43 Works

Data from: Dragons in our midst: phyloforensics of illegally traded Southeast Asian monitor lizards

Welton J. Luke, Cameron D. Siler, Charles W. Linkem, Arvin C. Diesmos, Mae L. Diesmos, Emerson Sy, Rafe M. Brown & Luke J. Welton
We provide a phylogenetic and population genetic evaluation of the illegal pet and bush meat trade of monitor lizards in the Philippines. We use a molecular dataset assembled from vouchered samples with known localities throughout the country, as a reference for statistical phylogenetic, population genetic, and DNA barcoding analyses of genetic material obtained during a three year survey of the Manila pet trade. Our results provide the first genetic evaluation of a major Southeast Asian...

Additional file 2 of Effectiveness of Bacille Calmette-Guerin vaccination policies in reducing infection and mortality of COVID-19: a systematic review

Joseph Christian Obnial, Mystie Suzuki, Catherine Joy Escuadra, Janine Trixia Austria, Ma. Jamaica Monique Ponce & Elaine Cunanan
Additional file 2. Initial record screening.

Additional file 7 of Elevation of serum interleukin-1β levels as a potential indicator for malarial infection and severe malaria: a meta-analysis

Aongart Mahittikorn, Pattamaporn Kwankaew, Pongruj Rattaprasert, Kwuntida Uthaisar Kotepui, Frederick Ramirez Masangkay & Manas Kotepui
Additional file 7: Table S1. Search terms.

Additional file 8 of Elevation of serum interleukin-1β levels as a potential indicator for malarial infection and severe malaria: a meta-analysis

Aongart Mahittikorn, Pattamaporn Kwankaew, Pongruj Rattaprasert, Kwuntida Uthaisar Kotepui, Frederick Ramirez Masangkay & Manas Kotepui
Additional file 8: Table S2. Quality of the included studies.

Additional file 9 of Elevation of serum interleukin-1β levels as a potential indicator for malarial infection and severe malaria: a meta-analysis

Aongart Mahittikorn, Pattamaporn Kwankaew, Pongruj Rattaprasert, Kwuntida Uthaisar Kotepui, Frederick Ramirez Masangkay & Manas Kotepui
Additional file 9: Table S3. Details of the included studies.

Elevation of serum interleukin-1β levels as a potential indicator for malarial infection and severe malaria: a meta-analysis

Aongart Mahittikorn, Pattamaporn Kwankaew, Pongruj Rattaprasert, Kwuntida Uthaisar Kotepui, Frederick Ramirez Masangkay & Manas Kotepui
Abstract Background Interleukin (IL)-1β is a proinflammatory cytokine that has a role in disease-related inflammation, including malaria. However, reports on the effect of IL-1β on malaria severity are inconsistent. Therefore, meta-analyses to compare differences in IL-1β levels between patients with severe malaria, patients with uncomplicated malaria and healthy controls were performed. Methods The PRISMA standards were used to perform a systematic review and meta-analysis. A search of PubMed, Scopus, EMBASE and reference lists was conducted...

Additional file 7 of Elevation of serum interleukin-1β levels as a potential indicator for malarial infection and severe malaria: a meta-analysis

Aongart Mahittikorn, Pattamaporn Kwankaew, Pongruj Rattaprasert, Kwuntida Uthaisar Kotepui, Frederick Ramirez Masangkay & Manas Kotepui
Additional file 7: Table S1. Search terms.

Additional file 10 of Elevation of serum interleukin-1β levels as a potential indicator for malarial infection and severe malaria: a meta-analysis

Aongart Mahittikorn, Pattamaporn Kwankaew, Pongruj Rattaprasert, Kwuntida Uthaisar Kotepui, Frederick Ramirez Masangkay & Manas Kotepui
Additional file 10. PRISMA 2020 abstract checklist.

Additional file 2 of Elevation of serum interleukin-1β levels as a potential indicator for malarial infection and severe malaria: a meta-analysis

Aongart Mahittikorn, Pattamaporn Kwankaew, Pongruj Rattaprasert, Kwuntida Uthaisar Kotepui, Frederick Ramirez Masangkay & Manas Kotepui
Additional file 2: Figure S2. Sensitivity analysis using the leave-one-out method demonstrated the difference in mean IL-1β levels (pg/mL) between patients with uncomplicated malaria and healthy control participants after excluding each study. Horizontal green line extending on either side of the green dot, CI; the green dots, the values of the overall effect size. CI: confidence interval; Mean Diff.: mean difference (MD); red vertical line, the overall effect size.

Additional file 4 of Elevation of serum interleukin-1β levels as a potential indicator for malarial infection and severe malaria: a meta-analysis

Aongart Mahittikorn, Pattamaporn Kwankaew, Pongruj Rattaprasert, Kwuntida Uthaisar Kotepui, Frederick Ramirez Masangkay & Manas Kotepui
Additional file 4: Figure S4. Contour enhanced funnel plot of studies included in the meta-analysis of MD of IL-1β levels (pg/mL) between severe and uncomplicated malaria. CI: confidence interval; Mean Diff.: mean difference (MD).

Additional file 4 of Elevation of serum interleukin-1β levels as a potential indicator for malarial infection and severe malaria: a meta-analysis

Aongart Mahittikorn, Pattamaporn Kwankaew, Pongruj Rattaprasert, Kwuntida Uthaisar Kotepui, Frederick Ramirez Masangkay & Manas Kotepui
Additional file 4: Figure S4. Contour enhanced funnel plot of studies included in the meta-analysis of MD of IL-1β levels (pg/mL) between severe and uncomplicated malaria. CI: confidence interval; Mean Diff.: mean difference (MD).

Consensus without Consent

Alvin Tan
For a critique of media technologies this paper aims to utilize the Propaganda Model (PM) from the first chapter of the book by Edward S. Herman and Noam Chomsky Manufacturing Consent: The Political Economy of the Mass Media (1988) which centers on the hegemonic role and power of media in the political process. A synoptic review of the model and more recent scholarship along similar lines affords a revitalization of Herman and Chomsky‘s radical critique....

Myxobacterial depsipeptide chondramides interrupt SARS-CoV-2 entry by targeting its broad, cell tropic spike protein

Rey Arturo Fernandez, Mark Tristan Quimque, Kin Israel Notarte, Joe Anthony Manzano, Delfin Yñigo Pilapil, Von Novi de Leon, John Jeric San Jose, Omar Villalobos, Nisha Harur Muralidharan, M. Michael Gromiha, Simone Brogi & Allan Patrick G. Macabeo
The severity of the COVID-19 pandemic has necessitated the search for drugs against SARS-CoV-2. In this study, we explored via in silico approaches myxobacterial secondary metabolites against various receptor-binding regions of SARS-CoV-2 spike which are responsible in recognition and attachment to host cell receptors mechanisms, namely ACE2, GRP78, and NRP1. In general, cyclic depsipeptide chondramides conferred high affinities toward the spike RBD, showing strong binding to the known viral hot spots Arg403, Gln493 and Gln498...

Additional file 4 of Effectiveness of Bacille Calmette-Guerin vaccination policies in reducing infection and mortality of COVID-19: a systematic review

Joseph Christian Obnial, Mystie Suzuki, Catherine Joy Escuadra, Janine Trixia Austria, Ma. Jamaica Monique Ponce & Elaine Cunanan
Additional file 4. Critical appraisal of studies using the adapted appraisal tool from Betran et al. and the JBI Critical Appraisal Instruments.

Data from: Conservation genetics of the Philippine tarsier: cryptic genetic variation restructures conservation priorities for an island archipelago primate

Rafe M. Brown, Jennifer A. Weghorst, Karen V. Olson, Mariano R. M. Duya, Anthony J. Barley, Melizar V. Duya, Myron Shekelle, Irene Neri-Arboleda, Jacob A. Esselstyn, Nathaniel J. Dominy, Perry S. Ong, Gillian L. Moritz, Adrian Luczon, Mae Lowe L. Diesmos, Arvin C. Diesmos & Cameron D. Siler
Establishment of conservation priorities for primates is a particular concern in the island archipelagos of Southeast Asia, where rates of habitat destruction are among the highest in the world. Conservation programs require knowledge of taxonomic diversity to ensure success. The Philippine tarsier is a flagship species that promotes environmental awareness and a thriving ecotourism economy in the Philippines. However, assessment of its conservation status has been impeded by taxonomic uncertainty, a paucity of field studies,...

Additional file 1 of Effectiveness of Bacille Calmette-Guerin vaccination policies in reducing infection and mortality of COVID-19: a systematic review

Joseph Christian Obnial, Mystie Suzuki, Catherine Joy Escuadra, Janine Trixia Austria, Ma. Jamaica Monique Ponce & Elaine Cunanan
Additional file 1. PROSPERO Registration.

Additional file 1 of Effectiveness of Bacille Calmette-Guerin vaccination policies in reducing infection and mortality of COVID-19: a systematic review

Joseph Christian Obnial, Mystie Suzuki, Catherine Joy Escuadra, Janine Trixia Austria, Ma. Jamaica Monique Ponce & Elaine Cunanan
Additional file 1. PROSPERO Registration.

Additional file 2 of Effectiveness of Bacille Calmette-Guerin vaccination policies in reducing infection and mortality of COVID-19: a systematic review

Joseph Christian Obnial, Mystie Suzuki, Catherine Joy Escuadra, Janine Trixia Austria, Ma. Jamaica Monique Ponce & Elaine Cunanan
Additional file 2. Initial record screening.

Additional file 3 of Effectiveness of Bacille Calmette-Guerin vaccination policies in reducing infection and mortality of COVID-19: a systematic review

Joseph Christian Obnial, Mystie Suzuki, Catherine Joy Escuadra, Janine Trixia Austria, Ma. Jamaica Monique Ponce & Elaine Cunanan
Additional file 3. Quality assessment checklist for ecological studies adapted from Betran et al.

Additional file 3 of Effectiveness of Bacille Calmette-Guerin vaccination policies in reducing infection and mortality of COVID-19: a systematic review

Joseph Christian Obnial, Mystie Suzuki, Catherine Joy Escuadra, Janine Trixia Austria, Ma. Jamaica Monique Ponce & Elaine Cunanan
Additional file 3. Quality assessment checklist for ecological studies adapted from Betran et al.

Effectiveness of Bacille Calmette-Guerin vaccination policies in reducing infection and mortality of COVID-19: a systematic review

Joseph Christian Obnial, Mystie Suzuki, Catherine Joy Escuadra, Janine Trixia Austria, Ma. Jamaica Monique Ponce & Elaine Cunanan
Abstract Background COVID-19 vaccination has been advocated as the most effective way to curb the pandemic. But with its inequitable distribution and slow rollout, especially in low- to middle- income countries, it will still take a long time before herd immunity is achieved. Alternative measures must therefore be explored to bolster current COVID-19 vaccination efforts. In particular, the Bacille Calmette-Guerin vaccine has been studied extensively as to its proposed conferment of non-specific immunity against different...

The Anesthesiologist amidst a Pandemic

Maria Minerva P. Calimag

Myxobacterial depsipeptide chondramides interrupt SARS-CoV-2 entry by targeting its broad, cell tropic spike protein

Rey Arturo Fernandez, Mark Tristan Quimque, Kin Israel Notarte, Joe Anthony Manzano, Delfin Yñigo Pilapil, Von Novi de Leon, John Jeric San Jose, Omar Villalobos, Nisha Harur Muralidharan, M. Michael Gromiha, Simone Brogi & Allan Patrick G. Macabeo
The severity of the COVID-19 pandemic has necessitated the search for drugs against SARS-CoV-2. In this study, we explored via in silico approaches myxobacterial secondary metabolites against various receptor-binding regions of SARS-CoV-2 spike which are responsible in recognition and attachment to host cell receptors mechanisms, namely ACE2, GRP78, and NRP1. In general, cyclic depsipeptide chondramides conferred high affinities toward the spike RBD, showing strong binding to the known viral hot spots Arg403, Gln493 and Gln498...

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