Additional file 3: Table S2. Enriched signaling pathways in endocrine hypertension.

Additional file 6: Table S6. Methylome-based estimation of blood cell composition.

Abstract Background Limitations of life-sustaining therapies (LST) practices are frequent and vary among intensive care units (ICUs). However, scarce data were available during the COVID-19 pandemic when ICUs were under intense pressure. We aimed to investigate the prevalence, cumulative incidence, timing, modalities, and factors associated with LST decisions in critically ill COVID-19 patients. Methods We did an ancillary analysis of the European multicentre COVID-ICU study, which collected data from 163 ICUs in France, Belgium and...

Abstract Background Conservative treatments including bracing and exercise therapy are prescribed on the first-line in adults with degenerative scoliosis. However, adherence to conservative treatments is low. We aimed to assess barriers and facilitators to bracing in adults with painful degenerative scoliosis. Methods We conducted a single-centred mixed-method pilot and feasibility study. All patients scheduled for a multidisciplinary custom-made bracing consultation, from July 2019 to January 2020, in a French tertiary care centre, were screened. Patients...

Additional file 1: Table S1. Demographic and inclusion criteria among patients with defined and ruled out NOMI. Table S2. Demographic and inclusion criteria among patients with gastrointestinal failure with defined and ruled out intestinal necrosis. Table S3. Digestive, biological parameters and CT results among patients with defined and ruled out NOMI. Table S4. Description of prognosis features according to ICU survival of patients with definite intestinal necrosis. Table S5. Description of prognosis features according to...

Abstract Background This French nationwide NETSARC exhaustive prospective cohort aims to explore the impact of systematic re-excision (RE) as adjuvant care on overall survival (OS), local recurrence free survival (LRFS), and local and distant control (RFS) in patients with soft tissue sarcoma (STS) with positive microscopic margins (R1) after initial resection performed outside of a reference center. Methods Eligible patients had experienced STS surgery outside a reference center from 2010 to 2017, and had R1...

Abstract Background This French nationwide NETSARC exhaustive prospective cohort aims to explore the impact of systematic re-excision (RE) as adjuvant care on overall survival (OS), local recurrence free survival (LRFS), and local and distant control (RFS) in patients with soft tissue sarcoma (STS) with positive microscopic margins (R1) after initial resection performed outside of a reference center. Methods Eligible patients had experienced STS surgery outside a reference center from 2010 to 2017, and had R1...

Abstract Purpose Identifying patients who will receive renal replacement therapy (RRT) during intensive care unit (ICU) stay is a major challenge for intensivists. The objective of this study was to evaluate the performance of physicians in predicting the need for RRT at ICU admission and at acute kidney injury (AKI) diagnosis. Methods Prospective, multicenter study including all adult patients hospitalized in 16 ICUs in October 2020. Physician prediction was estimated at ICU admission and at...

Abstract Background COVID-19 related acute respiratory distress syndrome (ARDS) has specific characteristics compared to ARDS in other populations. Proning is recommended by analogy with other forms of ARDS, but few data are available regarding its physiological effects in this population. This study aimed to assess the effects of proning on oxygenation parameters (PaO2/FiO2 and alveolo-arterial gradient (Aa-gradient)), blood gas analysis, ventilatory ratio (VR), respiratory system compliance (CRS) and estimated dead space fraction (VD/VT HB). We...

Supplemental Material for Interobserver Variability and Accuracy of Preoperative CT and MRI in Pancreatic Ductal Adenocarcinoma Size Estimation: A Retrospective Cohort Study by Romain Cocquempot, MD, Angèle Bonnin, MD, Maxime Barat, MD, MSc, Gaanan Naveendran, MD, Anthony Dohan, MD, PhD, David Fuks, MD, PhD, Benoit Terris, MD, PhD, Romain Coriat, MD, PhD, Christine Hoeffel, MD, PhD, Ugo Marchese, MD, MSc, Philippe Soyer, MD, PhD in Canadian Association of Radiologists Journal

Supplemental Material for Interobserver Variability and Accuracy of Preoperative CT and MRI in Pancreatic Ductal Adenocarcinoma Size Estimation: A Retrospective Cohort Study by Romain Cocquempot, MD, Angèle Bonnin, MD, Maxime Barat, MD, MSc, Gaanan Naveendran, MD, Anthony Dohan, MD, PhD, David Fuks, MD, PhD, Benoit Terris, MD, PhD, Romain Coriat, MD, PhD, Christine Hoeffel, MD, PhD, Ugo Marchese, MD, MSc, Philippe Soyer, MD, PhD in Canadian Association of Radiologists Journal

Supplemental Material for Interobserver Variability and Accuracy of Preoperative CT and MRI in Pancreatic Ductal Adenocarcinoma Size Estimation: A Retrospective Cohort Study by Romain Cocquempot, MD, Angèle Bonnin, MD, Maxime Barat, MD, MSc, Gaanan Naveendran, MD, Anthony Dohan, MD, PhD, David Fuks, MD, PhD, Benoit Terris, MD, PhD, Romain Coriat, MD, PhD, Christine Hoeffel, MD, PhD, Ugo Marchese, MD, MSc, Philippe Soyer, MD, PhD in Canadian Association of Radiologists Journal

Background: Epidemiological studies have reported high rates of post-traumatic stress disorder (PTSD) among asylum seekers from Sub-Saharan Africa. In order to provide appropriate and culturally sensitive mental health care for this group, further knowledge about treatment preferences might be necessary. Objective: We aimed to provide insights into help-seeking intentions and lay beliefs about cures for PTSD held by asylum seekers from Sub-Saharan Africa living in Germany. Methods: To address this objective, we used a quantitative...

Explore trial participants’ and research team members’ perceptions of the impact of the videoconference-based, supportive care program (SPIN-CHAT Program) during early COVID-19 for individuals with systemic sclerosis (SSc). Data were collected cross-sectionally. A social constructivist paradigm was adopted, and one-on-one videoconference-based, semi-structured interviews were conducted with SPIN-CHAT Trial participants and research team members. A hybrid inductive-deductive approach and reflexive thematic analysis were used. Of the 40 SPIN-CHAT Trial participants and 28 research team members approached,...

Scleroderma renal crisis is a severe complication of systemic sclerosis with a poor prognosis. Therefore, identifying precipitating factors is essential. Among known risk factors, only few are reversible. On the contrary, anti-C5 therapy appears effective, at least in some cases. We describe a 59-year-old man with diffuse cutaneous systemic sclerosis who developed life-threatening scleroderma renal crisis following ibuprofen administration. Despite aggressive management, he did not improve. Renal biopsy have displayed features of thrombotic microangiopathy but...

Scleroderma renal crisis is a severe complication of systemic sclerosis with a poor prognosis. Therefore, identifying precipitating factors is essential. Among known risk factors, only few are reversible. On the contrary, anti-C5 therapy appears effective, at least in some cases. We describe a 59-year-old man with diffuse cutaneous systemic sclerosis who developed life-threatening scleroderma renal crisis following ibuprofen administration. Despite aggressive management, he did not improve. Renal biopsy have displayed features of thrombotic microangiopathy but...

Introduction:Heart involvement is a common problem in systemic sclerosis. Recently, a definition of systemic sclerosis primary heart involvement had been proposed. Our aim was to establish consensus guidance on the screening, diagnosis and follow-up of systemic sclerosis primary heart involvement patients.Methods:A systematic literature review was performed to investigate the tests used to evaluate heart involvement in systemic sclerosis. The extracted data were categorized into relevant domains (conventional radiology, electrocardiography, echocardiography, cardiac magnetic resonance imaging, laboratory,...

Additional file 1: Figure S1. Flowchart of patient selection from participating ICUs. Table S1. Amount of Missing Data for Each Variable Included in the Analysis. Table S2. Characteristics of Severe Hypothyroidism Patients According to the Presence of a Circulatory Failure at ICU Admission. Table S3. Clinical and Biological Features at ICU Admission according to ICU survival. Table S4. Predictive Patient Factors Associated with 6-month Mortality in Critically ill Adults with Severe Hypothyroidism.

Abstract Background COVID-19 related acute respiratory distress syndrome (ARDS) has specific characteristics compared to ARDS in other populations. Proning is recommended by analogy with other forms of ARDS, but few data are available regarding its physiological effects in this population. This study aimed to assess the effects of proning on oxygenation parameters (PaO2/FiO2 and alveolo-arterial gradient (Aa-gradient)), blood gas analysis, ventilatory ratio (VR), respiratory system compliance (CRS) and estimated dead space fraction (VD/VT HB). We...

Additional file 1: Fig. S1. Components of variation in the whole methylome dataset. a) Scree plot representing the percentage of explained variability by the first five principal components of PCA performed on the whole dataset (n=731,635 CpG sites, n=255 samples). b) Singular value decomposition (SVD) plot assessing the correlation between the first five significant components of variation in the dataset and other biological factors of interest (Hypertension type –PHT, CS, PA, PPGL-, age, sex, cell...

Additional file 4: Table S3. Significant differentially methylated genes in endocrine hypertension.

Abstract Purpose Identifying patients who will receive renal replacement therapy (RRT) during intensive care unit (ICU) stay is a major challenge for intensivists. The objective of this study was to evaluate the performance of physicians in predicting the need for RRT at ICU admission and at acute kidney injury (AKI) diagnosis. Methods Prospective, multicenter study including all adult patients hospitalized in 16 ICUs in October 2020. Physician prediction was estimated at ICU admission and at...

Additional file 1: Table S1. Physiological, ventilatory and hemodynamic data for all the sessions considered together (n=191) and for the first (n=42), the second (n=37), the third (n=31), the fourth (n=18) and the fifth (n=14) proning sessions). Table S2. Variations in physiological and ventilatory parameters during the fourth (n=18), the fifth (n=14) proning sessions. Comparisons between the success and failure group.

Supplemental Material for Interobserver Variability and Accuracy of Preoperative CT and MRI in Pancreatic Ductal Adenocarcinoma Size Estimation: A Retrospective Cohort Study by Romain Cocquempot, MD, Angèle Bonnin, MD, Maxime Barat, MD, MSc, Gaanan Naveendran, MD, Anthony Dohan, MD, PhD, David Fuks, MD, PhD, Benoit Terris, MD, PhD, Romain Coriat, MD, PhD, Christine Hoeffel, MD, PhD, Ugo Marchese, MD, MSc, Philippe Soyer, MD, PhD in Canadian Association of Radiologists Journal

Supplemental material, sj-docx-1-tab-10.1177_1759720X231159712 for Systemic sclerosis associated interstitial lung disease: a survey of current practices in France by Amélie Nicolas, Sylvie Leroy, Luc Mouthon, Yurdagul Uzunhan, Vincent Cottin, Arsene Mekinian, Viviane Queyrel, Eric Hachulla, Benoit Gachet, David Launay and Nihal Martis in Therapeutic Advances in Musculoskeletal Disease