162 Works

Data from: Placebo effects in trials evaluating 12 selected minimally invasive interventions: a systematic review and meta-analysis

Robin Holtedahl, Jens Ivar Brox & Ole Tjomsland
Objectives: To analyse the impact of placebo effects on outcome in trials of selected minimally invasive procedures and to assess reported adverse events in both trial arms. Design: A systematic review and meta-analysis. Data sources and study selection: We searched MEDLINE and Cochrane library to identify systematic reviews of musculoskeletal, neurological and cardiac conditions published between January 2009 and January 2014 comparing selected minimally invasive with placebo (sham) procedures. We searched MEDLINE for additional randomised...

Stabilizing group treatment for childhood-abuse related PTSD: a randomized controlled trial

Harald Bækkelund, Ida Karlsrud, Asle Hoffart & Espen Ajo Arnevik
Background: Patients with PTSD related to childhood-abuse often experience additional problems such as emotional dysregulation and interpersonal difficulties. Psychotherapy focused on stabilization of symptoms, emotion-regulation, and skills training has been suggested as a treatment for this patient population, either as preparation for further treatment or as a stand-alone intervention. Objective: The present study tests the efficacy of treatment using a group-protocol for stabilizing treatment delivered adjunct with conventional individual therapy. Methods: In a delayed-treatment design...

Intracranial effect of osimertinib in relapsed EGFR-mutated T790M-positive and -negative non-small cell lung cancer patients: results from a phase II study

Inger Johanne Zwicky Eide, Harald Grut, Åslaug Helland, Simon Ekman, Jens Benn Sørensen, Karin Holmskov Hansen, Bjørn Henning Grønberg, Saulius Cicenas, Jussi Pekka Koivunen, Anders Mellemgaard & Odd Terje Brustugun
Osimertinib is effective for relapsed T790M-positive patients with brain metastases. The high brain permeability suggests that also such patients without T790M could benefit. Therefore, we evaluated the effect of osimertinib on brain metastases in both T790M-positive and -negative patients. The TREM-study was an investigator-initiated phase II, single-arm, multi-institutional clinical trial conducted in Northern Europe. Patients with resistance to prior EGFR-TKIs received osimertinib until radiological progression, unacceptable toxicity or death. Baseline brain scans were performed in...

Urinary orosomucoid is associated with diastolic dysfunction and carotid arteriopathy in the general population. Cross-sectional data from the Tromsø study

Runa M. Andreassen, Jens B. Kronborg, Henrik Schirmer, Ellisiv B. Mathiesen, Toralf Melsom, Bjørn O. Eriksen, Trond G. Jenssen & Marit D. Solbu
Objectives. Urinary albumin excretion is a risk marker for cardiovascular disease (CVD). Studies suggest that urinary orosomucoid may be a more sensitive marker of general endothelial dysfunction than albuminuria. The aim of this population-based cross-sectional study was to examine the associations between urinary orosomucoid to creatinine ratio (UOCR), urinary albumin to creatinine ratio (UACR) and subclinical CVD. Design. From the Tromsø Study (2007/2008), we included all men and women who had measurements of urinary orosomucoid...

Additional file 1 of Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium

Pål Møller, Toni Seppälä, James G. Dowty, Saskia Haupt, Mev Dominguez-Valentin, Lone Sunde, Inge Bernstein, Christoph Engel, Stefan Aretz, Maartje Nielsen, Gabriel Capella, Dafydd Gareth Evans, John Burn, Elke Holinski-Feder, Lucio Bertario, Bernardo Bonanni, Annika Lindblom, Zohar Levi, Finlay Macrae, Ingrid Winship, John-Paul Plazzer, Rolf Sijmons, Luigi Laghi, Adriana Della Valle, Karl Heinimann … & Mark A. Jenkins
Additional file 1.

Additional file 2 of The effect of an integrated care intervention of multidisciplinary mental health treatment and employment services for trauma-affected refugees: study protocol for a randomised controlled trial

Maja Bruhn, Henriette Laugesen, Matilde Kromann-Larsen, Cathrine Selnes Trevino, Lene Eplov, Carsten Hjorthøj & Jessica Carlsson
Additional file 2. CONSORT 2010 Flow Diagram.

Utility of a three-gene transcriptomic signature in the diagnosis of tuberculosis in a low-endemic hospital setting

Bih Hycenta Chendi, Tracey Jooste, Thomas Jens Scriba, Martin Kidd, Simon Mendelsohn, Kristian Tonby, Gerhard Walzl, Anne M. Dyrhol-Riise & Novel Njweipi Chegou
Host transcriptomic blood signatures have demonstrated diagnostic potential for tuberculosis (TB), requiring further validation across different geographical settings. Discriminating TB from other diseases with similar clinical manifestations is crucial for the development of an accurate immunodiagnostic tool. In this exploratory cohort study, we evaluated the performance of potential blood-based transcriptomic signatures in distinguishing TB disease from non-TB lower respiratory tract infections in hospitalised patients in a TB low-endemic country. Quantitative real-time polymerase chain reaction qPCR)...

sj-docx-1-cat-10.1177_10760296221141893 - Supplemental material for Genetic Variation in ADAMTS13 is Related to VWF Levels, Atrial Fibrillation and Cerebral Ischemic Events

Ellen M. K. Warlo, Vibeke Bratseth, Alf-Åge R. Pettersen, Pål Andre Holme, Harald Arnesen, Ingebjørg Seljeflot & Trine B. Opstad
Supplemental material, sj-docx-1-cat-10.1177_10760296221141893 for Genetic Variation in ADAMTS13 is Related to VWF Levels, Atrial Fibrillation and Cerebral Ischemic Events by Ellen M. K. Warlo, MD, Vibeke Bratseth, MSc, PhD, Alf-Åge R. Pettersen, MD, PhD, Pål Andre Holme, MD, PhD, Harald Arnesen, MD, PhD, Ingebjørg Seljeflot, PhD, and Trine B. Opstad, MSc, PhD in Clinical and Applied Thrombosis/Hemostasis

Additional file 2 of The role of personality traits and leisure activities in predicting wellbeing in young people

Sarah L. Asquith, Xu Wang, Daniel S. Quintana & Anna Abraham
Additional file 2. Copy of Table 4 with exact p values

Use of non-governmental maternity services and pregnancy outcomes among undocumented women: a cohort study from Norway

Frode Eick, Odd Martin Vallersnes, Heidi E. Fjeld, Ingvil Krarup Sørbye, Guro Storkås, Marthe Ekrem, Marie Børmer, Sara Andrea Løberg, Cathrine Ebbing, Nanna Voldner & Cecilie Dahl
Abstract Background In 2011 Norway granted undocumented women the right to antenatal care and to give birth at a hospital but did not include them in the general practitioner and reimbursement schemes. As a response to limited access to health care, Non-Governmental Organizations (NGO) have been running health clinics for undocumented migrants in Norway’s two largest cities. To further facilitate universal health coverage, there is a need to investigate how pregnant undocumented women use NGO...

Additional file 1 of Use of non-governmental maternity services and pregnancy outcomes among undocumented women: a cohort study from Norway

Frode Eick, Odd Martin Vallersnes, Heidi E. Fjeld, Ingvil Krarup Sørbye, Guro Storkås, Marthe Ekrem, Marie Børmer, Sara Andrea Løberg, Cathrine Ebbing, Nanna Voldner & Cecilie Dahl
Additional file 1. Directed Acyclic Graphs.

Children with a rare congenital genetic disorder: a systematic review of parent experiences

Charlotte von der Lippe, Ingrid Neteland & Kristin Billaud Feragen
Abstract Background Caring for a child with a chronic disease may be demanding and stressful. When a child has a rare condition, the impact of care on parents is amplified due to the rarity of the diagnosis. In order to address the lack of generalized and synthesized knowledge regarding parents’ experiences of having a child with a rare genetic disorder, and give a holistic picture of these experiences, a systematic review of the available qualitative...

Additional file 1 of Children with a rare congenital genetic disorder: a systematic review of parent experiences

Charlotte von der Lippe, Ingrid Neteland & Kristin Billaud Feragen
Additional file 1. Appendix I.

sj-docx-1-sjs-10.1177_14574969221127530 – Supplemental material for Body mass index and pancreatic adenocarcinoma: A nationwide registry-based cohort study

Usman Saeed, Tor Å. Myklebust, Trude E. Robsahm, Bjørn Møller, Tom Mala, Bjørn S. Skålhegg & Sheraz Yaqub
Supplemental material, sj-docx-1-sjs-10.1177_14574969221127530 for Body mass index and pancreatic adenocarcinoma: A nationwide registry-based cohort study by Usman Saeed, Tor Å. Myklebust, Trude E. Robsahm, Bjørn Møller, Tom Mala, Bjørn S. SkÅlhegg and Sheraz Yaqub in Scandinavian Journal of Surgery

sj-jpg-3-sjs-10.1177_14574969221127530 – Supplemental material for Body mass index and pancreatic adenocarcinoma: A nationwide registry-based cohort study

Usman Saeed, Tor Å. Myklebust, Trude E. Robsahm, Bjørn Møller, Tom Mala, Bjørn S. Skålhegg & Sheraz Yaqub
Supplemental material, sj-jpg-3-sjs-10.1177_14574969221127530 for Body mass index and pancreatic adenocarcinoma: A nationwide registry-based cohort study by Usman Saeed, Tor Å. Myklebust, Trude E. Robsahm, Bjørn Møller, Tom Mala, Bjørn S. SkÅlhegg and Sheraz Yaqub in Scandinavian Journal of Surgery

sj-docx-2-sjs-10.1177_14574969221127530 – Supplemental material for Body mass index and pancreatic adenocarcinoma: A nationwide registry-based cohort study

Usman Saeed, Tor Å. Myklebust, Trude E. Robsahm, Bjørn Møller, Tom Mala, Bjørn S. Skålhegg & Sheraz Yaqub
Supplemental material, sj-docx-2-sjs-10.1177_14574969221127530 for Body mass index and pancreatic adenocarcinoma: A nationwide registry-based cohort study by Usman Saeed, Tor Å. Myklebust, Trude E. Robsahm, Bjørn Møller, Tom Mala, Bjørn S. SkÅlhegg and Sheraz Yaqub in Scandinavian Journal of Surgery

Additional file 1 of Cost-effectiveness of a rule-out algorithm of acute myocardial infarction in low-risk patients: emergency primary care versus hospital setting

Tonje R. Johannessen, Sigrun Halvorsen, Dan Atar, John Munkhaugen, Anne Kathrine Nore, Torbjørn Wisløff & Odd Martin Vallersnes
Additional file 1.

Additional file 1 of Cri du chat syndrome patients have DNA methylation changes in genes linked to symptoms of the disease

Petter Holland, Mari Wildhagen, Mette Istre, Olaug Marie Reiakvam, John Arne Dahl & Arne Søraas
Additional file 1. Supplementary Figures 1–6.

Cri du chat syndrome patients have DNA methylation changes in genes linked to symptoms of the disease

Petter Holland, Mari Wildhagen, Mette Istre, Olaug Marie Reiakvam, John Arne Dahl & Arne Søraas
Abstract Background Cri du chat (also called 5p deletion, or monosomy 5p) syndrome is a genetic disease caused by deletions of various lengths in the short (p) arm of chromosome 5. Genetic analysis and phenotyping have been used to suggest dose-sensitive genes in this region that may cause symptoms when a gene copy is lost, but the heterogeneity of symptoms for patients with similar deletions complicates the picture. The epigenetics of the syndrome has only...

Additional file 2 of Public knowledge about dementia risk reduction in Norway

Grete Kjelvik, Anne Marie Mork Rokstad, Josephine Stuebs, Pernille Thingstad, Kay Deckers, Sebastian Köhler & Geir Selbæk
Additional file 2. Motivationto Change Lifestyle for Dementia Risk Reduction (MOHAD-10).

Public knowledge about dementia risk reduction in Norway

Grete Kjelvik, Anne Marie Mork Rokstad, Josephine Stuebs, Pernille Thingstad, Kay Deckers, Sebastian Köhler & Geir Selbæk
Abstract Background Several modifiable lifestyle risk factors for dementia have been identified, but it is unclear how much the Norwegian public knows about the relationship between lifestyle and brain health. Therefore, this study aimed to investigate knowledge about modifiable dementia risk and protective factors and beliefs and attitudes towards dementia and dementia risk reduction in a randomly selected subsample of the Norwegian population. Methods The total sample (n = 1435) included individuals aged 40–70 years...

Additional file 3 of Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk

Shannon D’Urso, Pooja Arumugam, Therese Weider, Liang-Dar Hwang, Tom A. Bond, John P. Kemp, Nicole M. Warrington, David M. Evans, Tracy A. O’Mara & Gunn-Helen Moen
Additional file 3.

Additional file 1 of Algebraic topology-based machine learning using MRI predicts outcomes in primary sclerosing cholangitis

Yashbir Singh, William A. Jons, John E. Eaton, Mette Vesterhus, Tom Karlsen, Ida Bjoerk, Andreas Abildgaard, Kristin Kaasen Jorgensen, Trine Folseraas, Derek Little, Aliya F. Gulamhusein, Kosta Petrovic, Anne Negard, Gian Marco Conte, Joseph D. Sobek, Jaidip Jagtap, Sudhakar K. Venkatesh, Gregory J. Gores, Nicholas F. LaRusso, Konstantinos N. Lazaridis & Bradley J. Erickson
Additional file 1.

Algebraic topology-based machine learning using MRI predicts outcomes in primary sclerosing cholangitis

Yashbir Singh, William A. Jons, John E. Eaton, Mette Vesterhus, Tom Karlsen, Ida Bjoerk, Andreas Abildgaard, Kristin Kaasen Jorgensen, Trine Folseraas, Derek Little, Aliya F. Gulamhusein, Kosta Petrovic, Anne Negard, Gian Marco Conte, Joseph D. Sobek, Jaidip Jagtap, Sudhakar K. Venkatesh, Gregory J. Gores, Nicholas F. LaRusso, Konstantinos N. Lazaridis & Bradley J. Erickson
Abstract Background Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease that can lead to cirrhosis and hepatic decompensation. However, predicting future outcomes in patients with PSC is challenging. Our aim was to extract magnetic resonance imaging (MRI) features that predict the development of hepatic decompensation by applying algebraic topology-based machine learning (ML). Methods We conducted a retrospective multicenter study among adults with large duct PSC who underwent MRI. A topological data analysis-inspired nonlinear...

Combined burden and functional impact tests for cancer driver discovery using DriverPower

Shimin Shuai, Federico Abascal, Samirkumar B Amin, Gary D Bader, Pratiti Bandopadhayay, Jonathan Barenboim, Rameen Beroukhim, Johanna Bertl, Keith A Boroevich, Søren Brunak, Peter J Campbell, Joana Carlevaro-Fita, Dimple Chakravarty, Calvin Wing Yiu Chan, Ken Chen, Jung Kyoon Choi, Jordi Deu-Pons, Priyanka Dhingra, Klev Diamanti, Lars Feuerbach, J Lynn Fink, Nuno A Fonseca, Joan Frigola, Carlo Gambacorti-Passerini, Dale W Garsed … & L van’t Veer
The discovery of driver mutations is one of the key motivations for cancer genome sequencing. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumour types, we describe DriverPower, a software package that uses mutational burden and functional impact evidence to identify driver mutations in coding and non-coding sites within cancer whole genomes. Using a total of 1373 genomic features...

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