116 Works

HIF-1α promotes the keloid development through the activation of TGF-β/Smad and TLR4/MyD88/NF-κB pathways

Rui Lei, Jian Li, Feng Liu, Weihan Li, Shizhen Zhang, Yang Wang, Xi Chu & Jinghong Xu
A keloid is defined as an overgrowth of the dense fibrous tissues that form around a wound. Since they destroy the vascular network, keloid tissues often exhibit anoxic conditions. Hypoxia-inducible factor-1α (HIF-1α) is a core factor that mediates hypoxia stress responses and regulates the hypoxic cellular and biological behaviors. In this study, we found that the expression level of HIF-1α in keloid tissue was significantly higher than that in the normal skin tissue. Hypoxia-induced HIF-1α...

Prognostic alternative splicing regulatory network of RBM25 in hepatocellular carcinoma

Yong-Fa Zhang, Yi-Xiu Wang, Ning- Zhang, Zhen-Hai Lin, Long-Rong Wang, Yun Feng, Qi Pan & Lu Wang
RNA-binding motif protein 25 (RBM25) is a poorly characterized RNA-binding protein that is involved in several biological processes and regulates the proliferation and metastasis of tumor cells. The regulatory role of RBM25 in hepatocellular carcinoma (HCC) is unknown. Here, RBM25 expression and outcomes in HCC patients were evaluated using The Cancer Genome Atlas database. RBM25 was overexpressed in HCC patients compared with the healthy group. The high expression of RBM25 in tumor tissues was significantly...

Bioinformatics analysis reveals the competing endogenous RNA (ceRNA) coexpression network in the tumor microenvironment and prognostic biomarkers in soft tissue sarcomas

Dandan Zou, Yang Wang, Meng Wang, Bo Zhao, Fei Hu, Yanguo Li & Bingming Zhang
Soft tissue sarcomas (STSs) are rare, heterogeneous mesenchymal neoplasias. Understanding the tumor microenvironment (TME) and identifying potential biomarkers for prognosis associated with the TME of STS might provide effective clues for immune therapy. We evaluated the immune scores and stromal scores of STS patients by using the RNA sequencing dataset from The Cancer Genome Atlas (TCGA) database and the ESTIMATE algorithm. Then, the differentially expressed mRNAs (DEGs), miRNAs (DEMs) and lncRNAs (DELs) were identified after...

Is the Discretionary Income Effect of Oil Price Shocks a Hoax?

Christiane Baumeister, Lutz Kilian & Xiaoqing Zhou
The transmission of oil price shocks has been a question of central interest in macroeconomics since the 1970s. There has been renewed interest in this question after the large and persistent fall in the real price of oil in 2014–16. In the context of this debate, Ramey (2017) makes the striking claim that the existing literature on the transmission of oil price shocks is fundamentally confused about the question of how to quantify the effect...

Data for Concordance-based approaches in phylogenomics

Joseph Walker, Stephen Smith, Edwige Moyroud & Richard Hodel
Gene tree conflict is common and finding methods to analyze and alleviate the negative effects that conflict has on species tree analysis is a crucial part of phylogenomics. This study aims to expand the discussion of inferring species trees and molecular branch lengths when conflict is present. Conflict is typically examined in two ways: inferring its prevalence, and inferring the influence of the individual genes (how strongly one gene supports any given topology compared to...

Genotypic variation in an ecologically important parasite is associated with host species, lake, and spore size

Clara Shaw, Rebecca Bilich, Bruce O'Brien, Carla Cáceres, Spencer Hall, Timothy James & Meghan Duffy
Genetic variation in parasites has important consequences for host-parasite interactions. Prior studies of the ecologically important parasite Metschnikowia bicuspidata have suggested low genetic variation in the species. Here, we collected M. bicuspidata from two host species (Daphnia dentifera and Ceriodaphnia dubia) and two regions (Michigan and Indiana, USA). Within a lake, outbreaks tended to occur in one host species but not the other. Using microsatellite markers, we identified six parasite genotypes grouped within three distinct...

Migration distance is a fundamental axis of the slow-fast continuum of life history in boreal birds

Benjamin Winger & Teresa Pegan
Seasonal migration is intrinsically connected to the balance of survival and reproduction, but whether migratory behavior influences species’ position on the slow-fast continuum of life history is poorly understood. We found that boreal-breeding birds that migrate long distances exhibit higher annual adult survival and lower annual reproductive investment relative to co-distributed boreal species that migrate shorter distances to winter closer to their breeding grounds. Our study uses “vital rates” data on reproductive output and survivorship...

Individual recognition and individual identity signals in Polistes fuscatus wasps vary geographically

Elizabeth Tibbetts, Michelle Fearon, Meagan Simons, L. Lacey Knowles, Christian Cely Ortiz & Giorgia Auteri
Geographic variation in animal phenotypes is common, yet we know surprisingly little about how communication varies across populations. Instead, most communication research focuses on one or a few populations and assumes recognition behavior is consistent across a species’ range. Here, we show that individual identity signals and individual recognition vary across the geographic range of Polistes fuscatus wasps. P. fuscatus in MI and NY have variable facial patterns that signal individual identity and are used...

Supplement to: Sex and race differences in the risk of ischemic stroke associated with fasting blood glucose in REGARDS

Tracy Madsen, D. Leann Long, April P. Carson, George Howard, Dawn O. Kleindorfer, Karen L. Furie, JoAnn E. Manson, Simin Liu & Virginia J. Howard
Background: To investigate sex and race differences in the association between fasting blood glucose (FBG) and risk of ischemic stroke (IS). Methods: This prospective longitudinal cohort study included adults age ≥45 years at baseline in the Reasons for Geographic And Racial Differences in Stroke Study, followed for a median of 11.4 years. The exposure was baseline FBG (mg/dL); suspected IS events were ascertained by phone every 6 months and were physician-adjudicated. Cox proportional hazards were...

Functional traits reveal the dominant drivers of long‐term community change across a North American Great Lake

James Sinclair, Michael Fraker, James Hood, Kenneth Frank, Mark DuFour, Ann Marie Gorman & Stuart Ludsin
The datasets here were used to determine annual sentinel fish species and trait composition in Lake Erie's western and central basins during 1969-2018 in relation to multiple anthropogenic stressors. Here, we provide three datasets, which are used in the paper by Sinclair et al. titled: "Functional traits reveal the dominant drivers of long-term community change across a North American Great Lake". Each dataset is provided as a separate tab in a single Excel worksheet. The...

Alternative Trading Systems: Does One Shoe Fit All?

Nicolas Audet, Toni Gravelle & Jing Yang
This paper examines the factors that lead liquidity-motivated investors to choose the type of market structure they prefer. We assume that investors can choose between a dealership and a limit-order-book market. This study builds a theoretical model for both the dealership and order-book markets and develops a numerical method to solve the Nash equiibrium strategies of heterogeneous market participants. We find that a dealership market would be preferred by investors in an environment where customer...

A Data-driven Approach to Crosslinguistic Structural Biases

Alex Kramer & Zoey Liu

Data from: A test for rate-coupling of trophic and cranial evolutionary dynamics in New World bats

Jeff Shi, Erin Westeen & Daniel Rabosky
Data supporting article Shi et al. 2021, Evolution: https://doi.org/10.1111/evo.14188 Morphological evolution is often assumed to be causally related to underlying patterns of ecological trait evolution. However, few studies have directly tested whether evolutionary dynamics of and major shifts in ecological resource use are coupled with morphological shifts that may facilitate trophic innovation. Using diet and multivariate cranial (microCT) data, we tested whether rates of trophic and cranial evolution are coupled in the radiation of New...

Is the age of plant communities predicted by the age, stability and soil composition of the underlying landscapes? An investigation of OCBILs

Maria Beatriz De Cortez, Ryan A Folk, Charles J Grady, Jonathan P Spoelhof, Stephen A Smith, Douglas E Soltis & Pamela S Soltis
Old, climatically buffered, infertile landscapes (OCBILs) have been hypothesized to harbour an elevated number of persistent plant lineages and are predicted to occur across different parts of the globe, interspersed with other types of landscapes. We tested whether the mean age of a plant community is associated with occurrence on OCBILs, as predicted by climatic stability and poor soil environments. Using digitized occurrence data for seed plants occurring in Australia (7033 species), sub-Saharan Africa (3990...

Relaxed feeding constraints facilitate the evolution of mouthbrooding in Neotropical cichlids

Hannah Weller, Hernán López-Fernández, Caleb McMahan & Elizabeth Brainerd
Multifunctionality is often framed as a core constraint of phenotypic evolution. Mouthbrooding, a form of parental care where offspring develop inside a parent’s mouth, increases multifunctionality by adding a major function (reproduction) to a structure already serving other vital functions (feeding and respiration). Despite increasing multifunctionality, mouthbrooding has evolved repeatedly from other forms of parental care in at least 7 fish families. We hypothesized that mouthbrooding is more likely to evolve in lineages with feeding...

No link between population isolation and speciation rate in squamate reptiles

Sonal Singhal, Guarino Colli, Maggie Grundler, Gabriel Costa, Ivan Prates & Daniel Rabosky
Rates of species formation vary widely across the tree of life and contribute to massive disparities in species richness among clades. This variation can emerge from differences in metapopulation-level processes that affect the rates at which lineages diverge, persist, and evolve reproductive barriers and ecological differentiation. For example, populations that evolve reproductive barriers quickly should form new species at faster rates than populations that acquire reproductive barriers more slowly. This expectation implicitly links microevolutionary processes...

Urinary metals and maternal circulating extracellular vesicle microRNA in the MADRES pregnancy cohort

Caitlin G. Howe, Helen B. Foley, Shohreh F. Farzan, Thomas A. Chavez, Mark Johnson, John D. Meeker, Theresa M. Bastain, Carmen J. Marsit & Carrie V. Breton
Exposure to metals increases risk for pregnancy complications. Extracellular vesicle (EV) miRNA contribute to maternal-foetal communication and are dysregulated in pregnancy complications. However, metal impacts on maternal circulating EV miRNA during pregnancy are unknown. Our objective was to investigate the impact of multiple metal exposures on EV miRNA in maternal circulation during pregnancy in the MADRES Study. Associations between urinary concentrations of nine metals and 106 EV miRNA in maternal plasma during pregnancy were investigated...

Novel mutation in TSPAN12 associated with familial exudative vitreoretinopathy in a Chinese pedigree

Zhen Song, Mo Li, Chang Wang, Yu Wang, Lihua Zhang, Na Li, Ruifang Yang & Ping Sun
Familial exudative vitreoretinopathy (FEVR) is a rare retinal disorder characterised by incomplete retinal vascular development. Symptoms vary widely from none to blindness even within the same family. Multiple genes related to the Wnt pathway have been found to be associated with FEVR. Recent studies identified tetraspanin 12 (TSPAN12) as a cause of the autosomal dominant inheritance form of FEVR. Here, we describe a novel TSPAN12 mutation in a Chinese family with FEVR. Targeted next-generation sequencing...

Salidroside orchestrates metabolic reprogramming by regulating the Hif-1α signalling pathway in acute mountain sickness

Xiaoning Yan, Jie Liu, Meixia Zhu, Lirong Liu, Yijun Chen, Yinhuan Zhang, Menghan Feng, Zhixin Jia & Hongbin Xiao
Rhodiola crenulata (Hook. f. et Thoms.) H. Ohba (Crassulaceae) is used to prevent and treat acute mountain sickness. However, the mechanisms underlying its effects on the central nervous system remain unclear. To investigate the effect of Rhodiola crenulata on cellular metabolism in the central nervous system. The viability and Hif-1α levels of microglia and neurons at 5% O2 for 1, 3, 5 and 24 h were examined. We performed the binding of salidroside (Sal), rhodiosin,...

Salidroside orchestrates metabolic reprogramming by regulating the Hif-1α signalling pathway in acute mountain sickness

Xiaoning Yan, Jie Liu, Meixia Zhu, Lirong Liu, Yijun Chen, Yinhuan Zhang, Menghan Feng, Zhixin Jia & Hongbin Xiao
Rhodiola crenulata (Hook. f. et Thoms.) H. Ohba (Crassulaceae) is used to prevent and treat acute mountain sickness. However, the mechanisms underlying its effects on the central nervous system remain unclear. To investigate the effect of Rhodiola crenulata on cellular metabolism in the central nervous system. The viability and Hif-1α levels of microglia and neurons at 5% O2 for 1, 3, 5 and 24 h were examined. We performed the binding of salidroside (Sal), rhodiosin,...

Revisions to the Young Schema Questionnaire using Rasch analysis: the YSQ-R

Ozgur Yalcin, Ida Marais, Christopher Lee & Helen Correia
The aim of this study was to refine the YSQ-L3 by identifying the most statistically and clinically appropriate items for each Early Maladaptive Schema (EMS) using Rasch analysis. A Rasch analysis was undertaken on a large sample (N = 838) that included a heterogeneous clinical sample (N = 574) and a smaller non-clinical group (N = 264). Overall, 116 out of 232 items showed misfit across a number of statistical indicators. After the removal of...

Risk of Ophthalmic Adverse Events in Patients Treated with Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-analysis

Yan-Li Hou, Di-Ya Wang, Jie-Xuan Hu, Ru-Yue Tian, Wei Wang, Qiang Su, Hongyang Li & Yan-Ling Wang
Immune checkpoint inhibitors (ICIs) -induced adverse events (AEs) have been reported affecting almost all human organs. However, studies about ocular AEs are few. A meta-analysis was performed to evaluate the risks of ICI-related ophthalmic AEs compare to chemotherapy. Methods: Eligible studies were selected from phase II/III randomized controlled trials investigating ICIs. The data were analyzed by R software and Stata. Odds ratio of treatment-related AE (trAEs) and nonspecific ophthalmic trAEs (NS-trAEs) were lower for PD-1/PD-L1...

Silencing circular RNA circ_0054537 and upregulating microRNA-640 suppress malignant progression of renal cell carcinoma via regulating neuronal pentraxin-2 (NPTX2)

Long Pei, Xianqiang Lv, Gaopei Jia, Xiaoliang Tan, Ming Li & Aili Zhang
Hsa_circ_0054537 (circ_0054537) is a novel tumor-related circular RNA in renal cell carcinoma (RCC), and we intended to ascertain its dysregulation and functions in RCC malignant progression, as well as the underlying mechanism via serving as competing endogenous RNA (ceRNA). In this research, using real-time quantitative PCR, we found circ_0054537 was upregulated in RCC tissues and cells, and distributed throughout the cytoplasm. Then, functional effects of circ_0054537 in RCC were detected using cell counting kit-8, transwell,...

Etomidate ameliorated advanced glycation end-products (AGEs)-induced reduction of extracellular matrix genes expression in chondrocytes

Xiaohua Sun, Jizheng Zhang, Yi Li, Wanlu Ren & Lijun Wang
Osteoarthritis (OA) is a rheumatic disease common in the elderly. AGEs are the end products of glycation reactions and play an important role in the development of OA. Etomidate is a general anesthesia-inducing agent recently reported to exert significant anti-inflammatory effects. The present study aims to explore the protective effect of Etomidate against advanced glycation end-products (AGEs)-induced reduction of extracellular matrix gene expression in chondrocytes. In the present study, we found that AGEs significantly reduced...

Data from: New forms of structure in ecosystems revealed with the Kuramoto model

John Vandermeer
This is the general Mathematica code for the article, "New forms of structure in ecosystems revealed with the Kuramoto model" by Vandermeer, Hajian-Forooshani, Medina and Perfecto. All results presented in the article can be obtained by running the code with appropriate parameter settings.

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  • 2021

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  • University of Michigan–Ann Arbor
  • University of Michigan-Ann Arbor
  • Chinese Academy of Medical Sciences & Peking Union Medical College
  • Chinese PLA General Hospital
  • Fudan University
  • Zhejiang University
  • Huazhong University of Science and Technology
  • Nanjing Medical University
  • Chongqing Medical University
  • First Affiliated Hospital of Chongqing Medical University