7 Works

Combining metabolomics and experimental evolution reveals key mechanisms underlying longevity differences in laboratory evolved Drosophila melanogaster populations

Mark Phillips, Kenneth R. Arnold, Zer Vue, Heather K. Beasley, Edgar Garza-Lopez, Andrea G. Marshall, Derrick J. Morton, Melanie R. McReynolds, Thomas T. Barter & Antentor Hinton
Experimental evolution with Drosophila melanogaster has been used extensively for decades to study aging and longevity. In recent years, the addition of DNA and RNA sequencing to this framework has allowed researchers to leverage the statistical power inherent to experimental evolution to study the genetic basis of longevity itself. Here, we incorporated metabolomic data into to this framework to generate even deeper insights into the physiological and genetic mechanisms underlying longevity differences in three groups...

Metformin regulates multiple signaling pathways within castration-resistant human prostate cancer cells

Emuejevoke Olokpa, Sammed N. Mandape, Siddharth Pratap & La Monica V. Stewart
Abstract Background The biguanide metformin has been shown to not only reduce circulating glucose levels but also suppress in vitro and in vivo growth of prostate cancer. However, the mechanisms underlying the anti-tumor effects of metformin in advanced prostate cancers are not fully understood. The goal of the present study was to define the signaling pathways regulated by metformin in androgen-receptor (AR) positive, castration-resistant prostate cancers. Methods Our group used RNA sequencing (RNA-seq) to examine...

Additional file 2 of Metformin regulates multiple signaling pathways within castration-resistant human prostate cancer cells

Emuejevoke Olokpa, Sammed N. Mandape, Siddharth Pratap & La Monica V. Stewart
Additional file 2.

Additional file 2 of Metformin regulates multiple signaling pathways within castration-resistant human prostate cancer cells

Emuejevoke Olokpa, Sammed N. Mandape, Siddharth Pratap & La Monica V. Stewart
Additional file 2.

Additional file 1 of Metformin regulates multiple signaling pathways within castration-resistant human prostate cancer cells

Emuejevoke Olokpa, Sammed N. Mandape, Siddharth Pratap & La Monica V. Stewart
Additional file 1.

Additional file 1 of Metformin regulates multiple signaling pathways within castration-resistant human prostate cancer cells

Emuejevoke Olokpa, Sammed N. Mandape, Siddharth Pratap & La Monica V. Stewart
Additional file 1.

Metformin regulates multiple signaling pathways within castration-resistant human prostate cancer cells

Emuejevoke Olokpa, Sammed N. Mandape, Siddharth Pratap & La Monica V. Stewart
Abstract Background The biguanide metformin has been shown to not only reduce circulating glucose levels but also suppress in vitro and in vivo growth of prostate cancer. However, the mechanisms underlying the anti-tumor effects of metformin in advanced prostate cancers are not fully understood. The goal of the present study was to define the signaling pathways regulated by metformin in androgen-receptor (AR) positive, castration-resistant prostate cancers. Methods Our group used RNA sequencing (RNA-seq) to examine...

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