Data from: Thyroid hormone protects primary cortical neurons exposed to hypoxia by reducing DNA methylation and apoptosis

Jianrong Li, Kiyomi Abe, Anna Milanesi, Yan-Yun Liu & Gregory A. Brent
Traumatic Brain Injury (TBI) is associated with disruption of cerebral blood flow leading to localized brain hypoxia. Thyroid hormone (TH) treatment, administered shortly after injury, has been shown to promote neural protection in rodent TBI models. The mechanism of TH protection, however, is not established. We used mouse primary cortical neurons to investigate the effectiveness and possible pathways of T3-promoted cell survival after exposure to hypoxic injury. Cultured primary cortical neurons were exposed to hypoxia...

Registration Year

  • 2019
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Resource Types

  • Dataset
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Affiliations

  • David Geffen School of Medicine at UCLA
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