8 Works

Heavy-load exercise in older adults activates vasculogenesis and has a stronger impact on muscle gene expression than in young adults

Kaare M. Gautvik, Ole K. Olstad, Ulrika Raue, Vigdis T. Gautvik, Karl J. Kvernevik, Tor P. Utheim, Solveig Ravnum, Camilla Kirkegaard, Håvard Wiig, Garan Jones, Luke C. Pilling, Scott Trappe, Truls Raastad & Sjur Reppe
Abstract Background A striking effect of old age is the involuntary loss of muscle mass and strength leading to sarcopenia and reduced physiological functions. However, effects of heavy-load exercise in older adults on diseases and functions as predicted by changes in muscle gene expression have been inadequately studied. Methods Thigh muscle global transcriptional activity (transcriptome) was analyzed in cohorts of older and younger adults before and after 12–13 weeks heavy-load strength exercise using Affymetrix microarrays....

Additional file 1 of Heavy-load exercise in older adults activates vasculogenesis and has a stronger impact on muscle gene expression than in young adults

Kaare M. Gautvik, Ole K. Olstad, Ulrika Raue, Vigdis T. Gautvik, Karl J. Kvernevik, Tor P. Utheim, Solveig Ravnum, Camilla Kirkegaard, Håvard Wiig, Garan Jones, Luke C. Pilling, Scott Trappe, Truls Raastad & Sjur Reppe
Addiitional file 1: Figure S1. Comparison of transcript signal levels between os ilium–associated muscle and thigh muscle. Figure S2. Genes within the Diseases and Function category Vasculogenesis with increased (red) or reduced (green) expression end vs start of the training period in elderly as compared to young. Table S1. Common annotated genes changed in elderly in both Oslo and BSU cohorts at Q-value<0.1.

Additional file 1 of Speed of cooling after cardiac arrest in relation to the intervention effect: a sub-study from the TTM2-trial

Rupert F. G. Simpson, Josef Dankiewicz, Grigoris V. Karamasis, Paolo Pelosi, Matthias Haenggi, Paul J. Young, Janus Christian Jakobsen, Jonathan Bannard-Smith, Pedro D. Wendel-Garcia, Fabio Silvio Taccone, Per Nordberg, Matt P. Wise, Anders M. Grejs, Gisela Lilja, Roy Bjørkholt Olsen, Alain Cariou, Jean Baptiste Lascarrou, Manoj Saxena, Jan Hovdenes, Matthew Thomas, Hans Friberg, John R. Davies, Niklas Nielsen & Thomas R. Keeble
Additional file 1: Fig. 1. Predicted probability of death across the 6 hypothermia groups as compared to the normothermia groups at the corresponding sites. Patients in group 1, with the lowest average temperature at 4 hours had a higher probability of death.

Speed of cooling after cardiac arrest in relation to the intervention effect: a sub-study from the TTM2-trial

Rupert F. G. Simpson, Josef Dankiewicz, Grigoris V. Karamasis, Paolo Pelosi, Matthias Haenggi, Paul J. Young, Janus Christian Jakobsen, Jonathan Bannard-Smith, Pedro D. Wendel-Garcia, Fabio Silvio Taccone, Per Nordberg, Matt P. Wise, Anders M. Grejs, Gisela Lilja, Roy Bjørkholt Olsen, Alain Cariou, Jean Baptiste Lascarrou, Manoj Saxena, Jan Hovdenes, Matthew Thomas, Hans Friberg, John R. Davies, Niklas Nielsen & Thomas R. Keeble
Abstract Background Targeted temperature management (TTM) is recommended following cardiac arrest; however, time to target temperature varies in clinical practice. We hypothesised the effects of a target temperature of 33 °C when compared to normothermia would differ based on average time to hypothermia and those patients achieving hypothermia fastest would have more favorable outcomes. Methods In this post-hoc analysis of the TTM-2 trial, patients after out of hospital cardiac arrest were randomized to targeted hypothermia...

Speed of cooling after cardiac arrest in relation to the intervention effect: a sub-study from the TTM2-trial

Rupert F. G. Simpson, Josef Dankiewicz, Grigoris V. Karamasis, Paolo Pelosi, Matthias Haenggi, Paul J. Young, Janus Christian Jakobsen, Jonathan Bannard-Smith, Pedro D. Wendel-Garcia, Fabio Silvio Taccone, Per Nordberg, Matt P. Wise, Anders M. Grejs, Gisela Lilja, Roy Bjørkholt Olsen, Alain Cariou, Jean Baptiste Lascarrou, Manoj Saxena, Jan Hovdenes, Matthew Thomas, Hans Friberg, John R. Davies, Niklas Nielsen & Thomas R. Keeble
Abstract Background Targeted temperature management (TTM) is recommended following cardiac arrest; however, time to target temperature varies in clinical practice. We hypothesised the effects of a target temperature of 33 °C when compared to normothermia would differ based on average time to hypothermia and those patients achieving hypothermia fastest would have more favorable outcomes. Methods In this post-hoc analysis of the TTM-2 trial, patients after out of hospital cardiac arrest were randomized to targeted hypothermia...

Additional file 1 of Speed of cooling after cardiac arrest in relation to the intervention effect: a sub-study from the TTM2-trial

Rupert F. G. Simpson, Josef Dankiewicz, Grigoris V. Karamasis, Paolo Pelosi, Matthias Haenggi, Paul J. Young, Janus Christian Jakobsen, Jonathan Bannard-Smith, Pedro D. Wendel-Garcia, Fabio Silvio Taccone, Per Nordberg, Matt P. Wise, Anders M. Grejs, Gisela Lilja, Roy Bjørkholt Olsen, Alain Cariou, Jean Baptiste Lascarrou, Manoj Saxena, Jan Hovdenes, Matthew Thomas, Hans Friberg, John R. Davies, Niklas Nielsen & Thomas R. Keeble
Additional file 1: Fig. 1. Predicted probability of death across the 6 hypothermia groups as compared to the normothermia groups at the corresponding sites. Patients in group 1, with the lowest average temperature at 4 hours had a higher probability of death.

Additional file 1 of Heavy-load exercise in older adults activates vasculogenesis and has a stronger impact on muscle gene expression than in young adults

Kaare M. Gautvik, Ole K. Olstad, Ulrika Raue, Vigdis T. Gautvik, Karl J. Kvernevik, Tor P. Utheim, Solveig Ravnum, Camilla Kirkegaard, Håvard Wiig, Garan Jones, Luke C. Pilling, Scott Trappe, Truls Raastad & Sjur Reppe
Addiitional file 1: Figure S1. Comparison of transcript signal levels between os ilium–associated muscle and thigh muscle. Figure S2. Genes within the Diseases and Function category Vasculogenesis with increased (red) or reduced (green) expression end vs start of the training period in elderly as compared to young. Table S1. Common annotated genes changed in elderly in both Oslo and BSU cohorts at Q-value<0.1.

Heavy-load exercise in older adults activates vasculogenesis and has a stronger impact on muscle gene expression than in young adults

Kaare M. Gautvik, Ole K. Olstad, Ulrika Raue, Vigdis T. Gautvik, Karl J. Kvernevik, Tor P. Utheim, Solveig Ravnum, Camilla Kirkegaard, Håvard Wiig, Garan Jones, Luke C. Pilling, Scott Trappe, Truls Raastad & Sjur Reppe
Abstract Background A striking effect of old age is the involuntary loss of muscle mass and strength leading to sarcopenia and reduced physiological functions. However, effects of heavy-load exercise in older adults on diseases and functions as predicted by changes in muscle gene expression have been inadequately studied. Methods Thigh muscle global transcriptional activity (transcriptome) was analyzed in cohorts of older and younger adults before and after 12–13 weeks heavy-load strength exercise using Affymetrix microarrays....

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