557 Works

Care Earnings in the United States and European Union: The Role of Social Policy and Labour Market Institutions (LIEPP Working Paper, n°115)

Emanuele Ferragina & Zachary Parolin
Care occupations are strongly gendered and remain relatively poorly paid, particularly in the United States. Prior research points to individual, relational, and market- valuation factors in explaining the relative earnings of care workers. In contrast, this study applies a comparative institutional perspective to investigate cross-national differences in the relative earnings of care workers. Using merged data from the U.S. Current Population Survey and EU-SILC, we find that national variance in labour market and welfare state...

Additional file 1 of A novel autosomal dominant GREB1L variant associated with non-syndromic hearing impairment in Ghana

Samuel Mawuli Adadey, Elvis Twumasi Aboagye, Kevin Esoh, Anushree Acharya, Thashi Bharadwaj, Nicole S. Lin, Lucas Amenga-Etego, Gordon A. Awandare, Isabelle Schrauwen, Suzanne M. Leal & Ambroise Wonkam
Additional file 1: Fig. S1. Secondary structure prediction of GREB1L protein. The effect of the variant on secondary structure formation was examined using PSIPRED [1], a bioinformatic tool. Predicted secondary structures for the (A) wildtype and (B) mutant proteins. Blue rectangles were used to indicate the absence and presence of a helix at the mutation site of the wildtype and mutant proteins respectively. Red rectangles were used to highlight the sites where differences were observed...

A novel autosomal dominant GREB1L variant associated with non-syndromic hearing impairment in Ghana

Samuel Mawuli Adadey, Elvis Twumasi Aboagye, Kevin Esoh, Anushree Acharya, Thashi Bharadwaj, Nicole S. Lin, Lucas Amenga-Etego, Gordon A. Awandare, Isabelle Schrauwen, Suzanne M. Leal & Ambroise Wonkam
Abstract Background Childhood hearing impairment (HI) is genetically heterogeneous with many implicated genes, however, only a few of these genes are reported in African populations. Methods This study used exome and Sanger sequencing to resolve the possible genetic cause of non-syndromic HI in a Ghanaian family. Results We identified a novel variant c.3041G > A: p.(Gly1014Glu) in GREB1L (DFNA80) in the index case. The GREB1L: p.(Gly1014Glu) variant had a CADD score of 26.5 and was...

Exosome-like nanovesicles derived from Phellinus linteus inhibit Mical2 expression through cross-kingdom regulation and inhibit ultraviolet-induced skin aging

Jingxia Han, Ting Wu, Jing Jin, Zhiyang Li, Wenjun Cheng, Xintong Dai, Kai Yang, Heng Zhang, Zhiyuan Zhang, Haohao Zhang, Rong Fan, Shaoting Zheng, Haoyang Liu, Yinan Li, Huan Zhao, Cheng Yao, Tingting Lin, Caibin Zhu & Huijuan Liu
Abstract Background Phellinus linteus (PL), which is a typical medicinal fungus, has been shown to have antitumor and anti-inflammatory activities. However, studies on the effect of anti-photoaging are limited. Studies have shown that exosome-like nanovesicles are functional components of many medicinal plants, and miRNAs in exosome-like nanovesicles play a cross-kingdom regulatory role. At present, research on fungi exosome-like nanovesicles (FELNVs) is few. Results We systematically evaluated the anti-aging effects of PL. FELNVs of PL were...

Additional file 2 of A scoping review of the unassisted physical exam conducted over synchronous audio-video telemedicine

Peter Yao, Mahad Adam, Sunday Clark, Hanson Hsu, Michael Stern, Rahul Sharma, Keith Mages, Peter Greenwald & Neel Naik
Additional file 2: Supplementary Appendix 1. Ovid MEDLINE search strategy. Supplementary Appendix 2. Data Extraction Definitions. Supplementary Appendix 3. Citations for all included articles.

The relationship of total progressive motile sperm count with the outcome of IUI? An analysis of 5171 cycles

Haiyan Lin, Yu Li, Songbang Ou, Xuedan Jiao, Wenjun Wang, Thor Haahr, Peter Humaidan & Qingxue Zhang
Background: The role of motile sperm count in intrauterine insemination (IUI) success rate is controversial. This retrospective cohort study performed among unselected infertile couples undergoing IUI was to explore the association between the total progressive motile sperm count (TPMSC) and the live birth rate (LBR) following IUI. Methods: The total cohort of 5363 cycles, 2666 infertile couples between January 2015 and December 2018 and finally 5171 cycles, 2647 couples were included for analysis in Sun...

The relationship of total progressive motile sperm count with the outcome of IUI? An analysis of 5171 cycles

Haiyan Lin, Yu Li, Songbang Ou, Xuedan Jiao, Wenjun Wang, Thor Haahr, Peter Humaidan & Qingxue Zhang
Background: The role of motile sperm count in intrauterine insemination (IUI) success rate is controversial. This retrospective cohort study performed among unselected infertile couples undergoing IUI was to explore the association between the total progressive motile sperm count (TPMSC) and the live birth rate (LBR) following IUI. Methods: The total cohort of 5363 cycles, 2666 infertile couples between January 2015 and December 2018 and finally 5171 cycles, 2647 couples were included for analysis in Sun...

Data from: The role of non-natural foods in the nutritional strategies of monkeys in a human-modified mosaic landscape

Maressa Q. Takahashi & Marina Cords
Many tropical animals inhabit mosaic landscapes including human-modified habitat. In such landscapes, animals commonly adjust feeding behavior, and may incorporate non-natural foods. These behavioral shifts can influence consumers’ nutritional states, with implications for population persistence. However, few studies have addressed the nutritional role of non-natural food. We examined nutritional ecology of wild blue monkeys to understand how dietary habits related to non-natural foods might support population persistence in a mosaic landscape. We documented prevalence and...

Additional file 1 of The Korean undiagnosed diseases program phase I: expansion of the nationwide network and the development of long-term infrastructure

Soo Yeon Kim, Seungbok Lee, Hyewon Woo, Jiyeon Han, Young Jun Ko, Youngkyu Shim, Soojin Park, Se Song Jang, Byung Chan Lim, Jung Min Ko, Ki Joong Kim, Anna Cho, Hunmin Kim, Hee Hwang, Ji Eun Choi, Man Jin Kim, Jangsup Moon, Moon-Woo Seong, Sung Sup Park, Sun Ah Choi, Ji Eun Lee, Young Se Kwon, Young Bae Sohn, Jon Soo Kim, Won Seop Kim … & Jong-Hee Chae
Additional file 1. Detailed information of genetically confirmed patients.

Qualitative Identification of Intervention Preferences to Support Men’s Engagement and Retention in TB Care in South Africa

Andrew Medina-Marino, Dana Bezuidenhout, Nondumiso Ngcelwane, Morna Cornell, Milton Wainberg, Chris Beyrer, Linda-Gail Bekker & Joseph Daniels
Globally and in South African specifically, men account for 56% and 62% of all tuberculosis (TB) cases, respectively. Men are at increased risk of not accessing TB testing or treatment, and having poor treatment outcomes. Unfortunately, no interventions exist to address these issues. Toward the development of targeted, patient-centered TB care and support interventions, we used semistructured interviews to explored men’s social network composition, TB testing behaviors, disclosure and treatment support, clinical experiences, and TB’s...

Platelet membrane-camouflaged nanoparticles carry microRNA inhibitor against myocardial ischaemia‒reperfusion injury

Tianyi Wang, Tingting Zhou, Mingming Xu, Shuo Wang, Anqi Wu, Mingyang Zhang, You Lang Zhou & Jiahai Shi
Abstract The incidence of myocardial ischaemia‒reperfusion injury (MIRI) is increasing every year, and there is an urgent need to develop new therapeutic approaches. Nrf2 is thought to play a protective role during MIRI and it is regulated by microRNAs (miRNAs). This study focused on PLGA nanoparticles camouflaged by platelet membrane vesicles (PMVs) (i.e., PMVs@PLGA complexes) carrying microRNA inhibitors, which regulate Nrf2 and can play a therapeutic role in the MIRI process. In vitro and in...

Additional file 3 of The landscape of hervRNAs transcribed from human endogenous retroviruses across human body sites

Jianqi She, Minghao Du, Zhanzhan Xu, Yueqi Jin, Yu Li, Daoning Zhang, Changyu Tao, Jian Chen, Jiadong Wang & Ence Yang
Additional file 3. Peer review history.

The landscape of hervRNAs transcribed from human endogenous retroviruses across human body sites

Jianqi She, Minghao Du, Zhanzhan Xu, Yueqi Jin, Yu Li, Daoning Zhang, Changyu Tao, Jian Chen, Jiadong Wang & Ence Yang
Abstract Background Human endogenous retroviruses (HERVs), the remnants of ancient retroviruses, account for 8% of the human genome, but most have lost their transcriptional abilities under physiological conditions. However, mounting evidence shows that several expressed HERVs do exert biological functions. Here, we systematically characterize physiologically expressed HERVs and examine whether they may give insight into the molecular fundamentals of human development and disease. Results We systematically identify 13,889 expressed HERVs across normal body sites and...

Supplemental Material - Marital Histories and Associations With Later-Life Dementia and Mild Cognitive Impairment Risk in the HUNT4 70+ Study in Norway

Vegard Skirbekk, Catherine E. Bowen, Asta Håberg, Astanand Jugessur, Bo Engdahl, Bernt Bratsberg, Ekaterina Zotcheva, Geir Selbæk, Hans-Peter Kohler, Jordan Weiss, Jennifer R. Harris, Sarah E. Tom, Steinar Krokstad, Yaakov Stern & Bjørn Heine Strand
Supplemental Material for Marital Histories and Associations With Later-Life Dementia and Mild Cognitive Impairment Risk in the HUNT4 70+ Study in Norway by Vegard Skirbekk, Asta Håberg, Ekaterina Zotcheva, Bo Lars Engdahl, Steinar Krokstad, Hans-Peter Kohler, Astanand Jugessur, PhD, Bernt Bratsberg, Jordan Weiss, PhD, Catherine Bowen, Sarah Tom, PhD, Jennifer Harris, PhD, Yaakov Stern, PhD, Geir Selbæk, and Heine Strand, PhD in Journal of Aging and Health

Black carbon content in airway macrophages is associated with increased severe exacerbations and worse COPD morbidity in SPIROMICS

Vickram Tejwani, Han Woo, Chen Liu, Anna K. Tillery, Amanda J. Gassett, Richard E. Kanner, Eric A. Hoffman, Fernando J. Martinez, Prescott G. Woodruff, R. Graham Barr, Ashraf Fawzy, Kirsten Koehler, Jeffrey L. Curtis, Christine M. Freeman, Christopher B. Cooper, Alejandro P. Comellas, Cheryl Pirozzi, Robert Paine, Donald Tashkin, Jerry A. Krishnan, Coralynn Sack, Nirupama Putcha, Laura M. Paulin, Marina Zusman, Joel D. Kaufman … & Nadia N. Hansel
Abstract Background Airway macrophages (AM), crucial for the immune response in chronic obstructive pulmonary disease (COPD), are exposed to environmental particulate matter (PM), which they retain in their cytoplasm as black carbon (BC). However, whether AM BC accurately reflects environmental PM2.5 exposure, and can serve as a biomarker of COPD outcomes, is unknown. Methods We analyzed induced sputum from participants at 7 of 12 sites SPIROMICS sites for AM BC content, which we related to...

Two sesquiterpene lactones, arnicolide B and arnicolide C, isolated from Centipeda minima, exert anti-inflammatory effects in LPS stimulated RAW 264.7 macrophages via inactivation of the MAPK pathway

Ge Wang, Hongfang Liu, Qingran Zhang, Xiaofeng Mou, Yan Zhao, Huaying Fan, Hui Xu, Daquan Chen, Feng Qiu & Feng Zhao
Arnicolide B and arnicolide C are two sesquiterpene lactones isolated and identified from Centipeda minima, but the anti-inflammatory effects and mechanisms of these two compounds have not been reported. In this study, LPS was used to establish RAW 264.7 macrophages inflammatory response model. Griess, ELISA, Western blot were used to investigate the anti-inflammatory effects in vitro and the molecular mechanisms of these two active compounds. The results showed that arnicolide B and arnicolide C could...

CRANIUM: a quasi-experimental study to improve metabolic screening and HIV testing in community mental health clinics compared to usual care

Alison R. Hwong, D. Nyasha Chagwedera, Marilyn Thomas, Grace Niu, Judy Quan, Eric Vittinghoff, Dean Schillinger, John W. Newcomer, Ana Gonzalez, Susan Essock & Christina Mangurian
Abstract Background Individuals with serious mental illness often do not receive guideline-concordant metabolic screening and human immunodeficiency virus (HIV) testing, contributing to increased morbidity and premature mortality. This study evaluates the effectiveness of CRANIUM (Cardiometabolic Risk Assessment and treatment through a Novel Integration model for Underserved populations with Mental illness), an intervention to increase metabolic screening and HIV testing among patients with serious mental illness in a community mental health clinic compared to usual care....

National COVID-19 lockdown and trends in help-seeking for violence against children in Zimbabwe: an interrupted time-series analysis

Ilan Cerna-Turoff, Robert Nyakuwa, Ellen Turner, Charles Muchemwa Nherera, Tendai Nhenga-Chakarisa & Karen Devries
Abstract Background An estimated 1.8 billion children live in countries where COVID-19 disrupted violence prevention and response. It is important to understand how government policies to contain COVID-19 impacted children’s ability to seek help, especially in contexts where there was limited formal help-seeking prior to the pandemic. We aimed to quantify how the national lockdown in Zimbabwe affected helpline calls for violence against children, estimated the number of calls that would have been received had...

Additional file 2 of Case report: novel PCDH15 variant causes usher syndrome type 1F with congenital hearing loss and syndromic retinitis pigmentosa

Nelson Chen, Hane Lee, Angela H. Kim, Pei-Kang Liu, Eugene Yu-Chuan Kang, Yun-Ju Tseng, Go Hun Seo, Rin Khang, Laura Liu, Kuan-Jen Chen, We-Chi Wu, Meng-Chang Hsiao & Nan-Kai Wang
Additional file 2: Supplementary Fig. 2. Sanger sequencing of the PCDH15 gene. The sequence trace shows the PCDH15 variant, which is consistent with whole exome sequencing (WES) test results.

Mean-standard deviation based electric vehicle routing problem using Lagrangian relaxation and extended alternating direction method of multipliers based decomposition algorithm

Xia Jieman & Siliang Liu
This is the experimental data of the manuscript entitled “ Mean-standard deviation based electric vehicle routing problem using Lagrangian relaxation and extended alternating direction method of multipliers based decomposition algorithm”. In this data set, small and large instances are included, and each instance gives the information of the links, such as the start node, end node and variance of the link.

Mean-standard deviation based electric vehicle routing problem using Lagrangian relaxation and extended alternating direction method of multipliers based decomposition algorithm

Xia Jieman & Siliang Liu
This is the experimental data of the manuscript entitled “ Mean-standard deviation based electric vehicle routing problem using Lagrangian relaxation and extended alternating direction method of multipliers based decomposition algorithm”. In this data set, small and large instances are included, and each instance gives the information of the links, such as the start node, end node and variance of the link.

Additional file 1 of Meta-analysis of 16S rRNA microbial data identified alterations of the gut microbiota in COVID-19 patients during the acute and recovery phases

Xiaomin Cheng, Yali Zhang, Yifan Li, Qin Wu, Jiani Wu, Soo-Kyung Park, Cheng Guo & Jiahai Lu
Additional file 1. .

Meta-analysis of 16S rRNA microbial data identified alterations of the gut microbiota in COVID-19 patients during the acute and recovery phases

Xiaomin Cheng, Yali Zhang, Yifan Li, Qin Wu, Jiani Wu, Soo-Kyung Park, Cheng Guo & Jiahai Lu
Abstract Background Dozens of studies have demonstrated gut dysbiosis in COVID-19 patients during the acute and recovery phases. However, a consensus on the specific COVID-19 associated bacteria is missing. In this study, we performed a meta-analysis to explore whether robust and reproducible alterations in the gut microbiota of COVID-19 patients exist across different populations. Methods A systematic review was conducted for studies published prior to May 2022 in electronic databases. After review, we included 16...

Additional file 2 of National COVID-19 lockdown and trends in help-seeking for violence against children in Zimbabwe: an interrupted time-series analysis

Ilan Cerna-Turoff, Robert Nyakuwa, Ellen Turner, Charles Muchemwa Nherera, Tendai Nhenga-Chakarisa & Karen Devries
Additional file 2. Characteristics of violence related calls in the sample

Additional file 3 of National COVID-19 lockdown and trends in help-seeking for violence against children in Zimbabwe: an interrupted time-series analysis

Ilan Cerna-Turoff, Robert Nyakuwa, Ellen Turner, Charles Muchemwa Nherera, Tendai Nhenga-Chakarisa & Karen Devries
Additional file 3. Violence call trends

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