3 Works

Data from: A quantitative proteomic analysis of cofilin phosphorylation in myeloid cells and its modulation using the LIM kinase inhibitor Pyr1

Renaud Prudent, Nathalie Demoncheaux, Hélène Diemer, Véronique Collin-Faure, Reuben Kapur, Fabrice Paublant, Laurence Lafanechère, Sarah Cianférani & Thierry Rabilloud
LIM kinases are located at a strategic crossroad, downstream of several signaling pathways and upstream of effectors such as microtubules and the actin cytoskeleton. Cofilin is the only LIM kinases substrate that is well described to date, and its phosphorylation on serine 3 by LIM kinases controls cofilin actin-severing activity. Consequently, LIM kinases inhibition leads to actin cytoskeleton disorganization and blockade of cell motility, which makes this strategy attractive in anticancer treatments. LIMK has also...

Data from: Regional paleoclimates and local consequences: Integrating GIS analysis of diachronic settlement patterns and process-based agroecosystem modeling of potential agricultural productivity in Provence (France)

Daniel Contreras, Eneko Hiriart, Alberte Bondeau, Alan Kirman, Joël Guiot, Loup Bernard, Romain Suarez, Sander Van Der Leeuw & Daniel A. Contreras
Holocene climate variability in the Mediterranean Basin is often cited as a potential driver of societal change, but the mechanisms of this putative influence are generally little explored. In this paper we integrate two tools - agro-ecosystem modeling of potential agricultural yields and spatial analysis of archaeological settlement pattern data - in order to examine the human consequences of past climatic changes. Focusing on a case study in Provence (France), we adapt an agro-ecosystem model...

Data from: HMP-1/α-catenin promotes junctional mechanical integrity during morphogenesis

Thanh TK Vuong-Brender, Arthur Boutillon, David Rodriguez, Vincent Lavilley, Michel Labouesse & Thanh Thi Kim Vuong-Brender
Adherens junctions (AJs) are key structures regulating tissue integrity and maintaining adhesion between cells. During morphogenesis, junctional proteins cooperate closely with the actomyosin network to drive cell movement and shape changes. How the junctions integrate the mechanical forces in space and in time during an in vivo morphogenetic event is still largely unknown, due to a lack of quantitative data. To address this issue, we inserted a functional Fluorescence Resonance Energy Transfer (FRET)-based force biosensor...

Registration Year

  • 2018
    3

Resource Types

  • Dataset
    3

Affiliations

  • University of Strasbourg
    3
  • Indiana University Bloomington
    1
  • Grenoble Alpes University
    1
  • Aix-Marseille University
    1
  • Arizona State University
    1
  • Michel de Montaigne University Bordeaux 3
    1
  • University of Maryland, College Park
    1
  • University of Upper Alsace
    1