162 Works

Additional file 3 of The role of personality traits and leisure activities in predicting wellbeing in young people

Sarah L. Asquith, Xu Wang, Daniel S. Quintana & Anna Abraham
Additional file 3. Exploratory analysis including gender and cohort as predictors

Speed of cooling after cardiac arrest in relation to the intervention effect: a sub-study from the TTM2-trial

Rupert F. G. Simpson, Josef Dankiewicz, Grigoris V. Karamasis, Paolo Pelosi, Matthias Haenggi, Paul J. Young, Janus Christian Jakobsen, Jonathan Bannard-Smith, Pedro D. Wendel-Garcia, Fabio Silvio Taccone, Per Nordberg, Matt P. Wise, Anders M. Grejs, Gisela Lilja, Roy Bjørkholt Olsen, Alain Cariou, Jean Baptiste Lascarrou, Manoj Saxena, Jan Hovdenes, Matthew Thomas, Hans Friberg, John R. Davies, Niklas Nielsen & Thomas R. Keeble
Abstract Background Targeted temperature management (TTM) is recommended following cardiac arrest; however, time to target temperature varies in clinical practice. We hypothesised the effects of a target temperature of 33 °C when compared to normothermia would differ based on average time to hypothermia and those patients achieving hypothermia fastest would have more favorable outcomes. Methods In this post-hoc analysis of the TTM-2 trial, patients after out of hospital cardiac arrest were randomized to targeted hypothermia...

Speed of cooling after cardiac arrest in relation to the intervention effect: a sub-study from the TTM2-trial

Rupert F. G. Simpson, Josef Dankiewicz, Grigoris V. Karamasis, Paolo Pelosi, Matthias Haenggi, Paul J. Young, Janus Christian Jakobsen, Jonathan Bannard-Smith, Pedro D. Wendel-Garcia, Fabio Silvio Taccone, Per Nordberg, Matt P. Wise, Anders M. Grejs, Gisela Lilja, Roy Bjørkholt Olsen, Alain Cariou, Jean Baptiste Lascarrou, Manoj Saxena, Jan Hovdenes, Matthew Thomas, Hans Friberg, John R. Davies, Niklas Nielsen & Thomas R. Keeble
Abstract Background Targeted temperature management (TTM) is recommended following cardiac arrest; however, time to target temperature varies in clinical practice. We hypothesised the effects of a target temperature of 33 °C when compared to normothermia would differ based on average time to hypothermia and those patients achieving hypothermia fastest would have more favorable outcomes. Methods In this post-hoc analysis of the TTM-2 trial, patients after out of hospital cardiac arrest were randomized to targeted hypothermia...

Additional file 1 of Speed of cooling after cardiac arrest in relation to the intervention effect: a sub-study from the TTM2-trial

Rupert F. G. Simpson, Josef Dankiewicz, Grigoris V. Karamasis, Paolo Pelosi, Matthias Haenggi, Paul J. Young, Janus Christian Jakobsen, Jonathan Bannard-Smith, Pedro D. Wendel-Garcia, Fabio Silvio Taccone, Per Nordberg, Matt P. Wise, Anders M. Grejs, Gisela Lilja, Roy Bjørkholt Olsen, Alain Cariou, Jean Baptiste Lascarrou, Manoj Saxena, Jan Hovdenes, Matthew Thomas, Hans Friberg, John R. Davies, Niklas Nielsen & Thomas R. Keeble
Additional file 1: Fig. 1. Predicted probability of death across the 6 hypothermia groups as compared to the normothermia groups at the corresponding sites. Patients in group 1, with the lowest average temperature at 4 hours had a higher probability of death.

sj-jpg-3-sjs-10.1177_14574969221127530 – Supplemental material for Body mass index and pancreatic adenocarcinoma: A nationwide registry-based cohort study

Usman Saeed, Tor Å. Myklebust, Trude E. Robsahm, Bjørn Møller, Tom Mala, Bjørn S. Skålhegg & Sheraz Yaqub
Supplemental material, sj-jpg-3-sjs-10.1177_14574969221127530 for Body mass index and pancreatic adenocarcinoma: A nationwide registry-based cohort study by Usman Saeed, Tor Å. Myklebust, Trude E. Robsahm, Bjørn Møller, Tom Mala, Bjørn S. SkÅlhegg and Sheraz Yaqub in Scandinavian Journal of Surgery

Additional file 1 of The effect of an integrated care intervention of multidisciplinary mental health treatment and employment services for trauma-affected refugees: study protocol for a randomised controlled trial

Maja Bruhn, Henriette Laugesen, Matilde Kromann-Larsen, Cathrine Selnes Trevino, Lene Eplov, Carsten Hjorthøj & Jessica Carlsson
Additional file 1. SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocol and related documents*.

The effect of an integrated care intervention of multidisciplinary mental health treatment and employment services for trauma-affected refugees: study protocol for a randomised controlled trial

Maja Bruhn, Henriette Laugesen, Matilde Kromann-Larsen, Cathrine Selnes Trevino, Lene Eplov, Carsten Hjorthøj & Jessica Carlsson
Abstract Background The complexity of past trauma and ongoing post-migration stressors challenges the existing mental health treatment for trauma-affected refugees. Therefore, interventions are needed to accommodate these complex challenges in mental health treatment. This study examines the effect of an add-on integrated care intervention compared to treatment as usual (TAU) for trauma-affected refugees in a randomised controlled trial (RCT). Methods The study is carried out at a Danish outpatient clinic and will include 197 treatment-seeking...

The effect of an integrated care intervention of multidisciplinary mental health treatment and employment services for trauma-affected refugees: study protocol for a randomised controlled trial

Maja Bruhn, Henriette Laugesen, Matilde Kromann-Larsen, Cathrine Selnes Trevino, Lene Eplov, Carsten Hjorthøj & Jessica Carlsson
Abstract Background The complexity of past trauma and ongoing post-migration stressors challenges the existing mental health treatment for trauma-affected refugees. Therefore, interventions are needed to accommodate these complex challenges in mental health treatment. This study examines the effect of an add-on integrated care intervention compared to treatment as usual (TAU) for trauma-affected refugees in a randomised controlled trial (RCT). Methods The study is carried out at a Danish outpatient clinic and will include 197 treatment-seeking...

Additional file 1 of Cri du chat syndrome patients have DNA methylation changes in genes linked to symptoms of the disease

Petter Holland, Mari Wildhagen, Mette Istre, Olaug Marie Reiakvam, John Arne Dahl & Arne Søraas
Additional file 1. Supplementary Figures 1–6.

Cri du chat syndrome patients have DNA methylation changes in genes linked to symptoms of the disease

Petter Holland, Mari Wildhagen, Mette Istre, Olaug Marie Reiakvam, John Arne Dahl & Arne Søraas
Abstract Background Cri du chat (also called 5p deletion, or monosomy 5p) syndrome is a genetic disease caused by deletions of various lengths in the short (p) arm of chromosome 5. Genetic analysis and phenotyping have been used to suggest dose-sensitive genes in this region that may cause symptoms when a gene copy is lost, but the heterogeneity of symptoms for patients with similar deletions complicates the picture. The epigenetics of the syndrome has only...

Lactate receptor HCAR1 regulates neurogenesis and microglia activation after neonatal hypoxia-ischemia

Johanne Egge Rinholm, Lauritz Hagen Kennedy, Emilie Rylund Glesaaen, Vuk Palibrk, Marco Pannone, Wei Wang, Ali Hussein Jafar Al-Jabri, Rajikala Suganthan, Niklas Meyer, Xiaolin Lin, Linda Hildegard Bergersen, Magnar Bjørås, Lauritz Kennedy, Emilie R Glesaaen, Ali Al-Jabri, Marie Landa Austbø, Linda H Bergersen & Johanne E Rinholm
Neonatal cerebral hypoxia-ischemia (HI) is the leading cause of death and disability in newborns with the only current treatment being hypothermia. An increased understanding of the pathways that facilitate tissue repair after HI may aid the development of better treatments. Here, we study the role of lactate receptor HCAR1 in tissue repair after neonatal HI in mice. We show that HCAR1 knockout mice have reduced tissue regeneration compared with wildtype mice. Furthermore, proliferation of neural...

Laparoscopic versus open liver resection for intrahepatic cholangiocarcinoma: a multicenter propensity score-matched study

Mushegh A. Sahakyan, Davit L. Aghayan, Bjørn Edwin, Ruslan Alikhanov, Natalia Britskaia, Kristoffer Watten Brudvik, Mathieu D’Hondt, Celine De Meyere, Mikhail Efanov, Åsmund A. Fretland, Rune Hoff, Warsan Ismail, Arpad Ivanecz, Airazat M. Kazaryan, Kristoffer Lassen, Tomislav Magdalenić, Isabelle Parmentier, Bård Ingvald Røsok, Olaug Villanger & Sheraz Yaqub
The role of laparoscopy in the treatment of intrahepatic cholangiocarcinoma (ICC) remains unclear. This multicenter study examined the outcomes of laparoscopic liver resection for ICC. Patients with ICC who had undergone laparoscopic or open liver resection between 2012 and 2019 at four European expert centers were included in the study. Laparoscopic and open approaches were compared in terms of surgical and oncological outcomes. Propensity score matching was used for minimizing treatment selection bias and adjusting...

Infarct quantification with cardiovascular magnetic resonance using \"standard deviation from remote\" is unreliable: validation in multi-centre multi-vendor data

Einar Heiberg, Henrik Engblom, Marcus Carlsson, David Erlinge, Dan Atar, Anthony H. Aletras & Håkan Arheden
Abstract Background The objective of the study was to investigate variability and agreement of the commonly used image processing method “n-SD from remote” and in particular for quantifying myocardial infarction by late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR). LGE-CMR in tandem with the analysis method “n-SD from remote” represents the current reference standard for infarct quantification. This analytic method utilizes regions of interest (ROIs) and defines infarct as the tissue with a set number...

Additional file 1 of Public knowledge about dementia risk reduction in Norway

Grete Kjelvik, Anne Marie Mork Rokstad, Josephine Stuebs, Pernille Thingstad, Kay Deckers, Sebastian Köhler & Geir Selbæk
Additional file 1. Dementia awareness questionnaire.

Additional file 2 of Public knowledge about dementia risk reduction in Norway

Grete Kjelvik, Anne Marie Mork Rokstad, Josephine Stuebs, Pernille Thingstad, Kay Deckers, Sebastian Köhler & Geir Selbæk
Additional file 2. Motivationto Change Lifestyle for Dementia Risk Reduction (MOHAD-10).

Additional file 3 of Public knowledge about dementia risk reduction in Norway

Grete Kjelvik, Anne Marie Mork Rokstad, Josephine Stuebs, Pernille Thingstad, Kay Deckers, Sebastian Köhler & Geir Selbæk
Additional file 3. Flowchart of the invited and participating sample.

Genetic Variation in ADAMTS13 is Related to VWF Levels, Atrial Fibrillation and Cerebral Ischemic Events

Ellen M. K. Warlo, Vibeke Bratseth, Alf-Åge R. Pettersen, Pål Andre Holme, Harald Arnesen, Ingebjørg Seljeflot & Trine B. Opstad
IntroductionADAMTS13 cleaves von Willebrand factor (VWF) multimers into less active fragments. Both markers have been related to cardiovascular disease (CVD). We aimed to investigate the influence of ADAMTS13 single nucleotide polymorphisms (SNPs) on levels of ADAMTS13 and VWF, and CVD.MethodsThe c.1342C>G, g.41635A>G and c.2699C>T polymorphisms were determined in patients with chronic coronary syndrome (n = 1000). VWF and ADAMTS13 were analyzed. Clinical endpoints after 2 years (n = 106) were unstable angina pectoris, myocardial infarction,...

Children with a rare congenital genetic disorder: a systematic review of parent experiences

Charlotte von der Lippe, Ingrid Neteland & Kristin Billaud Feragen
Abstract Background Caring for a child with a chronic disease may be demanding and stressful. When a child has a rare condition, the impact of care on parents is amplified due to the rarity of the diagnosis. In order to address the lack of generalized and synthesized knowledge regarding parents’ experiences of having a child with a rare genetic disorder, and give a holistic picture of these experiences, a systematic review of the available qualitative...

Additional file 2 of Children with a rare congenital genetic disorder: a systematic review of parent experiences

Charlotte von der Lippe, Ingrid Neteland & Kristin Billaud Feragen
Additional file 2. Appendix II.

Additional file 1 of The persistence of anti-Spike antibodies following two SARS-CoV-2 vaccine doses in patients on immunosuppressive therapy compared to healthy controls—a prospective cohort study

Ingrid Egeland Christensen, Ingrid Jyssum, Anne Therese Tveter, Joseph Sexton, Trung T. Tran, Siri Mjaaland, Grete Birkeland Kro, Tore K. Kvien, David John Warren, Jørgen Jahnsen, Ludvig A. Munthe, Espen A. Haavardsholm, John Torgils Vaage, Gunnveig Grødeland, Fridtjof Lund-Johansen, Kristin Kaasen Jørgensen, Silje Watterdal Syversen, Guro Løvik Goll & Sella Aarrestad Provan
Additional file 1: Section 1. Inclusion and Exclusion Criteria. Section 2. Supplementary Figures S1-S4. Fig. S1. Flow-chart of analyses population. Fig. S2. Margins plot of the estimated 30 days reduction at different intervals between first and second serum assessment. Fig. S3. Scatter plot of antibody levels and timing of blood sampling. Fig. S4. Levels of anti-RBD antibodies at first and second assessment across diagnoses. Section 3. Supplementary Tables S1-S5. Table S1. Predictors of anti-RBD level...

Public knowledge about dementia risk reduction in Norway

Grete Kjelvik, Anne Marie Mork Rokstad, Josephine Stuebs, Pernille Thingstad, Kay Deckers, Sebastian Köhler & Geir Selbæk
Abstract Background Several modifiable lifestyle risk factors for dementia have been identified, but it is unclear how much the Norwegian public knows about the relationship between lifestyle and brain health. Therefore, this study aimed to investigate knowledge about modifiable dementia risk and protective factors and beliefs and attitudes towards dementia and dementia risk reduction in a randomly selected subsample of the Norwegian population. Methods The total sample (n = 1435) included individuals aged 40–70 years...

Genomic footprints of activated telomere maintenance mechanisms in cancer

Lina Sieverling, Chen Hong, Sandra D Koser, Philip Ginsbach, Kortine Kleinheinz, Barbara Hutter, Delia M Braun, Isidro Cortés-Ciriano, Ruibin Xi, Rolf Kabbe, Peter J Park, Roland Eils, Matthias Schlesner, Kadir C Akdemir, Eva G Alvarez, Adrian Baez-Ortega, Rameen Beroukhim, Paul C Boutros, David DL Bowtell, Benedikt Brors, Kathleen H Burns, Peter J Campbell, Kin Chan, Ken Chen, Ana Dueso-Barroso … & Christian von Mering
Cancers require telomere maintenance mechanisms for unlimited replicative potential. They achieve this through TERT activation or alternative telomere lengthening associated with ATRX or DAXX loss. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we dissect whole-genome sequencing data of over 2500 matched tumor-control samples from 36 different tumor types aggregated within the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium to characterize the genomic footprints of these mechanisms. While the...

Speedometer for withdrawal time monitoring during colonoscopy: a clinical implementation trial

Ishita Barua, Masashi Misawa, Jeremy R. Glissen Brown, Trent Walradt, Shin-ei Kudo, Sunil G. Sheth, Judy Nee, Johanna Iturrino, Rupa Mukherjee, Catherine P. Cheney, Mandeep S. Sawhney, Douglas K. Pleskow, Kensaku Mori, Magnus Løberg, Mette Kalager, Paulina Wieszczy, Michael Bretthauer, Tyler M. Berzin & Yuichi Mori
Meticulous inspection of the mucosa during colonoscopy, represents a lengthier withdrawal time, but has been shown to increase adenoma detection rate (ADR). We investigated if artificial intelligence-aided speed monitoring can improve suboptimal withdrawal time. We evaluated the implementation of a computer-aided speed monitoring device during colonoscopy at a large academic endoscopy center. After informed consent, patients ≥18 years undergoing colonoscopy between 5 March and 29 April 2021 were examined without the use of the speedometer,...

Divergent mutational processes distinguish hypoxic and normoxic tumours

Vinayak Bhandari, Constance H Li, Robert G Bristow, Paul C Boutros, Lauri A Aaltonen, Federico Abascal, Adam Abeshouse, Hiroyuki Aburatani, David J Adams, Nishant Agrawal, Keun Soo Ahn, Sung-Min Ahn, Hiroshi Aikata, Rehan Akbani, Kadir C Akdemir, Hikmat Al-Ahmadie, Sultan T Al-Sedairy, Fatima Al-Shahrour, Malik Alawi, Monique Albert, Kenneth Aldape, Ludmil B Alexandrov, Adrian Ally, Kathryn Alsop, Eva G Alvarez … & Christian von Mering
Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly understood, with limited comprehension of its associations with specific mutational processes, non-coding driver genes and evolutionary features. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumour types, we quantify hypoxia in 1188 tumours spanning...

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