124 Works

Tit for Tat and Beyond: The Legendary Work of Anatol Rapoport

Shirli Kopelman

The oldest Devonian circumpolar ray-finned fish?

Rodrigo Figueroa, Luiz Carlos Weinschütz & Matthew Friedman
Actinopterygians (ray-finned fishes) are the most diverse group of living fishes, but have a sparse early fossil record restricted to low palaeolatitudes. Here we report a new actinopterygian from the Paraná Basin of Brazil, an area that occupied a circumpolar position in the Palaeozoic. Available geological evidence supports a Middle Devonian or older age for this taxon, which shares features of the mandibular symphysis with the latest Devonian Tegeolepis. A phylogenetic analysis resolves these two...

Increasing chitosanase production in Bacillus cereus by a novel mutagenesis and screen method

Chaozheng Zhang, Yi Li, Tianshuang Zhang & Hua Zhao
Chitosan hydrolysis by chitosanase is one of the most effective methods to produce chitosan oligosaccharides. One of the prerequisites of enzyme fermentation production is to select and breed enzyme-producing cells with good performance. So in the process of fermentation production, the low yield of chitosanase cannot meet the current requirement. In this paper, a strain producing chitosanase was screened and identified, and a novel mutagenesis system (Atmospheric and Room Temperature Plasma (ARTP)) was selected to...

Dosimetry for second cancer risk estimation in radiotherapy:measurements in water phantoms

R. M. Harrison, A. Di Fulvio, J. M. Bordy, S. Miljanić, L. Stolarczyk & Ž. Knežević
Abstract: This report describes dosimetry techniques used by EURADOS Working Group 9 (Radiation Dosimetry in Radiotherapy) to measure out-of -field doses for use in radiotherapy. Several passive dosimeter types were used, based on the physical principles of thermoluminescence (TLD), optically simulated luminescence (OSL) and radiophotoluminescence (RPL), in addition to an ionization chamber used as a reference standard. Superheated drop, bubble damage and track etch detectors were used specifically for neutron measurements. In this report, doses...

Bioinformatics analysis reveals the competing endogenous RNA (ceRNA) coexpression network in the tumor microenvironment and prognostic biomarkers in soft tissue sarcomas

Dandan Zou, Yang Wang, Meng Wang, Bo Zhao, Fei Hu, Yanguo Li & Bingming Zhang
Soft tissue sarcomas (STSs) are rare, heterogeneous mesenchymal neoplasias. Understanding the tumor microenvironment (TME) and identifying potential biomarkers for prognosis associated with the TME of STS might provide effective clues for immune therapy. We evaluated the immune scores and stromal scores of STS patients by using the RNA sequencing dataset from The Cancer Genome Atlas (TCGA) database and the ESTIMATE algorithm. Then, the differentially expressed mRNAs (DEGs), miRNAs (DEMs) and lncRNAs (DELs) were identified after...

Genetic mechanisms and correlational selection structure trait variation in a coral snake mimic

John David Curlis, Alison Davis Rabosky, Iris Holmes, Timothy Renney & Christian Cox
Covariation among traits shapes both phenotypic evolution and ecological interactions across space and time. However, rampant geographic variation in the strength and direction of such correlations can be particularly difficult to explain through generalized mechanisms. By integrating population genomics, surveys of natural history collections, and spatially-explicit analyses, we tested multiple drivers of trait correlations in a coral snake mimic that exhibits remarkable polymorphism in mimetic and non-mimetic color traits. We found that although such traits...

Prognostic alternative splicing regulatory network of RBM25 in hepatocellular carcinoma

Yong-Fa Zhang, Yi-Xiu Wang, Ning- Zhang, Zhen-Hai Lin, Long-Rong Wang, Yun Feng, Qi Pan & Lu Wang
RNA-binding motif protein 25 (RBM25) is a poorly characterized RNA-binding protein that is involved in several biological processes and regulates the proliferation and metastasis of tumor cells. The regulatory role of RBM25 in hepatocellular carcinoma (HCC) is unknown. Here, RBM25 expression and outcomes in HCC patients were evaluated using The Cancer Genome Atlas database. RBM25 was overexpressed in HCC patients compared with the healthy group. The high expression of RBM25 in tumor tissues was significantly...

Unraveling the roles of genotype and environment in the expression of plant defense phenotypes

Abigail Potts & Mark Hunter
1. Phenotypic variability results from interactions between genotype and environment and is a major driver of ecological and evolutionary interactions. Measuring the relative contributions of genetic variation, the environment, and their interaction to phenotypic variation remains a fundamental goal of evolutionary ecology. 2. In this study, we assess the question: How do genetic variation and local environmental conditions interact to influence phenotype within a single population? We explored this question using seed from a single...

Effect of data source on estimates of regional bird richness in northeastern United States

Roi Ankori-Karlinsky, Ronen Kadmon, Michael Kalyuzhny, Katherine F. Barnes, Andrew M. Wilson, Curtis Flather, Rosalind Renfrew, Joan Walsh & Edna Guk
Standardized data on large-scale and long-term patterns of species richness are critical for understanding the consequences of natural and anthropogenic changes in the environment. The North American Breeding Bird Survey (BBS) is one of the largest and most widely used sources of such data, but so far, little is known about the degree to which BBS data provide accurate estimates of regional richness. Here we test this question by comparing estimates of regional richness based...

Lack of phenological shift leads to increased camouflage mismatch in mountain hares

Marketa Zimova
Understanding whether organisms will be able to adapt to human-induced stressors currently endangering their existence is an urgent priority. Globally, multiple species moult from a dark summer to white winter coat to maintain camouflage against snowy landscapes. Decreasing snow cover duration due to climate change is increasing mismatch in seasonal camouflage. To directly test for adaptive responses to recent changes in snow cover, we repeated historical (1950s) field studies of moult phenology in mountain hares...

Open Data Toolkit Based on Diversity, Equity, Inclusion and Access Principles

Rachel Woodbrook
This is the slide presentation from the 2019 LYRASIS Leaders Summit documenting the University of Michigan Catalyst Fund project - Open Data Toolkit Based on Diversity, Equity, Inclusion and Access Principles.

A 16S rRNA gene sequencing based study of oral microbiota in migraine patients in China

Weiqing Jiang, Tingting Wang, Chen Liu, Mingzhu Deng, Xiao Ren, Fei Wang, Yaqing Zhang, Xueying Yu, Lingling Yao & Yonggang Wang
Migraine is a primary headache characterized by moderate or severe headache attacks, accompanied with reversible neurological and systemic symptoms. There are rare biomarkers for the disease. While emerging evidence has indicated the connection between gut microbiota and migraine, the relation between oral microbiota and migraine is barely known. Thus, the objective of the current study was to explore a possible correlation between oral microbiota and migraine. We compared the oral microbiota communities of migraine patients...

Data and code from: Spring phenological escape is critical for the survival of temperate tree seedlings

Benjamin Lee & Ines Ibanez
Understory plants in deciduous forests often rely on access to ephemeral light availability before the canopy closes in spring and after the canopy reopens in fall, a strategy commonly referred to as phenological escape. Although there is evidence for a relationship between understory plant phenology and demographic performance, a mechanistic link is still missing. In this study, we bridged this gap by estimating annual carbon assimilation as a function of foliar phenology and photosynthetic capacity...

Contrasting patterns of phylogenetic diversity and alpine specialization across the alpine flora of the American mountain range system

Hector Fox Figueroa, Hannah E. Marx, Maria Beatriz De Souza Cortez, Charles J. Grady, Nicholas Engle-Wrye, Jim Beach, Aimee Stewart, Ryan A. Folk, Douglas E. Soltis, Pamela S. Soltis & Stephen A. Smith
Although mountainous habitats contribute substantially to global biodiversity, comparatively little is known about biogeographic patterns of distributions of alpine species across multiple mountain ranges. Here, we present a detailed analysis of the distributions and phylogenetic affinities of alpine seed plant lineages across North, Central, and South American mountain systems. Using a comprehensive dataset that characterized the elevational niches of American seed plants in a continuously valued way, we were able to quantitatively investigate how the...

Etomidate ameliorated advanced glycation end-products (AGEs)-induced reduction of extracellular matrix genes expression in chondrocytes

Xiaohua Sun, Jizheng Zhang, Yi Li, Wanlu Ren & Lijun Wang
Osteoarthritis (OA) is a rheumatic disease common in the elderly. AGEs are the end products of glycation reactions and play an important role in the development of OA. Etomidate is a general anesthesia-inducing agent recently reported to exert significant anti-inflammatory effects. The present study aims to explore the protective effect of Etomidate against advanced glycation end-products (AGEs)-induced reduction of extracellular matrix gene expression in chondrocytes. In the present study, we found that AGEs significantly reduced...

Did the Renewable Fuel Standard Shift Market Expectations of the Price of Ethanol?

Christiane Baumeister, Reinhard Ellwanger & Lutz Kilian
It is commonly believed that the response of the price of corn ethanol (and hence of the price of corn) to shifts in biofuel policies operates in part through market expectations and shifts in storage demand, yet to date it has proved difficult to measure these expectations and to empirically evaluate this view. We utilize a recently proposed methodology to estimate the market’s expectations of the prices of ethanol, unfinished motor gasoline and crude oil...

STAT3-induced ZBED3-AS1 promotes the malignant phenotypes of melanoma cells by activating PI3K/AKT signaling pathway

Yang Wang, Nan Lou, Min Zuo, Fuqiang Zhu, Yan He, Zhiqiang Cheng & Xiaomei Wang
Melanoma is considered as the most frequent primary malignancy occurring in skin. Accumulating studies have suggested that long non-coding RNAs (lncRNAs) play critical parts in multiple cancers. In this study, we explored the molecular mechanism of ZBED3 antisense RNA 1 (ZBED3-AS1) in melanoma. We observed that ZBED3-AS1 expression was remarkably up-regulated in melanoma tissues, and high ZBED3-AS1 level was linked to unsatisfactory survival of melanoma patients. Then, we discovered that ZBED3-AS1 was overexpressed in melanoma...

Amborella pangenome and supplementary tables v4

, Ricky Hu, Armin Patrick Scheben, Brent Verpaalen, Soodeh Tirnaz, Jacqueline Batley, Douglas E. Soltis, Dave Edwards & Richard G.J. Hodel

Long noncoding RNAs are potentially involved in the degeneration of virulence in an aphid-obligate pathogen, Conidiobolus obscurus (Entomophthoromycotina)

Guofang Ye, Lvhao Zhang & Xiang Zhou
Virulence attenuation frequently occurs in in vitro culturing of pathogenic microbes. In this study, we investigated the total putative long noncoding RNAs (lncRNAs) in an aphid-obligate pathogen, Conidiobolus obscurus, and screened the differentially expressed (DE) lncRNAs and protein-coding genes involved in the virulence decline. The virulence was significantly attenuated after eight subculturing events, in which the median lethal concentration of the conidia ejected from mycelial mats relative to the bamboo aphid, Takecallis taiwanus, increased from...

Heterogeneous performances and consequences of China’s industrial environmental governance: clean production vs. end-of-pipe treatment

Shuai Shao, Chang Wang, Yue Guo, Bai-Chen Xie, Zhihua Tian & Shiyi Chen
Using a relational two-stage network data envelopment analysis (DEA) model considering undesirable outputs, this paper evaluates both the process and system performances of industrial environmental governance in China’s 30 provincial-level regions during 1998–2015. Furthermore, this is the first study to apply the spatial econometric models with a geographical distance matrix to investigate the local and spatial spillover effects of environmental regulations on heterogeneous environmental governance performance (i.e. clean production and end-of-pipe treatment performances). The results...

Social effects on annual fitness in red squirrels

Andrew McAdam, Quinn Webber, Ben Dantzer, Jeff Lane & Stan Boutin
When resources are limited, mean fitness is constrained and competition can cause genes and phenotypes to enhance an individual’s own fitness while reducing the fitness of their competitors. Negative social effects on fitness have the potential to constrain adaptation, but the interplay between ecological opportunity and social constraints on adaptation remains poorly studied in nature. Here, we tested for evidence of phenotypic social effects on annual fitness (survival and reproductive success) in a long-term study...

Sex difference in lipid levels in first-diagnosed drug-naïve depression patients: A case-control and 12-weeks follow-up study

Rui Yang, Lu Wang, Song Cao, Ming Chen, Chu-Jun Wu, Floyd Silva, Man-Jun Shen, Jin-Dong Chen, Mi-Mi Tang & Bi-Lian Liu
Patients with depression have a high prevalence of developing dyslipidemia. In this study, we aim to investigate the difference of serum lipids, including total cholesterol (TCH), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), between the depressed patients and healthy controls. Sex differences in lipids and their psychological correlations were also included. The study included 56 healthy controls (males/females = 26/30) and 110 first-diagnosed drug-naïve outpatients (males/females = 35/75). A total of...

High-resolution mapping of the period landscape reveals polymorphism in cell cycle frequency tuning

Zhengda Li, Shiyuan Wang, Meng Sun, Minjun Jin, Daniel Khain & Qiong Yang
Biological oscillators adapt to environmental changes with widely tunable frequencies, a property theoretical studies attributed to positive feedbacks. However, no experiments have tested this theory. Here, we created synthetic cells to independently tune the frequency and feedback strength of a cell-cycle oscillator, enabling continuous mapping of period landscape in response to network perturbations. We found that although inhibiting positive feedback of cyclin-dependent kinase (Cdk1) reduces the tunability, the reduction is not as significant as theoretically...

Urinary metals and maternal circulating extracellular vesicle microRNA in the MADRES pregnancy cohort

Caitlin G. Howe, Helen B. Foley, Shohreh F. Farzan, Thomas A. Chavez, Mark Johnson, John D. Meeker, Theresa M. Bastain, Carmen J. Marsit & Carrie V. Breton
Exposure to metals increases risk for pregnancy complications. Extracellular vesicle (EV) miRNA contribute to maternal-foetal communication and are dysregulated in pregnancy complications. However, metal impacts on maternal circulating EV miRNA during pregnancy are unknown. Our objective was to investigate the impact of multiple metal exposures on EV miRNA in maternal circulation during pregnancy in the MADRES Study. Associations between urinary concentrations of nine metals and 106 EV miRNA in maternal plasma during pregnancy were investigated...

Data for: Freeze tolerance influenced forest cover and hydrology during the Pennsylvanian

William Matthaeus, Sophia I. Macarewich, Jon D. Richey, Jonathan P. Wilson, Jennifer C. McElwin, Isabel P. Montañez, William A. DiMichele, Michael T. Hren, Christopher J. Poulsen & Joseph D. White
Global forest cover affects the Earth system by altering surface mass and energy exchange. Physiology determines plant environmental limits and influences geographical vegetation distribution. Ancient plant physiology, therefore, likely affected vegetation-climate feedbacks. We combine climate modeling and ecosystem-process modeling to simulate arboreal vegetation in the late Paleozoic ice age. Using GENESIS V3 GCM simulations, varying pCO2, pO2, and ice extent for the Pennsylvanian, and fossil-derived leaf C:N, maximum stomatal conductance, and specific conductivity for several...

Registration Year

  • 2021

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  • University of Michigan–Ann Arbor
  • University of Michigan-Ann Arbor
  • Chinese Academy of Medical Sciences & Peking Union Medical College
  • Fudan University
  • First Affiliated Hospital of Chongqing Medical University
  • Zhejiang University
  • Chinese PLA General Hospital
  • Huazhong University of Science and Technology
  • Shanghai Jiao Tong University
  • Peking University