291 Works

Optimization of the extraction conditions and dermal toxicity of oil body fused with acidic fibroblast growth factor (OLAF)

Yongxin Guo, Yaying Li, Qian Wu, Xinxin Lan, Guodong Chu, Weidong Qiang, Muhammad Noman, Tingting Gao, Jinnan Guo, Long Han, Jing Yang, Xiaokun Li & Linna Du
Oil body (OB), a subcellular organelle that stores oil in plant seeds, is considered a new transdermal drug delivery system. With the increasing understanding of the OB and its main protein (oleosin), numerous studies have been conducted on OB as “carrier” for the expression of exogenous proteins. In our previous study, oil body fused with aFGF (OLAF) was obtained using a plant oil body expression system that had been preliminarily proven to be effective in...

An enhanced methodology for predicting protein-protein interactions between human and hepatitis C virus via ensemble learning algorithms

Xin Liu, Liang Wang, Cheng-Hao Liang, Ya-Ping Lu, Ting Yang & Xiao Zhang
Hepatitis C virus (HCV) is responsible for a variety of human life-threatening diseases, which include liver cirrhosis, chronic hepatitis, fibrosis and hepatocellular carcinoma (HCC) . Computational study of protein-protein interactions between human and HCV could boost the findings of antiviral drugs in HCV therapy and might optimize the treatment procedures for HCV infections. In this analysis, we constructed a prediction model for protein-protein interactions between HCV and human by incorporating the features generated by pseudo...

Synthesis and anti-proliferative activities of 5,6,7-trimethoxyflavones and their derivatives

Liang Su, Wei Li, Kexiong Liu & Qiuan Wang
A series of 5,6,7-trimethoxyflavones 1a-1g and their derivatives 2a-2g, 3a-3d, 4 and 5, including the natural products 5,6,7-trimethoxy-4’-hydroxyflavone (1a), 5,6,7,3’,4’ -pentamethoxyflavone (sinensetin, 1 b), 5,6,7-trimethoxy-3’,4’-methyl enedioxy flavone (1c), 5,6,7,3’-tetramethoxy-4,5’-methylenedioxyflavone (1e), 5,6,7, 3’,4’,5’-hextamethoxyflavone (1 g), 5-hydroxy-3,4,2’,3’,4’-pentamethoxy chal-cone (2 b), 5,4’-dihydroxy-6,7-dimethoxy flavone (cirsimaritin, 3a) and 5-hydroxy-6,7,3’, 4’-tetramethoxyflavone (5-demethylsinensetin, 3 b), 3,5,6,7,3’,4’-hexamethoxyflavone (3-methoxysinensetin, 4) and 5’-hydroxy-3,6,7,3’,4’-pentamethoxyflavone (5) were synthesized. Their anti-proliferative activity in vitro was evaluated against a panel of four human cancer cell lines (Aspc-1, HCT-116, HepG-2...

A ferroptosis-related gene signature for graft loss prediction following renal allograft

Zhenlei Fan, Tao Liu, Hanfei Huang, Jie Lin & Zhong Zeng
Allogeneic kidney transplantation (renal allograft) is the most effective treatment for advanced kidney disease. Previous studies have indicated that ferroptosis participates in the progression of acute kidney injury and renal transplant failure. However, few studies have evaluated the prognostic value of ferroptosis on renal transplantation outcomes. In this study, a total of 22 differentially expressed ferroptosis-related genes (DFGs) were identified, which were mainly enriched in infection-related pathways. Next, a ferroptosis-related gene signature, including GA-binding protein...

An enhanced methodology for predicting protein-protein interactions between human and hepatitis C virus via ensemble learning algorithms

Xin Liu, Liang Wang, Cheng-Hao Liang, Ya-Ping Lu, Ting Yang & Xiao Zhang
Hepatitis C virus (HCV) is responsible for a variety of human life-threatening diseases, which include liver cirrhosis, chronic hepatitis, fibrosis and hepatocellular carcinoma (HCC) . Computational study of protein-protein interactions between human and HCV could boost the findings of antiviral drugs in HCV therapy and might optimize the treatment procedures for HCV infections. In this analysis, we constructed a prediction model for protein-protein interactions between HCV and human by incorporating the features generated by pseudo...

Construction of a novel risk model based on the random forest algorithm to distinguish pancreatic cancers with different prognoses and immune microenvironment features

Yalan Lei, Rong Tang, Jin Xu, Bo Zhang, Jiang Liu, Chen Liang, Qingcai Meng, Jie Hua, Xianjun Yu, Wei Wang & Si Shi
Immune-related long noncoding RNAs (irlncRNAs) are actively involved in regulating the immune status. This study aimed to establish a risk model of irlncRNAs and further investigate the roles of irlncRNAs in predicting prognosis and the immune landscape in pancreatic cancer. The transcriptome profiles and clinical information of 176 pancreatic cancer patients were retrieved from The Cancer Genome Atlas (TCGA). Immune-related genes (irgenes) downloaded from ImmPort were used to screen 1903 immune-related lncRNAs (irlncRNAs) using Pearson’s...

Biological mechanisms of growth performance and meat quality in porcine muscle tissue

Chen Fang, Fei Guo, Xiaoqi Zhao, Zining Zhang, Junlan Lu, Hongbin Pan, Taojie Xu, Weizhen Li, Minghua Yang, Ying Huang, Yanguang Zhao & Sumei Zhao
Growth performance and meat quality are important traits for pig production. The aim of the present study was to investigate the molecular mechanisms underlying growth performance and meat quality, and to identify novel target molecules for predicting the growth performance and meat quality. The differentially expressed genes (DEGs) in Diannan small ears pigs (DSP) and Landrace pigs (LP) were assessed by RNA-sequencing analyzing technology. A total of 339 DEGs were obtained between DSP and LP....

Association between atherosclerotic cardiovascular diseases risk and renal outcome in patients with type 2 diabetes mellitus

Honghong Ren, Lijun Zhao, Yutong Zou, Yiting Wang, Junlin Zhang, Yucheng Wu, Rui Zhang, Tingli Wang, Jiali Wang, Yitao Zhu, Ruikun Guo, Huan Xu, Lin Li, Mark E. Cooper & Fang Liu
Chronic kidney disease (CKD) and diabetes mellitus increase atherosclerotic cardiovascular diseases (ASCVD) risk. However, the association between renal outcome of diabetic kidney disease (DKD) and ASCVD risk is unclear. This retrospective study enrolled 218 type 2 diabetic patients with biopsy-proven DKD, and without known cardiovascular diseases. Baseline characteristics were obtained and the 10-year ASCVD risk score was calculated using the Pooled Cohort Equation (PCE). Renal outcome was defined as progression to end-stage renal disease (ESRD)....

S-adenosyl-L-homocysteine hydrolase FgSah1 is required for fungal development and virulence in Fusarium graminearum

Dongya Shi, Yu Zhang, Jin Wang, Weichao Ren, Jie Zhang, Jane Ifunanya Mbadianya, Yuanye Zhu, Changjun Chen & Hongyu Ma
The S-adenosyl-L-homocysteine hydrolase (Sah1) plays a crucial role in methylation and lipid metabolism in yeast and mammals, yet its function remains elusive in filamentous fungi. In this study, we characterized Sah1 in the phytopathogenic fungus F. graminearum by generating knockout and knockout-complemented strains of FgSAH1. We found that the FgSah1-GFP fusion protein was localized to the cytoplasm, and that deletion of FgSAH1 resulted in defects in vegetative growth, asexual and sexual reproduction, stress responses, virulence,...

S-adenosyl-L-homocysteine hydrolase FgSah1 is required for fungal development and virulence in Fusarium graminearum

Dongya Shi, Yu Zhang, Jin Wang, Weichao Ren, Jie Zhang, Jane Ifunanya Mbadianya, Yuanye Zhu, Changjun Chen & Hongyu Ma
The S-adenosyl-L-homocysteine hydrolase (Sah1) plays a crucial role in methylation and lipid metabolism in yeast and mammals, yet its function remains elusive in filamentous fungi. In this study, we characterized Sah1 in the phytopathogenic fungus F. graminearum by generating knockout and knockout-complemented strains of FgSAH1. We found that the FgSah1-GFP fusion protein was localized to the cytoplasm, and that deletion of FgSAH1 resulted in defects in vegetative growth, asexual and sexual reproduction, stress responses, virulence,...

Special electromagnetic field-treated water and far-infrared radiation alleviates lipopolysaccharide-induced acute respiratory distress syndrome in rats by regulating haptoglobin

Changyong Luo, Yan Li, Xu Liang, Yifan Chen, Qiao Zou, Yurong Kong, Zhengguang Guo, Wei Sun & Xin Wang
Special electromagnetic field-treated water (SEW) and far-infrared radiation (FIR) can reduce acute respiratory distress syndrome (ARDS) in rats inflicted by lipopolysaccharides (LPSs). However, little is known about its underlying molecular mechanism. Differentially expressed proteins (DEPs) of SEW and FIR interventions were obtained from a proteomics database. A total of 89 DEPs were identified. Enrichment analysis of DEPs was performed using the Database for Annotation, Visualization, and Integrated Discovery. These DEPs were associated with the responses...

Antibiotics: An overview on the environmental occurrence, toxicity, degradation, and removal methods

Qiulian Yang, Yuan Gao, Jian Ke, Pau Loke Show, Yuhui Ge, Yanhua Liu, Ruixin Guo & Jianqiu Chen
Antibiotics, as antimicrobial drugs, have been widely applied as human and veterinary medicines. Recently, many antibiotics have been detected in the environments due to their mass production, widespread use, but a lack of adequate treatment processes. The environmental occurrence of antibiotics has received worldwide attention due to their potential harm to the ecosystem and human health. Research status of antibiotics in the environment field is presented by bibliometrics. Herein, we provided a comprehensive overview on...

Additional file 1 of Data integration and evolutionary analysis of long non-coding RNAs in 25 flowering plants

Shiye Sang, Wen Chen, Di Zhang, Xuan Zhang, Wenjing Yang & Changning Liu
Additional file 1. Genomic sequences and their corresponding annotations of 25 flowering plants.

Additional file 3 of Data integration and evolutionary analysis of long non-coding RNAs in 25 flowering plants

Shiye Sang, Wen Chen, Di Zhang, Xuan Zhang, Wenjing Yang & Changning Liu
Additional file 3. GO annotations of 196 conserved lncRNAs.

The effects of different parity and delivery mode on wheezing disorders in the children—a retrospective cohort study in Fujian, China

Haiyan Gao, Chong Miao, Haibo Li, Meng Bai, Huijie Zhang, Zhengqin Wu, Wei Li, Wenjuan Liu, Libo Xu, Guanghua Liu & Yibing Zhu
The relationship between childbirth delivery methods and the risk of wheezing in children remains controversial. Few studies have explored it under different maternal conditions. To explore the influence of childbirth delivery method on the onset of wheezing in children of different parity. A total of 21716 patients were included in this retrospective observational study. Multivariable logistic regression was used to analyze the relationship between childbirth delivery method and wheezing in children under 18 years of...

Alterations of oral microbiota in patients with panic disorder

Zunli Xie, Weiqing Jiang, Mingzhu Deng, Wei Wang, Xian Xie, Xia Feng, Yinping Shi, Xueyan Zhang, Dong Song, Ziyu Yuan & Yonggang Wang
The main characteristics of panic disorder (PD) include recurrent panic attacks and persistent worry, accompanied by other physical and cognitive symptoms. While recent studies have revealed that gut bacteria play an important role in anxiety and depression, little is known about the relationship between oral microbiota and PD. Therefore, the objective of this study was to explore a possible correlation between oral microbiota and PD. We conducted 16S rRNA sequencing to compare differences in the...

Long non-coding RNA LINC00958 promotes colorectal cancer progression by enhancing the expression of LEM domain containing 1 via microRNA miR-3064-5p

Zhaoxia Luo, Shunxin Hao, Jian Yuan, Kai Zhu, Shuo Liu, Jing Zhang & Lei Yao
Colorectal cancer is a common cause of cancer-related death worldwide. Thus, there is an urgent need to determine the mechanism of progression of colorectal cancer. In this study, we investigated the function and mechanism of long non-coding RNA LINC00958, providing a new biomarker for colorectal cancer. The expression of LINC00958, miR-3064-5p, and LEM domain containing 1 (LEMD1) in colorectal cancer tissues and cell lines was analyzed using reverse transcription quantitative polymerase chain reaction (RT-qPCR). The...

Additional file 7 of Temporal expression study of miRNAs in the crown tissues of winter wheat grown under natural growth conditions

Menglei Wang, Chenhui Yang, Kangning Wei, Miao Zhao, Liqiang Shen, Jie Ji, Li Wang, Daijing Zhang, Junqiang Guo, Yun Zheng, Juanjuan Yu, Mo Zhu, Haiying Liu & Yong-Fang Li
Additional file 7: Figure S3. miRNAs with different expression patterns in crown and leaf tissues at the winter dormancy stage, spring green-up stage and jointing stage.

Cryogenian crustal evolution in western Nigeria shield: whole-rock geochemistry, Sr-Nd and zircon U-Pb-Hf isotopic evidence from Bakoshi-Gadanya granites

Safiyanu Muhammad Elatikpo, Huan Li, Han Zheng, Musa Bala Girei, Jinghua Wu & Abdulgafar Kayode Amuda
The Bakoshi-Gadanya area, with widespread Neoproterozoic granites, is located within the Pan-African Trans-Sahara Belt, sandwiched between the West African and the Sahara metacraton. The whole-rock geochemistry, Sr-Nd isotope systematics and LA-(MC)-ICP-MS U-Pb-Hf isotopes of zircon were analysed to shed light on the age and genesis of the Bakoshi-Gadanya granites in the Precambrian basement of the northern western Nigeria shield. The granites are silicic (SiO2: 72.8–77.2 wt.%), ferroan, high-K, calc-alkalic to alkali-calcic in composition, with A-type...

Single-machine scheduling with energy generation and storage systems

Hyun-Jung Kim, Eun-Seok Kim, Jun-Ho Lee, Lixin Tang & Yang Yang
This paper considers a single-machine scheduling problem with sequence-dependent setup times and energy-generation and storage systems. Each job requires a sequence-dependent setup to be processed on the machine, and both setup and processing of the job require job-dependent amounts of energy. The energy consumed by the machine can be bought from an Electric Power Company (EPC) or generated by own Distributed Energy Resource (DER), such as solar photovoltaic or wind, and the energy can be...

Study of calcitriol anti-aging effects on human natural killer cells in vitro

Weiran Li, Xu Che, Xuemei Chen, Meiling Zhou, Xiaoping Luo & Tao Liu
Vitamin D is widely considered to have a regulatory effect on the immune system. Some clinical investigations have shown that the demand for vitamin D increases with age. Calcitriol is the biologically active form of vitamin D. However, its effect on human natural killer (NK) cells remains unclear. Therefore, in this study, we investigated the anti-aging and immunomodulatory effects of calcitriol on NK cells using a series of immunological methods to explore its important role...

Additional file 6 of Data integration and evolutionary analysis of long non-coding RNAs in 25 flowering plants

Shiye Sang, Wen Chen, Di Zhang, Xuan Zhang, Wenjing Yang & Changning Liu
Additional file 6. The collected transcriptome analysis data.

Four new cembranoids from the South China Sea soft coral Sarcophyton trocheliophorum

Lu Ren, Xue Leng, Te Li, Jing Liu, Wei Wang, Xiaojun Yan, Xia Yan & Shan He
Four new cembrane diterpenes, 1,13-di-epi-13-acetoxy launine P (1), 13-oxo-thunbergol (2), isocrassumol B (3) and 7α, 8α-sarcophine (4), together with two known launine P (5) and sarcophytonin B (6), were isolated from the extract of the South China Sea soft coral Sarcophyton trocheliophorum. The structures were elucidated by spectroscopic analysis, ECD analysis and comparison with literature data. All compounds were tested for their antimicrobial activity and antiviral activity. Compounds 1, 2 and 5 were found to...

Multiple Imputation Inference with Integer-Valued Point Estimates

Bo Liu & Jerome P. Reiter
We consider settings where an analyst of multiply imputed data desires an integer-valued point estimate and an associated interval estimate, for example, a count of the number of individuals with certain characteristics in a population. Even when the point estimate in each completed dataset is an integer, the multiple imputation point estimator, that is, the average of these completed-data estimators, is not guaranteed to be an integer. One natural approach is to round the standard...

Additional file 2 of Temporal expression study of miRNAs in the crown tissues of winter wheat grown under natural growth conditions

Menglei Wang, Chenhui Yang, Kangning Wei, Miao Zhao, Liqiang Shen, Jie Ji, Li Wang, Daijing Zhang, Junqiang Guo, Yun Zheng, Juanjuan Yu, Mo Zhu, Haiying Liu & Yong-Fang Li
Additional file 2: Figure S1. Common and specific known miRNAs expressed in wheat crown tissues at four different growth and development stages.

Registration Year

  • 2021
    291

Resource Types

  • Dataset
    148
  • Text
    107
  • Image
    16
  • Collection
    14
  • Other
    5
  • Audiovisual
    1

Affiliations

  • Air Force Medical University
    291
  • Shanghai Jiao Tong University
    206
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    202
  • Fudan University
    189
  • Sun Yat-sen University
    185
  • Chinese Academy of Sciences
    169
  • Huazhong University of Science and Technology
    165
  • Sichuan University
    165
  • Zhejiang University
    153
  • Capital Medical University
    151