274 Works

Data from: The basic keratin 10-binding domain of the virulence-associated pneumococcal serine-rich protein PsrP adopts a novel MSCRAMM fold

Tim Schulte
Streptococcus pneumoniae is a major human pathogen, and a leading cause of disease and death worldwide. Pneumococcal invasive disease is triggered by initial asymptomatic colonization of the human upper respiratory tract. The pneumococcal serine-rich repeat protein (PsrP) is a lung-specific virulence factor whose functional binding region (BR) binds to keratin-10 (KRT10) and promotes pneumococcal biofilm formation through self-oligomerization. We present the crystal structure of the KRT10-binding domain of PsrP (BR187–385) determined to 2.0 Å resolution....

Data from: Genetic differences between willow warbler migratory phenotypes are few and cluster in large haplotype blocks

Max Lundberg, Miriam Liedvogel, Keith Larson, Hanna Sigeman, Mats Grahn, Anthony Wright, Susanne Åkesson & Staffan Bensch
It is well established that differences in migratory behavior between populations of songbirds have a genetic basis but the actual genes underlying these traits remains largely unknown. In an attempt to identify such candidate genes we de novo assembled the genome of the willow warbler Phylloscopus trochilus, and used whole-genome resequencing and a SNP array to associate genomic variation with migratory phenotypes across two migratory divides around the Baltic Sea that separate SW migrating P....

Intracranial effect of osimertinib in relapsed EGFR-mutated T790M-positive and -negative non-small cell lung cancer patients: results from a phase II study

Inger Johanne Zwicky Eide, Harald Grut, Åslaug Helland, Simon Ekman, Jens Benn Sørensen, Karin Holmskov Hansen, Bjørn Henning Grønberg, Saulius Cicenas, Jussi Pekka Koivunen, Anders Mellemgaard & Odd Terje Brustugun
Osimertinib is effective for relapsed T790M-positive patients with brain metastases. The high brain permeability suggests that also such patients without T790M could benefit. Therefore, we evaluated the effect of osimertinib on brain metastases in both T790M-positive and -negative patients. The TREM-study was an investigator-initiated phase II, single-arm, multi-institutional clinical trial conducted in Northern Europe. Patients with resistance to prior EGFR-TKIs received osimertinib until radiological progression, unacceptable toxicity or death. Baseline brain scans were performed in...

Comparison of EM-seq and PBAT methylome library methods for low-input DNA

Yanan Han, Galina Yurevna Zheleznyakova, Yanara Marincevic-Zuniga, Majid Pahlevan Kakhki, Amanda Raine, Maria Needhamsen & Maja Jagodic
DNA methylation is the most studied epigenetic mark involved in regulation of gene expression. For low input samples, a limited number of methods for quantifying DNA methylation genome-wide has been evaluated. Here, we compared a series of input DNA amounts (1-10ng) from two methylome library preparation protocols, enzymatic methyl-seq (EM-seq) and post-bisulfite adaptor tagging (PBAT) adapted from single-cell PBAT. EM-seq takes advantage of enzymatic activity while PBAT relies on conventional bisulfite conversion for detection of...

Considering lightness: how the lightness of app icon backgrounds affects consumers’ download intention through risk perception

Ming Chen, Shih-Heng Yu & Yu Gao
The number of mobile apps has rapidly increased in recent years, but the distribution of app downloads is uneven. As the first and only visual image of apps before downloading, app icons are vital tools through which app publishers promote their apps. Thus, identifying the elements of app icons that can increase consumers’ download intention is crucial. This research examines how the distribution of the lightness of yellow colour in app icon backgrounds influences consumers’...

Considering lightness: how the lightness of app icon backgrounds affects consumers’ download intention through risk perception

Ming Chen, Shih-Heng Yu & Yu Gao
The number of mobile apps has rapidly increased in recent years, but the distribution of app downloads is uneven. As the first and only visual image of apps before downloading, app icons are vital tools through which app publishers promote their apps. Thus, identifying the elements of app icons that can increase consumers’ download intention is crucial. This research examines how the distribution of the lightness of yellow colour in app icon backgrounds influences consumers’...

sj-pdf-1-jcb-10.1177_0271678X221126830 - Supplemental material for Quantification of the purinergic P2X7 receptor with [11C]SMW139 improves through correction for brain-penetrating radiometabolites

Joachim Brumberg, Richard Aarnio, Anton Forsberg, Päivi Marjamäki, Vera Kerstens, Mohammad M Moein, Sangram Nag, Saara Wahlroos, Michael Kassiou, Albert D Windhorst, Christer Halldin, Merja Haaparanta-Solin, Patrik Fazio, Vesa Oikonen, Juha O Rinne & Andrea Varrone
Supplemental material, sj-pdf-1-jcb-10.1177_0271678X221126830 for Quantification of the purinergic P2X7 receptor with [11C]SMW139 improves through correction for brain-penetrating radiometabolites by Joachim Brumberg, Richard Aarnio, Anton Forsberg, Päivi Marjamäki, Vera Kerstens, Mohammad M Moein, Sangram Nag, Saara Wahlroos, Michael Kassiou, Albert D Windhorst, Christer Halldin, Merja Haaparanta-Solin, Patrik Fazio, Vesa Oikonen, Juha O Rinne and Andrea Varrone in Journal of Cerebral Blood Flow & Metabolism

German translation of the JAVELIN Bladder 100 study: avelumab maintenance treatment for advanced urothelial cancer

Petros Grivas, John A. Blake-Haskins, Nuno Costa, Bo Huang, Robert J. Laliberte, Daniel P. Petrylak, Jeanny B. Aragon-Ching, Joaquim Bellmunt, Cora N. Sternberg, Evgeny Kopyltsov, Norihiko Tsuchiya, Srikala S. Sridhar, Yohann Loriot, Anders Ullén, Wim Demey, Sinisa Radulović, Haralabos Kalofonos, Howard Gurney, Begoña P. Valderrama, Claudia Caserta, Eric Voog, Se-Hoon Park & Thomas Powles
German translation of the JAVELIN Bladder 100 study: avelumab maintenance treatment for advanced urothelial cancer

Additional file 2 of Potential living kidney donors’ positive experiences of an information letter from healthcare: a descriptive qualitative study

Eva Lagging, Kjerstin Larsson, Jonas Wadström, Linda Gyllström Krekula & Annika Tibell
The interview guide including survey questions.

Potential living kidney donors’ positive experiences of an information letter from healthcare: a descriptive qualitative study

Eva Lagging, Kjerstin Larsson, Jonas Wadström, Linda Gyllström Krekula & Annika Tibell
Abstract Background Patients who need a live donor kidney transplant (LDKT) must often ask potential donors (PLDs) themselves. This is a difficult task and healthcare could unburden them by making this first contact, ensuring also that PLDs receive correct information. We investigated how PLDs experience receiving a letter from healthcare about LDKT, live kidney donation, and inviting them to meet with professionals to get more information. Methods The letter (LD-letter) was sent to a cohort...

Additional file 2 of Changes in concentrations of cervicovaginal immune mediators across the menstrual cycle: a systematic review and meta-analysis of individual patient data

Sean M. Hughes, Claire N. Levy, Ronit Katz, Erica M. Lokken, Melis N. Anahtar, Melissa Barousse Hall, Frideborg Bradley, Philip E. Castle, Valerie Cortez, Gustavo F. Doncel, Raina Fichorova, Paul L. Fidel, Keith R. Fowke, Suzanna C. Francis, Mimi Ghosh, Loris Y. Hwang, Mariel Jais, Vicky Jespers, Vineet Joag, Rupert Kaul, Jordan Kyongo, Timothy Lahey, Huiying Li, Julia Makinde, Lyle R. McKinnon … & Florian Hladik
Additional file 2. Amendments to the pre-registered protocol.

Additional file 4 of Changes in concentrations of cervicovaginal immune mediators across the menstrual cycle: a systematic review and meta-analysis of individual patient data

Sean M. Hughes, Claire N. Levy, Ronit Katz, Erica M. Lokken, Melis N. Anahtar, Melissa Barousse Hall, Frideborg Bradley, Philip E. Castle, Valerie Cortez, Gustavo F. Doncel, Raina Fichorova, Paul L. Fidel, Keith R. Fowke, Suzanna C. Francis, Mimi Ghosh, Loris Y. Hwang, Mariel Jais, Vicky Jespers, Vineet Joag, Rupert Kaul, Jordan Kyongo, Timothy Lahey, Huiying Li, Julia Makinde, Lyle R. McKinnon … & Florian Hladik
Additional file 4. Concentration and forest plots for each individual immune mediator. Concentration plots - Each symbol shows the concentration of the indicated immune mediator in a single sample. Each study is plotted separately. Lines connect samples from the same participant; in some cases participants provided multiple samples in the same phase, in which case multiple symbols within the same phase may be connected. Pale grey symbols are below the lower limit of detection and...

Changes in concentrations of cervicovaginal immune mediators across the menstrual cycle: a systematic review and meta-analysis of individual patient data

Sean M. Hughes, Claire N. Levy, Ronit Katz, Erica M. Lokken, Melis N. Anahtar, Melissa Barousse Hall, Frideborg Bradley, Philip E. Castle, Valerie Cortez, Gustavo F. Doncel, Raina Fichorova, Paul L. Fidel, Keith R. Fowke, Suzanna C. Francis, Mimi Ghosh, Loris Y. Hwang, Mariel Jais, Vicky Jespers, Vineet Joag, Rupert Kaul, Jordan Kyongo, Timothy Lahey, Huiying Li, Julia Makinde, Lyle R. McKinnon … & Florian Hladik
Abstract Background Hormonal changes during the menstrual cycle play a key role in shaping immunity in the cervicovaginal tract. Cervicovaginal fluid contains cytokines, chemokines, immunoglobulins, and other immune mediators. Many studies have shown that the concentrations of these immune mediators change throughout the menstrual cycle, but the studies have often shown inconsistent results. Our understanding of immunological correlates of the menstrual cycle remains limited and could be improved by meta-analysis of the available evidence. Methods...

Additional file 1 of Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium

Pål Møller, Toni Seppälä, James G. Dowty, Saskia Haupt, Mev Dominguez-Valentin, Lone Sunde, Inge Bernstein, Christoph Engel, Stefan Aretz, Maartje Nielsen, Gabriel Capella, Dafydd Gareth Evans, John Burn, Elke Holinski-Feder, Lucio Bertario, Bernardo Bonanni, Annika Lindblom, Zohar Levi, Finlay Macrae, Ingrid Winship, John-Paul Plazzer, Rolf Sijmons, Luigi Laghi, Adriana Della Valle, Karl Heinimann … & Mark A. Jenkins
Additional file 1.

Additional file 1 of Changes in concentrations of cervicovaginal immune mediators across the menstrual cycle: a systematic review and meta-analysis of individual patient data

Sean M. Hughes, Claire N. Levy, Ronit Katz, Erica M. Lokken, Melis N. Anahtar, Melissa Barousse Hall, Frideborg Bradley, Philip E. Castle, Valerie Cortez, Gustavo F. Doncel, Raina Fichorova, Paul L. Fidel, Keith R. Fowke, Suzanna C. Francis, Mimi Ghosh, Loris Y. Hwang, Mariel Jais, Vicky Jespers, Vineet Joag, Rupert Kaul, Jordan Kyongo, Timothy Lahey, Huiying Li, Julia Makinde, Lyle R. McKinnon … & Florian Hladik
Additional file 1. Supporting methods documents. PRISMA-P and PRISMA-IPD checklists, database search strategies, manuscript screening form, risk of bias instrument, and strength of evidence tool.

Arabic translation of the JAVELIN Bladder 100 study: avelumab maintenance treatment for advanced urothelial cancer

Petros Grivas, John A. Blake-Haskins, Nuno Costa, Bo Huang, Robert J. Laliberte, Daniel P. Petrylak, Jeanny B. Aragon-Ching, Joaquim Bellmunt, Cora N. Sternberg, Evgeny Kopyltsov, Norihiko Tsuchiya, Srikala S. Sridhar, Yohann Loriot, Anders Ullén, Wim Demey, Sinisa Radulović, Haralabos Kalofonos, Howard Gurney, Begoña P. Valderrama, Claudia Caserta, Eric Voog, Se Hoon Park & Thomas Powles
Arabic translation of the JAVELIN Bladder 100 study: avelumab maintenance treatment for advanced urothelial cancer

Quantification of the purinergic P2X7 receptor with [11C]SMW139 improves through correction for brain-penetrating radiometabolites

Joachim Brumberg, Richard Aarnio, Anton Forsberg, Päivi Marjamäki, Vera Kerstens, Mohammad M Moein, Sangram Nag, Saara Wahlroos, Michael Kassiou, Albert D Windhorst, Christer Halldin, Merja Haaparanta-Solin, Patrik Fazio, Vesa Oikonen, Juha O Rinne & Andrea Varrone
The membrane-based purinergic 7 receptor (P2X7R) is expressed on activated microglia and the target of the radioligand [11C]SMW139 for in vivo assessment of neuroinflammation. This study investigated the contribution of radiolabelled metabolites which potentially affect its quantification. Ex vivo high-performance liquid chromatography with a radio detector (radioHPLC) was used to evaluate the parent and radiometabolite fractions of [11C]SMW139 in the brain and plasma of eleven mice. Twelve healthy humans underwent 90-min [11C]SMW139 brain PET with...

Arabic translation of the JAVELIN Bladder 100 study: avelumab maintenance treatment for advanced urothelial cancer

Petros Grivas, John A. Blake-Haskins, Nuno Costa, Bo Huang, Robert J. Laliberte, Daniel P. Petrylak, Jeanny B. Aragon-Ching, Joaquim Bellmunt, Cora N. Sternberg, Evgeny Kopyltsov, Norihiko Tsuchiya, Srikala S. Sridhar, Yohann Loriot, Anders Ullén, Wim Demey, Sinisa Radulović, Haralabos Kalofonos, Howard Gurney, Begoña P. Valderrama, Claudia Caserta, Eric Voog, Se Hoon Park & Thomas Powles
Arabic translation of the JAVELIN Bladder 100 study: avelumab maintenance treatment for advanced urothelial cancer

The WID-CIN test identifies women with, and at risk of, cervical intraepithelial neoplasia grade 3 and invasive cervical cancer

James E. Barrett, Karin Sundström, Allison Jones, Iona Evans, Jiangrong Wang, Chiara Herzog, Joakim Dillner & Martin Widschwendter
Abstract Background Cervical screening is transitioning from primary cytology to primary human papillomavirus (HPV) testing. HPV testing is highly sensitive but there is currently no high-specificity triage method for colposcopy referral to detect cervical intraepithelial neoplasia grade 3 or above (CIN3+) in women positive for high-risk (hr) HPV subtypes. An objective, automatable test that could accurately perform triage, independently of sample heterogeneity and age, is urgently required. Methods We analyzed DNA methylation at ~850,000 CpG...

Additional file 2 of Characteristics and outcome of traumatic cardiac arrest at a level 1 trauma centre over 10 years in Sweden

Daniel Ohlén, Magnus Hedberg, Paula Martinsson, Erik von Oelreich, Therese Djärv & Malin Jonsson Fagerlund
Supplementary Material 2

Additional file 1 of Individual and organisational factors in the psychosocial work environment are associated with home care staffs’ job strain: a Swedish cross-sectional study

Assander Susanne, Bergström Aileen, Olt Helen, Guidetti Susanne & Boström Anne-Marie
Additional file 1.

Factors affecting the blockchain application in construction management in China: an ANP-SWOT hybrid approach

Yu Gao, Oskar Casasayas, Jiayuan Wang & Xiaoxiao Xu
As a decentralised ledger and data management technology, blockchain has attracted increasing interest and has been effectively applied in various areas. Despite its promising potential, there are few studies proposing effective strategies for promoting blockchain, particularly in providing a strategic analysis of blockchain in China's construction management. This study aims to investigate the external and internal environments of blockchain application and determine the roadmaps and strategies for blockchain application in construction management in China. A...

Plain language summary of results from the JAVELIN Bladder 100 study: avelumab maintenance treatment for advanced urothelial cancer. Spanish translation.

Petros Grivas, John A. Blake-Haskins, Nuno Costa, Bo Huang, Robert J. Laliberte, Daniel P. Petrylak, Jeanny B. Aragon-Ching, Joaquim Bellmunt, Cora N. Sternberg, Evgeny Kopyltsov, Norihiko Tsuchiya, Srikala S. Sridhar, Yohann Loriot, Anders Ullén, Wim Demey, Sinisa Radulović, Haralabos Kalofonos, Howard Gurney, Begoña P. Valderrama, Claudia Caserta, Eric Voog, Se-Hoon Park & Thomas Powles
Spanish translation of plain language summary of results from the JAVELIN Bladder 100 study

Additional file 1 of DNA methylation-based detection and prediction of cervical intraepithelial neoplasia grade 3 and invasive cervical cancer with the WID™-qCIN test

Chiara Herzog, Karin Sundström, Allison Jones, Iona Evans, James E. Barrett, Jiangrong Wang, Elisa Redl, Lena Schreiberhuber, Laura Costas, Sonia Paytubi, Lukas Dostalek, Michal Zikan, David Cibula, Gaby Sroczynski, Uwe Siebert, Joakim Dillner & Martin Widschwendter
Additional file 1: Additional figures and tables.

Fragmental optical vortex for the detection of rotating object based on rotational Doppler effect

song qiu, You Ding, Tong Liu, Zhengliang Liu, hao wu & yuan ren
Rotational Doppler effect (RDE), as a counterpart of the conventional linear Doppler effect in the rotating frame, has attracted increasing attention in recent years on rotational object detection. Many previous works have investigated the RDE based on the whole optical vortex field. In this work, we report on the RDE of the partially obstructed optical vortex and the corresponding rotational speed extraction method. Based on the orbital angular momentum (OAM) mode expansion technique, we establish...

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