84 Works

Quantifying the Prosecutorial Preauthorization Intake System and the Costs of ‘No Action’ Cases

Pablo A. Ormachea, Sasha Davenport, Gabe Haarsma & David M. Eagleman
In most jurisdictions, a police officer arrests and books a defendant, then files the criminal complaint before a judge. The judge sets bail, and if necessary, appoints defense counsel for the accused. Inadequate cases are later dropped – often weeks or months later – by prosecutors. This happens only after extensive investigation and usually not before the accused spent several nights in detention. In 1973, Harris County, Texas developed a solution to this inefficiency: prosecutors...

Hormonal and neural correlates of care in active versus observing poison frog parents

Eva K. Fischer & Lauren A. O'Connell
The occasional reversal of sex-typical behavior suggests that many of the neural circuits underlying behavior are conserved between males and females and can be activated in response to the appropriate social condition or stimulus. Most poison frog species (Family Dendrobatidae) exhibit male uniparental care, but flexible compensation has been observed in some species, where females will take over parental care duties when males disappear. We investigated hormonal and neural correlates of sex-typical and sex-reversed parental...

Genetic Adaptation in New York City Rats

Arbel Harpak, Nandita Garud, Noah Rosenberg, Dmitri Petrov, Pleuni Pennings & Jason Munshi-South
Brown rats (Rattus norvegicus) thrive in urban environments by navigating the anthropocentric environment and taking advantage of human resources and by-products. From the human perspective, rats are a chronic problem that causes billions of dollars in damage to agriculture, health and infrastructure. Did genetic adaptation play a role in the spread of rats in cities? To approach this question, we collected whole-genome sequences from 29 brown rats from New York City (NYC) and scanned for...

Data from: The effects of ground-irregularity-cancelling prosthesis control on balance over uneven surfaces

Vincent Chiu, Alexandra Voloshina & Steven Collins
Over half of individuals with a lower-limb amputation are unable to walk on uneven terrain. Using a prosthesis emulator system, we developed an irregularity-cancelling controller intended to reduce the effect of disturbances resulting from uneven surfaces. This controller functions by changing the neutral angles of two forefoot digits in response to local terrain heights. To isolate the effects of the controller, we also programmed a spring-like controller that maintained fixed neutral angles. Five participants with...

Maps of northern peatland extent, depth, carbon storage and nitrogen storage

Gustaf Hugelius, Julie Loisel, Sarah Chadburn, Robert B. Jackson, Miriam Jones, Glen MacDonald, Maija Marushchak, David Olefeldt, Maara Packalen, Matthias B. Siewert, Claire Treat, Merritt Turestsky, Carolina Voigt & Zicheng Yu
This dataset is grids of peatland extent, peat depth, peatland organic carbon storage, peatland total nitrogen storage and approximate extent of ombrotrophic/minerotrophic peatlands. The grids are geotiff files in 10 km pixel resolution projected in the World Azimuthal Equidistant projection. Note that the peat depth grid shows potential peat depth everywhere,also where there is no peatland cover. For files on peatland organic carbon, total nitrogen extent and extent of ombrotrophic/minerotrophic peatlands, there are separate files...

Data from: Gene expression correlates of social evolution in coral reef butterflyfishes

Jessica Nowicki, Morgan Pratchett, Stefan Walker, Darren Coker & Lauren O'Connell
Animals display remarkable variation in social behavior. However, outside of rodents, little is known about the neural mechanisms of social variation, and whether they are shared across species and sexes, limiting our understanding of how sociality evolves. Using coral reef butterflyfishes, we examined gene expression correlates of social variation (i.e., pair bonding vs. solitary living) within and between species and sexes. In several brain regions, we quantified gene expression of receptors important for social variation...

Bio-optical Database of the Arctic Ocean

Kate Lewis, Gert Van Dijken & Kevin Arrigo
The Arctic bio-optical database assembles a diverse suite of biological and optical data from 34 expeditions throughout the Arctic Ocean. Data combined into a single AO database following the OBPG criteria (Pegau et al. 2003), as was done in the development of the global NASA Bio-optical Marine Algorithm Data Set (NOMAD) (Werdell 2005, Werdell & Bailey 2005). This Arctic database combines coincident in situ observations of IOPs, apparent optical properties (AOPs), Chl a, environmental data...

Versatile simulations of admixture and accurate local ancestry inference with mixnmatch and ancestryinfer

Molly Schumer, Daniel Powell & Russell Corbett-Detig
It is now clear that hybridization between species is much more common than previously recognized. As a result, we now know that the genomes of many modern species, including our own, are a patchwork of regions derived from past hybridization events. Increasingly researchers are interested in disentangling which regions of the genome originated from each parental species using local ancestry inference methods. Due to the diverse effects of admixture, this interest is shared across disparate...

Raw images of targeted gearshifting in actin-based active nematic liquid crystals

Steven Redford, Rui Zhang, Paul Ruijgrok, Nitin Kumar, Ali Mozaffari, Sasha Zemsky, Aaron Dinner, Vincenzo Vitelli, Zev Bryant, Margaret Gardel & Juan De Pablo
Active materials are capable of converting free energy into mechanical work to produce autonomous motion, and exhibit striking collective dynamics that biology relies on for essential functions. Controlling those dynamics and transport in synthetic systems has been particularly challenging. Here, we introduce the concept of spatially structured activity as a means to control and manipulate transport in active nematic liquid crystals consisting of actin filaments and light-sensitive myosin motors. Simulations and experiments are used to...

Landscape simplification increases vineyard pest outbreaks and insecticide use

Daniel Paredes, Jay Rosenheim, Rebecca Chaplin-Kramer, Silvia Winter & Daniel Karp
Diversifying agricultural landscapes may mitigate biodiversity declines and improve pest management. Yet landscapes are rarely managed to suppress pests, in part because researchers seldom measure key variables related to pest outbreaks and insecticides that drive management decisions. We used a 13-year government database to analyze landscape effects on European grapevine moth (Lobesia botrana) outbreaks and insecticides across ~400 Spanish vineyards. At harvest, we found pest outbreaks increased four-fold in simplified, vineyard-dominated landscapes compared to complex...

Analysis of measles-mumps-rubella (MMR) titers of recovered COVID-19 patients

Jeffrey Gold, William Baumgartl, Ramazan Okyay, Warren Licht, Paul Fidel, Mairi Noverr, Larry Tilley, David Hurley, Balázs Rada & John Ashford
The measles-mumps-rubella (MMR) vaccine has been theorized to provide protection against COVID-19. Our aim was to determine whether any MMR IgG titers are inversely correlated with severity in recovered COVID-19 patients previously vaccinated with MMR II. We divided 80 subjects into two groups, comparing MMR titers to recent COVID-19 severity. The MMR II group consisted of 50 subjects who would primarily have MMR antibodies from the MMR II vaccine, and a comparison group of 30...

Transmission of West Nile and five other temperate mosquito-borne viruses peaks at temperatures between 23-26ºC

Marta Shocket, Anna Verwillow, Mailo Numazu, Hani Slamani, Jeremy Cohen, Fadoua El Moustaid, Jason Rohr, Leah Johnson & Erin Mordecai
The temperature-dependence of many important mosquito-borne diseases has never been quantified. These relationships are critical for understanding current distributions and predicting future shifts from climate change. We used trait-based models to characterize temperature-dependent transmission of 10 vector–pathogen pairs of mosquitoes (Culex pipiens, Cx. quinquefascsiatus, Cx. tarsalis, and others) and viruses (West Nile, Eastern and Western Equine Encephalitis, St. Louis Encephalitis, Sindbis, and Rift Valley Fever viruses), most with substantial transmission in temperate regions. Transmission is...

Variable prediction accuracy of polygenic scores within an ancestry group

Hakhamanesh Mostafavi, Arbel Harpak, Ipsita Agarwal, Dalton Conley, Jonathan Pritchard & Molly Przeworski
Fields as diverse as human genetics and sociology are increasingly using polygenic scores based on genome-wide association studies (GWAS) for phenotypic prediction. However, recent work has shown that polygenic scores have limited portability across groups of different genetic ancestries, restricting the contexts in which they can be used reliably and potentially creating serious inequities in future clinical applications. Using the UK Biobank data, we demonstrate that even within a single ancestry group (i.e., when there...

Data from: Predators can influence the host-parasite dynamics of their prey via non-consumptive effects

Nicolette Zukowski, Devin Kirk, Kiran Wadhawan, Dylan Shea, Denon Start & Martin Krkosek
Ecological communities are partly structured by indirect interactions, where one species can indirectly affect another by altering its interactions with a third species. In the absence of direct predation, non-consumptive effects of predators on prey have important implications for subsequent community interactions. To better understand these interactions, we used a Daphnia-parasite-predator cue system to evaluate if predation risk affects Daphnia responses to a parasite. We investigated the effects of predator cues on two aspects of...

Data from: Age influences the thermal suitability of Plasmodium falciparum transmission in the Asian malaria vector Anopheles stephensi

Courtney Murdock, Kerri Miazgowicz, Erin Mordecai, Sadie Ryan, Richard Hall, Harry Owen, Temitayo Adanlawo, Kavya Balaji, Marta Shocket, Oswaldo Villena, Leah Johnson, Blanka Tesla, Leah Demakovsky, Matt Bonds, Calistus Ngonghala & Melinda Brindley
Models predicting disease transmission are vital tools for long-term planning of malaria reduction efforts, particularly for mitigating impacts of climate change. We compared temperature-dependent malaria transmission models when mosquito life history traits were estimated from a truncated portion of the lifespan (a common practice) to traits measured across the full lifespan. We conducted an experiment on adult female Anopheles stephensi, the Asian urban malaria mosquito, to generate daily per capita values for mortality, egg production,...

Data from: Depth dependent dive kinematics suggest cost-efficient foraging strategies by tiger sharks

Samantha Andrzejaczek, Adrian Gleiss, Karissa Lear, Charitha Pattiaratchi, Taylor Chapple & Mark Meekan
Tiger sharks Galeocerdo cuvier are a keystone, top-order predator that are assumed to engage in cost-efficient movement and foraging patterns. To investigate the extent to which patterns of oscillatory diving by these animals conform to these patterns, we used a biologging approach to model their cost of transport. High-resolution biologging tags with tri-axial sensors were deployed on 21 tiger sharks at Ningaloo Reef for durations of 5-48 hours. Using overall dynamic body acceleration (ODBA) as...

Elevated atmospheric concentrations of CO2 increase endogenous immune function in a specialist herbivore

Leslie Decker, Chris Jeffrey, Kaitlin Ochsenrider, Abigail Potts, Jaap De Roode, Angela Smilanich & Mark Hunter
1. Animals rely on a balance of endogenous and exogenous sources of immunity to mitigate parasite attack. Understanding how environmental context affects that balance is increasingly urgent under rapid environmental change. In herbivores, immunity is determined, in part, by phytochemistry which is plastic in response to environmental conditions. Monarch butterflies, Danaus plexippus, consistently experience infection by a virulent parasite, Ophryocystis elektroscirrha, and some medicinal milkweed (Asclepias) species, with high concentrations of toxic steroids (cardenolides), provide...

Human Responses to Visually Evoked Threat

Melis Yilmaz Balban, Erin Cafaro, Lauren Saue-Fletcher, Marlon Joseph Washington, Maryam Bijanzadeh, Andrew Moses Lee, Edward Chang & Andrew Huberman
Vision is the primary sense humans use to evaluate and respond to threats. Understanding the biological underpinnings of the human threat response has been hindered by lack of realistic in-lab threat paradigms. We established an immersive Virtual Reality (VR) platform to simultaneously measure behavior, physiological state and neural activity from the human brain using chronically implanted electrodes. Subjects with high anxiety showed increased visual scanning in response to threats as compared to healthy controls. In...

A single heat stress bout induces rapid and prolonged heat acclimation in the California mussel, Mytilus californianus

Nicole Moyen, Rachel Crane, George Somero & Mark Denny
Climate change is not only causing steady increases in average global temperatures but also increasing the frequency with which extreme heating events occur. These extreme events may be pivotal in determining the ability of organisms to persist in their current habitats. Thus, it is important to understand how quickly an organism’s heat tolerance can be gained and lost relative to the frequency with which extreme heating events occur in the field. We show that the...

Small shelly fossils and carbon isotopes from the early Cambrian (Stage 3-4) Mural Formation of western Laurentia

Christian B. Skovsted, Uwe Balthasar, Jakob Vinther & Erik Sperling
The extraordinary window of phosphatised and phosphatic Small Shelly Fossils (SSFs) during the early and middle Cambrian is an important testament to the radiation of biomineralising metazoans. While SSF are well known from most Cambrian palaeocontinents during this time interval, western Laurentia has relatively few SSF faunas. Here we describe a diverse SSF fauna from the early Cambrian (Stage 3-4) Mural Formation at three localities in Alberta and British Columbia, Canada, complemented by carbon isotope...

Association of CSF biomarkers with hippocampal-dependent memory in preclinical Alzheimer disease

Alexandra Trelle
Objective: To determine if memory tasks with demonstrated sensitivity to hippocampal function can detect variance related to preclinical Alzheimer’s disease (AD) biomarkers, we examined associations between performance in three memory tasks and CSF Ab42/Ab40 and p-tau181 in cognitively unimpaired older adults (CU). Methods: CU enrolled in the Stanford Aging and Memory Study (N=153; age 68.78 ± 5.81 yrs; 94 female) completed a lumbar puncture and memory assessments. CSF Ab42, Ab40, and phosopho-tau181 (p-tau181) were measured...

Supplemental Online Materials of Trends in Land Surface Phenology across the Conterminous United States (1982-2016) Analyzed by NEON Domains

Liang Liang, Geoffrey Henebry, lingling liu, Xiaoyang Zhang & Li-Chih Hsu
This research investigated land surface phenology trends across the conterminous United States (1982-2016)by National Ecological Observatory Network (NEON) domains. The Supplemental Online Materials (SOM) contain two Appendices. Appendix S1 contains NEON domain-specific results, supplemental tables and figures. Appendix S2 contains datasets of the analysis results. Users can utilize these data to perform customized analysis in lieu of the published outcomes.

Modeling Behavior in Truth Value Judgment Task Experiments

Brandon Waldon & Judith Degen

WiDS (Women in Data Science) Datathon 2020: ICU Mortality Prediction

Meredith Lee, Jesse Raffa, Marzyeh Ghassemi, Tom Pollard, Sharada Kalanidhi, Omar Badawi, Karen Matthys & Leo Anthony Celi
WiDS (Women in Data Science) Datathon 2020: ICU Mortality Prediction focuses on patient health through data from MIT’s GOSSIS (Global Open Source Severity of Illness Score) initiative. Brought to you by the Global WiDS team, the West Big Data Innovation Hub, and the WiDS Datathon Committee, this year’s datathon is launching on Kaggle: bit.ly/WiDSdatathon2020kaggle.

DialectGram: Detecting Dialectal Variation at Multiple Geographic Resolutions

Hang Jiang, Haoshen Hong, Yuxing Chen & Vivek Kulkarni

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