Previous empirical evaluations of training programs aimed at improving dog adoption rates assume that dogs exhibiting certain behaviors are more adoptable. However, no systematic data are available to indicate that the spontaneous behavior of shelter dogs has an effect on adopter preference. The aim of the present study was to determine whether any behaviors that dogs exhibit spontaneously in the presence of potential adopters were associated with the dogs' length of stay in the shelter....

The ability to solve cognitive tasks depends upon adaptive changes in the organization of whole-brain functional networks. However, the link between task-induced network reconfigurations and their underlying energy demands is poorly understood. We address this by multimodal network analyses integrating functional and molecular neuroimaging acquired concurrently during a complex cognitive task. Task engagement elicited a marked increase in the association between glucose consumption and functional brain network reorganization. This convergence between metabolic and neural processes...

1. Emerging infectious diseases are one of the greatest threats to global biodiversity. Chytridiomycosis in amphibians is perhaps the most extreme example of this phenomenon known to science. Translocations are increasingly used to fight disease-induced extinctions. However, many programs fail because disease is still present or subsequently establishes in the translocation environment. There is a need for studies in real-world scenarios to test whether environmental manipulation could improve survival in populations by generating unfavourable environmental...

Social learning of novel threats coupled with adaptive generalization from learned to novel cues together provide the cognitive mechanisms by which adaptive avoidance of threats can spread rapidly both within and across generations. Whereas attention to effects of fishing and hunting on prey is increasing, nothing is known about how human predation can alter the behavior of invasive animals. Here, we examined whether common (Indian) mynas, Acridotheres tristis, one of the most widespread invasive birds...

Although classified among the greatest threats to the world's biodiversity, the effects of land use and their scale dependency are left unexplored in many taxonomic groups. Reptiles are among the most data‐deficient vertebrates in this respect, although their ecological traits make them highly sensitive to habitat modifications. We tested whether land use gradients shape the distributions of Mediterranean reptiles at regional and local scales, and whether species’ ecological traits and phylogeny explain these patterns. Reptiles...

Although corporate environmental responsibility (CER) can influence employees’ attitudes and behaviors, little research has been done to explain the effect of different dimensions of CER (e.g. substantive and symbolic CER) on employees’ pro-environmental behaviors at work, and further to explore the underlying mechanism and the boundary condition of this effect. This research built a theoretical model to explain how and when substantive and symbolic CER influences employees’ pro-environmental behaviors. 188 matched supervisor-subordinate dyads were collected...

Duloxetine is a commonly used antidepressant that is a serotonin and norepinephrine reuptake inhibitor. We aimed to investigate the frequency and severity of clinical effects following duloxetine overdose. We undertook a retrospective review of duloxetine overdoses (>120 mg) admitted to two tertiary toxicology units between March 2007 and May 2021. Demographic information, details of ingestion (dose, co-ingestants), clinical effects, investigations (ECG parameters including QT interval), complications (coma [GCS < 9], serotonin toxicity, seizures and cardiovascular...

Each year over 10,000 Australians who are treated for shock in intensive care unit (ICU) develop acute kidney injury (AKI). According to some series, up to half of these patients could die before leaving hospital. The annual burden of death due to shock with AKI is nearly thrice that of the annual road toll. Development of AKI during shock is an independent predictor of mortality, and its attributable excess treatment cost in Australia exceeds $80...

A phytochemical investigation of Bidens procera L.C.Xu ex X.W.Zheng afforded two novel polyacetylenes, tridecane-2E-monoene-4,6,8-triyntylen-1,13-diol-12-O-β-glucoside (1) and tetradecane-2E,8E-diene-4,6-diyne-1,14-diol-13-O-β-glucoside (2), together with ten known compounds (3 − 12). Their chemical structures were elucidated by NMR and MS spectrums as well as the comparison of the published data. Furthermore, the chemotaxonomy of the yielded compounds was also discussed.

Additional file 4: Supplemental Table S4. Primers used for qRT- PCR

Abstract Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the ninth member of the proprotein convertase family that regulates lipoprotein homeostasis and altered PCSK9 expression was reportedly associated with tumor development and progression. This study assessed PCSK9 expression and functions in human colon cancer and then explored the underlying molecular events. Methods Colon cancer tissues were utilized for analysis of PCSK9 expression for association with clinicopathological factors from patients by immunohistochemistry assay. Manipulation of PCSK9...

Additional file 2. CRE-IQI network survey, 2019.

Abstract Background From 2014 to 2019, the Centre for Research Excellence in Integrated Quality Improvement (CRE-IQI) was evaluated as an innovation platform focusing on continuous quality improvement in Indigenous Australian primary healthcare. Although social network analysis (SNA) is a recognized method for evaluating the functioning, collaboration and effectiveness of innovation platforms, applied research is limited. This study applies SNA to evaluate the CRE-IQI’s functioning as an innovation platform. Methods Two surveys (2017, 2019) were conducted...

Additional file 1: Supplemental Figure 1. The cytotoxicity of B7-H3CAR-T cells against solid tumor cell lines was analyzed by RTCA assay. The redarrow represents the time point of effector cell addition.

Additional file 2: Supplemental Table S2. ThesiRNA sequences of NC and siPCSK9

Abstract Introduction The past decade has increasingly seen systems approaches as a featured theme in public health studies and policy documents. This trend is evident in the area of physical activity, which is a significant global health risk factor that is addressed in WHO’s Global Action Plan on Physical Activity. We undertook a comprehensive scoping review to characterize the application of systems approaches to physical activity, to develop a typology of the objectives, themes and...

Additional file 4. Women's interview codebook.

Additional file 1. COREQ checklist.

Understanding species-specific resource requirements is paramount in managing and protecting biodiversity in a world where environmental quality is in decline. Dietary data can inform predator–prey relationships and how changes in prey availability impact different species. However, for many coral reef fishes, prey and predatory events can be difficult to observe and identify, both in situ and within examined stomach samples. Here we applied DNA metabarcoding of stomach content samples for eleven Red Sea butterflyfish species...

Additional file 2. CHEERS checklist.

Abstract Background Genomic analysis indicated that the genomes of ascomycetes might carry dozens of biosynthetic gene clusters (BGCs), yet many clusters have remained enigmatic. The ascomycete genus Epicoccum, belonging to the family Didymellaceae, is ubiquitous that colonizes different types of substrates and is associated with phyllosphere or decaying vegetation. Species of this genus are prolific producers of bioactive substances. The epicoccamides, as biosynthetically distinct mannosylated tetramate, were first isolated in 2003 from Epicoccum sp. In...

Rationale:The evidence base for acute post-stroke rehabilitation is inadequate and global guideline recommendations vary.Aim:To define optimal early mobility intervention regimens for ischemic stroke patients of mild and moderate severity.Hypotheses:Compared with a prespecified reference arm, the optimal dose regimen(s) will result in more participants experiencing little or no disability (mRS 0–2) at 3 months post-stroke (primary), fewer deaths at 3 months, fewer and less severe complications during the intervention period, faster recovery of unassisted walking, and...

There is limited information on the risk of chronic kidney disease (CKD) following snakebite and its relationship with chronic interstitial nephritis in agricultural communities (CINAC). We aimed to investigate CKD in patients with a confirmed snakebite in rural Sri Lanka. Patients prospectively recruited to the Anuradhapura snakebite cohort with authenticated bites were followed up. Two groups of patients were followed up: 199 patients in group I with a snakebite (August 2013–October 2014), reviewed after 4...

There is limited information on the risk of chronic kidney disease (CKD) following snakebite and its relationship with chronic interstitial nephritis in agricultural communities (CINAC). We aimed to investigate CKD in patients with a confirmed snakebite in rural Sri Lanka. Patients prospectively recruited to the Anuradhapura snakebite cohort with authenticated bites were followed up. Two groups of patients were followed up: 199 patients in group I with a snakebite (August 2013–October 2014), reviewed after 4...

Contents of the Supplementary Information: Appendix 1. Rapid review protocol Appendix 2. Summary of searches undertaken Appendix 3. Detailed characteristics of all sources included in the study Appendix 4. Policy options in detail
Checklist for: "Options for modifying UK alcohol and tobacco tax: A rapid scoping review of the evidence over the period 1997–2018"
The reporting follows the PRISMA extension for scoping reviews (PRISMA-ScR)
Tricco AC, Lillie E, Zarin W. Prisma...