3 Works

Data from: Cognitive approach to rehabilitation in children with hyperkinetic movement disorders post-DBS

Hortensia Gimeno, Richard G. Brown, Jean-Pierre Lin, Victoria Cornelius & Helene J. Polatajko
Objective: This proof-of-concept feasibility trial examined the potential of the Cognitive Orientation to daily Occupational Performance (CO-OP) ApproachTM to augment deep brain stimulation (DBS) outcomes in childhood-onset hyperkinetic movement disorders (HMD) including dystonia and dyskinetic cerebral palsy. Methods: Single case experimental design using multiple baseline as N-of-1 trial comprised of 10 intervention sessions, with replications across participants (n=10). Treatment focused on three participant-selected goals. Transfer was assessed on two additional untreated goals. Individuals enrolled were...

Data from: Cannabis analgesia in chronic neuropathic pain is associated with altered brain connectivity

Libat Weizman, Lior Dayan, Silviu Brill, Hadas Nahman-Averbuch, Talma Hendler, Giris Jacob & Haggai Sharon
Objective: The purpose of this study was to characterize the functional brain changes involved in THC modulation of chronic neuropathic pain. Methods: Fifteen patients with chronic radicular neuropathic pain participated in a randomized, double-blind, placebo-controlled trial employing a counterbalanced, within-subjects design. Pain assessments and functional resting state brain scans were performed at baseline and after sublingual THC administration. We examined functional connectivity of the anterior cingulate cortex (ACC) and pain related network dynamics using graph...

Subjective sleep quality and sleep architecture in patients with migraine: a meta-analysis

Emily Stanyer, Hannah Creeney, Jan Hoffmann, Alexander Nesbitt, Philip Holland & Jan Hoffmann
Objectives: Sleep disturbance is often associated with migraine. However, there is a paucity of research investigating objective and subjective measures of sleep in migraine patients. This meta-analysis aims to determine whether there are differences in subjective sleep quality measured using the Pittsburgh Sleep Quality Index (PSQI), and objective sleep physiology measured using polysomnography between adult and pediatric patients, and healthy controls. Methods: This review was pre-registered on PROSPERO (CRD42020209325). A systematic search of five databases...

Registration Year

  • 2021
  • 2018

Resource Types

  • Dataset


  • Guy's and St Thomas' NHS Foundation Trust
  • South London and Maudsley NHS Foundation Trust
  • Cincinnati Children's Hospital Medical Center
  • King's College London
  • University of Toronto
  • Imperial College London
  • Tel Aviv University
  • Tel Aviv Sourasky Medical Center