  • Kuopio University Hospital
    18
  • Tampere University
    15
  • Oulu University Hospital
    11
  • Karolinska Institute
    11
  • Tampere University Hospital
    10