46 Works

Outcomes of mild-to-moderate postresuscitation shock after non-shockable cardiac arrest and association with temperature management: a post hoc analysis of HYPERION trial data

Ines Ziriat, Aurélie Le Thuaut, Gwenhael Colin, Hamid Merdji, Guillaume Grillet, Patrick Girardie, Bertrand Souweine, Pierre-François Dequin, Thierry Boulain, Jean-Pierre Frat, Pierre Asfar, Bruno Francois, Mickael Landais, Gaëtan Plantefeve, Jean-Pierre Quenot, Jean-Charles Chakarian, Michel Sirodot, Stéphane Legriel, Nicolas Massart, Didier Thevenin, Arnaud Desachy, Arnaud Delahaye, Vlad Botoc, Sylvie Vimeux, Frederic Martino … & Jean Baptiste Lascarrou
Abstract Background Outcomes of postresuscitation shock after cardiac arrest can be affected by targeted temperature management (TTM). A post hoc analysis of the “TTM1 trial” suggested higher mortality with hypothermia at 33 °C. We performed a post hoc analysis of HYPERION trial data to assess potential associations linking postresuscitation shock after non-shockable cardiac arrest to hypothermia at 33 °C on favourable functional outcome. Methods We divided the patients into groups with vs. without postresuscitation (defined...

Additional file 1 of Accuracy of clinicians’ ability to predict the need for renal replacement therapy: a prospective multicenter study

Alexandre Sitbon, Michael Darmon, Guillaume Geri, Paul Jaubert, Pauline Lamouche-Wilquin, Clément Monet, Lucie Le Fèvre, Marie Baron, Marie-Line Harlay, Côme Bureau, Olivier Joannes-Boyau, Claire Dupuis, Damien Contou, Virginie Lemiale, Marie Simon, Christophe Vinsonneau, Clarisse Blayau, Frederic Jacobs & Lara Zafrani
Additional file 1: Figure S1. Physician prediction: Visual Likert Scale. Figure S2. PresagEER study timeline. Table S1. Delays between ICU admission, AKI diagnosis and RRT initiation. Table S2. RRT characteristics. Table S3. Characteristics and outcomes of AKI patients (n (%) or median (IQR)). Table S4. Multivariate analysis including variables associated with the risk of requiring RRT (without physician prediction).

Additional file 1 of Overall survival in patients with re-excision of positive microscopic margins of limb and trunk wall soft tissue sarcoma operated outside of a reference center: a nationwide cohort analysis

Francois Gouin, Eberhard Stoeckle, Charles Honoré, Mickael Ropars, Mehrdad Jafari, Jean Camille Mattei, Alexandre Rochwerger, Sébastien Carrere, Denis Waast, Gwenaël Ferron, Jean-Christophe Machiavello, Philippe Anract, Frédéric Marchal, François Sirveaux, Oren Marco, Jérôme Guiramand, Brice Paquette, Antonio Di Marco, Sylvain Causeret, Jean-Marc Guilloit, Pauline Soibinet, Dimitri Tzanis, Pierre Gimbergues, Fabrice Fiorenza, Franck Dujardin … & Jean-Yves Blay
Additional file 1: Supplementary material S1, S2, S3 and S4

Whole blood methylome-derived features to discriminate endocrine hypertension

Roberta Armignacco, Parminder S. Reel, Smarti Reel, Anne Jouinot, Amandine Septier, Cassandra Gaspar, Karine Perlemoine, Casper K. Larsen, Lucas Bouys, Leah Braun, Anna Riester, Matthias Kroiss, Fidéline Bonnet-Serrano, Laurence Amar, Anne Blanchard, Anne-Paule Gimenez-Roqueplo, Aleksander Prejbisz, Andrzej Januszewicz, Piotr Dobrowolski, Eleanor Davies, Scott M. MacKenzie, Gian Paolo Rossi, Livia Lenzini, Filippo Ceccato, Carla Scaroni … & Guillaume Assié
Abstract Background Arterial hypertension represents a worldwide health burden and a major risk factor for cardiovascular morbidity and mortality. Hypertension can be primary (primary hypertension, PHT), or secondary to endocrine disorders (endocrine hypertension, EHT), such as Cushing's syndrome (CS), primary aldosteronism (PA), and pheochromocytoma/paraganglioma (PPGL). Diagnosis of EHT is currently based on hormone assays. Efficient detection remains challenging, but is crucial to properly orientate patients for diagnostic confirmation and specific treatment. More accurate biomarkers would...

Whole blood methylome-derived features to discriminate endocrine hypertension

Roberta Armignacco, Parminder S. Reel, Smarti Reel, Anne Jouinot, Amandine Septier, Cassandra Gaspar, Karine Perlemoine, Casper K. Larsen, Lucas Bouys, Leah Braun, Anna Riester, Matthias Kroiss, Fidéline Bonnet-Serrano, Laurence Amar, Anne Blanchard, Anne-Paule Gimenez-Roqueplo, Aleksander Prejbisz, Andrzej Januszewicz, Piotr Dobrowolski, Eleanor Davies, Scott M. MacKenzie, Gian Paolo Rossi, Livia Lenzini, Filippo Ceccato, Carla Scaroni … & Guillaume Assié
Abstract Background Arterial hypertension represents a worldwide health burden and a major risk factor for cardiovascular morbidity and mortality. Hypertension can be primary (primary hypertension, PHT), or secondary to endocrine disorders (endocrine hypertension, EHT), such as Cushing's syndrome (CS), primary aldosteronism (PA), and pheochromocytoma/paraganglioma (PPGL). Diagnosis of EHT is currently based on hormone assays. Efficient detection remains challenging, but is crucial to properly orientate patients for diagnostic confirmation and specific treatment. More accurate biomarkers would...

Additional file 1 of Speed of cooling after cardiac arrest in relation to the intervention effect: a sub-study from the TTM2-trial

Rupert F. G. Simpson, Josef Dankiewicz, Grigoris V. Karamasis, Paolo Pelosi, Matthias Haenggi, Paul J. Young, Janus Christian Jakobsen, Jonathan Bannard-Smith, Pedro D. Wendel-Garcia, Fabio Silvio Taccone, Per Nordberg, Matt P. Wise, Anders M. Grejs, Gisela Lilja, Roy Bjørkholt Olsen, Alain Cariou, Jean Baptiste Lascarrou, Manoj Saxena, Jan Hovdenes, Matthew Thomas, Hans Friberg, John R. Davies, Niklas Nielsen & Thomas R. Keeble
Additional file 1: Fig. 1. Predicted probability of death across the 6 hypothermia groups as compared to the normothermia groups at the corresponding sites. Patients in group 1, with the lowest average temperature at 4 hours had a higher probability of death.

Additional file 1 of Physiological response to prone positioning in intubated adults with COVID-19 acute respiratory distress syndrome: a retrospective study

Andrea Boffi, Maximilien Ravenel, Ermes Lupieri, Antoine Schneider, Lucas Liaudet, Michel Gonzalez, Jean-Daniel Chiche & Lise Piquilloud
Additional file 1: Table S1. Physiological, ventilatory and hemodynamic data for all the sessions considered together (n=191) and for the first (n=42), the second (n=37), the third (n=31), the fourth (n=18) and the fifth (n=14) proning sessions). Table S2. Variations in physiological and ventilatory parameters during the fourth (n=18), the fifth (n=14) proning sessions. Comparisons between the success and failure group.

Additional file 1 of Multimodal co-therapy for unaccompanied minors: a qualitative study

Sélim Benjamin Guessoum, Sevan Minassian, Pauline de Staël, Fatima Touhami, Madeline DiGiovanni, Rahmeth Radjack, Marie Rose Moro & Laelia Benoit
Additional file 1. COREQ (COnsolidated criteria for REporting Qualitative research) Checklist.

Accuracy of clinicians’ ability to predict the need for renal replacement therapy: a prospective multicenter study

Alexandre Sitbon, Michael Darmon, Guillaume Geri, Paul Jaubert, Pauline Lamouche-Wilquin, Clément Monet, Lucie Le Fèvre, Marie Baron, Marie-Line Harlay, Côme Bureau, Olivier Joannes-Boyau, Claire Dupuis, Damien Contou, Virginie Lemiale, Marie Simon, Christophe Vinsonneau, Clarisse Blayau, Frederic Jacobs & Lara Zafrani
Abstract Purpose Identifying patients who will receive renal replacement therapy (RRT) during intensive care unit (ICU) stay is a major challenge for intensivists. The objective of this study was to evaluate the performance of physicians in predicting the need for RRT at ICU admission and at acute kidney injury (AKI) diagnosis. Methods Prospective, multicenter study including all adult patients hospitalized in 16 ICUs in October 2020. Physician prediction was estimated at ICU admission and at...

Additional file 1 of Whole blood methylome-derived features to discriminate endocrine hypertension

Roberta Armignacco, Parminder S. Reel, Smarti Reel, Anne Jouinot, Amandine Septier, Cassandra Gaspar, Karine Perlemoine, Casper K. Larsen, Lucas Bouys, Leah Braun, Anna Riester, Matthias Kroiss, Fidéline Bonnet-Serrano, Laurence Amar, Anne Blanchard, Anne-Paule Gimenez-Roqueplo, Aleksander Prejbisz, Andrzej Januszewicz, Piotr Dobrowolski, Eleanor Davies, Scott M. MacKenzie, Gian Paolo Rossi, Livia Lenzini, Filippo Ceccato, Carla Scaroni … & Guillaume Assié
Additional file 1: Fig. S1. Components of variation in the whole methylome dataset. a) Scree plot representing the percentage of explained variability by the first five principal components of PCA performed on the whole dataset (n=731,635 CpG sites, n=255 samples). b) Singular value decomposition (SVD) plot assessing the correlation between the first five significant components of variation in the dataset and other biological factors of interest (Hypertension type –PHT, CS, PA, PPGL-, age, sex, cell...

Additional file 4 of Whole blood methylome-derived features to discriminate endocrine hypertension

Roberta Armignacco, Parminder S. Reel, Smarti Reel, Anne Jouinot, Amandine Septier, Cassandra Gaspar, Karine Perlemoine, Casper K. Larsen, Lucas Bouys, Leah Braun, Anna Riester, Matthias Kroiss, Fidéline Bonnet-Serrano, Laurence Amar, Anne Blanchard, Anne-Paule Gimenez-Roqueplo, Aleksander Prejbisz, Andrzej Januszewicz, Piotr Dobrowolski, Eleanor Davies, Scott M. MacKenzie, Gian Paolo Rossi, Livia Lenzini, Filippo Ceccato, Carla Scaroni … & Guillaume Assié
Additional file 4: Table S3. Significant differentially methylated genes in endocrine hypertension.

Additional file 1 of Physiological response to prone positioning in intubated adults with COVID-19 acute respiratory distress syndrome: a retrospective study

Andrea Boffi, Maximilien Ravenel, Ermes Lupieri, Antoine Schneider, Lucas Liaudet, Michel Gonzalez, Jean-Daniel Chiche & Lise Piquilloud
Additional file 1: Table S1. Physiological, ventilatory and hemodynamic data for all the sessions considered together (n=191) and for the first (n=42), the second (n=37), the third (n=31), the fourth (n=18) and the fifth (n=14) proning sessions). Table S2. Variations in physiological and ventilatory parameters during the fourth (n=18), the fifth (n=14) proning sessions. Comparisons between the success and failure group.

Supplemental Material - Interobserver Variability and Accuracy of Preoperative CT and MRI in Pancreatic Ductal Adenocarcinoma Size Estimation: A Retrospective Cohort Study

Romain Cocquempot, Angèle Bonnin, Maxime Barat, Gaanan Naveendran, Anthony Dohan, David Fuks, Benoit Terris, Romain Coriat, Christine Hoeffel, Ugo Marchese & Philippe Soyer
Supplemental Material for Interobserver Variability and Accuracy of Preoperative CT and MRI in Pancreatic Ductal Adenocarcinoma Size Estimation: A Retrospective Cohort Study by Romain Cocquempot, MD, Angèle Bonnin, MD, Maxime Barat, MD, MSc, Gaanan Naveendran, MD, Anthony Dohan, MD, PhD, David Fuks, MD, PhD, Benoit Terris, MD, PhD, Romain Coriat, MD, PhD, Christine Hoeffel, MD, PhD, Ugo Marchese, MD, MSc, Philippe Soyer, MD, PhD in Canadian Association of Radiologists Journal

Physiological response to prone positioning in intubated adults with COVID-19 acute respiratory distress syndrome: a retrospective study

Andrea Boffi, Maximilien Ravenel, Ermes Lupieri, Antoine Schneider, Lucas Liaudet, Michel Gonzalez, Jean-Daniel Chiche & Lise Piquilloud
Abstract Background COVID-19 related acute respiratory distress syndrome (ARDS) has specific characteristics compared to ARDS in other populations. Proning is recommended by analogy with other forms of ARDS, but few data are available regarding its physiological effects in this population. This study aimed to assess the effects of proning on oxygenation parameters (PaO2/FiO2 and alveolo-arterial gradient (Aa-gradient)), blood gas analysis, ventilatory ratio (VR), respiratory system compliance (CRS) and estimated dead space fraction (VD/VT HB). We...

Accuracy of clinicians’ ability to predict the need for renal replacement therapy: a prospective multicenter study

Alexandre Sitbon, Michael Darmon, Guillaume Geri, Paul Jaubert, Pauline Lamouche-Wilquin, Clément Monet, Lucie Le Fèvre, Marie Baron, Marie-Line Harlay, Côme Bureau, Olivier Joannes-Boyau, Claire Dupuis, Damien Contou, Virginie Lemiale, Marie Simon, Christophe Vinsonneau, Clarisse Blayau, Frederic Jacobs & Lara Zafrani
Abstract Purpose Identifying patients who will receive renal replacement therapy (RRT) during intensive care unit (ICU) stay is a major challenge for intensivists. The objective of this study was to evaluate the performance of physicians in predicting the need for RRT at ICU admission and at acute kidney injury (AKI) diagnosis. Methods Prospective, multicenter study including all adult patients hospitalized in 16 ICUs in October 2020. Physician prediction was estimated at ICU admission and at...

Overall survival in patients with re-excision of positive microscopic margins of limb and trunk wall soft tissue sarcoma operated outside of a reference center: a nationwide cohort analysis

Francois Gouin, Eberhard Stoeckle, Charles Honoré, Mickael Ropars, Mehrdad Jafari, Jean Camille Mattei, Alexandre Rochwerger, Sébastien Carrere, Denis Waast, Gwenaël Ferron, Jean-Christophe Machiavello, Philippe Anract, Frédéric Marchal, François Sirveaux, Oren Marco, Jérôme Guiramand, Brice Paquette, Antonio Di Marco, Sylvain Causeret, Jean-Marc Guilloit, Pauline Soibinet, Dimitri Tzanis, Pierre Gimbergues, Fabrice Fiorenza, Franck Dujardin … & Jean-Yves Blay
Abstract Background This French nationwide NETSARC exhaustive prospective cohort aims to explore the impact of systematic re-excision (RE) as adjuvant care on overall survival (OS), local recurrence free survival (LRFS), and local and distant control (RFS) in patients with soft tissue sarcoma (STS) with positive microscopic margins (R1) after initial resection performed outside of a reference center. Methods Eligible patients had experienced STS surgery outside a reference center from 2010 to 2017, and had R1...

Overall survival in patients with re-excision of positive microscopic margins of limb and trunk wall soft tissue sarcoma operated outside of a reference center: a nationwide cohort analysis

Francois Gouin, Eberhard Stoeckle, Charles Honoré, Mickael Ropars, Mehrdad Jafari, Jean Camille Mattei, Alexandre Rochwerger, Sébastien Carrere, Denis Waast, Gwenaël Ferron, Jean-Christophe Machiavello, Philippe Anract, Frédéric Marchal, François Sirveaux, Oren Marco, Jérôme Guiramand, Brice Paquette, Antonio Di Marco, Sylvain Causeret, Jean-Marc Guilloit, Pauline Soibinet, Dimitri Tzanis, Pierre Gimbergues, Fabrice Fiorenza, Franck Dujardin … & Jean-Yves Blay
Abstract Background This French nationwide NETSARC exhaustive prospective cohort aims to explore the impact of systematic re-excision (RE) as adjuvant care on overall survival (OS), local recurrence free survival (LRFS), and local and distant control (RFS) in patients with soft tissue sarcoma (STS) with positive microscopic margins (R1) after initial resection performed outside of a reference center. Methods Eligible patients had experienced STS surgery outside a reference center from 2010 to 2017, and had R1...

Additional file 3 of Whole blood methylome-derived features to discriminate endocrine hypertension

Roberta Armignacco, Parminder S. Reel, Smarti Reel, Anne Jouinot, Amandine Septier, Cassandra Gaspar, Karine Perlemoine, Casper K. Larsen, Lucas Bouys, Leah Braun, Anna Riester, Matthias Kroiss, Fidéline Bonnet-Serrano, Laurence Amar, Anne Blanchard, Anne-Paule Gimenez-Roqueplo, Aleksander Prejbisz, Andrzej Januszewicz, Piotr Dobrowolski, Eleanor Davies, Scott M. MacKenzie, Gian Paolo Rossi, Livia Lenzini, Filippo Ceccato, Carla Scaroni … & Guillaume Assié
Additional file 3: Table S2. Enriched signaling pathways in endocrine hypertension.

Additional file 6 of Whole blood methylome-derived features to discriminate endocrine hypertension

Roberta Armignacco, Parminder S. Reel, Smarti Reel, Anne Jouinot, Amandine Septier, Cassandra Gaspar, Karine Perlemoine, Casper K. Larsen, Lucas Bouys, Leah Braun, Anna Riester, Matthias Kroiss, Fidéline Bonnet-Serrano, Laurence Amar, Anne Blanchard, Anne-Paule Gimenez-Roqueplo, Aleksander Prejbisz, Andrzej Januszewicz, Piotr Dobrowolski, Eleanor Davies, Scott M. MacKenzie, Gian Paolo Rossi, Livia Lenzini, Filippo Ceccato, Carla Scaroni … & Guillaume Assié
Additional file 6: Table S6. Methylome-based estimation of blood cell composition.

Supplemental Material - Interobserver Variability and Accuracy of Preoperative CT and MRI in Pancreatic Ductal Adenocarcinoma Size Estimation: A Retrospective Cohort Study

Romain Cocquempot, Angèle Bonnin, Maxime Barat, Gaanan Naveendran, Anthony Dohan, David Fuks, Benoit Terris, Romain Coriat, Christine Hoeffel, Ugo Marchese & Philippe Soyer
Supplemental Material for Interobserver Variability and Accuracy of Preoperative CT and MRI in Pancreatic Ductal Adenocarcinoma Size Estimation: A Retrospective Cohort Study by Romain Cocquempot, MD, Angèle Bonnin, MD, Maxime Barat, MD, MSc, Gaanan Naveendran, MD, Anthony Dohan, MD, PhD, David Fuks, MD, PhD, Benoit Terris, MD, PhD, Romain Coriat, MD, PhD, Christine Hoeffel, MD, PhD, Ugo Marchese, MD, MSc, Philippe Soyer, MD, PhD in Canadian Association of Radiologists Journal

Supplemental Material - Interobserver Variability and Accuracy of Preoperative CT and MRI in Pancreatic Ductal Adenocarcinoma Size Estimation: A Retrospective Cohort Study

Romain Cocquempot, Angèle Bonnin, Maxime Barat, Gaanan Naveendran, Anthony Dohan, David Fuks, Benoit Terris, Romain Coriat, Christine Hoeffel, Ugo Marchese & Philippe Soyer
Supplemental Material for Interobserver Variability and Accuracy of Preoperative CT and MRI in Pancreatic Ductal Adenocarcinoma Size Estimation: A Retrospective Cohort Study by Romain Cocquempot, MD, Angèle Bonnin, MD, Maxime Barat, MD, MSc, Gaanan Naveendran, MD, Anthony Dohan, MD, PhD, David Fuks, MD, PhD, Benoit Terris, MD, PhD, Romain Coriat, MD, PhD, Christine Hoeffel, MD, PhD, Ugo Marchese, MD, MSc, Philippe Soyer, MD, PhD in Canadian Association of Radiologists Journal

Supplemental Material - Interobserver Variability and Accuracy of Preoperative CT and MRI in Pancreatic Ductal Adenocarcinoma Size Estimation: A Retrospective Cohort Study

Romain Cocquempot, Angèle Bonnin, Maxime Barat, Gaanan Naveendran, Anthony Dohan, David Fuks, Benoit Terris, Romain Coriat, Christine Hoeffel, Ugo Marchese & Philippe Soyer
Supplemental Material for Interobserver Variability and Accuracy of Preoperative CT and MRI in Pancreatic Ductal Adenocarcinoma Size Estimation: A Retrospective Cohort Study by Romain Cocquempot, MD, Angèle Bonnin, MD, Maxime Barat, MD, MSc, Gaanan Naveendran, MD, Anthony Dohan, MD, PhD, David Fuks, MD, PhD, Benoit Terris, MD, PhD, Romain Coriat, MD, PhD, Christine Hoeffel, MD, PhD, Ugo Marchese, MD, MSc, Philippe Soyer, MD, PhD in Canadian Association of Radiologists Journal

Physiological response to prone positioning in intubated adults with COVID-19 acute respiratory distress syndrome: a retrospective study

Andrea Boffi, Maximilien Ravenel, Ermes Lupieri, Antoine Schneider, Lucas Liaudet, Michel Gonzalez, Jean-Daniel Chiche & Lise Piquilloud
Abstract Background COVID-19 related acute respiratory distress syndrome (ARDS) has specific characteristics compared to ARDS in other populations. Proning is recommended by analogy with other forms of ARDS, but few data are available regarding its physiological effects in this population. This study aimed to assess the effects of proning on oxygenation parameters (PaO2/FiO2 and alveolo-arterial gradient (Aa-gradient)), blood gas analysis, ventilatory ratio (VR), respiratory system compliance (CRS) and estimated dead space fraction (VD/VT HB). We...

Additional file 1 of Accuracy of clinicians’ ability to predict the need for renal replacement therapy: a prospective multicenter study

Alexandre Sitbon, Michael Darmon, Guillaume Geri, Paul Jaubert, Pauline Lamouche-Wilquin, Clément Monet, Lucie Le Fèvre, Marie Baron, Marie-Line Harlay, Côme Bureau, Olivier Joannes-Boyau, Claire Dupuis, Damien Contou, Virginie Lemiale, Marie Simon, Christophe Vinsonneau, Clarisse Blayau, Frederic Jacobs & Lara Zafrani
Additional file 1: Figure S1. Physician prediction: Visual Likert Scale. Figure S2. PresagEER study timeline. Table S1. Delays between ICU admission, AKI diagnosis and RRT initiation. Table S2. RRT characteristics. Table S3. Characteristics and outcomes of AKI patients (n (%) or median (IQR)). Table S4. Multivariate analysis including variables associated with the risk of requiring RRT (without physician prediction).

Additional file 2 of Whole blood methylome-derived features to discriminate endocrine hypertension

Roberta Armignacco, Parminder S. Reel, Smarti Reel, Anne Jouinot, Amandine Septier, Cassandra Gaspar, Karine Perlemoine, Casper K. Larsen, Lucas Bouys, Leah Braun, Anna Riester, Matthias Kroiss, Fidéline Bonnet-Serrano, Laurence Amar, Anne Blanchard, Anne-Paule Gimenez-Roqueplo, Aleksander Prejbisz, Andrzej Januszewicz, Piotr Dobrowolski, Eleanor Davies, Scott M. MacKenzie, Gian Paolo Rossi, Livia Lenzini, Filippo Ceccato, Carla Scaroni … & Guillaume Assié
Additional file 2: Table S1. Differentially methylated CpG sites in endocrine hypertension.

Registration Year

  • 2022
    46

Resource Types

  • Text
    18
  • Collection
    16
  • Dataset
    10
  • Image
    2

Affiliations

  • Hôpital Cochin
    46
  • Paris Cardiovascular Research Center
    20
  • University Hospital of Zurich
    18
  • Centre Hospitalier Universitaire de Nantes
    14
  • University of Paris
    14
  • University of Glasgow
    12
  • PSL Research University
    12
  • Hôpital Européen Georges-Pompidou
    12
  • LMU Klinikum
    12
  • Centre for Research in Epidemiology and Population Health
    11