17 Works

Identification of GGC repeat expansion in the NOTCH2NLC gene in amyotrophic lateral sclerosis

Yanchun Yuan, Zhen Liu, Xuan Hou, Wanzhen Li, Jie Ni, Ling Huang, Yiting Hu, Pan Liu, Xiaorong Hou, Jin Xue, Qiying Sun, Yun Tian, Bin Jiao, Ranhui Duan, Hong Jiang, Lu Shen, Beisha Tang & Junling Wang
Objective: To determine whether the GGC repeats in the NOTCH2NLC gene contribute to amyotrophic lateral sclerosis (ALS). Methods In this study, 545 ALS patients and 1305 healthy controls from mainland China were recruited. Several pathogenic mutations in known ALS-causative genes, including polynucleotide repeat expansions in the C9ORF72, ATXN2, NOP56, and AR genes, had already been excluded. Repeat-primed PCR (RP-PCR) and GC-rich PCR were performed to determine the GGC repeat size in NOTCH2NLC. Systematic and targeted...

Data from: Peripheral blood mitochondrial DNA copy number is associated with prostate cancer risk and tumor burden

Weimin Zhou, Min Zhu, Ming Gui, Lihua Huang, Zhi Long, Li Wang, Hui Chen, Yinghao Yin, Xianzhen Jiang, Yingbo Dai, Yuxin Tang, Leye He & Kuangbiao Zhong
Alterations of mitochondrial DNA (mtDNA) have been associated with the risk of a number of human cancers; however, the relationship between mtDNA copy number in peripheral blood leukocytes (PBLs) and the risk of prostate cancer (PCa) has not been investigated. In a case-control study of 196 PCa patients and 196 age-paired healthy controls in a Chinese Han population, the association between mtDNA copy number in PBLs and PCa risk was evaluated. The relative mtDNA copy...

Data from: Shifts of tundra bacterial and archaeal communities along a permafrost thaw gradient in Alaska

Jie Deng, Yunfu Gu, Jin Zhang, Kai Xue, Yujia Qin, Mengting Yuan, Huaqun Yin, Zhili He, Liyou Wu, Edward Schuur, James Tiedje, Jizhong Zhou, James M. Tiedje & Edward A. G. Schuur
Understanding the response of permafrost microbial communities to climate warming is crucial for evaluating ecosystem feedbacks to global change. This study investigated soil bacterial and archaeal communities by Illumina MiSeq sequencing of 16S rRNA gene amplicons across a permafrost thaw gradient at different depths in Alaska with thaw progression for over three decades. Over 4.6 million passing 16S rRNA gene sequences were obtained from a total of 97 samples, corresponding to 61 known classes and...

Data from: iTRAQ-based quantitative proteomic analysis on S100 calcium binding protein A2 in metastasis of laryngeal cancer

Cong Zha, Xue-Hua Jiang, Shi Fang Peng & Xue Hua Jiang
Laryngeal cancer is the most frequent neoplasm in the head and neck region, with the vast majority of tumors originating from squamous cells. The survival rate of patients with laryngeal cancer has not improved substantially over the past 25 years. To acquire further knowledge regarding the molecules responsible for laryngeal cancer oncogenesis and, in turn, to improve target therapy,iTRAQ and mass spectrometry analysis were utilized to detect differences in protein expression from 15 paired laryngeal...

Data from: Design and tailoring of inks for inkjet patterning of metal oxides

Mei Fang, Tianli Li, Sangjian Zhang, Venkat Rao & Lyuba Belova
Inkjet printing has become a promising, efficient, inexpensive, scalable technique for materials deposition, mask-less and digital patterning in many device applications. Meanwhile, the ink preparation remains a challenge especially for printing functional oxide materials. Based on the principles of inkjet printing (especially relevant for piezoelectric drop-on-demand inkjet printer) and the process of the conversion of liquid ink into solid thin films of oxide materials, we present two approaches to the design and tailoring of inks:...

Subduction thermal regime, slab dehydration, and seismicity distribution beneath Hikurangi based on 3-D simulations

Nobuaki Suenaga, Yingfeng Ji, Shoichi Yoshioka & Deshan Feng
The downdip limit of seismogenic interfaces inferred from the subduction thermal regime by thermal models has suggested relating to the faulting instability caused by brittle failure regime in various plate convergent systems. However, the featured three-dimensional (3-D) temperature structure especially along the horizontal two-dimensional (2-D) dimension of a subduction zone remains still poorly constrained. To robustly investigate and further map the horizontal distribution of subduction regime and subsequently induced slab dewatering in a decent plate...

Data from: Preparation of nanoporous BiVO4/TiO2/Ti film through electrodeposition for photoelectrochemical water splitting

Hongxing Dong, Qiuping Liu, Yuehui He, He Yuehui & Liu Qiuping
A nanoporous BiVO4/TiO2/Ti film was successfully fabricated by electrodepositing a nanoporous BiOI film on nanoporous TiO2 arrays followed by annealing at 450°C for 2 h. The electrodeposition of BiOI film was carried out at different times (10, 30, 100, 500, and 1000 s) in Bi(NO3)3 and KI solution. The morphological, crystallographic, and photoelectrochemical properties of the prepared BiVO4/TiO2/Ti heterojunction film were examined by using different characterization techniques. UV-vis spectrum absorption studies confirmed an increase in...

Data from: Assessment of dynamic material properties of intact rocks using seismic wave attenuation: an experimental study

W.A.M. Wanniarachchi, P.G. Ranjith, M.S.A. Perera, Tharaka D. Rathnaweera, Qiao Lyu, Bankim Mahanta, M. S. A. Perera, P. G. Ranjith & W. A. M. Wanniarachchi
The mechanical properties of any substance are essential facts to understand its behaviour and make the maximum use of the particular substance. Rocks are indeed an important substance, as they are of significant use in the energy industry, specifically for fossil fuels and geothermal energy. Attenuation of seismic waves is a non-destructive technique to investigate mechanical properties of reservoir rocks under different conditions. The attenuation characteristics of five different rock types, siltstone, shale, Australian sandstone,...

Data from: Biphasic decline pattern of beta-cell function in adult-onset latent autoimmune diabetes: an 8-year prospective study

Xia Li, Yan Chen, Yuting Xie, Yufei Xiang, Xiang Yan, Gan Huang & Zhiguang Zhou
Objective: To explore the decline pattern and possible determinants of beta-cell function progression in patients with adult-onset latent autoimmune diabetes (LADA). Research Design and Methods: 106 LADA individuals were enrolled and followed up annually in this 8-year prospective study and pattern of beta-cell function progression was assessed. Beta-cell function failure was defined by the fasting C-peptide (FCP) <75 pmol/L. Other clinical characteristics including age of onset, body mass index (BMI), GAD autoantibody (GADA) titer were...

Data from: The microbially-mediated soil organic carbon loss under degenerative succession in an alpine meadow

Yuguang Zhang, Xiao Liu, Jing Cong, Hui Lu, Yuyu Sheng, Xiulei Wang, Diqiang Li, Xueduan Liu, Huaqun Yin, Jizhong Zhou & Ye Deng
Land-cover change has long been recognized as having marked effect on the amount of soil organic carbon (SOC). However, the microbially-mediated processes and mechanisms on SOC are still unclear. In this study, the soil samples in a degenerative succession from alpine meadow to alpine steppe meadow in the Qinghai-Tibetan Plateau were analyzed using high-throughput technologies, including Illumina sequencing and GeoChip functional gene arrays. The soil microbial community structure and diversity were significantly (P < 0.05)...

Data from: Association of serum neurofilament light (sNfL) and disease severity in patients with spinocerebellar ataxia type 3

Yun Peng, Youming Zhang, Zhao Chen, Huirong Peng, Na Wan, Jennifer Zhang, Jingyi Tang, Puzhi Wang, Yue Xie, Qiyong Cai, Shaohui Liu, Xuewei Zhang, Chunrong Wang, Hongyu Yuan, Tianjiao Li, Linlin Wan, Yuting Shi, Rong Qiu, Thomas Klockgether, Beisha Tang, Weihua Liao & Hong Jiang
Objective: To investigate serum neurofilament light protein (sNfL) levels in patients with spinocerebellar ataxia type 3 (SCA3) and to determine whether they are associated with disease severity. Methods: This cross-sectional study enrolled 185 healthy controls and 235 ATXN3 mutation carriers (17 asymptomatic stage, 20 preclinical stage, and 198 ataxic stage). We measured sNfL levels with the single molecule array (Simoa) platform. Clinical disease severity was assessed using the scale of assessment and rating of ataxia...

The effect of precursor speciation on the growth of scorodite in an atmospheric scorodite synthesis

Zhihao Rong, Xincun Tang, Liping Wu, Xi Chen, Wei Dang, Liuchun Huang, Xing Li & Yang Wang
In this study, we propose a growth pathaway of scorodite in an atmospheric scorodite synthesis. Scorodite is a non-direct product, which is derived from the transformation of its precursor, ferrihydrite or poorly crystalline ferric arsenate. Different precursor speciation leads to different crystallinity and morphology of synthesized scorodite. At 10 and 20 g·L-1 initial arsenic concentration, the precursor of scorodite is identified as ferrihydrite. At 10 g·L-1 initial arsenic concentrtaion, low arsenic concentrtaion is unfavourable to...

Data from: A new method for evaluating the rock mass damage index based on the field point load strength

Lei Wen, Zhou Quan Luo, Shi Jiao Yang, Ya Guang Qin, Shao Wei Ma & Hong Jiang
The damage index is a crucial controlling parameter for rock mass strength and deformation in civil, geological and mining engineering projects. In this study, a new method was proposed for computing the damage index of a rock mass based on the field point load strength. This method provides a strength ratio whose numerator is the point load strength (PLS) of splitting along the pre-existing joint and whose denominator is the PLS of intact rock failure....

Data from: Single-dose intra-articular bupivacaine plus morphine after knee arthroscopic surgery: a meta-analysis of randomized placebo-controlled studies

Yi-Lun Wang, Chao Zeng, Dong-Xing Xie, Ye Yang, Jie Wei, Tuo Yang, Hui Li & Guang-Hua Lei
Objectives: To evaluate the efficacy and safety of single-dose intra-articular bupivacaine plus morphine after knee arthroscopic surgery. Design: Meta-analysis. Data sources and study eligibility criteria: A comprehensive literature search, using Medline (1966–2014), the Cochrane Central Register of Controlled Trials and Embase databases, was conducted to identify randomised placebo-controlled trials that used a combination of single-dose intra-articular bupivacaine and morphine for postoperative pain relief. Results: 12 articles were included in this meta-analysis. The mean visual analogue...

Data from: Effects of stand age, richness and density on productivity in subtropical forests in China

Shuai Ouyang, Wenhua Xiang, Xiangping Wang, Wen-Fa Xiao, Liang Chen, Shenggong Li, Han Sun, Xiangwen Deng, David Forrester, Lixiong Zeng, Pifeng Lei, Xiangdong Lei, Mengmeng Gou & Changhui Peng
1. Forest productivity may be determined not only by biodiversity but also by environmental factors and stand structure attributes. However, the relative importance of these factors in determining productivity is still controversial for subtropical forests. 2. Based on a large dataset from 600 permanent forest inventory plots across subtropical China, we examined the relationship between biodiversity and forest productivity and tested whether stand structural attributes (stand density in terms of trees per ha, age and...

Data from: Mechanism of Ca2+, Mg2+ and Fe3+ in fine cassiterite flotation using octanohydroxamic acid

Liuyi Ren, Hang Qiu, Wenqing Qin, Ming Zhang, Yubiao Li & Penggang Wei
The existence of metal ion should not be ignored in both hydrometallurgy and flotation. In this study, the effects of Ca2+, Mg2+ and Fe3+ on the flotation performance of cassiterite using octanohydroxamic acid (OHA) as the collector were investigated by the micro-flotation tests, X-ray photoelectron spectroscopy (XPS), fourier transform infrared spectroscopy (FTIR), contact angle, zeta (ζ) potential measurements and atomic force microscopy (AFM) imaging. The results of the flotation and contact angle experiments showed that...

Identification of GGC repeat expansion in the NOTCH2NLC gene in amyotrophic lateral sclerosis

Yanchun Yuan, Zhen Liu, Xuan Hou, Wanzhen Li, Jie Ni, Ling Huang, Yiting Hu, Pan Liu, Xiaorong Hou, Jin Xue, Qiying Sun, Yun Tian, Bin Jiao, Ranhui Duan, Hong Jiang, Lu Shen, Beisha Tang & Junling Wang
Objective To determine whether the GGC repeats in the NOTCH2NLC gene contribute to amyotrophic lateral sclerosis (ALS). Methods In this study, 545 ALS patients and 1305 healthy controls from mainland China were recruited. Several pathogenic mutations in known ALS-causative genes (including C9ORF72 and ATXN2) and polynucleotide repeat expansions in NOP56 and AR genes were excluded. Repeat-primed polymerase chain reaction PCR (RP-PCR) and GC-rich PCR were performed to determine the GGC repeat size in NOTCH2NLC. Systematic...

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  • Xiangya Hospital Central South University
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