98 Works

Data from: Prognostic value of cerebral tissue oxygen saturation during neonatal extracorporeal membrane oxygenation

Marie Philippine Clair, Jérôme Rambaud, Adrien Flahault, Romain Guedj, Julia Guilbert, Isabelle Guellec, Amélie Durandy, Maryne Demoulin, Sandrine Jean, Delphine Mitanchez, François Chalard, Chiara Sileo, Ricardo Carbajal, Sylvain Renolleau & Pierre-Louis Léger
Objectives: Extracorporeal membrane oxygenation support is indicated in severe and refractory respiratory or circulatory failures. Neurological complications are typically represented by acute ischemic or hemorrhagic lesions, which induce higher morbidity and mortality. The primary goal of this study was to assess the prognostic value of cerebral tissue oxygen saturation (StcO2) on mortality in neonates and young infants treated with ECMO. A secondary objective was to evaluate the association between StcO2 and the occurrence of cerebral...

Data from: Characterizing and comparing the seasonality of influenza-like illnesses and invasive pneumococcal diseases using seasonal waveforms

Matthieu Domenech De Cellès, Helene Arduin, Emmanuelle Varon, Cécile Souty, Pierre-Yves Boëlle, Daniel Lévy-Bruhl, Sylvie Van Der Werf, Jean-Claude Soulary, Didier Guillemot, Laurence Watier & Lulla Opatowski
The seasonalities of influenza-like illnesses (ILIs) and invasive pneumococcal diseases (IPDs) remain incompletely understood. Experimental evidence indicates that influenza-virus infection predisposes to pneumococcal disease, so that a correspondence in the seasonal patterns of ILIs and IPDs might exist at the population level. We developed a method to characterize seasonality by means of easily interpretable summary statistics of seasonal shape—or seasonal waveforms. Non-linear mixed-effects models were used to estimate those waveforms based on weekly case reports...

Generation of functional NaV1.5 current by endogenous transcriptional activation of SCN5A

Liang Xu & Rui Shi
The sodium channel NaV1.5, which is encoded by the SCN5A gene, underlies the fast upstroke of cardiac action potential and thus plays a crucial role in cardiac electrophysiology, but the mechanism governing the regulation of NaV1.5 has not been fully elucidated. The newly developed clustered regularly interspaced short palindromic repeats (CRSPR)/Cas9 transcription factors offer a powerful and precise approach for modulating gene expression. We investigated the potential of this new tool for activating stringently silenced...

Effect of the measurement of the work of breathing on the respiratory outcome of preterms

Benjamin Dudoignon, Sonia Khirani, Alessandro Amaddeo, Rafik Ben Ammar, Daniele De Luca, Heloise Torchin, Alexandre Lapillonne, Pierre-Henri Jarreau & Brigitte Fauroux
There are no validated criteria for the choice of the optimal type of noninvasive respiratory support (NRS) and most appropriate settings in preterms. The work of breathing (WOB) during oxygen (O2) alone, nasal continuous positive pressure (nCPAP) and high flow nasal cannula (HFNC) was compared in preterm babies (23–30 weeks’ gestation, “physiological group”) needing any type of noninvasive respiratory support (“baseline” NRS) at 4 weeks of life. Babies were thereafter treated with the NRS associated...

Effect of the measurement of the work of breathing on the respiratory outcome of preterms

Benjamin Dudoignon, Sonia Khirani, Alessandro Amaddeo, Rafik Ben Ammar, Daniele De Luca, Heloise Torchin, Alexandre Lapillonne, Pierre-Henri Jarreau & Brigitte Fauroux
There are no validated criteria for the choice of the optimal type of noninvasive respiratory support (NRS) and most appropriate settings in preterms. The work of breathing (WOB) during oxygen (O2) alone, nasal continuous positive pressure (nCPAP) and high flow nasal cannula (HFNC) was compared in preterm babies (23–30 weeks’ gestation, “physiological group”) needing any type of noninvasive respiratory support (“baseline” NRS) at 4 weeks of life. Babies were thereafter treated with the NRS associated...

Additional file 2 of Association between in-ICU red blood cells transfusion and 1-year mortality in ICU survivors

Alice Blet, Joel B. McNeil, Julie Josse, Bernard Cholley, Raphaël Cinotti, Gad Cotter, Agnès Dauvergne, Beth Davison, Kévin Duarte, Jacques Duranteau, Marie-Céline Fournier, Etienne Gayat, Samir Jaber, Sigismond Lasocki, Thomas Merkling, Katell Peoc’h, Imke Mayer, Malha Sadoune, Pierre-François Laterre, Romain Sonneville, Lorraine Ware, Alexandre Mebazaa & Antoine Kimmoun
Additional file 2: Supplemental Text.

Additional file 1 of Oropharyngeal and intestinal concentrations of opportunistic pathogens are independently associated with death of SARS-CoV-2 critically ill adults

Juliette Patrier, Khanh Villageois-Tran, Piotr Szychowiak, Stéphane Ruckly, Rémi Gschwind, Paul-Henri Wicky, Signara Gueye, Laurence Armand-Lefevre, Mehdi Marzouk, Romain Sonneville, Lila Bouadma, Marie Petitjean, Fariza Lamara, Etienne de Montmollin, Jean-Francois Timsit & Etienne Ruppé
Additional file 1: Table S1. Result of the initial 16S rDNA sequencing in rectal samples. Table S2. Per pathogen rectal and oropharyngeal culture positivity, time to first positivity and abundance at first positivity. Table S3. Adjusted impact of abundance of Enterococcus spp., S. aureus and Candida spp. in oropharynx and rectum on day 90 mortality. (one adjusted model for each). Table S4. Univariate analysis of day 90 mortality* comparing survivors versus descedents. Fig S1. Quantitative...

Additional file 1 of Accuracy of clinicians’ ability to predict the need for renal replacement therapy: a prospective multicenter study

Alexandre Sitbon, Michael Darmon, Guillaume Geri, Paul Jaubert, Pauline Lamouche-Wilquin, Clément Monet, Lucie Le Fèvre, Marie Baron, Marie-Line Harlay, Côme Bureau, Olivier Joannes-Boyau, Claire Dupuis, Damien Contou, Virginie Lemiale, Marie Simon, Christophe Vinsonneau, Clarisse Blayau, Frederic Jacobs & Lara Zafrani
Additional file 1: Figure S1. Physician prediction: Visual Likert Scale. Figure S2. PresagEER study timeline. Table S1. Delays between ICU admission, AKI diagnosis and RRT initiation. Table S2. RRT characteristics. Table S3. Characteristics and outcomes of AKI patients (n (%) or median (IQR)). Table S4. Multivariate analysis including variables associated with the risk of requiring RRT (without physician prediction).

Telomere length and mitochondrial DNA copy number in bipolar disorder: A sibling study

Luana Spano, Bruno Etain, Jean-Louis Laplanche, Marion Leboyer, Sébastien Gard, Frank Bellivier & Cynthia Marie-Claire
An accelerated cellular ageing has been observed in bipolar disorder (BD) using biomarkers such as telomere length (TL) and mitochondrial DNA copy number (mtDNAcn). Several risk factors might drive premature ageing in individuals with BD, including a familial predisposition. This study compared TL and mtDNAcn between individuals with BD and their (un)-affected siblings, and explored factors that may explain proband-sibling differences. Sixty individuals with BD and seventy-four siblings (34 affected with BD or mood disorders...

Additional file 2 of Transcriptomics and miRNomics data integration in lymphoblastoid cells highlights the key role of immune-related functions in lithium treatment response in Bipolar disorder

Nadia Cattane, Cindie Courtin, Elisa Mombelli, Carlo Maj, Cristina Mora, Bruno Etain, Frank Bellivier, Cynthia Marie-Claire & Annamaria Cattaneo
Additional file 2 Supplementary Table 2. List of 57 common transcripts between those differentially expressed in our dataset (BD responders (R) versus non-responders (NR)) and other available transcriptomic studies in Pubmed. *: LCLs from Li-responders versus Li non-responders patients diagnosed with BD. #: Li-treated vs vehicle-treated LCLs from patients diagnosed with BD. Δ: before Li-treatment versus after Li-treatment in healthy controls. +: Li-treated vs vehicle-treated LCLs from Li-responders and Li non-responders patients diagnosed with BD....

Additional file 2 of Transcriptomics and miRNomics data integration in lymphoblastoid cells highlights the key role of immune-related functions in lithium treatment response in Bipolar disorder

Nadia Cattane, Cindie Courtin, Elisa Mombelli, Carlo Maj, Cristina Mora, Bruno Etain, Frank Bellivier, Cynthia Marie-Claire & Annamaria Cattaneo
Additional file 2 Supplementary Table 2. List of 57 common transcripts between those differentially expressed in our dataset (BD responders (R) versus non-responders (NR)) and other available transcriptomic studies in Pubmed. *: LCLs from Li-responders versus Li non-responders patients diagnosed with BD. #: Li-treated vs vehicle-treated LCLs from patients diagnosed with BD. Δ: before Li-treatment versus after Li-treatment in healthy controls. +: Li-treated vs vehicle-treated LCLs from Li-responders and Li non-responders patients diagnosed with BD....

Additional file 1 of Delivery decision in pregnant women rescued by ECMO for severe ARDS: a retrospective multicenter cohort study

Sarah Aissi James, Christophe Guervilly, Mathieu Lesouhaitier, Alexandre Coppens, Clément Haddadi, Guillaume Lebreton, Jacky Nizard, Nicolas Brechot, Benjamin Assouline, Ouriel Saura, David Levy, Lucie Lefèvre, Pétra Barhoum, Juliette Chommeloux, Guillaume Hékimian, Charles-Edouard Luyt, Antoine Kimmoun, Alain Combes & Matthieu Schmidt
Additional file 1 Study flowchart. ECMO, extracorporeal membrane oxygenation; VV, veno venous; ARDS, acute respiratory distress syndrome.

Additional file 1 of Clinical outcome of wild-type AmpC-producing Enterobacterales infection in critically ill patients treated with β-lactams: a prospective multicenter study

Roman Mounier, Ronan Le Guen, Paul-Louis Woerther, Mathieu Nacher, Clément Bonnefon, Nicolas Mongardon, Olivier Langeron, Eric Levesque, Séverine Couffin, Stéphanie Houcke, Michel Wolff, Ariane Roujansky, Caroline Schimpf, Armand Mekontso Dessap, Fabrice Cook, Keyvan Razazi & Hatem Kallel
Additional file 1. supplementary data on the methods and outcomes of the secondary objectives of the study.

Clinical outcome of wild-type AmpC-producing Enterobacterales infection in critically ill patients treated with β-lactams: a prospective multicenter study

Roman Mounier, Ronan Le Guen, Paul-Louis Woerther, Mathieu Nacher, Clément Bonnefon, Nicolas Mongardon, Olivier Langeron, Eric Levesque, Séverine Couffin, Stéphanie Houcke, Michel Wolff, Ariane Roujansky, Caroline Schimpf, Armand Mekontso Dessap, Fabrice Cook, Keyvan Razazi & Hatem Kallel
Abstract Background β-lactams are the main antibiotics used against wild-type AmpC-producing Enterobacterales (wtAE). However, they may fail or select AmpC-overproducing mutants. Our aim was to assess factors associated with clinical failure of β-lactams in the treatment of wtAE infection. Methods From September 2017 to December 2020, we prospectively included all consecutive patients treated by definitive β-lactams therapy for wtAE infection in four university ICUs. Clinical failure was defined as inadequate response to antimicrobial therapy leading...

Acute severe hepatitis outbreak in children: A perfect storm. What do we know, and what questions remain?

Philippa C Matthews, Cori Campbell, Oana Săndulescu, Mojca Matičič, Simona Maria Ruta, Antonio Rivero-Juárez, Berend Joost van Welzen, Boun Kim Tan, Federico Garcia, George Sebastian Gherlan, Güle Çınar, İmran Hasanoğlu, Ivana Gmizić, Laura Ambra Nicolini, Lurdes Santos, Narina Sargsyants, Petar Velikov, Selma Habibović, Slim Fourati, Snježana Židovec-Lepej, Vanessa Herder, Susanne Dudman, Victor Daniel Miron, William Irving, Gülşen Özkaya Şahin … & ESCMID Study Group for Viral Hepatitis
During the first half of 2022, the World Health Organization reported an outbreak of acute severe hepatitis of unknown aetiology (AS-Hep-UA) in children, following initial alerts from the United Kingdom (UK) where a cluster of cases was first observed in previously well children aged <6 years. Sporadic cases were then reported across Europe and worldwide, although in most countries incidence did not increase above the expected baseline. There were no consistent epidemiological links between cases,...

Data from: Predictors of alcohol responsiveness in dystonia

Johanna Junker, Valerie Brandt, Brian D. Berman, Marie Vidailhet, Emmanuel Roze, Anne Weissbach, Cynthia Comella, Irene A. Malaty, Joseph Jankovic, Mark S. LeDoux, Alfredo Berardelli, Richard Barbano, Stephen G. Reich, Joel S. Perlmutter, Hyder A. Jinnah & Norbert Brüggemann
Objective: To determine predictors of alcohol responsiveness in a large cohort of dystonia patients. Methods: 2159 participants with dystonia were prospectively enrolled in the cross-sectional Dystonia Coalition multicenter study. Patients with secondary, combined or confirmed genetic dystonia (total n=164) or unknown alcohol responsiveness (n= 737) were excluded. Patients answered a standardized questionnaire and were clinically examined using a standardized video protocol and the Burke-Fahn-Marsden Dystonia Rating Scale. Alcohol responsiveness was determined by patients’ self-report. Results:...

Comparative metabolic profiling of root, leaf, fruit, and stem tissues of Panax notoginseng

Rui Shi, Bingjie Xiong, Shu He, Can Liu, Jiftah Ben-Asher, Abraham Rami Horowitz, Shu Wang & Xiahong He
Panax notoginseng is highly used in traditional Chinese medicine, and its root is valued for ginsenoside contents. However, evidence suggests that other plant parts such as fruit, leaves, and stem are also potential sources of bioactive compounds. Therefore, this study aimed at providing insight into the differential accumulation of metabolites in fruit, leaf, root, and stem tissues collected from P. notoginseng. A total of 808 metabolites from 11 major metabolite classes were identified. Furthermore, 32...

Additional file 1 of Delivery decision in pregnant women rescued by ECMO for severe ARDS: a retrospective multicenter cohort study

Sarah Aissi James, Christophe Guervilly, Mathieu Lesouhaitier, Alexandre Coppens, Clément Haddadi, Guillaume Lebreton, Jacky Nizard, Nicolas Brechot, Benjamin Assouline, Ouriel Saura, David Levy, Lucie Lefèvre, Pétra Barhoum, Juliette Chommeloux, Guillaume Hékimian, Charles-Edouard Luyt, Antoine Kimmoun, Alain Combes & Matthieu Schmidt
Additional file 1 Study flowchart. ECMO, extracorporeal membrane oxygenation; VV, veno venous; ARDS, acute respiratory distress syndrome.

Delivery decision in pregnant women rescued by ECMO for severe ARDS: a retrospective multicenter cohort study

Sarah Aissi James, Christophe Guervilly, Mathieu Lesouhaitier, Alexandre Coppens, Clément Haddadi, Guillaume Lebreton, Jacky Nizard, Nicolas Brechot, Benjamin Assouline, Ouriel Saura, David Levy, Lucie Lefèvre, Pétra Barhoum, Juliette Chommeloux, Guillaume Hékimian, Charles-Edouard Luyt, Antoine Kimmoun, Alain Combes & Matthieu Schmidt
Abstract Background Although rarely addressed in the literature, a key question in the care of critically pregnant women with severe acute respiratory distress syndrome (ARDS), especially at the time of extracorporeal membrane oxygenation (ECMO) decision, is whether delivery might substantially improve the mother’s and child’s conditions. This multicenter, retrospective cohort aims to report maternal and fetal short- and long-term outcomes of pregnant women with ECMO-rescued severe ARDS according to the timing of the delivery decision...

Additional file 2 of Delivery decision in pregnant women rescued by ECMO for severe ARDS: a retrospective multicenter cohort study

Sarah Aissi James, Christophe Guervilly, Mathieu Lesouhaitier, Alexandre Coppens, Clément Haddadi, Guillaume Lebreton, Jacky Nizard, Nicolas Brechot, Benjamin Assouline, Ouriel Saura, David Levy, Lucie Lefèvre, Pétra Barhoum, Juliette Chommeloux, Guillaume Hékimian, Charles-Edouard Luyt, Antoine Kimmoun, Alain Combes & Matthieu Schmidt
Additional file 2 Comparison of health-related quality of life assessed by mean SF-36 scores in ECMO-rescued ARDS survivors according to the timing of delivery. ECMO, extracorporeal membrane oxygenation; ARDS, acute respiratory distress syndrome; ICU, intensive care unit; IES, impact of event scales; PTSD, post-traumatic stress disorder.

Additional file 4 of Transcriptomics and miRNomics data integration in lymphoblastoid cells highlights the key role of immune-related functions in lithium treatment response in Bipolar disorder

Nadia Cattane, Cindie Courtin, Elisa Mombelli, Carlo Maj, Cristina Mora, Bruno Etain, Frank Bellivier, Cynthia Marie-Claire & Annamaria Cattaneo
Additional file 4 Supplementary Table 4. List of 21 relevant functional networks identified by performing a network analysis in IPA on 335 differentially expressed mRNAs.

Additional file 8 of Transcriptomics and miRNomics data integration in lymphoblastoid cells highlights the key role of immune-related functions in lithium treatment response in Bipolar disorder

Nadia Cattane, Cindie Courtin, Elisa Mombelli, Carlo Maj, Cristina Mora, Bruno Etain, Frank Bellivier, Cynthia Marie-Claire & Annamaria Cattaneo
Additional file 8 Supplementary Table 8. List of 2027 significant mature miRNA-mRNA interactions with p-value ≤0.05 and Pearson correlation index ρ ≤ − 0.5.

Accuracy of clinicians’ ability to predict the need for renal replacement therapy: a prospective multicenter study

Alexandre Sitbon, Michael Darmon, Guillaume Geri, Paul Jaubert, Pauline Lamouche-Wilquin, Clément Monet, Lucie Le Fèvre, Marie Baron, Marie-Line Harlay, Côme Bureau, Olivier Joannes-Boyau, Claire Dupuis, Damien Contou, Virginie Lemiale, Marie Simon, Christophe Vinsonneau, Clarisse Blayau, Frederic Jacobs & Lara Zafrani
Abstract Purpose Identifying patients who will receive renal replacement therapy (RRT) during intensive care unit (ICU) stay is a major challenge for intensivists. The objective of this study was to evaluate the performance of physicians in predicting the need for RRT at ICU admission and at acute kidney injury (AKI) diagnosis. Methods Prospective, multicenter study including all adult patients hospitalized in 16 ICUs in October 2020. Physician prediction was estimated at ICU admission and at...

Transcriptomics and miRNomics data integration in lymphoblastoid cells highlights the key role of immune-related functions in lithium treatment response in Bipolar disorder

Nadia Cattane, Cindie Courtin, Elisa Mombelli, Carlo Maj, Cristina Mora, Bruno Etain, Frank Bellivier, Cynthia Marie-Claire & Annamaria Cattaneo
Abstract Background Bipolar Disorder (BD) is a complex mental disease characterized by recurrent episodes of mania and depression. Lithium (Li) represents the mainstay of BD pharmacotherapy, despite the narrow therapeutic index and the high variability in treatment response. However, although several studies have been conducted, the molecular mechanisms underlying Li therapeutic effects remain unclear. Methods In order to identify molecular signatures and biological pathways associated with Li treatment response, we conducted transcriptome and miRNome microarray...

Additional file 1 of Physiological response to prone positioning in intubated adults with COVID-19 acute respiratory distress syndrome: a retrospective study

Andrea Boffi, Maximilien Ravenel, Ermes Lupieri, Antoine Schneider, Lucas Liaudet, Michel Gonzalez, Jean-Daniel Chiche & Lise Piquilloud
Additional file 1: Table S1. Physiological, ventilatory and hemodynamic data for all the sessions considered together (n=191) and for the first (n=42), the second (n=37), the third (n=31), the fourth (n=18) and the fifth (n=14) proning sessions). Table S2. Variations in physiological and ventilatory parameters during the fourth (n=18), the fifth (n=14) proning sessions. Comparisons between the success and failure group.

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