143 Works

New steroids from the pericarps of Datura metel L

Yan Liu, Yuan Liu, Hai-dan Zou, Yong-qiang Zhou, Juan Pan, Wei Guan, Adnan Mohammed Algradi, Bing-you Yang & Hai-xue Kuang
Three new steroids (1–3) and 13 reported analogs (4–16) were extracted from Datura metel L. pericarps. Structure analysis of these extracted compounds was performed by 1 D-NMR and 2 D-NMR spectroscopy, and their spectra were compared with those of similar compounds previously described in the literature. The extracted steroids (1–3) and known compounds (4–16) were evaluated for anti-inflammatory activity against LPS-activated RAW 264.7 cells. Compounds 5, 7, 9, 12 and 15 showed potential anti-inflammatory activity...

MicroRNA-455-3p accelerate malignant progression of tumor by targeting H2AFZ in colorectal cancer

Lizhen Ye, Tingting Fan, Ying Qin, Cheng Qiu, Lulu Li, Mengmeng Dai, Yaoyao Zhou, Yan Chen & Yuyang Jiang
Colorectal cancer (CRC) becomes the second leading cause of cancer-related deaths in 2020. Emerging studies have indicated that microRNAs (miRNAs) play a key role in tumorigenesis and progression. The dysfunctions of miR-455-3p are observed in many cancers. However, its biological function in CRC remains to be confirmed. By sequencing serum sample, miR-455-3p was found to be up-regulated in CRC patients. RT-qPCR demonstrated that the miR-455-3p expression was both higher in the serum and tumor tissues...

Additional file 1 of Specific triacylglycerol, diacylglycerol, and lyso-phosphatidylcholine species for the prediction of type 2 diabetes: a ~ 16-year prospective study in Chinese

Junda Zhong, Chloe Y. Y. Cheung, Xiuli Su, Chi-Ho Lee, Yi Ru, Carol H. Y. Fong, Yan Liu, Cynthia K. Y. Cheung, Karen S. L. Lam, Zongwei Cai & Aimin Xu
Additional file 1. Methods. Figure S1. WGCNA of the lipid species profile. Figure S2. Boruta analysis result. Figure S3. Violin Plot of the Targeted Lipidomics. Figure S4. Correlation among identified lipid species.

Specific triacylglycerol, diacylglycerol, and lyso-phosphatidylcholine species for the prediction of type 2 diabetes: a ~ 16-year prospective study in Chinese

Junda Zhong, Chloe Y. Y. Cheung, Xiuli Su, Chi-Ho Lee, Yi Ru, Carol H. Y. Fong, Yan Liu, Cynthia K. Y. Cheung, Karen S. L. Lam, Zongwei Cai & Aimin Xu
Abstract Background Bioactive lipids play an important role in insulin secretion and sensitivity, contributing to the pathophysiology of type 2 diabetes (T2D). This study aimed to identify novel lipid species associated with incident T2D in a nested case–control study within a long-term prospective Chinese community-based cohort with a median follow-up of ~ 16 years. Methods Plasma samples from 196 incident T2D cases and 196 age- and sex-matched non-T2D controls recruited from the Hong Kong Cardiovascular...

Diagnostic accuracy of linked colour imaging versus white light imaging for early gastric cancers: a prospective, multicentre, randomized controlled trial study

Min Min, Xiaotian Sun, Jianying Bai, Qinsheng Zhang, Xiaocui Yang, Qiang Guo, Rong Wang, Bangmao Wang, Zhiwu Lv, Jie Pan, Chunmeng Jiang, Duanmin Hu, Bing Nong, Enqiang Linghu & Yan Liu
Linked colour imaging (LCI) is a novel new image-enhanced endoscopy (IEE) technology that produces bright and vivid images. The aim of this study was to assess the ability of LCI to improve the diagnostic accuracy of early gastric cancer (EGC) relative to white light imaging (WLI). We performed this study on patients undergoing screening endoscopy from 12 medical institutions in China. Patients were randomly assigned to receive WLI followed by LCI or LCI followed by...

High-yield production of protopanaxadiol from sugarcane molasses by metabolically engineered Saccharomyces cerevisiae

Yuan Zhu, Jianxiu Li, Longyun Peng, Lijun Meng, Mengxue Diao, Shuiyuan Jiang, Jianbin Li & Nengzhong Xie
Abstract Background Ginsenosides are Panax plant-derived triterpenoid with wide applications in cardiovascular protection and immunity-boosting. However, the saponins content of Panax plants is fairly low, making it time-consuming and unsustainable by direct extraction. Protopanaxadiol (PPD) is a common precursor of dammarane-type saponins, and its sufficient supply is necessary for the efficient synthesis of ginsenoside. Results In this study, a combinational strategy was used for the construction of an efficient yeast cell factory for PPD production....

Supplementary document for Deep learning-enabled volumetric cone photoreceptor segmentation in adaptive optics optical coherence tomography images of normal and diseased eyes - 6244377.pdf

Somayyeh Soltanian-Zadeh, Zhuolin Liu, Yan Liu, Ayoub Lassoued, Catherine Cukras, Donald Miller, Daniel Hammer & Sina Farsiu
Supplementary Material

Data from: Petrocodon retroflexus sp. nov. (Gesneriaceae) from a karst cave in Guizhou, China

Jing Guo, Tao Meng, Hongbo Pang & Qiang Zhang
Petrocodon retroflexus Q. Zhang & J. Guo, a new species of Gesneriaceae from Guizhou, China, is described and illustrated. The new species is morphologically similar to Petrocodon viridescens W. H. Chen, Mich. Möller & Y. M. Shui, but differs by its leaf blade being ovate, broadly ovate to elliptic, 8–20 × 5–15 cm and densely pilose on both surfaces, narrowly triangular, 9 mm long, densely pilose bracts, white corolla that is decurved near the middle,...

Environment filtering and dispersal limitation jointly shaped the taxonomic and phylogenetic beta diversity of natural forests in southern China

Wei Shi, Yong-Qiang Wang, Wu-Sheng Xiang, Xian-Kun Li & Kun-Fang Cao
Aim The mechanisms underlying the maintenance of biodiversity remain to be elucidated. Taxonomic diversity alone remains an unresolved issue, especially in terms of the mechanisms of species co-existence. We hypothesized that phylogenetic information could help to elucidate the mechanism of community assembly and the services and functions of ecosystems. The aim of this study was to explore the mechanisms driving floral diversity in subtropical forests and evaluate the relative effects of these mechanisms on diversity...

Additional file 4 of Transcriptomic analysis of paternal behaviors in prairie voles

Florian Duclot, Yan Liu, Samantha K. Saland, Zuoxin Wang & Mohamed Kabbaj
Additional file 4. Depiction of individual behavioral bouts across the parental behavior test. The bouts of the autogroom, carry, huddling, licking & grooming, nest building, and sniffing behaviors are depicted across time throughout the entire parental behavior test session. Each row represents a distinct animal.

Additional file 5 of Transcriptomic analysis of paternal behaviors in prairie voles

Florian Duclot, Yan Liu, Samantha K. Saland, Zuoxin Wang & Mohamed Kabbaj
Additional file 5. Analysis of variance (ANOVA) results for behavioral bouts analysis.

Additional file 8 of Transcriptomic analysis of paternal behaviors in prairie voles

Florian Duclot, Yan Liu, Samantha K. Saland, Zuoxin Wang & Mohamed Kabbaj
Additional file 8. Comparisons of slopes for linear regressions between behaviors scored during the parental behaviors test. Slopes (a) and their differences between groups (b) are listed for all linear regressions with a significant interaction with Group (see Additional file 7).

Additional file 14 of Transcriptomic analysis of paternal behaviors in prairie voles

Florian Duclot, Yan Liu, Samantha K. Saland, Zuoxin Wang & Mohamed Kabbaj
Additional file 14. Functional enrichment of genes differentially expressed in the medial preoptic area (MPOA), the nucleus accumbens (NAc), or the lateral septum (LS). For each pairwise comparison, the functional enrichments in gene ontologies of the biological processes (BP), cellular components (CC), and molecular functions (MF) categories as well as in pathways from the Kyoto Encyclopedia of Genes and Genomes (KEGG) were tested for the differentially expressed genes up- or down-regulated (UP, and DOWN, respectively)....

Additional file 15 of Transcriptomic analysis of paternal behaviors in prairie voles

Florian Duclot, Yan Liu, Samantha K. Saland, Zuoxin Wang & Mohamed Kabbaj
Additional file 15. Functional enrichment of overlapping and distinct sets of differentially expressed genes in the medial preoptic area (MPOA). In (A), the number of differentially expressed genes overlapping or distinct between all sets of sexually biased comparisons in the MPOA is depicted. For each set, the functional enrichments in gene ontologies of the biological processes (B), cellular components (C), and molecular functions (D) categories are displayed. ***p < 0.001, hypergeometric test for overlaps between...

Additional file 16 of Transcriptomic analysis of paternal behaviors in prairie voles

Florian Duclot, Yan Liu, Samantha K. Saland, Zuoxin Wang & Mohamed Kabbaj
Additional file 16. Representation of the number of genes differentially expressed in the medial preoptic area (MPOA, top), nucleus accumbens (NAc, middle), and lateral septum (LS, bottom) across all chromosomes and linkage groups in the prairie vole assembly. Only cases with at least one differentially expressed gene are depicted.

Additional file 19 of Transcriptomic analysis of paternal behaviors in prairie voles

Florian Duclot, Yan Liu, Samantha K. Saland, Zuoxin Wang & Mohamed Kabbaj
Additional file 19. Estimated cell type proportions. The proportions of various cell types were estimated in our dataset using a publicly-available single-cell RNA sequencing dataset. While panel (A) shows the estimated proportions for all genes detected in our study, panels (B) and (C) depict the estimated proportion of the “Astrocytes” and “Neurons” cell types, or only “Neurons”, respectively, in genes differentially expressed in the given structure.

Additional file 21 of Transcriptomic analysis of paternal behaviors in prairie voles

Florian Duclot, Yan Liu, Samantha K. Saland, Zuoxin Wang & Mohamed Kabbaj
Additional file 21. Number of immediate early genes (IEG) in the genes differentially expressed in the medial preoptic area (MPOA), nucleus accumbens (NAc), and lateral septum (LS).

Additional file 22 of Transcriptomic analysis of paternal behaviors in prairie voles

Florian Duclot, Yan Liu, Samantha K. Saland, Zuoxin Wang & Mohamed Kabbaj
Additional file 22. Structure-specific associations of gene coexpression modules with parental behaviors. The correlation of each co-expression module from the weighted gene coexpression network analysis with behavioral traits (behaviors scored during parental behavior test and phenotype status) is depicted for each structure. The correlation value is detailed alongside its corresponding p-value in parentheses. Note that within each structure, only modules with at least one significant association are depicted. MPOA: medial preoptic area, NAc: nucleus accumbens,...

Additional file 23 of Transcriptomic analysis of paternal behaviors in prairie voles

Florian Duclot, Yan Liu, Samantha K. Saland, Zuoxin Wang & Mohamed Kabbaj
Additional file 23. Functional enrichment for modules and groups of modules derived from the weighted gene co-expression analysis (WGCNA). For each pairwise group of modules, the functional enrichments in gene ontologies (GO) of the biological processes (BP), cellular components (CC), and molecular functions (MF) categories as well as in pathways from the Kyoto Encyclopedia of Genes and Genomes (KEGG).

Additional file 23 of Transcriptomic analysis of paternal behaviors in prairie voles

Florian Duclot, Yan Liu, Samantha K. Saland, Zuoxin Wang & Mohamed Kabbaj
Additional file 23. Functional enrichment for modules and groups of modules derived from the weighted gene co-expression analysis (WGCNA). For each pairwise group of modules, the functional enrichments in gene ontologies (GO) of the biological processes (BP), cellular components (CC), and molecular functions (MF) categories as well as in pathways from the Kyoto Encyclopedia of Genes and Genomes (KEGG).

Additional file 24 of Transcriptomic analysis of paternal behaviors in prairie voles

Florian Duclot, Yan Liu, Samantha K. Saland, Zuoxin Wang & Mohamed Kabbaj
Additional file 24. Functional enrichment of gene ontologies of the biological processes category in gene co-expression modules derived from the weighted gene coexpression network analysis (WGCNA).

Additional file 26 of Transcriptomic analysis of paternal behaviors in prairie voles

Florian Duclot, Yan Liu, Samantha K. Saland, Zuoxin Wang & Mohamed Kabbaj
Additional file 26. Functional enrichment of gene ontologies of the molecular functions category in gene co-expression modules derived from the weighted gene coexpression network analysis (WGCNA).

Additional file 28 of Transcriptomic analysis of paternal behaviors in prairie voles

Florian Duclot, Yan Liu, Samantha K. Saland, Zuoxin Wang & Mohamed Kabbaj
Additional file 28. Representative location of tissue punches collection. As no atlas in stereotaxic coordinates exists for the prairie vole brain, representative plates from the rat brain atlas [95] are depicted. Tissue punches were taken from sections ranging from plates 12–18 for the nucleus accumbens (NAc, A), plates 19–27 for the lateral septum (LS, B), and plates 32–40 for the medial preoptic area (MPOA, C).

Mechanical artifacts in optical projection tomography: classification and automatic calibration

Yan Liu, Jonathan Dong, Thanh-An Pham, Francois Marelli & Michael Unser
Optical projection tomography (OPT) is a powerful tool for biomedical studies. It achieves 3D visualization of mesoscopic biological samples with high spatial resolution using conventional tomographic-reconstruction algorithms. However, various artifacts degrade the quality of the reconstructed images due to experimental imperfections in the OPT instruments. While many efforts have been made to characterize and correct for these artifacts, they focus on one specific type of artifacts, whereas a comprehensive catalog of all sorts of mechanical...

Complete genome sequencing and comparative genomic analyses of a new spotted-fever Rickettsia heilongjiangensis strain B8

Maozhang He, Lifeng Zhang, Haoran Hu, Xiaohan Liu, Cong Zhang, Yu Xin, Boyu Liu, Zhen Chen, Kehan Xu & Yan Liu
Rickettsia heilongjiangensis, a tick-borne obligate intracellular bacterium and causative agent of spotted fever in China, has attracted increasing concern regarding its capability in causing human rickettsiosis. Here, we conducted a genomic analysis of a new Rickettsia heilongjiangensis strain B8 (B8) isolated from the serum of a patient who had been bitten by a Haemaphysalis longicornis tick in Anhui Province, China. The present study sought to identify exclusive genes that might be associated with the pathogenicity...

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