8 Works

Intra-articular delivery of flurbiprofen sustained release thermogel: improved therapeutic outcome of collagenase II-induced rat knee osteoarthritis

Peinan Li, Haokun Li, Xiaohong Shu, Moli Wu, Jia Liu, Tangna Hao, Hongxia Cui & Lianjie Zheng
Knee osteoarthritis (OA) is a common degenerative disease. Intra-articular administration of flurbiprofen is frequently employed in clinic to treat OA, while repeated injections are required because of the limited effective duration. To improve therapeutic outcome and prolong the treatment interval, a poly(ε-caprolactone-co-lactide)-b-poly(ethylene glycol)-b-poly(ε-caprolactone-co-lactide) (PCLA–PEG–PCLA) triblock copolymer based flurbiprofen thermosensitive gel for the sustained intra-articular drug delivery was designed in this study. The anti-OA effects of this flurbiprofen thermogel were investigated on collagenase II-induced rat knee...

Intra-articular delivery of flurbiprofen sustained release thermogel: improved therapeutic outcome of collagenase II-induced rat knee osteoarthritis

Peinan Li, Haokun Li, Xiaohong Shu, Moli Wu, Jia Liu, Tangna Hao, Hongxia Cui & Lianjie Zheng
Knee osteoarthritis (OA) is a common degenerative disease. Intra-articular administration of flurbiprofen is frequently employed in clinic to treat OA, while repeated injections are required because of the limited effective duration. To improve therapeutic outcome and prolong the treatment interval, a poly(ε-caprolactone-co-lactide)-b-poly(ethylene glycol)-b-poly(ε-caprolactone-co-lactide) (PCLA–PEG–PCLA) triblock copolymer based flurbiprofen thermosensitive gel for the sustained intra-articular drug delivery was designed in this study. The anti-OA effects of this flurbiprofen thermogel were investigated on collagenase II-induced rat knee...

Env diversity-dependent protection of the attenuated equine infectious anaemia virus vaccine

Yuezhi Lin, Xue-Feng Wang, Yuhong Wang, Cheng Du, Huiling Ren, Cong Liu, Dantong Zhu, Jie Chen, Lei Na, Diqiu Liu, Zhibiao Yang & Xiaojun Wang
Lentiviruses harbour high genetic variability for efficient evasion from host immunity. An attenuated equine infectious anaemia (EIA) vaccine was developed decades ago in China and presented remarkably robust protection against EIA. The vaccine was recently proven to have high genomic diversity, particular in env. However, how and to what extent the high env diversity relates to immune protection remains unclear. In this study, we compared immune protections and responses of three groups of horses stimulated...

Ventromedial prefrontal cortex drives the prioritization of self-associated stimuli in working memory

Shouhang Yin, Taiyong Bi, Antao Chen & Tobias Egner
Humans show a pervasive bias for processing self- over other-related information, including in working memory (WM), where people prioritize the maintenance of self- (over other-) associated cues. To elucidate the neural mechanisms underlying this self-bias, we paired a self- vs. other-associated spatial WM task with functional magnetic resonance imaging (fMRI) and transcranial direct current stimulation (tDCS). Maintaining self- (over other-) associated cues resulted in enhanced delay-period activity in classic WM regions (frontoparietal cortex), and in...

Env diversity-dependent protection of the attenuated equine infectious anaemia virus vaccine

Yuezhi Lin, Xue-Feng Wang, Yuhong Wang, Cheng Du, Huiling Ren, Cong Liu, Dantong Zhu, Jie Chen, Lei Na, Diqiu Liu, Zhibiao Yang & Xiaojun Wang
Lentiviruses harbour high genetic variability for efficient evasion from host immunity. An attenuated equine infectious anaemia (EIA) vaccine was developed decades ago in China and presented remarkably robust protection against EIA. The vaccine was recently proven to have high genomic diversity, particular in env. However, how and to what extent the high env diversity relates to immune protection remains unclear. In this study, we compared immune protections and responses of three groups of horses stimulated...

Development of an immune-related prognostic index associated with osteosarcoma

Chao-Dong Yin, Ying-Lan Hou, Xiao-Ren Liu, Yu-Sheng He, Xin-Ping Wang, Cheng-Jie Li, Xiao-Hong Tan & Jun Liu
Tumor immunity is closely associated with the prognosis of tumors, including osteosarcoma (OS). The aim of the present study was to construct an immune-related prognostic index (PI) to predict the prognosis of OS. Herein, OS expression data were sourced from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database. We divided the OS patients into nonmetastatic and metastatic groups, allowing differentially immune-related genes (DIRGs) to be selected. After DIRGs were further investigated by enrichment...

An infectious clone of enterovirus 71(EV71) that is capable of infecting neonatal immune competent mice without adaptive mutations

Huiying Zhang, Zhigang Song, Jingyi Zou, Yanling Feng, Jing Zhang, Lehao Ren, Xiaonan Zhang, Yunwen Hu, Zhenghong Yuan & Zhigang Yi
Enterovirus 71 (EV71) is a major pathogen that causes hand, foot and mouth disease (HFMD), which is a life threatening disease in certain children. The pathogenesis of EV71-caused HFMD is poorly defined due to the lack of simple and robust animal models with severe phenotypes that recapitulate symptoms observed in humans. Here, we generated the infectious clone of a clinical isolate from a severe HFMD patient. Virus rescued from the cDNA clone was infectious in...

Development of an immune-related prognostic index associated with osteosarcoma

Chao-Dong Yin, Ying-Lan Hou, Xiao-Ren Liu, Yu-Sheng He, Xin-Ping Wang, Cheng-Jie Li, Xiao-Hong Tan & Jun Liu
Tumor immunity is closely associated with the prognosis of tumors, including osteosarcoma (OS). The aim of the present study was to construct an immune-related prognostic index (PI) to predict the prognosis of OS. Herein, OS expression data were sourced from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database. We divided the OS patients into nonmetastatic and metastatic groups, allowing differentially immune-related genes (DIRGs) to be selected. After DIRGs were further investigated by enrichment...

Registration Year

  • 2020
    8

Resource Types

  • Text
    4
  • Dataset
    2
  • Image
    2

Affiliations

  • Zunyi Medical University
    8
  • Huazhong University of Science and Technology
    6
  • Zhejiang University
    5
  • Central South University
    4
  • Capital Medical University
    4
  • Shandong University
    4
  • Sun Yat-sen University
    3
  • The Ohio State University
    3
  • Fudan University
    3
  • Sun Yat-sen Memorial Hospital
    3