Abstract Background Temporomandibular joint osteoarthritis (TMJOA) is characterized by abnormal subchondral bone remodeling and cartilage degeneration. As a non-invasive biophysical technology, pulsed electromagnetic field (PEMF) treatment has been proven to be efficient in promoting osteogenesis. However, the potential bone protective effect and mechanism of PEMF on abnormal subchondral bone remodeling in TMJOA are unknown. Methods Unilateral anterior crossbite (UAC) was used to create TMJOA model in rats, and 17β-estradiol (E2) were injected daily to mimic...

Additional file 3. Table S3. Clinical and laboratory data between survivors and non-survivors of sepsis.

Additional file 3. Table S3. Clinical and laboratory data between survivors and non-survivors of sepsis.

Additional file 2 Supplementary Fig. 2. A phylogenetic tree demonstrates the genetic distance among all mouse KRAB-Zfp genes. The detailed description is the same as that in Fig. 1B.

This study aimed to explore whether assisted biomimetic electrostimulation (BES) therapy can improve clinical outcomes in patients with abnormal endometrial receptivity undergoing frozen-thawed embryo transfer (FET) cycles. We retrospectively collected data from 132 patients who underwent FET cycles and divided them into the BES (n = 86) and non-BES (NBES) groups (n = 46). The clinical pregnancy rate (55.8 vs. 37.0%), biochemical pregnancy rate (59.3 vs. 41.3%), and live birth rate (44.2 vs. 23.9%) of...

Supplementary figures 1-8

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X221135841 for Endothelial progenitor cell transplantation attenuates synaptic loss associated with enhancing complement receptor 3-dependent microglial/macrophage phagocytosis in ischemic mice by Yuanyuan Ma, Ze Liu, Lu Jiang, Liping Wang, Yongfang Li, Yanqun Liu, Yongting Wang, Guo-Yuan Yang, Jing Ding and Zhijun Zhang in Journal of Cerebral Blood Flow & Metabolism

Article full text The above features represent the opinions of the authors. For a full list of declarations, including funding and author disclosure statements, please see the full text online (see “read the peer-reviewed publication” opposite). © The authors, CC-BY-NC 2022

Supplemental Material for Predicting housing construction period based on a cox proportional hazard model––an empirical study of housing completions in the greater Toronto and Hamilton area by Yu Zhang and Eric J Miller in Environment and Planning B: Urban Analytics and City Science

Endothelial progenitor cell (EPC) transplantation has therapeutic effects in cerebral ischemia. However, how EPCs modulate microglial activity remains unclear. In the study, we explored whether EPCs modulated microglial/macrophage activity and facilitated injured brain repair. Adult male mice (n = 184) underwent transient middle cerebral artery occlusion, and EPCs were transplanted into the brain immediately after ischemia. Microglial/macrophage activity and complement receptor 3 (CR3) expression were evaluated in ischemic brains and cultured microglia. CR3 agonist leukadherin-1...

Additional file 12: Fig. S12. Multi-omics characteristics of the three proteomic subtypes, related to Fig. 6. A Bar plot showing the number of overexpressed molecules in each proteomic subtypes at both proteome and transcriptome level. B Heatmap of the characteristic molecules of each proteomic subtypes at proteome (left) and transcriptome (right) level. Molecules previously reported to be associated with PDAC are marked in red. C Scatter plot displaying the significance of molecules that highest expressed...

Additional file 13: Fig. S13. Proteomic subtypes divided early-stage PDAC patients into subtypes with different prognosis, related to Fig. 6. A Summary of the relationship between proteomic subtypes and TNM stage subtypes. B Kaplan-Meier curves for overall survival of early-stage (IA and IB) PDAC patients based on 3 proteomic subtypes (log-rank test). C Bar plot indicating the enriched pathways in early-stage patients who were divided into three proteomic subtypes. D Heatmap of differentially expressed kinase...

Additional file 14: Fig. S14. Proteomic subtypes of CPTAC PDAC patients based on Fudan’s proteomic stratification, related to Fig. 6. A Consensus matrices of identified clusters (k = 2 to 5) of proteomic subtypes in CPTAC cohort based on Fudan’s proteomic stratification. B, C The consensus CDF (B) and delta area (change in CDF area) plots (C) are shown. D The heatmap depicting the relative abundance of signature proteins among three proteomic subtypes. E The...

Additional file 15: Fig. S15. Protein markers for three PDAC proteomic subtypes, related to Fig. 6. A The boxplot indicating the comparison of tumor purity across the proteomic subtypes. B Heatmap indicating the expression of protein biomarkers in the three proteomic subtypes. C Kaplan-Meier curves for overall survival based on proteomic abundance of ACOX1, S100A4 and MCM6 (log-rank test). D IHC profiling of proteomic subtype markers in PDAC. FFPE sections were stained for ACOX1, S100A4...

Additional file 16: Fig. S16. Characterization of immune infiltration in PDAC, related to Fig. 7. A Boxplot showing the age among five immune clusters. B Heatmap of xCell score between samples in old/young group of TCGA cohort. C Distribution of the percentage of proteomics subtypes across different immune subtypes (Fisher’s exact test). D The Sankey plot revealing the association between proteomics subtypes and immune subtypes. E Kaplan-Meier curves for overall survival based on immune subtypes...

Additional file 18: Fig. S18. Characterization of ECM subtypes in PDAC, related to Fig. 7. A H&E-stained slides of samples of deserted, inter, reactive ECM subtypes. B The expression heatmap describing differentially expressed proteins and phosphoproteins among three ECM subtypes. The enriched biological pathways were annotated on the right. C Boxplot illustrating the purity of sample among ECM subtypes. D Boxplots showing the expression of ECM markers among ECM subtypes. E IHC profiling of ECM...

Abstract Heat-imposed crop failure is often attributed to reduced thermotolerance of floral tissues; however, the underlying mechanism remains unknown. Here, we demonstrate that m6A RNA methylation increases in Arabidopsis flowers and negatively regulates gene expression variability. Stochastic gene expression provides flexibility to cope with environmental stresses. We find that reduced transcriptional fluctuation is associated with compromised activation of heat-responsive genes. Moreover, disruption of an RNA demethylase AtALKBH10B leads to lower gene expression variability, suppression of...

A new method, bypass-current plasma-MIG hybrid arc welding, was proposed to weld AA 5083 aluminium alloy. A comparative investigation between simulation and experiment was performed to quantify different effects of bypass-current and out plasma current on droplet transfer behaviours. The results show that when the bypass-current is 15 A, the droplets present a projected transfer mode, and its period is 22 ms. But if the outer plasma current is 15 A, the transfer frequency increases...

Additional file 5: Table S4. Summary of sequencing data generated in this study.

A global phase diagram of bound states in the continuum (BICs) in photonic-crystal slabs is obtained based on a universal classification of BICs by their different Friedrich-Wintgen origins. Previously, BICs in photonic-crystal slabs are classified into three types: single-resonance parametric, symmetry-protected and Friedrich-Wintgen BICs. Here, we show that the single-resonance parametric BICs come from the coupling between the guided resonance (GR) and Fabry-Pérot (FP) modes, and the symmetry-protected BICs from the coupling between two degenerate...

Supplement 1-Phase diagram of BIC

Using panel data for Chinese listed firms from 2009 to 2015, this research examines the impact of the green credit policy on the audit fees of heavily polluting firms by adopting a difference-in-difference (DID) model. The results show that the green credit policy increases the audit fees of heavily polluting firms, suggesting that auditors can perceive the risks imposed by the green credit policy on heavily polluting firms. Mechanism tests reveal that the implementation of...

Additional file 1. Supplementary.

Additional file 2: Supplementary Table 1. Subgroup analysis for the association between categorized BMI and lymph node metastasis.

The diagnosis of alcoholic liver disease (ALD) is still a great challenge. Therefore, the purpose of this study is to identify and characterize new metabolomic biomarkers for the diagnosis and staging of ALD. A total of 127 patients with early liver injury, 40 patients with alcoholic cirrhosis (ALC) and 40 healthy controls were included in this study. Patients with early liver injury included 45 patients with alcoholic liver disease (ALD), 40 patients with non-alcoholic fatty...