46 Works

Prehospital Comparison of the HEAR and HE-MACS Scores for 30-Day Adverse Cardiac Events

Lucas M. Popp, Nicklaus P. Ashburn, Brennan E. Paradee, Anna C. Snavely, James C. O’Neill, Kate M. Boyer, Richard Body, Simon A. Mahler & Jason P. Stopyra
The History, Electrocardiogram (ECG), Age, and Risk factor (HEAR) and History and ECG-only Manchester Acute Coronary Syndromes (HE-MACS) risk scores can risk stratify chest pain patients without troponin measures. The objective of this study was to determine if either risk score could achieve the ≥99% negative predictive value (NPV) required to rule out major adverse cardiovascular events (MACE; a composite of all-cause death, myocardial infarction, or coronary revascularization) at 30 days or the ≥50% positive...

Additional file 1 of A general framework for selecting work participation outcomes in intervention studies among persons with health problems: a concept paper

Margarita Ravinskaya, Jos H. Verbeek, Miranda W. Langendam, Ira Madan, Suzanne M. M. Verstappen, Regina Kunz, Carel T. J. Hulshof & Jan L. Hoving
Additional file 1: search strategy.

Supplemental Material - Examining the variability of multiple daily symptoms over time among individuals with multiple long-term conditions (MLTC-M/multimorbidity): an exploratory analysis of a longitudinal smartwatch feasibility study

Khalid Kazi, Syed Mustafa Ali, David A Selby, John McBeth, Sabine van der Veer & William G Dixon
Supplemental Material for Examining the variability of multiple daily symptoms over time among individuals with multiple long-term conditions (MLTC-M/multimorbidity): an exploratory analysis of a longitudinal smartwatch feasibility study by Khalid Kazi, Syed Mustafa Ali, David A Selby, John McBeth, Sabine van der Veer and William G Dixon in Journal of Multimorbidity and Comorbidity

Supplemental Material - Examining the variability of multiple daily symptoms over time among individuals with multiple long-term conditions (MLTC-M/multimorbidity): an exploratory analysis of a longitudinal smartwatch feasibility study

Khalid Kazi, Syed Mustafa Ali, David A Selby, John McBeth, Sabine van der Veer & William G Dixon
Supplemental Material for Examining the variability of multiple daily symptoms over time among individuals with multiple long-term conditions (MLTC-M/multimorbidity): an exploratory analysis of a longitudinal smartwatch feasibility study by Khalid Kazi, Syed Mustafa Ali, David A Selby, John McBeth, Sabine van der Veer and William G Dixon in Journal of Multimorbidity and Comorbidity

Examining the variability of multiple daily symptoms over time among individuals with multiple long-term conditions (MLTC-M/multimorbidity): An exploratory analysis of a longitudinal smartwatch feasibility study

Khalid Kazi, Syed Mustafa Ali, David A Selby, John McBeth, Sabine van der Veer & William G Dixon
IntroductionPeople living with multiple long-term conditions (MLTC-M) (multimorbidity) experience a range of inter-related symptoms. These symptoms can be tracked longitudinally using consumer technology, such as smartphones and wearable devices, and then summarised to provide useful clinical insight.AimWe aimed to perform an exploratory analysis to summarise the extent and trajectory of multiple symptom ratings tracked via a smartwatch, and to investigate the relationship between these symptom ratings and demographic factors in people living with MLTC-M in...

Acceptability and feasibility of a parent-mediated social-communication therapy for young autistic children in Brazil: A qualitative implementation study of Paediatric Autism Communication Therapy

Priscilla Brandi Gomes Godoy, Lorna McWilliams, Leticia Rodrigues da Silveira, Mirian de Cesaro Revers Biasão, Fernanda Speggiorin Pereira Alarcão, Leonardo Seda, Renata Generoso Campoli, Holan Liang, Gauri Divan, Kathy Leadbitter, Jonathan Green & Elizabeth Shephard
Effective support for autistic individuals is lacking in Brazil. Few centres offer services and those that do are limited in therapeutic options and geographical location. Paediatric Autism Communication Therapy is a low-intensity, evidence-based parent-mediated social-communication intervention that may be useful for this scenario. This implementation study aimed to assess the acceptability and feasibility of Paediatric Autism Communication Therapy for young autistic children (aged 2–10 years) in Brazil. Parents (n = 18) of 2- to 10-year-old...

Additional file 2 of Healthcare professionals’ views following implementation of risk stratification into a national breast cancer screening programme

Rachel Hawkins, Lorna McWilliams, Fiona Ulph, D Gareth Evans & David P French
Supplementary Material 2

Additional file 3 of Healthcare professionals’ views following implementation of risk stratification into a national breast cancer screening programme

Rachel Hawkins, Lorna McWilliams, Fiona Ulph, D Gareth Evans & David P French
Supplementary Material 3

Healthcare professionals’ views following implementation of risk stratification into a national breast cancer screening programme

Rachel Hawkins, Lorna McWilliams, Fiona Ulph, D Gareth Evans & David P French
Abstract Background It is crucial to determine feasibility of risk-stratified screening to facilitate successful implementation. We introduced risk-stratification (BC-Predict) into the NHS Breast Screening Programme (NHSBSP) at three screening sites in north-west England from 2019 to 2021. The present study investigated the views of healthcare professionals (HCPs) on acceptability, barriers, and facilitators of the BC-Predict intervention and on the wider implementation of risk-based screening after BC-Predict was implemented in their screening site. Methods Fourteen semi-structured...

Additional file 1 of The co-development of personalised 10-year breast cancer risk communications: a ‘think-aloud’ study

Louise S. Gorman, Helen Ruane, Victoria G. Woof, Jake Southworth, Fiona Ulph, D. Gareth Evans & David P. French
Additional file 1.

The co-development of personalised 10-year breast cancer risk communications: a ‘think-aloud’ study

Louise S. Gorman, Helen Ruane, Victoria G. Woof, Jake Southworth, Fiona Ulph, D. Gareth Evans & David P. French
Abstract Background Risk stratified breast cancer screening is being considered as a means of improving the balance of benefits and harms of mammography. Stratified screening requires the communication of risk estimates. We aimed to co-develop personalised 10-year breast cancer risk communications for women attending routine mammography. Methods We conducted think-aloud interviews on prototype breast cancer risk letters and accompanying information leaflets with women receiving breast screening through the UK National Breast Screening Programme. Risk information...

Supplemental Material, sj-docx-1-ptd-10.1177_08968608221144395 - Outcomes of COVID-19 in peritoneal dialysis patients: A report by the European Renal Association COVID-19 Database

Alferso C Abrahams, Marlies Noordzij, Eric Goffin, J Emilio Sanchez, Casper FM Franssen, Priya Vart, Kitty J Jager, Madelon van Agteren, Adrian Covic, Sandip Mitra, Carlo Basile, Constantijn Konings, Marc H Hemmelder, Raphaël Duivenvoorden, Luuk B Hilbrands & Ron T Gansevoort
Supplemental Material, sj-docx-1-ptd-10.1177_08968608221144395 for Outcomes of COVID-19 in peritoneal dialysis patients: A report by the European Renal Association COVID-19 Database by Alferso C Abrahams, Marlies Noordzij, Eric Goffin, J Emilio Sanchez, Casper FM Franssen, Priya Vart, Kitty J Jager, Madelon van Agteren, Adrian Covic, Sandip Mitra, Carlo Basile, Constantijn Konings, Marc H Hemmelder, Raphaël Duivenvoorden, Luuk B Hilbrands, Ron T Gansevoort and ERACODA Collaborators in Peritoneal Dialysis International

Outcomes of COVID-19 in peritoneal dialysis patients: A report by the European Renal Association COVID-19 Database

Alferso C Abrahams, Marlies Noordzij, Eric Goffin, J Emilio Sanchez, Casper FM Franssen, Priya Vart, Kitty J Jager, Madelon van Agteren, Adrian Covic, Sandip Mitra, Carlo Basile, Constantijn Konings, Marc H Hemmelder, Raphaël Duivenvoorden, Luuk B Hilbrands & Ron T Gansevoort
Background:The clinical course of COVID-19 in peritoneal dialysis (PD) patients has so far only been analysed in relatively small, often single-centre case series. Therefore, we studied patient- and disease-related characteristics and outcomes of COVID-19 in a larger European cohort of PD patients.Methods:We used data from the European Renal Association COVID-19 Database (ERACODA) on PD and haemodialysis (HD) patients with COVID-19 (presentation between February 2020 and April 2021). Hazard ratios (HR) for mortality at 3 months...

Enhancing maritime security in the Indo-Pacific - Policy Brief

Hillary Briffa, Ian Hall, Alessio Patalano & Rebecca Strating
No description supplied

Data from: Chemical signals from eggs facilitate cryptic female choice in humans

John Fitzpatrick, Charlotte Willis, Alessandro Devigili, Amy Young, Michael Carroll, Helen Hunter & Daniel Brison
Mate choice can continue after mating via chemical communication between the female reproductive system and sperm. While there is a growing appreciation that females can bias sperm use and paternity by exerting cryptic female choice for preferred males, we know surprisingly little about the mechanisms underlying these post-mating choices. In particular, whether chemical signals released from eggs (chemoattractants) allow females to exert cryptic female choice to favour sperm from specific males remains an open question,...

Data from: Molecular insights into genome-wide association studies of chronic kidney disease-defining traits

Xiaoguang Xu, James M. Eales, Artur Akbarov, Hui Guo, Lorenz Becker, David Talavera, Fezhan Ashraf, Jabran Nawaz, Sanjeev Pramanik, John Bowes, Xiao Jiang, John Dormer, Matthew Denniff, Andrzej Antczak, Monika Szulinska, Ingrid Wise, Priscilla R. Prestes, Maciej Glyda, Pawel Bogdanski, Ewa Zukowska-Szczechowska, Carlo Berzuini, Adrian S. Woolf, Nilesh J. Samani, Fadi J. Charchar & Maciej Tomaszewski
Genome-wide association studies (GWAS) have identified >100 loci of chronic kidney disease-defining traits (CKD-dt). Molecular mechanisms underlying these associations remain elusive. Using 280 kidney transcriptomes and 9958 gene expression profiles from 44 non-renal tissues we uncover gene expression partners (eGenes) for 88.9% of CKD-dt GWAS loci. Through epigenomic chromatin segmentation analysis and variant effect prediction we annotate functional consequences to 74% of these loci. Our colocalisation analysis and Mendelian randomisation in >130,000 subjects demonstrate causal...

Additional file 1 of Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium

Pål Møller, Toni Seppälä, James G. Dowty, Saskia Haupt, Mev Dominguez-Valentin, Lone Sunde, Inge Bernstein, Christoph Engel, Stefan Aretz, Maartje Nielsen, Gabriel Capella, Dafydd Gareth Evans, John Burn, Elke Holinski-Feder, Lucio Bertario, Bernardo Bonanni, Annika Lindblom, Zohar Levi, Finlay Macrae, Ingrid Winship, John-Paul Plazzer, Rolf Sijmons, Luigi Laghi, Adriana Della Valle, Karl Heinimann … & Mark A. Jenkins
Additional file 1.

Enhancing maritime security in the Indo-Pacific - Policy Brief

Hillary Briffa, Ian Hall, Alessio Patalano & Rebecca Strating
No description supplied

Prehospital Comparison of the HEAR and HE-MACS Scores for 30-Day Adverse Cardiac Events

Lucas M. Popp, Nicklaus P. Ashburn, Brennan E. Paradee, Anna C. Snavely, James C. O’Neill, Kate M. Boyer, Richard Body, Simon A. Mahler & Jason P. Stopyra
The History, Electrocardiogram (ECG), Age, and Risk factor (HEAR) and History and ECG-only Manchester Acute Coronary Syndromes (HE-MACS) risk scores can risk stratify chest pain patients without troponin measures. The objective of this study was to determine if either risk score could achieve the ≥99% negative predictive value (NPV) required to rule out major adverse cardiovascular events (MACE; a composite of all-cause death, myocardial infarction, or coronary revascularization) at 30 days or the ≥50% positive...

sj-docx-1-aut-10.1177_13623613221144501 – Supplemental material for Acceptability and feasibility of a parent-mediated social-communication therapy for young autistic children in Brazil: A qualitative implementation study of Paediatric Autism Communication Therapy

Priscilla Brandi Gomes Godoy, Lorna McWilliams, Leticia Rodrigues da Silveira, Mirian de Cesaro Revers Biasão, Fernanda Speggiorin Pereira Alarcão, Leonardo Seda, Renata Generoso Campoli, Holan Liang, Gauri Divan, Kathy Leadbitter, Jonathan Green & Elizabeth Shephard
Supplemental material, sj-docx-1-aut-10.1177_13623613221144501 for Acceptability and feasibility of a parent-mediated social-communication therapy for young autistic children in Brazil: A qualitative implementation study of Paediatric Autism Communication Therapy by Priscilla Brandi Gomes Godoy, Lorna McWilliams, Leticia Rodrigues da Silveira, Mirian de Cesaro Revers Biasão, Fernanda Speggiorin Pereira Alarcão, Leonardo Seda, Renata Generoso Campoli, Holan Liang, Gauri Divan, Kathy Leadbitter, Jonathan Green and Elizabeth Shephard in Autism

sj-docx-1-aut-10.1177_13623613221144501 – Supplemental material for Acceptability and feasibility of a parent-mediated social-communication therapy for young autistic children in Brazil: A qualitative implementation study of Paediatric Autism Communication Therapy

Priscilla Brandi Gomes Godoy, Lorna McWilliams, Leticia Rodrigues da Silveira, Mirian de Cesaro Revers Biasão, Fernanda Speggiorin Pereira Alarcão, Leonardo Seda, Renata Generoso Campoli, Holan Liang, Gauri Divan, Kathy Leadbitter, Jonathan Green & Elizabeth Shephard
Supplemental material, sj-docx-1-aut-10.1177_13623613221144501 for Acceptability and feasibility of a parent-mediated social-communication therapy for young autistic children in Brazil: A qualitative implementation study of Paediatric Autism Communication Therapy by Priscilla Brandi Gomes Godoy, Lorna McWilliams, Leticia Rodrigues da Silveira, Mirian de Cesaro Revers Biasão, Fernanda Speggiorin Pereira Alarcão, Leonardo Seda, Renata Generoso Campoli, Holan Liang, Gauri Divan, Kathy Leadbitter, Jonathan Green and Elizabeth Shephard in Autism

Acceptability and feasibility of a parent-mediated social-communication therapy for young autistic children in Brazil: A qualitative implementation study of Paediatric Autism Communication Therapy

Priscilla Brandi Gomes Godoy, Lorna McWilliams, Leticia Rodrigues da Silveira, Mirian de Cesaro Revers Biasão, Fernanda Speggiorin Pereira Alarcão, Leonardo Seda, Renata Generoso Campoli, Holan Liang, Gauri Divan, Kathy Leadbitter, Jonathan Green & Elizabeth Shephard
Effective support for autistic individuals is lacking in Brazil. Few centres offer services and those that do are limited in therapeutic options and geographical location. Paediatric Autism Communication Therapy is a low-intensity, evidence-based parent-mediated social-communication intervention that may be useful for this scenario. This implementation study aimed to assess the acceptability and feasibility of Paediatric Autism Communication Therapy for young autistic children (aged 2–10 years) in Brazil. Parents (n = 18) of 2- to 10-year-old...

Supplemental Material, sj-docx-1-ptd-10.1177_08968608221144395 - Outcomes of COVID-19 in peritoneal dialysis patients: A report by the European Renal Association COVID-19 Database

Alferso C Abrahams, Marlies Noordzij, Eric Goffin, J Emilio Sanchez, Casper FM Franssen, Priya Vart, Kitty J Jager, Madelon van Agteren, Adrian Covic, Sandip Mitra, Carlo Basile, Constantijn Konings, Marc H Hemmelder, Raphaël Duivenvoorden, Luuk B Hilbrands & Ron T Gansevoort
Supplemental Material, sj-docx-1-ptd-10.1177_08968608221144395 for Outcomes of COVID-19 in peritoneal dialysis patients: A report by the European Renal Association COVID-19 Database by Alferso C Abrahams, Marlies Noordzij, Eric Goffin, J Emilio Sanchez, Casper FM Franssen, Priya Vart, Kitty J Jager, Madelon van Agteren, Adrian Covic, Sandip Mitra, Carlo Basile, Constantijn Konings, Marc H Hemmelder, Raphaël Duivenvoorden, Luuk B Hilbrands, Ron T Gansevoort and ERACODA Collaborators in Peritoneal Dialysis International

Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium

Pål Møller, Toni Seppälä, James G. Dowty, Saskia Haupt, Mev Dominguez-Valentin, Lone Sunde, Inge Bernstein, Christoph Engel, Stefan Aretz, Maartje Nielsen, Gabriel Capella, Dafydd Gareth Evans, John Burn, Elke Holinski-Feder, Lucio Bertario, Bernardo Bonanni, Annika Lindblom, Zohar Levi, Finlay Macrae, Ingrid Winship, John-Paul Plazzer, Rolf Sijmons, Luigi Laghi, Adriana Della Valle, Karl Heinimann … & Mark A. Jenkins
Abstract Objective To compare colorectal cancer (CRC) incidences in carriers of pathogenic variants of the MMR genes in the PLSD and IMRC cohorts, of which only the former included mandatory colonoscopy surveillance for all participants. Methods CRC incidences were calculated in an intervention group comprising a cohort of confirmed carriers of pathogenic or likely pathogenic variants in mismatch repair genes (path_MMR) followed prospectively by the Prospective Lynch Syndrome Database (PLSD). All had colonoscopy surveillance, with...

Additional file 1 of Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium

Pål Møller, Toni Seppälä, James G. Dowty, Saskia Haupt, Mev Dominguez-Valentin, Lone Sunde, Inge Bernstein, Christoph Engel, Stefan Aretz, Maartje Nielsen, Gabriel Capella, Dafydd Gareth Evans, John Burn, Elke Holinski-Feder, Lucio Bertario, Bernardo Bonanni, Annika Lindblom, Zohar Levi, Finlay Macrae, Ingrid Winship, John-Paul Plazzer, Rolf Sijmons, Luigi Laghi, Adriana Della Valle, Karl Heinimann … & Mark A. Jenkins
Additional file 1.

Registration Year

  • 2023
    18
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    26
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    1
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    1

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Affiliations

  • Manchester University NHS Foundation Trust
    46
  • University of Manchester
    46
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    12
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    10
  • Oslo University Hospital
    8
  • Karolinska University Hospital
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