We describe the clinical course of a recurrent case of congenital fibrosarcoma diagnosed in a 9-mo-old boy with a history of hemimelia. Following complete surgical resection of the primary tumor, the patient subsequently presented with bulky bilateral pulmonary metastases 6 mo following surgery. Molecular characterization of the tumor revealed the absence of the prototypical ETV6-NTRK3 translocation. However, tumor characterization incorporating cytogenetic, array comparative genomic hybridization, and RNA sequencing analyses, revealed a somatic t(2;15)(2p21;15q25) translocation resulting...

Improving environmental adaptation in crops is essential for food security under global change, but phenotyping adaptive traits remains a major bottleneck. If associations between single-nucleotide polymorphism (SNP) alleles and environment of origin in crop landraces reflect adaptation, then these could be used to predict phenotypic variation for adaptive traits. We tested this proposition in the global food crop Sorghum bicolor, characterizing 1943 georeferenced landraces at 404,627 SNPs and quantifying allelic associations with bioclimatic and soil...

To improve fishery management, there is an increasing need to understand the long-term consequences of natural and anthropogenic climate variability for ecological systems. New England’s iconic cod populations have been in decline for several decades and have recently reached unprecedented lows. We find that 17% of the overall decline in Gulf of Maine cod biomass since 1980 can be attributed to positive phases of the North Atlantic Oscillation (NAO). This is a consequence of three...

Avian eggs are at risk of microbial infection prior to and during incubation. A large number of defence mechanisms have evolved in response to the severe costs imposed by these infections. The eggshell's cuticle is an important component of antimicrobial defence, and its role in preventing contamination by microorganisms in domestic chickens is well known. Nanometer-scale cuticular spheres that reduce microbial attachment and penetration have recently been identified on eggs of several wild avian species....

Re-establishing connectivity between protected areas isolated by habitat clearing is a key conservation goal in the humid tropics. In northeastern Costa Rica, payments for environmental services (PES) and a government ban on deforestation have subsidized forest protection and reforestation in the San Juan–La Selva Biological Corridor (SJLSBC), resulting in a decline in mature forest loss and the expansion of tree plantations. We use field studies and graph models to assess how conservation efforts have altered...

Supplemental material, sj-docx-1-gae-10.1177_25168657221126314 for Stress Overload and DNA Methylation in African American Women in the Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure Study by Jolaade Kalinowski, Yunfeng Huang, Martin A Rivas, Veronica Barcelona, Michelle L Wright, Cindy Crusto, Tanya Spruill, Yan V Sun and Jacquelyn Y Taylor in Epigenetics Insights

Supplemental material, sj-docx-1-gae-10.1177_25168657221126314 for Stress Overload and DNA Methylation in African American Women in the Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure Study by Jolaade Kalinowski, Yunfeng Huang, Martin A Rivas, Veronica Barcelona, Michelle L Wright, Cindy Crusto, Tanya Spruill, Yan V Sun and Jacquelyn Y Taylor in Epigenetics Insights

Introduction:Experiencing psychosocial stress is associated with poor health outcomes such as hypertension and obesity, which are risk factors for developing cardiovascular disease. African American women experience disproportionate risk for cardiovascular disease including exposure to high levels of psychosocial stress. We hypothesized that psychosocial stress, such as perceived stress overload, may influence epigenetic marks, specifically DNA methylation (DNAm), that contribute to increased risk for cardiovascular disease in African American women.Methods:We conducted an epigenome-wide study evaluating the...

Supplemental material, sj-docx-1-css-10.1177_24705470221128004 for Proton Magnetic Resonance Spectroscopy in Post-Traumatic Stress Disorder—Updated Systematic Review and Meta-Analysis by Kelley M. Swanberg, Leonardo Campos, Chadi G. Abdallah and Christoph Juchem in Chronic Stress

Abstract Background This scoping review aims to provide a broad overview of the research on the unassisted virtual physical exam performed over synchronous audio-video telemedicine to identify gaps in knowledge and guide future research. Methods Searches for studies on the unassisted virtual physical exam were conducted in 3 databases. We included primary research studies in English on the virtual physical exam conducted via patient-to-provider synchronous, audio-video telemedicine in the absence of assistive technology or personnel....

This study aimed to examine the factors that may influence physicians’ choice of antidiabetic agents. In addition, we investigated physicians’ decision-making process and treatment of T2DM patients with chronic kidney disease (CKD). Finally, we wanted to determine whether physicians knew the latest recommendations for T2DM treatment. The study was conducted as a cross-sectional survey using an online self-administered questionnaire to collect data from physicians in Taiwan. We enrolled licensed physicians who worked in hospitals or...

Supplemental material, sj-docx-1-cix-10.1177_11769351221126285 for Transcription Elongation Factor A (SII)-Like (TCEAL) Gene Family Member-TCEAL2: A Novel Prognostic Marker in Pan-Cancer by Yu Sun and Jun Zhao in Cancer Informatics

Supplemental material, sj-docx-1-cix-10.1177_11769351221126285 for Transcription Elongation Factor A (SII)-Like (TCEAL) Gene Family Member-TCEAL2: A Novel Prognostic Marker in Pan-Cancer by Yu Sun and Jun Zhao in Cancer Informatics

Supplemental material, sj-docx-2-cix-10.1177_11769351221126285 for Transcription Elongation Factor A (SII)-Like (TCEAL) Gene Family Member-TCEAL2: A Novel Prognostic Marker in Pan-Cancer by Yu Sun and Jun Zhao in Cancer Informatics

Supplemental material, sj-pdf-3-cix-10.1177_11769351221126285 for Transcription Elongation Factor A (SII)-Like (TCEAL) Gene Family Member-TCEAL2: A Novel Prognostic Marker in Pan-Cancer by Yu Sun and Jun Zhao in Cancer Informatics

Additional file 1. Quantitative survey.

Supplemental material, sj-docx-1-jmh-10.1177_15579883221129349 for Qualitative Identification of Intervention Preferences to Support Men’s Engagement and Retention in TB Care in South Africa by Andrew Medina-Marino, Dana Bezuidenhout, Nondumiso Ngcelwane, Morna Cornell, Milton Wainberg, Chris Beyrer, Linda-Gail Bekker and Joseph Daniels in American Journal of Men's Health

Globally and in South African specifically, men account for 56% and 62% of all tuberculosis (TB) cases, respectively. Men are at increased risk of not accessing TB testing or treatment, and having poor treatment outcomes. Unfortunately, no interventions exist to address these issues. Toward the development of targeted, patient-centered TB care and support interventions, we used semistructured interviews to explored men’s social network composition, TB testing behaviors, disclosure and treatment support, clinical experiences, and TB’s...

Additional file 4: Figure S2. The principal coordinate analysis (PCoA) of the (A) bacterial and (B) fungal communities in the rhizosphere of wild rice populations of the in situ natural reserves (ZTI, Zhangtang; AJSI, Anjiashan; STSI, Shuitaoshu) and ex situ (ZT, Zhangtang; AJS, Anjiashan; STS, Shuitaoshu).

Additional file 1: Table S1. Statistics for the quality assessment of the sequencing data.

Supplemental Material for Longitudinal Link Between Bullying Victimization and Bullying Perpetration: A Multilevel Moderation Analysis of Perceived School Climate by Qian Nie, Chunyan Yang, Meg Stomski, Zhanfeng Zhao, Zhaojun Teng and Cheng Guo, in Journal of Interpersonal Violence