Cost-effectiveness of a rule-out algorithm of acute myocardial infarction in low-risk patients: emergency primary care versus hospital settingTonje R. Johannessen, Sigrun Halvorsen, Dan Atar, John Munkhaugen, Anne Kathrine Nore, Torbjørn Wisløff & Odd Martin Vallersnes
Abstract Aims Hospital admissions of patients with chest pain considered as low risk for acute coronary syndrome contribute to increased costs and crowding in the emergency departments. This study aims to estimate the cost-effectiveness of assessing these patients in a primary care emergency setting, using the European Society of Cardiology (ESC) 0/1-h algorithm for high-sensitivity cardiac troponin T, compared to routine hospital management. Methods A cost-effectiveness analysis was conducted. For the primary care estimates, costs...
Additional file 1 of Use of non-governmental maternity services and pregnancy outcomes among undocumented women: a cohort study from NorwayFrode Eick, Odd Martin Vallersnes, Heidi E. Fjeld, Ingvil Krarup Sørbye, Guro Storkås, Marthe Ekrem, Marie Børmer, Sara Andrea Løberg, Cathrine Ebbing, Nanna Voldner & Cecilie Dahl
Additional file 1. Directed Acyclic Graphs.
Heavy-load exercise in older adults activates vasculogenesis and has a stronger impact on muscle gene expression than in young adultsKaare M. Gautvik, Ole K. Olstad, Ulrika Raue, Vigdis T. Gautvik, Karl J. Kvernevik, Tor P. Utheim, Solveig Ravnum, Camilla Kirkegaard, Håvard Wiig, Garan Jones, Luke C. Pilling, Scott Trappe, Truls Raastad & Sjur Reppe
Abstract Background A striking effect of old age is the involuntary loss of muscle mass and strength leading to sarcopenia and reduced physiological functions. However, effects of heavy-load exercise in older adults on diseases and functions as predicted by changes in muscle gene expression have been inadequately studied. Methods Thigh muscle global transcriptional activity (transcriptome) was analyzed in cohorts of older and younger adults before and after 12–13 weeks heavy-load strength exercise using Affymetrix microarrays....
Additional file 1 of The persistence of anti-Spike antibodies following two SARS-CoV-2 vaccine doses in patients on immunosuppressive therapy compared to healthy controls—a prospective cohort studyIngrid Egeland Christensen, Ingrid Jyssum, Anne Therese Tveter, Joseph Sexton, Trung T. Tran, Siri Mjaaland, Grete Birkeland Kro, Tore K. Kvien, David John Warren, Jørgen Jahnsen, Ludvig A. Munthe, Espen A. Haavardsholm, John Torgils Vaage, Gunnveig Grødeland, Fridtjof Lund-Johansen, Kristin Kaasen Jørgensen, Silje Watterdal Syversen, Guro Løvik Goll & Sella Aarrestad Provan
Additional file 1: Section 1. Inclusion and Exclusion Criteria. Section 2. Supplementary Figures S1-S4. Fig. S1. Flow-chart of analyses population. Fig. S2. Margins plot of the estimated 30 days reduction at different intervals between first and second serum assessment. Fig. S3. Scatter plot of antibody levels and timing of blood sampling. Fig. S4. Levels of anti-RBD antibodies at first and second assessment across diagnoses. Section 3. Supplementary Tables S1-S5. Table S1. Predictors of anti-RBD level...
Supplemental Material - Marital Histories and Associations With Later-Life Dementia and Mild Cognitive Impairment Risk in the HUNT4 70+ Study in NorwayVegard Skirbekk, Catherine E. Bowen, Asta Håberg, Astanand Jugessur, Bo Engdahl, Bernt Bratsberg, Ekaterina Zotcheva, Geir Selbæk, Hans-Peter Kohler, Jordan Weiss, Jennifer R. Harris, Sarah E. Tom, Steinar Krokstad, Yaakov Stern & Bjørn Heine Strand
Supplemental Material for Marital Histories and Associations With Later-Life Dementia and Mild Cognitive Impairment Risk in the HUNT4 70+ Study in Norway by Vegard Skirbekk, Asta Håberg, Ekaterina Zotcheva, Bo Lars Engdahl, Steinar Krokstad, Hans-Peter Kohler, Astanand Jugessur, PhD, Bernt Bratsberg, Jordan Weiss, PhD, Catherine Bowen, Sarah Tom, PhD, Jennifer Harris, PhD, Yaakov Stern, PhD, Geir Selbæk, and Heine Strand, PhD in Journal of Aging and Health
Additional file 1 of Infarct quantification with cardiovascular magnetic resonance using \"standard deviation from remote\" is unreliable: validation in multi-centre multi-vendor dataEinar Heiberg, Henrik Engblom, Marcus Carlsson, David Erlinge, Dan Atar, Anthony H. Aletras & Håkan Arheden
Additional file 1: Table S1. Sequence details for the different sites. Table S2. Optimal “n-SD” per site. Figure S1. Animated gifs showing correlation between reference infarct size and measured infarct size. A) Impact of ROI position, B) Impact of ROI size, C) Impact of “n-SD from remote”. Note the large impact on bias when changing “n-SD from remote”.
Additional file 1 of Algebraic topology-based machine learning using MRI predicts outcomes in primary sclerosing cholangitisYashbir Singh, William A. Jons, John E. Eaton, Mette Vesterhus, Tom Karlsen, Ida Bjoerk, Andreas Abildgaard, Kristin Kaasen Jorgensen, Trine Folseraas, Derek Little, Aliya F. Gulamhusein, Kosta Petrovic, Anne Negard, Gian Marco Conte, Joseph D. Sobek, Jaidip Jagtap, Sudhakar K. Venkatesh, Gregory J. Gores, Nicholas F. LaRusso, Konstantinos N. Lazaridis & Bradley J. Erickson
Additional file 1.
Additional file 1 of The Prospective Lynch Syndrome Database: background, design, main results and complete MySQL codePål Møller
Additional file 1.
Additional file 1: Supplement Figure S1. Bar graph for the different SPPB subtests.
Abstract Background The relationship between wellbeing and personality has been studied extensively, but few studies have examined these in the period of adolescence and emerging adulthood. Moreover, the influence of contextual factors such as engagement in leisure activities are rarely considered. Methods The present study employs a combination of frequentist and Bayesian analyses to evaluate the concurrent impact of personality traits and leisure activities on five conceptions of wellbeing (life satisfaction; positive affect; negative affect;...
Additional file 1 of The role of personality traits and leisure activities in predicting wellbeing in young peopleSarah L. Asquith, Xu Wang, Daniel S. Quintana & Anna Abraham
Additional file 1. Leisure Questionnaire
Meticulous inspection of the mucosa during colonoscopy, represents a lengthier withdrawal time, but has been shown to increase adenoma detection rate (ADR). We investigated if artificial intelligence-aided speed monitoring can improve suboptimal withdrawal time. We evaluated the implementation of a computer-aided speed monitoring device during colonoscopy at a large academic endoscopy center. After informed consent, patients ≥18 years undergoing colonoscopy between 5 March and 29 April 2021 were examined without the use of the speedometer,...
sj-docx-1-cat-10.1177_10760296221141893 - Supplemental material for Genetic Variation in ADAMTS13 is Related to VWF Levels, Atrial Fibrillation and Cerebral Ischemic EventsEllen M. K. Warlo, Vibeke Bratseth, Alf-Åge R. Pettersen, Pål Andre Holme, Harald Arnesen, Ingebjørg Seljeflot & Trine B. Opstad
Supplemental material, sj-docx-1-cat-10.1177_10760296221141893 for Genetic Variation in ADAMTS13 is Related to VWF Levels, Atrial Fibrillation and Cerebral Ischemic Events by Ellen M. K. Warlo, MD, Vibeke Bratseth, MSc, PhD, Alf-Åge R. Pettersen, MD, PhD, Pål Andre Holme, MD, PhD, Harald Arnesen, MD, PhD, Ingebjørg Seljeflot, PhD, and Trine B. Opstad, MSc, PhD in Clinical and Applied Thrombosis/Hemostasis
Urinary orosomucoid is associated with diastolic dysfunction and carotid arteriopathy in the general population. Cross-sectional data from the Tromsø studyRuna M. Andreassen, Jens B. Kronborg, Henrik Schirmer, Ellisiv B. Mathiesen, Toralf Melsom, Bjørn O. Eriksen, Trond G. Jenssen & Marit D. Solbu
Objectives. Urinary albumin excretion is a risk marker for cardiovascular disease (CVD). Studies suggest that urinary orosomucoid may be a more sensitive marker of general endothelial dysfunction than albuminuria. The aim of this population-based cross-sectional study was to examine the associations between urinary orosomucoid to creatinine ratio (UOCR), urinary albumin to creatinine ratio (UACR) and subclinical CVD. Design. From the Tromsø Study (2007/2008), we included all men and women who had measurements of urinary orosomucoid...
Additional file 2 of The effect of an integrated care intervention of multidisciplinary mental health treatment and employment services for trauma-affected refugees: study protocol for a randomised controlled trialMaja Bruhn, Henriette Laugesen, Matilde Kromann-Larsen, Cathrine Selnes Trevino, Lene Eplov, Carsten Hjorthøj & Jessica Carlsson
Additional file 2. CONSORT 2010 Flow Diagram.
Utility of a three-gene transcriptomic signature in the diagnosis of tuberculosis in a low-endemic hospital settingBih Hycenta Chendi, Tracey Jooste, Thomas Jens Scriba, Martin Kidd, Simon Mendelsohn, Kristian Tonby, Gerhard Walzl, Anne M. Dyrhol-Riise & Novel Njweipi Chegou
Host transcriptomic blood signatures have demonstrated diagnostic potential for tuberculosis (TB), requiring further validation across different geographical settings. Discriminating TB from other diseases with similar clinical manifestations is crucial for the development of an accurate immunodiagnostic tool. In this exploratory cohort study, we evaluated the performance of potential blood-based transcriptomic signatures in distinguishing TB disease from non-TB lower respiratory tract infections in hospitalised patients in a TB low-endemic country. Quantitative real-time polymerase chain reaction qPCR)...
Additional file 1 of Cost-effectiveness of a rule-out algorithm of acute myocardial infarction in low-risk patients: emergency primary care versus hospital settingTonje R. Johannessen, Sigrun Halvorsen, Dan Atar, John Munkhaugen, Anne Kathrine Nore, Torbjørn Wisløff & Odd Martin Vallersnes
Additional file 1.
Abstract Background Caring for a child with a chronic disease may be demanding and stressful. When a child has a rare condition, the impact of care on parents is amplified due to the rarity of the diagnosis. In order to address the lack of generalized and synthesized knowledge regarding parents’ experiences of having a child with a rare genetic disorder, and give a holistic picture of these experiences, a systematic review of the available qualitative...
Additional file 1 of Children with a rare congenital genetic disorder: a systematic review of parent experiencesCharlotte von der Lippe, Ingrid Neteland & Kristin Billaud Feragen
Additional file 1. Appendix I.
Additional file 1 of Cri du chat syndrome patients have DNA methylation changes in genes linked to symptoms of the diseasePetter Holland, Mari Wildhagen, Mette Istre, Olaug Marie Reiakvam, John Arne Dahl & Arne Søraas
Additional file 1. Supplementary Figures 1–6.
Cri du chat syndrome patients have DNA methylation changes in genes linked to symptoms of the diseasePetter Holland, Mari Wildhagen, Mette Istre, Olaug Marie Reiakvam, John Arne Dahl & Arne Søraas
Abstract Background Cri du chat (also called 5p deletion, or monosomy 5p) syndrome is a genetic disease caused by deletions of various lengths in the short (p) arm of chromosome 5. Genetic analysis and phenotyping have been used to suggest dose-sensitive genes in this region that may cause symptoms when a gene copy is lost, but the heterogeneity of symptoms for patients with similar deletions complicates the picture. The epigenetics of the syndrome has only...
sj-docx-1-sjs-10.1177_14574969221127530 – Supplemental material for Body mass index and pancreatic adenocarcinoma: A nationwide registry-based cohort studyUsman Saeed, Tor Å. Myklebust, Trude E. Robsahm, Bjørn Møller, Tom Mala, Bjørn S. Skålhegg & Sheraz Yaqub
Supplemental material, sj-docx-1-sjs-10.1177_14574969221127530 for Body mass index and pancreatic adenocarcinoma: A nationwide registry-based cohort study by Usman Saeed, Tor Å. Myklebust, Trude E. Robsahm, Bjørn Møller, Tom Mala, Bjørn S. SkÅlhegg and Sheraz Yaqub in Scandinavian Journal of Surgery
sj-docx-2-sjs-10.1177_14574969221127530 – Supplemental material for Body mass index and pancreatic adenocarcinoma: A nationwide registry-based cohort studyUsman Saeed, Tor Å. Myklebust, Trude E. Robsahm, Bjørn Møller, Tom Mala, Bjørn S. Skålhegg & Sheraz Yaqub
Supplemental material, sj-docx-2-sjs-10.1177_14574969221127530 for Body mass index and pancreatic adenocarcinoma: A nationwide registry-based cohort study by Usman Saeed, Tor Å. Myklebust, Trude E. Robsahm, Bjørn Møller, Tom Mala, Bjørn S. SkÅlhegg and Sheraz Yaqub in Scandinavian Journal of Surgery
sj-jpg-3-sjs-10.1177_14574969221127530 – Supplemental material for Body mass index and pancreatic adenocarcinoma: A nationwide registry-based cohort studyUsman Saeed, Tor Å. Myklebust, Trude E. Robsahm, Bjørn Møller, Tom Mala, Bjørn S. Skålhegg & Sheraz Yaqub
Supplemental material, sj-jpg-3-sjs-10.1177_14574969221127530 for Body mass index and pancreatic adenocarcinoma: A nationwide registry-based cohort study by Usman Saeed, Tor Å. Myklebust, Trude E. Robsahm, Bjørn Møller, Tom Mala, Bjørn S. SkÅlhegg and Sheraz Yaqub in Scandinavian Journal of Surgery
Additional file 1 of Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortiumPål Møller, Toni Seppälä, James G. Dowty, Saskia Haupt, Mev Dominguez-Valentin, Lone Sunde, Inge Bernstein, Christoph Engel, Stefan Aretz, Maartje Nielsen, Gabriel Capella, Dafydd Gareth Evans, John Burn, Elke Holinski-Feder, Lucio Bertario, Bernardo Bonanni, Annika Lindblom, Zohar Levi, Finlay Macrae, Ingrid Winship, John-Paul Plazzer, Rolf Sijmons, Luigi Laghi, Adriana Della Valle, Karl Heinimann … & Mark A. Jenkins
Additional file 1.
Oslo University Hospital125
University of Oslo84
Sykehuset i Vestfold20
Norwegian University of Science and Technology20
Akershus University Hospital14
Imperial College London14
Vrije Universiteit Amsterdam13
University of Bergen10
Norwegian Institute of Public Health9