254 Works

Synthesis of novel, DNA binding heterocyclic dehydroabietylamine derivatives as potential antiproliferative and apoptosis-inducing agents

Fengyi Zhao, Xu Sun, Wen Lu, Li Xu, Jiuzhou Shi, Shilong Yang, Mengyi Zhou, Fan Su, Feng Lin & Fuliang Cao
Several dehydroabietylamine derivatives containing heterocyclic moieties such as thiophene and pyrazine ring were successfully synthesized. The antiproliferative activities of these thiophene-based Schiff-bases, thiophene amides, and pyrazine amides were investigated in vitro against Hela (cervix), MCF-7 (breast), A549 (lung), HepG2 (liver), and HUVEC (umbilical vein) cells by MTT assay. The toxicity of L1−L10 (IC50 = 5.92− >100 μM) was lower than L0 (1.27 μM) and DOX (4.40 μM) in every case. Compound L1 had higher anti-HepG2...

sj-pdf-2-ppa-10.1177_09520767211034664 - Supplemental material for The evolution of collaborative networks: A social network analysis of Chinese environmental protection policy

Yanwei Li & Jing Huang
Supplemental material, sj-pdf-2-ppa-10.1177_09520767211034664 for The evolution of collaborative networks: A social network analysis of Chinese environmental protection policy by Yanwei Li and Jing Huang in Public Policy and Administration

Acute kidney injury in idiopathic membranous nephropathy with nephrotic syndrome

Tianxin Chen, Ying Zhou, Xinxin Chen, Bo Chen & Jingye Pan
The impact of acute kidney injury (AKI) on the progression of renal function in idiopathic membranous nephropathy (iMN) with nephrotic syndrome (NS) patients have not yet been reported, we sought to investigate the incidence, clinical features and prognosis of AKI in iMN with NS patients and determine clinical predictors for progression from AKI to advanced chronic kidney disease (CKD) stage. We analyzed clinical and pathological data of iMN with NS patients retrospectively collected from Jan...

Glycolysis related gene expression signature in predicting prognosis of laryngeal squamous cell carcinoma

Hui-Ching Lau, Yujie Shen, Qiang Huang, Hui-Ying Huang & Liang Zhou
Researches have suggested that aerobic glycolysis can reflect the development and progression of most carcinomas. We aimed to investigate whether glycolysis-related genes (GRGs) are associated with overall survival in laryngeal squamous cell carcinoma (LSCC). Here, we identified differentially expressed GRGs in TCGA dataset and microarray sample of GSE27020 from GEO database. A set of two glycolytic gene signatures, including DDIT4 and PLOD2 was screened through Cox and Lasso regression. The risk score was calculated using...

Additional file 3 of Using a WeChat mini-program-based lactation consultant intervention to increase the consumption of mother’s own milk by preterm infants in the neonatal intensive care unit: a study protocol for a cluster randomized controlled trial

Jie Huo, Xinping Wu, Chuanli Gu, Zhangbin Yu, Jun Zhang, Xiaohui Chen, Jingai Zhu, Feng Liu, Beibei Liu, Qianqian Li & Shuping Han
Additional file 3.

Synthesis, crystal structure and coordination behaviors of two unexpected tetranuclear Zn(II) and Co(II) supramolecular boxes derived from structural variation of coumarin schiff base ligand

Yin-Xia Sun, Juan Li, Jin-Guo Li, Zhe-Peng Deng, Yu Sun & Li Xu
Two unexpected tetranuclear supramolecular boxes, [Zn4(L')4(CH3OH)2]·2CH3OH (1) and [Co4(L)2(L')2(CH3OH)2]·acetone (2), with M4(μ3-O)2(μ2-O)4 core were obtained through reacting coumarin Schiff base H2L (H2L = 4-hydroxy-3-((2-hydroxyphenyl-imino)-methyl)-2hchrome-2-one) with Zn(OAc)2·4H2O and Co(OAc)2·4H2O, respectively. Interestingly, the original ligand (H2L) has changed into a new structure (H2L') in the process of forming single crystals. The structures of 1 and 2 were characterized by X-ray single crystal diffraction. 1 and 2 are tetranuclear structures including four metal centers (Zn(II) or Co(II)), four...

Sample Size Calculation and Timing of Dose Selection in a Multiple-Dose Clinical Trial

Liji Shen, Jin Zhang & Paul DeLucca
In a two-stage design for multiple-dose clinical trial, a dose that has the highest observed response rate is often chosen to carry to the next stage, then to compare against the control group. The observed response rate could overestimate the true response rate of the selected dose. If it is used to compare with the response rate of the control group without any adjustment, the Type I error of this statistical inference will not be...

Additional file 1 of Expression profile and prognostic values of LSM family in skin cutaneous melanoma

Xiaofang Sun, Jianping Zhang, Can Xiao & Zili Ge
Additional file 1. Supplementary Fig S1. The expression of LSM family members in SKCM was analyzed using univariate Cox regression as a predictor of OS. The results are presented as forest plots. LSM2, LSM4, and LSM6 significantly influenced the OS of patients with SKCM.

A comparative study to determine the association of gut microbiome with schizophrenia in Zhejiang, China

Fuyang Yan, Lehong Xia, Li Xu, Liyun Deng & Guolin Jin
Abstract Background With the rapid progress of high-throughput sequencing technology, characterization of schizophrenia (SZ) with underlying probing of the gut microbiome can explore pathogenic mechanisms, estimate disease risk, and allow customization of therapeutic and prophylactic modalities. In this study, we compared the differences in gut microbial diversity and composition between 50 SZ subjects and 50 healthy matched subjects in Zhejiang, China via targeted next-generation sequencing (16S rRNA amplicon). Results Accordingly, the alpha diversity indices (observed...

Four new compounds from the fruits of Chinese dwarf cherry (Prunus humilis Bunge)

Sheng Dong, Ying Zhou, Ji-Chao Wang, Yi-Lin Zhuo, Yi-Han Sun, Jun-Gang Wang & Guo-Gang Zhang
A new flavonoid (bunge A) (1), a new sesquiterpene (bunge B) (8), a new furan derivative (bunge C) (12) and a new alkenoic acid (bunge D) (14), together with ten known ones [four flavonoids (2, 3, 4, 5), two phenylpropanoids (6, 7), three sesquiterpenes (9, 10, 11) and one lactone (13)] were isolated from the fruits of Prunus humilis Bunge [Cerasus humilis (Bunge) Sokolov]. Their structures were elucidated based on extensive spectroscopic analysis (including HR-ESI-MS...

Phylogenomics, plastome degradation and mycoheterotrophy evolution of Neottieae (Orchidaceae), with emphasis on the systematic position and Loess Plateau-Changbai Mountains disjunction of Diplandrorchis

Huan-Wen Peng, Lian Lian, Jun Zhang, Andrey S. Erst & Wei Wang
Abstract Background Mycoheterotrophy is a unique survival strategy adapted to dense forests and has attracted biologists’ attention for centuries. However, its evolutionary origin and related plastome degradation are poorly understood. The tribe Neottieae contains various nutrition types, i.e., autotrophy, mixotrophy, and mycoheterotrophy. Here, we present a comprehensive phylogenetic analysis of the tribe based on plastome and nuclear ITS data. We inferred the evolutionary shift of nutrition types, constructed the patterns of plastome degradation, and estimated...

Additional file 1 of Prediction and prognosis of adverse maternal and foetal/neonatal outcomes in pulmonary hypertension: an observational study and nomogram construction

Yuqin Chen, Dansha Zhou, Mingmei Xiong, Xin Xi, Wenni Zhang, Ruifeng Zhang, Lishi Chen, Qian Jiang, Ning Lai, Xiang Li, Jieer Luo, Xuanyi Li, Weici Feng, Chuhui Gao, Jiyuan Chen, Xin Fu, Wei Hong, Mei Jiang, Kai Yang, Wenju Lu, Yiping Luo, Jun Zhang, Zhe Cheng, Chunli Liu & Jian Wang
Additional file 1. Supplementary materials for the prediction and prognosis of adverse maternal and foetal/neonatal outcomes in pulmonary hypertension.

Two new chromone derivatives from the rhizosphere soil fungus Ilyonectria robusta

Min Kuang, Wei-Wei Peng, Yuan-Tao Huang, Mei-Fang Li, Si-Yu Qin, Yu-Ting Zheng, Li Xu, Qi Huang & Zhen-Xing Zou
Two new chromone derivatives (1 and 2), and two known compounds (3 and 4) were isolated from the rhizosphere soil fungus Ilyonectria robusta. Their planar structures and absolute configurations were determined by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. Additionally, all the isolated compounds were evaluated for their antibacterial activity against Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa and Escherichia coli, but no obvious activity was observed at a concentration of 128 μg/mL.

Additional file 1 of Interaction of miR-200a-3p with YAP regulates cell proliferation and metastasis differentially in HPV-positive and HPV-negative cervical cancer cells

Hong Chen, Lingling Gu, Min Zhang, Huifen Chen, Hong Liao, Xueping Cao, Lu Yu & Jun Zhang
Additional file 1: Supplementary Fig. S1. qRT-PCRassessmentsoftransfectionefficiencies The transfection efficiencies of miR-200a-3p mimics (A), sh-miR-200a-3p (B), and YAP(C)wereperformedinC33A,SihaandHelacells.*p<0.05, **p<0.01,***p<0.001,ns:notsignificant. The authors declare that they have no competing interests. Supplementary Fig. S2. themRNAandproteinlevelsofYAPinHelacells Significant decreases in levels of YAP mRNA (A) and YAP protein (B) following up-regulations of miR-200a-3p, or significant increases in levels of YAP mRNA (C) and protein (D) following down-regulations of miR-200a-3p were not observed in Helacells.*p<0.05,**p<0.01,***p<0.001,ns:notsignificant.

Interaction of miR-200a-3p with YAP regulates cell proliferation and metastasis differentially in HPV-positive and HPV-negative cervical cancer cells

Hong Chen, Lingling Gu, Min Zhang, Huifen Chen, Hong Liao, Xueping Cao, Lu Yu & Jun Zhang
Abstract Background Although evidence has revealed that miR-200a-3p is involved in the malignant progression of various tumors, the regulatory mechanism of miR-200a-3p in the development of cervical cancer (CC) cells with different HPV statuses remains unknown. The present study was to investigate the differential effects of either miR-200a-3p or YAP on tumorous cells’ fate in vitro in HPV-negative and HPV-positive cervical cancer cell models, and to explore if the changes in proliferation, migration, and invasion...

sj-docx-1-cll-10.1177_09636897221124485 – Supplemental material for Identification of Immune Infiltration and Effective Immune Biomarkers in Acute Lung Injury by Bioinformatics Analysis

Dandan Ling, Xiang Zhang, Jiamin Wu, Qianyun Xu, Zhiyong He & Jun Zhang
Supplemental material, sj-docx-1-cll-10.1177_09636897221124485 for Identification of Immune Infiltration and Effective Immune Biomarkers in Acute Lung Injury by Bioinformatics Analysis by Dandan Ling, Xiang Zhang, Jiamin Wu, Qianyun Xu, Zhiyong He and Jun Zhang in Cell Transplantation

sj-docx-1-cll-10.1177_09636897221124485 – Supplemental material for Identification of Immune Infiltration and Effective Immune Biomarkers in Acute Lung Injury by Bioinformatics Analysis

Dandan Ling, Xiang Zhang, Jiamin Wu, Qianyun Xu, Zhiyong He & Jun Zhang
Supplemental material, sj-docx-1-cll-10.1177_09636897221124485 for Identification of Immune Infiltration and Effective Immune Biomarkers in Acute Lung Injury by Bioinformatics Analysis by Dandan Ling, Xiang Zhang, Jiamin Wu, Qianyun Xu, Zhiyong He and Jun Zhang in Cell Transplantation

Supplementary document for Spatio-temporal doubly periodic waves in phase-mismatched second-harmonic generation - 6094077.pdf

Zhixiang Deng, Jin Zhang, Dianyuan Fan & LIFU ZHANG
1. Transformation of the quadratic nonlinear system into the cubic nonlinear system in the regime of cascading limit;2. Doubly-periodic waves from the cubic nonlinearity

Supplementary document for Spatio-temporal doubly periodic waves in phase-mismatched second-harmonic generation - 6094077.pdf

Zhixiang Deng, Jin Zhang, Dianyuan Fan & LIFU ZHANG
1. Transformation of the quadratic nonlinear system into the cubic nonlinear system in the regime of cascading limit;2. Doubly-periodic waves from the cubic nonlinearity

A high-quality Buxus austro-yunnanensis (Buxales) genome provides new insights into karyotype evolution in early eudicots

Zhenyue Wang, Ying Li, Pengchuan Sun, Mingjia Zhu, Dandan Wang, Zhiqiang Lu, Hongyin Hu, Renping Xu, Jin Zhang, Jianxiang Ma, Jianquan Liu & Yongzhi Yang
Abstract Background Eudicots are the most diverse group of flowering plants that compromise five well-defined lineages: core eudicots, Ranunculales, Proteales, Trochodendrales, and Buxales. However, the phylogenetic relationships between these five lineages and their chromosomal evolutions remain unclear, and a lack of high-quality genome analyses for Buxales has hindered many efforts to address this knowledge gap. Results Here, we present a high-quality chromosome-level genome of Buxus austro-yunnanensis (Buxales). Our phylogenomic analyses revealed that Buxales and Trochodendrales...

Supplementary document for A polarization tunable transmitted full-color display with enhanced switchability - 6213452.pdf

Xufeng Gao, Qi Wang, Shijie Zhang, Ruijin Hong, Dawei Zhang & Songlin Zhuang
Clean revised manuscript

Hepatic Arterial Infusion of Oxaliplatin, Fluorouracil, and Leucovorin Versus Sorafenib for Hepatocellular Carcinoma Refractory to Transarterial Chemoembolization: Retrospective Subgroup Analysis of 2 Prospective Trials

YeXing Huang, LiHong Zhang, MinKe He, ZhiCheng Lai, XiaoYun Bu, DongSheng Wen, QiJiong Li, Li Xu, Wei Wei, YaoJun Zhang, ZhongGuo Zhou, MinShan Chen, RongPing Guo, Ming Shi & Anna Kan
Purpose:Sorafenib is recommended for patients with hepatocellular carcinoma refractory to transarterial chemoembolization but with unsatisfactory overall survival and tumor response rate. Previously published studies showed hepatic arterial infusion chemotherapy of oxaliplatin, fluorouracil, and leucovorin was an effective and safe treatment. The aims of this study were to compare the clinical efficacy and safety of oxaliplatin, fluorouracil, and leucovorin-based hepatic arterial infusion chemotherapy with sorafenib in patients with hepatocellular carcinoma refractory to transarterial chemoembolization. Methods: This...

Additional file 1 of Smoking-mediated nicotinic acetylcholine receptors (nAChRs) for predicting outcomes for head and neck squamous cell carcinomas

Yujie Shen, Qiang Huang, Mengyou Ji, Chi-Yao Hsueh & Liang Zhou
Additional file 1: Supplementary Figure 1. Prognosticanalysis of the nAChR-based prognostic signature. (A) Expression profile of β3nAChR; blue and red dots represent normal adjacent and tumor tissues,respectively. **p < 0.01; (B) Kaplan-Meier survivalanalysis of HPV- HNSCC patients using the prognostic signature; (C) Kaplan-Meier survivalanalysis of HPV+ HNSCC patients using the prognostic signature; ROCcurves without calculating signature expression for (D) one-year OS, (E) three-year OS, (F) five-year OS, and (G) seven-year OS.

Additional file 3 of Smoking-mediated nicotinic acetylcholine receptors (nAChRs) for predicting outcomes for head and neck squamous cell carcinomas

Yujie Shen, Qiang Huang, Mengyou Ji, Chi-Yao Hsueh & Liang Zhou
Additional file 3: Supplementary Table 1. Clinical information of smoking HNSCC cohort.

Additional file 4 of Smoking-mediated nicotinic acetylcholine receptors (nAChRs) for predicting outcomes for head and neck squamous cell carcinomas

Yujie Shen, Qiang Huang, Mengyou Ji, Chi-Yao Hsueh & Liang Zhou
Additional file 4: Supplementary Table 2. Clinical information of adjacent normal samples.

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