162 Works

Data from: Apolipoprotein (ApoE) polymorphism is related to differences in potential fertility in women: a case of antagonistic pleiotropy?

Grazyna Jasienska, Peter T. Ellison, Andrzej Galbarczyk, Michal Jasienski, Malgorzata Kalemba-Drozdz, Maria Kapiszewska, Ilona Nenko, Inger Thune & Anna Ziomkiewicz
The alleles that are detrimental to health, especially in older age, are thought to persist in populations because they also confer some benefits for individuals (through antagonistic pleiotropy). The ApoE4 allele at the ApoE locus, encoding apolipoprotein E (ApoE), significantly increases risk of poor health, and yet it is present in many populations at relatively high frequencies. Why has it not been replaced by natural selection with the health-beneficial ApoE3 allele? ApoE is a major...

Data from: Getting to the heart of emotion regulation in youth: the role of interoceptive sensitivity, heart rate variability, and parental psychopathology

Nele A. J. De Witte, Stefan Sütterlin, Caroline Braet & Sven C. Mueller
Emotion regulation and associated autonomic activation develop throughout childhood and adolescence under the influence of the family environment. Specifically, physiological indicators of autonomic nervous system activity such as interoceptive sensitivity and vagally mediated heart rate variability (HRV) can inform on emotion regulation. Although the effect of parental emotion socialization on emotion regulation appears to be influenced by autonomic processes, research on physiological regulation and the influence of parental factors remains scarce. This study investigated the...

Data from: Persistent low toxoplasma IgG avidity is common in pregnancy: experience from antenatal testing in Norway

Gry Findal, Babill Stray-Pedersen, Ellen K. Holter, Tone Berge & Pål A. Jenum
The parasite Toxoplasma gondii might harm the fetus if a woman is infected during pregnancy. IgG seroconversion and significant increase in IgG antibody amount in pregnancy indicates maternal infection. Presence of toxoplasma immunoglobulin M (IgM), immunoglobulin G (IgG) and low IgG avidity in a single serum sample indicates possible maternal infection, but positive toxoplasma IgM and low IgG avidity may persist for months and even years. We aimed to evaluate avidity development during pregnancy in...

Sick leave and return to work after surgery for type II SLAP lesions of the shoulder. A secondary analysis of a randomised sham - controlled study

Jens Ivar Brox, Øystein Skare, Petter Mowinckel, Jostein Skranes Brox, Olav Reikerås & Cecilie Piene Schrøder
Objectives: To compare days on sick leave and assess predictors of return to work following shoulder surgery. Design: A secondary analysis of a randomised controlled trial. Setting: Orthopaedic Department. Participants: 114 patients with type II superior labral tear from anterior to posterior (SLAP) lesions of the shoulder. Interventions: Labral repair, biceps tenodesis or sham surgery. Outcome measures: Sick leave was obtained from national registers for the last year before and two years following surgery. Total...

An electrophysiological marker of arousal level in humans

Janna Lendner, Randolph Helfrich, Bryce Mander, Luis Romundstad, Jack Lin, Matthew Walker, Pal Larsson & Robert Knight
Deep non-rapid eye movement sleep (NREM) and general anesthesia with propofol are prominent states of reduced arousal linked to the occurrence of synchronized oscillations in the electroencephalogram (EEG). Although rapid eye movement (REM) sleep is also associated with diminished arousal levels, it is characterized by a desynchronized, 'wake-like' EEG. This observation implies that reduced arousal states are not necessarily only defined by synchronous oscillatory activity. Using intracranial and surface EEG recordings in four independent data...

Criteria for defining interictal epileptiform discharges in EEG: a clinical validation study

Mustafa Aykut Kural, Lene Duez, Vibeke Sejer Hansen, Pål Gunnar Larsson, Stefan Rampp, Reinhard Schulz, Hatice Tankisi, Richard Wennberg, Bo Bibby, Michael Scherg & Sandor Beniczky
Objective: To define and validate criteria for accurate identification of EEG interictal epileptiform discharges (IEDs) using: (a) the six sensor space criteria proposed by the International Federation of Clinical Neurophysiology (IFCN), and, (b) a novel source space method. Criteria yielding high specificity are needed because EEG “over-reading” is a common cause of epilepsy misdiagnosis. Methods: Seven raters reviewed EEG segments containing sharp waveforms from 100 patients with and without epilepsy. Clinical diagnosis gold standard was...

Additional file 1 of A progressive three-state model to estimate time to cancer: a likelihood-based approach

Eddymurphy U. Akwiwu, Thomas Klausch, Henriette C. Jodal, Beatriz Carvalho, Magnus Løberg, Mette Kalager, Johannes Berkhof & Veerle M. H. Coupé
Additional file 1 R implementation codes.

sj-docx-1-sjs-10.1177_14574969221127530 – Supplemental material for Body mass index and pancreatic adenocarcinoma: A nationwide registry-based cohort study

Usman Saeed, Tor Å. Myklebust, Trude E. Robsahm, Bjørn Møller, Tom Mala, Bjørn S. Skålhegg & Sheraz Yaqub
Supplemental material, sj-docx-1-sjs-10.1177_14574969221127530 for Body mass index and pancreatic adenocarcinoma: A nationwide registry-based cohort study by Usman Saeed, Tor Å. Myklebust, Trude E. Robsahm, Bjørn Møller, Tom Mala, Bjørn S. SkÅlhegg and Sheraz Yaqub in Scandinavian Journal of Surgery

sj-docx-2-sjs-10.1177_14574969221127530 – Supplemental material for Body mass index and pancreatic adenocarcinoma: A nationwide registry-based cohort study

Usman Saeed, Tor Å. Myklebust, Trude E. Robsahm, Bjørn Møller, Tom Mala, Bjørn S. Skålhegg & Sheraz Yaqub
Supplemental material, sj-docx-2-sjs-10.1177_14574969221127530 for Body mass index and pancreatic adenocarcinoma: A nationwide registry-based cohort study by Usman Saeed, Tor Å. Myklebust, Trude E. Robsahm, Bjørn Møller, Tom Mala, Bjørn S. SkÅlhegg and Sheraz Yaqub in Scandinavian Journal of Surgery

Additional file 2 of A progressive three-state model to estimate time to cancer: a likelihood-based approach

Eddymurphy U. Akwiwu, Thomas Klausch, Henriette C. Jodal, Beatriz Carvalho, Magnus Løberg, Mette Kalager, Johannes Berkhof & Veerle M.H. Coupé
Additional file 2 Supplementary Material.

A progressive three-state model to estimate time to cancer: a likelihood-based approach

Eddymurphy U. Akwiwu, Thomas Klausch, Henriette C. Jodal, Beatriz Carvalho, Magnus Løberg, Mette Kalager, Johannes Berkhof & Veerle M.H. Coupé
Abstract Background To optimize colorectal cancer (CRC) screening and surveillance, information regarding the time-dependent risk of advanced adenomas (AA) to develop into CRC is crucial. However, since AA are removed after diagnosis, the time from AA to CRC cannot be observed in an ethically acceptable manner. We propose a statistical method to indirectly infer this time in a progressive three-state disease model using surveillance data. Methods Sixteen models were specified, with and without covariates. Parameters...

Exercise-induced change in circulating NT-proBNP could not distinguish between patients with and without coronary artery disease: the CADENCE study

Joanna Cwikiel, Morten W. Fagerland, Kristian Wachtell, Harald Arnesen, Ingebjørg Seljeflot & Arnljot Flaa
Objective. In patients with chest pain, exercise stress test has a moderate accuracy for coronary artery disease (CAD). Adding a reliable cardiac biomarker to the exercise test could potentially improve the precision of the test. We investigated circulating NT-proBNP levels before and during exercise stress test in patients with and without angiographically verified CAD. We hypothesized that NT-proBNP would give an additive diagnostic value to the exercise stress test. Methods. In patients presenting with symptoms...

Adipose-derived stromal cells preserve pancreatic islet function in a transplantable 3D bioprinted scaffold

Shadab Abadpour
Intra-portal islet transplantation is the method of choice for treatment of insulin dependent type 1 diabetes, but its outcome is hindered by limited islet survival due to the immunological and metabolic stress post transplantation. Adipose-derived stromal cells (ASCs) promise to improve significantly the islet micro-environment but an efficient long-term delivery method has not been achieved. We therefore explore the potential of generating ASC enriched islet transplant structure by 3D bioprinting. Here, we fabricate a double-layered...

A progressive three-state model to estimate time to cancer: a likelihood-based approach

Eddymurphy U. Akwiwu, Thomas Klausch, Henriette C. Jodal, Beatriz Carvalho, Magnus Løberg, Mette Kalager, Johannes Berkhof & Veerle M.H. Coupé
Abstract Background To optimize colorectal cancer (CRC) screening and surveillance, information regarding the time-dependent risk of advanced adenomas (AA) to develop into CRC is crucial. However, since AA are removed after diagnosis, the time from AA to CRC cannot be observed in an ethically acceptable manner. We propose a statistical method to indirectly infer this time in a progressive three-state disease model using surveillance data. Methods Sixteen models were specified, with and without covariates. Parameters...

A progressive three-state model to estimate time to cancer: a likelihood-based approach

Eddymurphy U. Akwiwu, Thomas Klausch, Henriette C. Jodal, Beatriz Carvalho, Magnus Løberg, Mette Kalager, Johannes Berkhof & Veerle M. H. Coupé
Abstract Background To optimize colorectal cancer (CRC) screening and surveillance, information regarding the time-dependent risk of advanced adenomas (AA) to develop into CRC is crucial. However, since AA are removed after diagnosis, the time from AA to CRC cannot be observed in an ethically acceptable manner. We propose a statistical method to indirectly infer this time in a progressive three-state disease model using surveillance data. Methods Sixteen models were specified, with and without covariates. Parameters...

Additional file 1 of Cost-effectiveness of a rule-out algorithm of acute myocardial infarction in low-risk patients: emergency primary care versus hospital setting

Tonje R. Johannessen, Sigrun Halvorsen, Dan Atar, John Munkhaugen, Anne Kathrine Nore, Torbjørn Wisløff & Odd Martin Vallersnes
Additional file 1.

Physical performance in older age by sex and educational level: the HUNT Study

Kjerstin N. Melsæter, Gro G. Tangen, Håvard K. Skjellegrind, Beatrix Vereijken, Bjørn H. Strand & Pernille Thingstad
Abstract Background Population-based studies on physical performance provide important information on older people’s health but rarely include the oldest and least-healthy segment of the population. The aim of this study was to provide representative estimates of physical performance by age, sex, and educational level based on recent data from a population-based health study in Norway that includes older people with a wide range in age and function. Methods In the fourth wave of the Trøndelag...

Physical performance in older age by sex and educational level: the HUNT Study

Kjerstin N. Melsæter, Gro G. Tangen, Håvard K. Skjellegrind, Beatrix Vereijken, Bjørn H. Strand & Pernille Thingstad
Abstract Background Population-based studies on physical performance provide important information on older people’s health but rarely include the oldest and least-healthy segment of the population. The aim of this study was to provide representative estimates of physical performance by age, sex, and educational level based on recent data from a population-based health study in Norway that includes older people with a wide range in age and function. Methods In the fourth wave of the Trøndelag...

The persistence of anti-Spike antibodies following two SARS-CoV-2 vaccine doses in patients on immunosuppressive therapy compared to healthy controls—a prospective cohort study

Ingrid Egeland Christensen, Ingrid Jyssum, Anne Therese Tveter, Joseph Sexton, Trung T. Tran, Siri Mjaaland, Grete Birkeland Kro, Tore K. Kvien, David John Warren, Jørgen Jahnsen, Ludvig A. Munthe, Espen A. Haavardsholm, John Torgils Vaage, Gunnveig Grødeland, Fridtjof Lund-Johansen, Kristin Kaasen Jørgensen, Silje Watterdal Syversen, Guro Løvik Goll & Sella Aarrestad Provan
Abstract Background The durability of vaccine-induced humoral immunity against SARS-CoV-2 in patients with immune-mediated inflammatory diseases (IMIDs) on immunosuppressive therapy is not known. The aim of this study was to compare the persistence of anti-Spike antibodies following two-dose SARS-CoV-2 vaccination between IMID patients and healthy controls and to identify factors associated with antibody decline. Methods IMID patients on immunosuppressive medication enrolled in the prospective observational Nor-vaC study were included. Participants received two-dose SARS-CoV-2 vaccination. Serum...

The persistence of anti-Spike antibodies following two SARS-CoV-2 vaccine doses in patients on immunosuppressive therapy compared to healthy controls—a prospective cohort study

Ingrid Egeland Christensen, Ingrid Jyssum, Anne Therese Tveter, Joseph Sexton, Trung T. Tran, Siri Mjaaland, Grete Birkeland Kro, Tore K. Kvien, David John Warren, Jørgen Jahnsen, Ludvig A. Munthe, Espen A. Haavardsholm, John Torgils Vaage, Gunnveig Grødeland, Fridtjof Lund-Johansen, Kristin Kaasen Jørgensen, Silje Watterdal Syversen, Guro Løvik Goll & Sella Aarrestad Provan
Abstract Background The durability of vaccine-induced humoral immunity against SARS-CoV-2 in patients with immune-mediated inflammatory diseases (IMIDs) on immunosuppressive therapy is not known. The aim of this study was to compare the persistence of anti-Spike antibodies following two-dose SARS-CoV-2 vaccination between IMID patients and healthy controls and to identify factors associated with antibody decline. Methods IMID patients on immunosuppressive medication enrolled in the prospective observational Nor-vaC study were included. Participants received two-dose SARS-CoV-2 vaccination. Serum...

Use of non-governmental maternity services and pregnancy outcomes among undocumented women: a cohort study from Norway

Frode Eick, Odd Martin Vallersnes, Heidi E. Fjeld, Ingvil Krarup Sørbye, Guro Storkås, Marthe Ekrem, Marie Børmer, Sara Andrea Løberg, Cathrine Ebbing, Nanna Voldner & Cecilie Dahl
Abstract Background In 2011 Norway granted undocumented women the right to antenatal care and to give birth at a hospital but did not include them in the general practitioner and reimbursement schemes. As a response to limited access to health care, Non-Governmental Organizations (NGO) have been running health clinics for undocumented migrants in Norway’s two largest cities. To further facilitate universal health coverage, there is a need to investigate how pregnant undocumented women use NGO...

Additional file 2 of The role of personality traits and leisure activities in predicting wellbeing in young people

Sarah L. Asquith, Xu Wang, Daniel S. Quintana & Anna Abraham
Additional file 2. Copy of Table 4 with exact p values

Additional file 1 of The effect of an integrated care intervention of multidisciplinary mental health treatment and employment services for trauma-affected refugees: study protocol for a randomised controlled trial

Maja Bruhn, Henriette Laugesen, Matilde Kromann-Larsen, Cathrine Selnes Trevino, Lene Eplov, Carsten Hjorthøj & Jessica Carlsson
Additional file 1. SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocol and related documents*.

Laparoscopic versus open liver resection for intrahepatic cholangiocarcinoma: a multicenter propensity score-matched study

Mushegh A. Sahakyan, Davit L. Aghayan, Bjørn Edwin, Ruslan Alikhanov, Natalia Britskaia, Kristoffer Watten Brudvik, Mathieu D’Hondt, Celine De Meyere, Mikhail Efanov, Åsmund A. Fretland, Rune Hoff, Warsan Ismail, Arpad Ivanecz, Airazat M. Kazaryan, Kristoffer Lassen, Tomislav Magdalenić, Isabelle Parmentier, Bård Ingvald Røsok, Olaug Villanger & Sheraz Yaqub
The role of laparoscopy in the treatment of intrahepatic cholangiocarcinoma (ICC) remains unclear. This multicenter study examined the outcomes of laparoscopic liver resection for ICC. Patients with ICC who had undergone laparoscopic or open liver resection between 2012 and 2019 at four European expert centers were included in the study. Laparoscopic and open approaches were compared in terms of surgical and oncological outcomes. Propensity score matching was used for minimizing treatment selection bias and adjusting...

Novel psychoactive substances-related presentations to the emergency departments of the European drug emergencies network plus (Euro-DEN plus) over the six-year period 2014–2019

Benjamin Crulli, Alison M. Dines, Georgina Blanco, Isabelle Giraudon, Florian Eyer, Matthias E. Liechti, Òscar Miró, Knut E. Hovda, Fridtjof Heyerdahl, Christopher Yates, Odd Martin Vallersnes, David M. Wood & Paul I. Dargan
Novel psychoactive substances (NPS) have been increasingly reported in the last 15–20 years. We aimed to describe presentations to the emergency department (ED) with acute recreational drug toxicity involving NPS. Data were extracted from the European Drug Emergencies Network (Euro-DEN) Plus database for all presentations to ED (36 EDs in 24 European countries) with acute toxicity between January 2014 and December 2019. Patient demographics, agents involved, and clinical outcomes were described and the subgroup of...

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