119 Works

Additional file 1 of What is the impact of the COVID-19 pandemic on emergency medicine residency training: an observational study

Hsiang-Yun Lo, Shen-Che Lin, Chung-Hsien Chaou, Yu-Che Chang, Chip-Jin Ng & Shou-Yen Chen
Additional file 1.

Association of capsular types with carbapenem resistance, disease severity, and mortality in Acinetobacter baumannii

Yu-Chia Hsieh, Shi-Heng Wang, Yi-Yin Chen, Tzu-Lung Lin, Shian-Sen Shie, Ching-Tai Huang, Chen-Hsiang Lee, Yi-Ching Chen, Tran Lam Tu Quyen & Yi-Jiun Pan
Acinetobacter baumannii emerged as one of the most important pathogens that causes nosocomial infections due to its increased multidrug resistance. Identifying capsular epidemiology in A. baumannii can aid in the development of effective treatments and preventive measures against this emerging pathogen. Here we established a wzc-based method, and combined it with wzy-PCR to determine capsular types of A. baumannii causing nosocomial bacteraemia collected at two medical centres in Taiwan from 2015 to 2017. Among the...

BST-1 as a serum protein biomarker involved in neutrophil infiltration in schizophrenia

Liang-Jen Wang, Yu-Chi Huang, Pao-Yen Lin, Yu Lee, Chi-Fa Hung, Su-Ting Hsu, Lien-Hung Huang & Sung-Chou Li
Schizophrenia is a serious mental illness. The serum protein biomarkers of schizophrenia were explored using isobaric tags for relative and absolute quantitation (iTRAQ) technology. The underlying function of the identified protein biomarker was also investigated. We first collected serum samples from 12 schizophrenia patients and 12 healthy control (HC) subjects, followed by global screening with iTRAQ and tandem mass spectrometry (LC-MS/MS). In total, 691 serum proteins were detected and eight proteins, including ZYX, OSCAR, TPM4,...

Impact of baseline renal function on the efficacy and safety of different Anticoagulants in Atrial Fibrillation Patients – A cohort study

Wei-Chieh Lee, Ting-Wei Liao, Hsiu-Yu Fang, Po-Jui Wu, Yen-Nan Fang, Huang-Chung Chen, Yu-Sheng Lin, Shang-Hung Chang, Ping-Yen Liu & Mien-Cheng Chen
Abstract Background Vitamin K antagonists and different direct oral anticoagulants (DOACs) have different renal clearance rates. However, the impact of different stages of chronic renal impairment on the efficacy and safety of warfarin, dabigatran, rivaroxaban, apixaban, and edoxaban in atrial fibrillation (AF) patients remains unclear. Methods This study enrolled AF patients from the Chang Gung Research Database. The study endpoints included thromboembolic events, major/fatal bleeding, gastrointestinal (GI) bleeding and intracranial hemorrhage (ICH). The risks of...

Additional file 3 of Impact of baseline renal function on the efficacy and safety of different Anticoagulants in Atrial Fibrillation Patients – A cohort study

Wei-Chieh Lee, Ting-Wei Liao, Hsiu-Yu Fang, Po-Jui Wu, Yen-Nan Fang, Huang-Chung Chen, Yu-Sheng Lin, Shang-Hung Chang, Ping-Yen Liu & Mien-Cheng Chen
Supplementary Material 3

Role of air pollutants in dengue fever incidence: evidence from two southern cities in Taiwan

Hao-Chun Lu, Fang-Yu Lin, Yao-Huei Huang, Yu-Tung Kao & El-Wui Loh
Air pollution may be involved in spreading dengue fever (DF) besides rainfalls and warmer temperatures. While particulate matter (PM), especially those with diameter of 10 μm (PM10) or 2.5 μm or less (PM25), and NO2 increase the risk of coronavirus 2 infection, their roles in triggering DF remain unclear. We explored if air pollution factors predict DF incidence in addition to the classic climate factors. Public databases and DF records of two southern cities in...

Application of the electronic book to promote self-directed learning in medical technologist continuing education: a cross-sectional study

Chiao-Ni Wen, Chung-Guei Huang, Pi-Yueh Chang, Tsung-Han Yang, Huey-Ling You, Hsiao-Chen Ning & Kuo-Chien Tsao
Abstract Background Continuing education (CE) is essential for health professionals to improve competence in clinical practice, yet many medical technologists still experience barriers to learning in complex clinical settings. To better manage CE and address medical technologists’ learning needs, we developed a learner-centred electronic book (e-book) to promote self-directed learning for medical technologists. Methods A cross-sectional study was conducted to explore the acceptability and learning impacts of the e-book as CE material for medical technologists...

Association between oral intake magnesium and sarcopenia: a cross-sectional study

Shih-Wei Yang, Yuan-Yuei Chen & Wei-Liang Chen
Abstract Background Sarcopenia is a common skeletal muscle disorder in the elderly population. The patients with sarcopenia increased the cost of care and the risk for hospitalization. Magnesium deficiency might increase reactive oxygen species and protein damage. The purpose of our study was to demonstrate the relation between oral intake magnesium and sarcopenia by European Working Group on Sarcopenia in Older People (EWGSOP) 2 definition. Methods Our study included 2532 participants with 1310 males and...

Additional file 1 of Dysregulation of SOX17/NRF2 axis confers chemoradiotherapy resistance and emerges as a novel therapeutic target in esophageal squamous cell carcinoma

Chih-Hsiung Hsieh, Wen-Hui Kuan, Wei-Lun Chang, I-Ying Kuo, Hsun Liu, Dar-Bin Shieh, Hsuan Liu, Bertrand Tan & Yi-Ching Wang
Additional file 1. Supplementary figures and tables.

Additional file 1 of Comparative accuracy of biomarkers for the prediction of hospital-acquired acute kidney injury: a systematic review and meta-analysis

Heng-Chih Pan, Shao-Yu Yang, Terry Ting-Yu Chiou, Chih-Chung Shiao, Che-Hsiung Wu, Chun-Te Huang, Tsai-Jung Wang, Jui-Yi Chen, Hung-Wei Liao, Sheng-Yin Chen, Tao-Min Huang, Ya-Fei Yang, Hugo You-Hsien Lin, Ming-Jen Chan, Chiao-Yin Sun, Yih-Ting Chen, Yung-Chang Chen & Vin-Cent Wu
Additional file 1: Supplementary appendix.

Additional file 1 of Comparative accuracy of biomarkers for the prediction of hospital-acquired acute kidney injury: a systematic review and meta-analysis

Heng-Chih Pan, Shao-Yu Yang, Terry Ting-Yu Chiou, Chih-Chung Shiao, Che-Hsiung Wu, Chun-Te Huang, Tsai-Jung Wang, Jui-Yi Chen, Hung-Wei Liao, Sheng-Yin Chen, Tao-Min Huang, Ya-Fei Yang, Hugo You-Hsien Lin, Ming-Jen Chan, Chiao-Yin Sun, Yih-Ting Chen, Yung-Chang Chen & Vin-Cent Wu
Additional file 1: Supplementary appendix.

Additional file 1 of Oral presentation assessment and image reading behaviour on brain computed tomography reading in novice clinical learners: an eye-tracking study

Chi-Hung Liu, June Hung, Chun-Wei Chang, John J. H. Lin, Elaine Shinwei Huang, Shu-Ling Wang, Li-Ang Lee, Cheng-Ting Hsiao, Pi-Shan Sung, Yi-Ping Chao & Yeu-Jhy Chang
Supplementary Material 1

Oral presentation assessment and image reading behaviour on brain computed tomography reading in novice clinical learners: an eye-tracking study

Chi-Hung Liu, June Hung, Chun-Wei Chang, John J. H. Lin, Elaine Shinwei Huang, Shu-Ling Wang, Li-Ang Lee, Cheng-Ting Hsiao, Pi-Shan Sung, Yi-Ping Chao & Yeu-Jhy Chang
Abstract Background To study whether oral presentation (OP) assessment could reflect the novice learners’ interpretation skills and reading behaviour on brain computed tomography (CT) reading. Methods Eighty fifth-year medical students were recruited, received a 2-hour interactive workshop on how to read brain CT, and were assigned to read two brain CT images before and after instruction. We evaluated their image reading behaviour in terms of overall OP post-test rating, the lesion identification, and competency in...

Synergic Effect of Combined Therapy of Hyperbaric Oxygen and Adipose-Derived Mesenchymal Stem Cells on Improving Locomotor Recovery After Acute Traumatic Spinal Cord Injury in Rat Mainly Through Downregulating Inflammatory and Cell-Stress Signalings

Tsung-Cheng Yin, Pei-Lin Shao, Kuan-Hung Chen, Kun-Chen Lin, John Y. Chiang, Pei-Hsun Sung, Shun-Cheng Wu, Yi-Chen Li, Hon-Kan Yip & Mel S. Lee
This study tested whether combined hyperbaric oxygen (HBO) and allogenic adipose-derived mesenchymal stem cells (ADMSCs) would be superior to either one for improving the locomotor recovery in rat after acute traumatic spinal cord injury (TSCI) in rat. Adult-male Sprague–Dawley rats were equally categorized into group 1 (sham-operated control), group 2 (TSCI), group 3 (TSCI + HBO for 1.5 h/day for 14 consecutive days after TSCI), group 4 (TSCI + ADMSCs/1.2 × 106 cells by intravenous...

Assessing the causal relationships between gout and hypertension: a bidirectional Mendelian randomisation study with coarsened exposures

Benjamin Lai, Huang-Ping Yu, Yu-Jing Chang, Liang-Chin Wang, Che-Kai Chen, Weiya Zhang, Michael Doherty, Shang-Hung Chang, Jun-Te Hsu, Kuang-Hui Yu & Chang-Fu Kuo
Abstract Objectives Observational studies have demonstrated associations between gout and hypertension, but whether they are causal remains unclear. Our work aims to assess the causal relationship between gout and hypertension. Methods We obtained genetic information from the Taiwan Biobank, including 88,347 participants and 686,439 single-nucleotide polymorphisms (SNPs). A novel model of Mendelian randomisation (MR) with coarsened exposures was used to examine the causality between the liability of gout on hypertension and vice versa, using 4...

Additional file 2 of How symptoms of prolonged grief disorder, posttraumatic stress disorder, and depression relate to each other for grieving ICU families during the first two years of bereavement

Fur-Hsing Wen, Holly G. Prigerson, Wen-Chi Chou, Chung-Chi Huang, Tsung-Hui Hu, Ming Chu Chiang, Li-Pang Chuang & Siew Tzuh Tang
Additional file 2. Table S2: Comparisons of psychological distress across participation status during bereavement follow-ups (N =293).

Additional file 3 of How symptoms of prolonged grief disorder, posttraumatic stress disorder, and depression relate to each other for grieving ICU families during the first two years of bereavement

Fur-Hsing Wen, Holly G. Prigerson, Wen-Chi Chou, Chung-Chi Huang, Tsung-Hui Hu, Ming Chu Chiang, Li-Pang Chuang & Siew Tzuh Tang
Additional file 3. Table S3. Comparisons of patient characteristics across participation status during bereavement follow-ups (N = 303).

Development and validation of machine learning-based risk prediction models of oral squamous cell carcinoma using salivary autoantibody biomarkers

Yi-Ju Tseng, Yi-Cheng Wang, Pei-Chun Hsueh & Chih-Ching Wu
Abstract Introduction The incidence of oral cavity squamous cell carcinoma (OSCC) continues to rise. OSCC is associated with a low average survival rate, and most patients have a poor disease prognosis because of delayed diagnosis. We used machine learning techniques to predict high-risk cases of OSCC by using salivary autoantibody levels and demographic and behavioral data. Methods We collected the salivary samples of patients recruited from a teaching hospital between September 2008 and December 2012....

sj-docx-1-aut-10.1177_13623613221138690 – Supplemental material for Association of labor epidural analgesia exposure with long-term risk of autism spectrum disorder in offspring: A meta-analysis of observational studies

Kuo-Chuan Hung, Jen-Yin Chen, Chung-Hsi Hsing, Chih-Wei Hsu, Ping-Hsin Liu, Ying-Jen Chang, Jui-Yi Chen, Sheng-Fu Chiu & Cheuk-Kwan Sun
Supplemental material, sj-docx-1-aut-10.1177_13623613221138690 for Association of labor epidural analgesia exposure with long-term risk of autism spectrum disorder in offspring: A meta-analysis of observational studies by Kuo-Chuan Hung, Jen-Yin Chen, Chung-Hsi Hsing, Chih-Wei Hsu, Ping-Hsin Liu, Ying-Jen Chang, Jui-Yi Chen, Sheng-Fu Chiu and Cheuk-Kwan Sun in Autism

Additional file 2 of Case report: novel PCDH15 variant causes usher syndrome type 1F with congenital hearing loss and syndromic retinitis pigmentosa

Nelson Chen, Hane Lee, Angela H. Kim, Pei-Kang Liu, Eugene Yu-Chuan Kang, Yun-Ju Tseng, Go Hun Seo, Rin Khang, Laura Liu, Kuan-Jen Chen, We-Chi Wu, Meng-Chang Hsiao & Nan-Kai Wang
Additional file 2: Supplementary Fig. 2. Sanger sequencing of the PCDH15 gene. The sequence trace shows the PCDH15 variant, which is consistent with whole exome sequencing (WES) test results.

Additional file 1 of Case report: novel PCDH15 variant causes usher syndrome type 1F with congenital hearing loss and syndromic retinitis pigmentosa

Nelson Chen, Hane Lee, Angela H. Kim, Pei-Kang Liu, Eugene Yu-Chuan Kang, Yun-Ju Tseng, Go Hun Seo, Rin Khang, Laura Liu, Kuan-Jen Chen, We-Chi Wu, Meng-Chang Hsiao & Nan-Kai Wang
Additional file 1: Supplementary Fig. 1. Full-field electroretinography (ffERG) at presentation shows extinguished rod response, combined rod-cone response, cone response and 30 Hz flicker response in both eyes.

sj-doc-3-tct-10.1177_15330338221123634 - Supplemental material for Ixazomib Combined With Autologous Stem Cell Transplantation for POEMS Syndrome: A Case Report and Meta-Analysis

Ji Ma, Xiaoyue Wang, Hui Lu, Zhihao Liang & Liang Wang
Supplemental material, sj-doc-3-tct-10.1177_15330338221123634 for Ixazomib Combined With Autologous Stem Cell Transplantation for POEMS Syndrome: A Case Report and Meta-Analysis by Ji Ma, Xiaoyue Wang, Hui Lu, Zhihao Liang and Liang Wang in Technology in Cancer Research & Treatment

Association of capsular types with carbapenem resistance, disease severity, and mortality in Acinetobacter baumannii

Yu-Chia Hsieh, Shi-Heng Wang, Yi-Yin Chen, Tzu-Lung Lin, Shian-Sen Shie, Ching-Tai Huang, Chen-Hsiang Lee, Yi-Ching Chen, Tran Lam Tu Quyen & Yi-Jiun Pan
Acinetobacter baumannii emerged as one of the most important pathogens that causes nosocomial infections due to its increased multidrug resistance. Identifying capsular epidemiology in A. baumannii can aid in the development of effective treatments and preventive measures against this emerging pathogen. Here we established a wzc-based method, and combined it with wzy-PCR to determine capsular types of A. baumannii causing nosocomial bacteraemia collected at two medical centres in Taiwan from 2015 to 2017. Among the...

What is the impact of the COVID-19 pandemic on emergency medicine residency training: an observational study

Hsiang-Yun Lo, Shen-Che Lin, Chung-Hsien Chaou, Yu-Che Chang, Chip-Jin Ng & Shou-Yen Chen
Abstract Background The coronavirus disease 2019 (COVID-19) pandemic has engendered difficulties for health systems globally; however, the effect of the pandemic on emergency medicine (EM) residency training programs is unknown. The pandemic has caused reduced volumes of emergency department (ED) patients, except for those with COVID-19 infections, and this may reduce the case exposure of EM residents. The primary objective of this study was to compare the clinical exposure of EM residents between the prepandemic...

What is the impact of the COVID-19 pandemic on emergency medicine residency training: an observational study

Hsiang-Yun Lo, Shen-Che Lin, Chung-Hsien Chaou, Yu-Che Chang, Chip-Jin Ng & Shou-Yen Chen
Abstract Background The coronavirus disease 2019 (COVID-19) pandemic has engendered difficulties for health systems globally; however, the effect of the pandemic on emergency medicine (EM) residency training programs is unknown. The pandemic has caused reduced volumes of emergency department (ED) patients, except for those with COVID-19 infections, and this may reduce the case exposure of EM residents. The primary objective of this study was to compare the clinical exposure of EM residents between the prepandemic...

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