Additional file 1: Fig. S1. Plot of population-averaged input function. The y-axis is in logarithmic scale. Fig. S2. Bland–Altman plot of lesion Ki differences obtained with the IDIF minus the PIF scaled to the scan time interval at 30–60 min p.i. (PIF_30) (A), and the PIF scaled to the IDIF at shorter scan time intervals p.i. (PIF_40 and PIF_50) (B and C). For readability, the scales have been adjusted per subfigure.

Additional file 1: Fig. S1. Plot of population-averaged input function. The y-axis is in logarithmic scale. Fig. S2. Bland–Altman plot of lesion Ki differences obtained with the IDIF minus the PIF scaled to the scan time interval at 30–60 min p.i. (PIF_30) (A), and the PIF scaled to the IDIF at shorter scan time intervals p.i. (PIF_40 and PIF_50) (B and C). For readability, the scales have been adjusted per subfigure.

Abstract Background Excellent performance characteristics of the Vision Quadra PET/CT, e.g. a substantial increase in sensitivity, allow for precise measurements of image-derived input functions (IDIF) and tissue time activity curves. Previously we have proposed a method for a reduced 30 min (as opposed to 60 min) whole body 18F-FDG Patlak PET imaging procedure using a previously published population-averaged input function (PIF) scaled to IDIF values at 30–60 min post-injection (p.i.). The aim of the present...

Additional file 1: search strategy.

Additional file 1. Appendix 1.

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X221141139 for Gray matter hypoperfusion is a late pathological event in the course of Alzheimer’s disease by Khazar Ahmadi, Joana B Pereira, David Berron, Jacob Vogel, Silvia Ingala, Olof T Strandberg, Shorena Janelidze, Frederik Barkhof, Josef Pfeuffer, Linda Knutsson, Danielle van Westen, Sebastian Palmqvist, Henk JMM Mutsaerts and Oskar Hansson in Journal of Cerebral Blood Flow & Metabolism

Background:Compassionate Communities have been put forward as a new model for community-based palliative care to positively impact the health and wellbeing of those experiencing challenges of serious illness, death, dying, and loss. Despite the growing international movement to develop these public health initiatives to end-of-life care, only a handful of initiatives have undergone some form of evaluation.Aim:To provide guidance on designing evaluation research by identifying theoretical frameworks to understand the development, implementation, and underlying mechanisms...

Supplemental material, sj-pdf-1-pmj-10.1177_02692163221135616 for Effectiveness of transmural team-based palliative care in prevention of hospitalizations in patients at the end of life: A systematic review and meta-analysis by Isabelle Flierman, Elske Gieteling, Marjon Van Rijn, Bastiaan Van Grootven, Iris van Doorne, Faridi S Jamaludin, Dick L Willems, Majon Muller and Bianca M Buurman in Palliative Medicine

Background:Team-based palliative care interventions have shown positive results for patients at the end of life in both hospital and community settings. However, evidence on the effectiveness of transmural, that is, spanning hospital and home, team-based palliative care collaborations is limited.Aim:To systematically review whether transmural team-based palliative care interventions can prevent hospital admissions and increase death at home.Design:Systematic review and meta-analysis.Data sources:MEDLINE (Ovid), Embase (Ovid), CINAHL (Ebsco), PsychINFO (Ovid), and Cochrane Library (Wiley) were systematically searched...

Additional file 1: Table S1. Comparison of demographic and clinical characteristics of RECoVERED study participants who did and did not complete at least 1 HRQL questionnaire.

Abstract Background Currently, there is limited evidence about the long-term impact on physical, social and emotional functioning, i.e. health-related quality of life (HRQL) after mild or moderate COVID-19 not requiring hospitalization. We compared HRQL among persons with initial mild, moderate or severe/critical COVID-19 at 1 and 12 months following illness onset with Dutch population norms and investigated the impact of restrictive public health control measures on HRQL. Methods RECoVERED, a prospective cohort study in Amsterdam,...

Abstract Purpose Two commonly used imaging techniques to aid in the diagnosis of neurodegenerative parkinsonian syndromes are dopamine transporter (DAT) imaging with [123I]-FP-CIT single-photon emission computed tomography (DAT-SPECT) and positron emission tomography with [18F]-FDOPA (FDOPA-PET). This paper provides a unique series of parkinsonian patients who received both FDOPA-PET and DAT-SPECT in routine clinical practice and compares the reported results to assess potential differences between these two imaging techniques. Methods We present 11 patients with a...

Additional file 1. Supplemental material includes supplementary methods and supplementary figure S1 and S2.

Abstract Introduction Many people with psychotic disorders experience symptoms of post-traumatic stress disorder (PTSD). In recent years, several trauma-focused therapies (TFTs), including cognitive restructuring (CR), prolonged exposure (PE), and eye movement desensitization and reprocessing (EMDR) have been studied and found to be safe and effective in reducing PTSD symptoms in individuals with psychosis. However, studies were conducted in different countries, with varying inclusion criteria, therapy duration, control groups, and trial outcomes. RE.PROCESS will be the...

Abstract Background During adolescence, depressive and anxiety disorders are among the most common mental health disorders. Both disorders tend to persist, are predictive for other mental disorders, and are associated with severe impairment in diverse areas. Although Cognitive Behavioral Therapy (CBT) has proven to be an effective treatment, a considerable number of adolescents do not respond to CBT and residual symptoms often remain. Therefore, it is of great importance to improve treatment outcomes for depressed...

Alzheimer’s disease is characterized by regional reductions in cerebral blood flow (CBF). Although the gold standard for measuring CBF is [15O]H2O PET, proxies of relative CBF, derived from the early distribution phase of amyloid and tau tracers, have gained attention. The present study assessed precision of [15O]H2O derived relative and absolute CBF, and compared precision of these measures with that of (relative) CBF proxies. Dynamic [15O]H2O, [18F]florbetapir and [18F]flortaucipir PET test-retest (TrT) datasets with eleven,...

Abstract Backgrounds Individuals with chronic medical conditions are considered highly exposed to COVID-19 pandemic stress, but emerging evidence is demonstrating that resilience is common even among them. We aimed at identifying sustained resilient outcomes and their predictors in chronically ill people during the first year of the pandemic. Methods This international 4-wave 1-year longitudinal online survey included items on socio-demographic characteristics, economic and living situation, lifestyle and habits, pandemic-related issues, and history of mental disorders....

Supplemental material, sj-pdf-2-pmj-10.1177_02692163221142950 for Healthcare use and healthcare costs for patients with advanced cancer; the international ACTION cluster-randomised trial on advance care planning by Ida J Korfage, Suzanne Polinder, Nancy Preston, Johannes JM van Delden, A)JLM Geraerds, Lesley Dunleavy, Kristof Faes, Guido Miccinesi, Giulia Carreras, Caroline Moeller Arnfeldt, Marijke C Kars, Giuseppe Lippi, Urska Lunder, Ceu Mateus, Kristian Pollock, Luc Deliens, Mogens Groenvold, Agnes van der Heide and Judith AC Rietjens in Palliative Medicine

Supplemental material, sj-pdf-6-pmj-10.1177_02692163221142950 for Healthcare use and healthcare costs for patients with advanced cancer; the international ACTION cluster-randomised trial on advance care planning by Ida J Korfage, Suzanne Polinder, Nancy Preston, Johannes JM van Delden, A)JLM Geraerds, Lesley Dunleavy, Kristof Faes, Guido Miccinesi, Giulia Carreras, Caroline Moeller Arnfeldt, Marijke C Kars, Giuseppe Lippi, Urska Lunder, Ceu Mateus, Kristian Pollock, Luc Deliens, Mogens Groenvold, Agnes van der Heide and Judith AC Rietjens in Palliative Medicine

Background:Advance care planning supports patients to reflect on and discuss preferences for future treatment and care. Studies of the impact of advance care planning on healthcare use and healthcare costs are scarce.Aim:To determine the impact on healthcare use and costs of an advance care planning intervention across six European countries.Design:Cluster-randomised trial, registered as ISRCTN63110516, of advance care planning conversations supported by certified facilitators.Setting/participants:Patients with advanced lung or colorectal cancer from 23 hospitals in Belgium, Denmark,...

Background:Advance care planning supports patients to reflect on and discuss preferences for future treatment and care. Studies of the impact of advance care planning on healthcare use and healthcare costs are scarce.Aim:To determine the impact on healthcare use and costs of an advance care planning intervention across six European countries.Design:Cluster-randomised trial, registered as ISRCTN63110516, of advance care planning conversations supported by certified facilitators.Setting/participants:Patients with advanced lung or colorectal cancer from 23 hospitals in Belgium, Denmark,...

To explore experienced health- and work-related problems of partners of patients with cancer, and their needs for support. Semi-structured interviews were conducted with Dutch partners of patients with cancer. Interviews were transcribed verbatim. Data were analysed thematically, following the six steps of Braun & Clarke. Of 20 included partners (mean age: 50 years [31–63]), 60% was female. Five themes consistently emerged from the data: 1) overwhelming chaos calls for taking control; 2) impact of prolonged...

To explore experienced health- and work-related problems of partners of patients with cancer, and their needs for support. Semi-structured interviews were conducted with Dutch partners of patients with cancer. Interviews were transcribed verbatim. Data were analysed thematically, following the six steps of Braun & Clarke. Of 20 included partners (mean age: 50 years [31–63]), 60% was female. Five themes consistently emerged from the data: 1) overwhelming chaos calls for taking control; 2) impact of prolonged...

Additional file 1: Procedures for model identification. Fig. S1. Flowchart of sample identification. Table S1. Descriptive statistics of resilience indicators across the survey waves (N = 1052)*. Table S2. Frequency of each chronic medical condition in the whole sample. Table S3. Comparison between participants with and without chronic medical conditions at baseline*. Table S4. Descriptive statistics at the first wave of socio-demographic and clinical characteristics of participants with a chronic condition included vs excluded (because...

Additional file 1: Procedures for model identification. Fig. S1. Flowchart of sample identification. Table S1. Descriptive statistics of resilience indicators across the survey waves (N = 1052)*. Table S2. Frequency of each chronic medical condition in the whole sample. Table S3. Comparison between participants with and without chronic medical conditions at baseline*. Table S4. Descriptive statistics at the first wave of socio-demographic and clinical characteristics of participants with a chronic condition included vs excluded (because...