481 Works

Supplemental Material - The association between preoperative blood calcium and postoperative blood loss in patients undergoing heart valve replacement surgery

Mingke Li, Yawei Dai, Shuai Hu, Yansong Li, Dasheng Lu, Rui Zheng & Kai Wang
Supplementary Material for The association between preoperative blood calcium and postoperative blood loss in patients undergoing heart valve replacement surgery by Mingke Li, Yawei Dai, Shuai Hu, Yansong Li, Dasheng Lu, Rui Zheng, and Kai Wang in Perfusion.

Additional file 2 of SWI/SNF complex gene variations are associated with a higher tumor mutational burden and a better response to immune checkpoint inhibitor treatment: a pan-cancer analysis of next-generation sequencing data corresponding to 4591 cases

Yue Li, Xinhua Yang, Weijie Zhu, Yuxia Xu, Jiangjun Ma, Caiyun He & Fang Wang
Additional file 2: Fig. S2 The progression-free survival (PFS) of patients receiving immune checkpoint inhibitor (ICI) treatment based on cancer types. The survival analysis was performed for individual cancer types that contained at least 10 cases in the SWI/SNF-mutant or SWI/SNF-non-mutant groups. The PFS of the SWI/SNF-mutant group was significantly superior to that of the SWI/SNF-non-mutant group in colorectal cancer (a) and gastric cancer (b), the same tendency was significant numerically by not statistically in...

Additional file 1 of Genome-wide screening for differentially methylated long noncoding RNAs identifies LIFR-AS1 as an epigenetically regulated lncRNA that inhibits the progression of colorectal cancer

Peng Song, Ying Li, Feng Wang, Lingxiao Pu, Linsen Bao, Hengfei Gao, Chuandong Zhu, Meng Wang & Liang Tao
Additional file 1: Figure S1. Pie chart shows the number of differentially expressed lncRNAs in each category.

Additional file 1 of Cisplatin-loaded metal–phenolic network with photothermal-triggered ROS generation for chemo-photothermal therapy of cancer

Xiaoxiao Chen, Lulu Wang, Sijia Liu, Xuezhen Luo, Kai Wang & Qizhi He
Additional file 1: Figure S1. SEM image of TAFP. Figure S2. Elements mapping of TAFP including C, N, O, Pt elements. Figure S3. XPS spectrum of Pt 4f in TAFP indicating the existence of Pt element. Figure S4. Standard curve of DDP determined by HPLC at 254 nm. Figure S5. Zeta potential of TAFP dispersed in DI water. Figure S6. Fluorescence images of the uptake of TAFP by SKOV3 cells after co-incubation with TAFP for...

Cisplatin-loaded metal–phenolic network with photothermal-triggered ROS generation for chemo-photothermal therapy of cancer

Xiaoxiao Chen, Lulu Wang, Sijia Liu, Xuezhen Luo, Kai Wang & Qizhi He
Abstract Developing multifunctional composites has received widespread attention for cancer treatment. Herein, a metal–phenolic network (MPN)-based composite loading with chemotherapy agents (TAFP) exhibits high anti-tumor therapeutic efficacy via photothermal therapy (PTT), chemo-dynamic therapy (CDT), and chemotherapy. The nanocomposite was formed by mixing the chemotherapeutic drugs (cisplatin, DDP) into the tannic acid (TA) and Fe3+ network (TAFe) to integrate the synergistic effect of PTT, CDT, and chemotherapy. Due to the acidic tumor microenvironment, the active substances...

Development and validation of a combined model based on dual-sequence MRI radiomics for predicting the efficacy of high-intensity focused ultrasound ablation for hysteromyoma

Shize Qin, Yu Jiang, Fang Wang, Lingling Tang & Xiaohua Huang
To determine the value of dual-sequence magnetic resonance imaging (MRI)-based radiomics in predicting the efficacy of high-intensity focused ultrasound (HIFU) ablation for hysteromyoma. A total of 142 patients with 172 hysteromyomas (95 hysteromyomas from the sufficient ablation group, and 77 hysteromyomas from the insufficient ablation group) were enrolled in the study. The clinical–radiological model was constructed with independent clinical–radiological risk factors, the radiomics model was constructed based on the optimal radiomics features of hysteromyoma from...

The effect of a single escalating dose of long-acting recombinant human follicle-stimulating hormone Fc fusion protein (KN015) on healthy, pituitary-suppressed women: first-in-human and randomized study on its pharmacokinetics, pharmacodynamics, and tolerability

Hong Zhang, Yanyan Fan, Lei Gao, Boguang Wang, Ting Xu, Min Wu, Jingrui Liu, Xiaoxue Zhu, Xiaojiao Li, Hong Chen, Cuiyun Li, Meng Wang, Chengjiao Liu, Yanhong Mao, Mingtang Yang & Yanhua Ding
KN015 is a long-acting, recombinant human follicle-stimulating hormone Fc fusion protein that induces follicle development. This first-in-human study evaluated the effect of KN015 on healthy, pituitary-suppressed women and examined its pharmacokinetics, pharmacodynamics, and tolerability. This phase I study was a double-blind, randomized, and placebo-controlled design with a single ascending dose (20, 40, and 60 μg, respectively). After subcutaneous administration of a single dose, the maximum serum KN015 concentrations reached 1.57, 2.78, and 3.62 ng/mL, respectively,...

Non-small-cell lung cancer patients harboring TP53/KRAS co-mutation could benefit from a PD-L1 inhibitor Supplementary Figure 2

Chenyue Zhang, Kai Wang, Jiamao Lin & Haiyong Wang
Non-small-cell lung cancer patients harboring TP53/KRAS co-mutation could benefit from a PD-L1 inhibitor Supplementary Figure 2

Supplementary document for Global Phase Diagram of Bound States in the Continuum - 6128177.pdf

Peng Hu, Jiajun Wang, Qiao Jiang, Jun Wang, Lei Shi, Dezhuan Han, Zhao-Qing Zhang, Che Ting Chan & Jian Zi
Supplement 1-Phase diagram of BIC

Decreased echinocandin susceptibility in Candida parapsilosis causing candidemia and emergence of a pan-echinocandin resistant case in China

Yating Ning, Meng Xiao, David S. Perlin, Yanan Zhao, Minya Lu, Yi Li, Zhengyu Luo, Rongchen Dai, Shengjie Li, Jiajun Xu, Lingli Liu, Hong He, Yun Liu, Fushun Li, Yuguang Guo, Zhongju Chen, Yingchun Xu, Tianshu Sun & Li Zhang
Candida parapsilosis is becoming a predominant non-albicans cause of invasive candidiasis (IC). Echinocandins are the preferred choice for IC treatment and prophylaxis. Resistance to echinocandins in C. parapsilosis has emerged in several countries, but little is known about the susceptibility profile in China or about mechanisms of resistance. Here, we investigated the echinocandin susceptibilities of 2523 C. parapsilosis isolates collected from China and further explored the resistance mechanism among echinocandin-resistant isolates. Anidulafungin exhibited the highest...

Decreased echinocandin susceptibility in Candida parapsilosis causing candidemia and emergence of a pan-echinocandin resistant case in China

Yating Ning, Meng Xiao, David S. Perlin, Yanan Zhao, Minya Lu, Yi Li, Zhengyu Luo, Rongchen Dai, Shengjie Li, Jiajun Xu, Lingli Liu, Hong He, Yun Liu, Fushun Li, Yuguang Guo, Zhongju Chen, Yingchun Xu, Tianshu Sun & Li Zhang
Candida parapsilosis is becoming a predominant non-albicans cause of invasive candidiasis (IC). Echinocandins are the preferred choice for IC treatment and prophylaxis. Resistance to echinocandins in C. parapsilosis has emerged in several countries, but little is known about the susceptibility profile in China or about mechanisms of resistance. Here, we investigated the echinocandin susceptibilities of 2523 C. parapsilosis isolates collected from China and further explored the resistance mechanism among echinocandin-resistant isolates. Anidulafungin exhibited the highest...

Visualization 2.mp4

Yuhang Yin, Qilin Duan, Jing Li, Chengwei Qiu & Huanyang Chen
The dynamic evolution of rays in 3D geodesic lens.

Visualization 1.mp4

Yuhang Yin, Qilin Duan, Jing Li, Chengwei Qiu & Huanyang Chen
The dynamic evolution of waves in 2D MFE lens.

Supplementary document for Evolution of optical vortices in gradient media and curved spaces - 6196806.pdf

Yuhang Yin, Qilin Duan, Jing Li, Chengwei Qiu & Huanyang Chen
Supplemental Document

A DNA Damage Response Related Signature to Predict Prognosis in Patients with Acute Myeloid Leukemia

Jun Wang, Jiafei Wu, Yijing Wang, Yu Wang, Chuanyan Jiang, Mengying Zou, Xiaokang Jin, Xiaoran Sun, Yu Zhang, Sijia Ma, Guoqiang Wang, Xin Zhu, Huafei Lu, Chunwei Xu, Wenxian Wang, Leo Li, Yusheng Han, Shangli Cai & Hui Li
The prognosis of acute myeloid leukemia (AML) is disappointing in most subtypes and varies widely. DNA damage response (DDR) is associated with prognosis and immunotherapy in multiple cancers. Here, we identify a signature of eight DDR-related genes associated with overall survival, which stratifies AML patients into high- and low-risk groups. Patients in low-risk group were more likely to respond to sorafenib. The signature could be an independent prognostic predictor for patients treated with ADE and...

sj-docx-1-jbr-10.1177_07487304221141939 – Supplemental material for Validation of the Self-Rating of Biological Rhythm Disorder for Adolescents (SBRDA) Scale by Dim Light Melatonin Onset in Healthy Young Adults

Yang Xie, Xiaoyan Wu, Xingyue Mou, Meng Wang, Shuman Tao, Yuhui Wan & Fangbiao Tao
Supplemental material, sj-docx-1-jbr-10.1177_07487304221141939 for Validation of the Self-Rating of Biological Rhythm Disorder for Adolescents (SBRDA) Scale by Dim Light Melatonin Onset in Healthy Young Adults by Yang Xie, Xiaoyan Wu, Xingyue Mou, Meng Wang, Shuman Tao, Yuhui Wan and Fangbiao Tao in Journal of Biological Rhythms

Validation of the Self-Rating of Biological Rhythm Disorder for Adolescents (SBRDA) Scale by Dim Light Melatonin Onset in Healthy Young Adults

Yang Xie, Xiaoyan Wu, Xingyue Mou, Meng Wang, Shuman Tao, Yuhui Wan & Fangbiao Tao
Understanding the biological rhythms that influence young adult health is vital because the combination of biological changes and a circadian phase delay lead to young adults being at high risk of circadian misalignment. We have previously established a self-rating of biological rhythm disorder for adolescents (SBRDA). However, we did not externally validate the SBRDA against objective measures of biological rhythms such as dim light melatonin onset (DLMO)—the gold standard of the endogenous circadian phase. The...

Development and validation of an LC-MS/MS method for pharmacokinetic study of lobetyolin in rats

Haitao Tian, Pan Zhao, Jing Li, Zhipeng Deng, Gaobin Pu & Hong Wang
Abstract A simple and selective liquid chromatography tandem with mass spectrometry (LC-MS/ MS) method for quantification of lobetyolin in rat plasma was developed and validated. Chromatographic separation was achieved on a Thermo ODS C18 reversed-phase column using 0.1% aqueous formic acid-methanol (50:50, v/v) in an isocratic elution mode at a flow rate of 0.4 mL.min-1. LC/MS performance was done in a positive ion ESI mode and the MS/MS transitions were monitored at m/z 419.3 [M+Na]+...

Supplementary document for Evolution of optical vortices in gradient media and curved spaces - 6196806.pdf

Yuhang Yin, Qilin Duan, Jing Li, Chengwei Qiu & Huanyang Chen
Supplemental Document

Nanowire-in-Bowl-shaped Piezoelectric Cavity Structure for SERS Directional Detection of Nanoplastics less than 50 nm

Enze Lv, Junkun Wang, Jing Li, Xiaofei Zhao, Yu Jing, shicai xu, Zhen Li, yuan man, Mei xue & JiHua Xu
The accurate detection of nanoplastics is crucial due to their harmful effects on the environment and human beings. In this research, we successfully constructed an Ag/CuO nanowire (NW)/BaTiO3@PVDF Bowl-shaped substrate with a nanowire-in-Bowl-shaped piezoelectric cavity structure that can modulate surface-enhanced Raman scattering (SERS) by the piezoelectric effect by the virtue of the molecular gripper of the CuO NW and optical field amplifier of the Bowl-shaped cavity. Due to its unique nanowire-in-Bowl-shaped structure and piezoelectrically modifiable...

Supplementary document for Nanowire-in-Bowl-shaped Piezoelectric Cavity Structure for SERS Directional Detection of Nanoplastics less than 50 nm - 6228293.pdf

Enze Lv, Junkun Wang, Jing Li, Xiaofei Zhao, Yu Jing, shicai xu, Zhen Li, yuan man, Mei xue & JiHua Xu
Supplementary Material

RETRACTED ARTICLE: Sevoflurane suppresses migration and invasion of glioma cells by regulating miR-146b-5p and MMP16

Le Zhang, Jun Wang, Zhijie Fu, YanQiu Ai, Yanrong Li, Ying Wang & Yanping Wang
We, the Editors and Publisher of the journal Artificial Cells, Nanomedicine, and Biotechnology, have retracted the following article: Le Zhang, Jun Wang, Zhijie Fu, YanQiu Ai, Yanrong Li, Ying Wang & Yanping Wang (2019) Sevoflurane suppresses migration and invasion of glioma cells by regulating miR-146b-5p and MMP16. Artificial Cells, Nanomedicine, and Biotechnology, 47:1, 3306–3314, DOI: 10.1080/21691401.2019.1648282 Since publication, concerns have been raised about the integrity of the data in the article. When approached for an...

Co-encapsulation of magnetic Fe3O4 nanoparticles and doxorubicin into biocompatible PLGA-PEG nanocarriers for early detection and treatment of tumours

Chenghua Liang, Nan Li, Zikai Cai, Rongpu Liang, Xiaoming Zheng, Li Deng, Longbao Feng, Rui Guo & Bo Wei
At present, cancer is the first cause of death for humans, but early detection and treatment can help improve prognoses and reduce mortality. However, further development of carrier-assistant drug delivery systems (DDSs) is retarded by the aspects such as the low drug-carrying capacity, carrier-induced toxicity and immunogenicity, complex synthesis manipulation. The development of nanoscale drug delivery systems (NDDS) have been rapidly developed to address these issues. In this article, we used PLGA-PEG with good biocompatibility...

Population genetics and forensic efficiency of 30 InDel markers in four Chinese ethnic groups residing in Sichuan

Fei Wang, Guanglin He, Zheng Wang, Mengge Wang, Jing Liu, Xing Zou, Shouyu Wang, Mengyuan Song, Ziwei Ye, Mingkun Xie & Yiping Hou
Sichuan Province is located at the transitional junction regions of the Qinghai-Tibet Plateau and the low-altitude plains. It also serves as the corridor of Sino-Tibetan-speaking population migration and expansion since neolithic expansion of Proto-Tibeto-Burman populations from Middle/Upper Yellow River during Majiayao period (3300–2000 BC). However, the population structure and the corresponding genetic diversity of forensic-related markers in this region remain unclear. Thus, we genotyped 30 insertion-deletion (InDel) markers in 444 samples from four ethnic groups...

Development of an automatic integrated gene detection system for novel severe acute respiratory syndrome-related coronavirus (SARS-CoV2)

Yuchang Li, Jing Li, Ying Zhang, Lizhong Dai, Lin Li, Juan Liu, Sen Zhang, Xiaoyan Wu, Yi Hu, Chenfeng Qin, Tao Jiang & Xiaoping Kang
In December 2019, Wuhan, China suffered a serious outbreak of a novel coronavirus infectious disease (COVID) caused by novel severe acute respiratory syndrome-related coronavirus (SARS-CoV 2). To quickly identify the pathogen, we designed and screened primer sets, and established a sensitive and specific qRT-PCR assay for SARS-CoV 2; the lower limit of detection (LOD) was 14.8 (95% CI: 9.8–21) copies per reaction. We combined this qRT-PCR assay with an automatic integration system for nucleic acid...

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