Abstract Fluid protein biomarkers are important tools in clinical research and health care to support diagnosis and to monitor patients. Especially within the field of dementia, novel biomarkers could address the current challenges of providing an early diagnosis and of selecting trial participants. While the great potential of fluid biomarkers is recognized, their implementation in routine clinical use has been slow. One major obstacle is the often unsuccessful translation of biomarker candidates from explorative high-throughput...

Insufficient physical activity (PA) is one of major risk factors for serious diseases and premature mortality worldwide. Public policies to enhance PA across society are recognized as an effective tool against the problem. This paper presents the results of a comprehensive assessment of national-level PA policy approach in Poland. A standardized survey of Word Health Organization named the Health-Enhancing Physical Activity Policy Audit Tool (HEPA PAT) was used for data collection. Content analysis and strengths,...

Purpose: There is strong evidence of the links between car-dependence and the physical inactivity pandemic. Physical inactivity accounts for 6–10% of major non-communicable diseases. Research consistently shows that unlike passive transport, active transport is associated with higher total daily physical activity (PA). While there are public policies that support PA in transport and, as a result, overall PA levels, the specific quantitative effect of such policies on PA behaviour has not been sufficiently investigated. The...

Purpose: There is strong evidence of the links between car-dependence and the physical inactivity pandemic. Physical inactivity accounts for 6–10% of major non-communicable diseases. Research consistently shows that unlike passive transport, active transport is associated with higher total daily physical activity (PA). While there are public policies that support PA in transport and, as a result, overall PA levels, the specific quantitative effect of such policies on PA behaviour has not been sufficiently investigated. The...

Additional file 1. Supplemental material includes supplementary methods and supplementary figure S1 and S2.

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X221135270 for Precision estimates of relative and absolute cerebral blood flow in Alzheimer’s disease and cognitively normal individuals by Fiona Heeman, Denise Visser, Maqsood Yaqub, Sander Verfaillie, Tessa Timmers, Yolande AL Pijnenburg, Wiesje M van der Flier, Bart NM van Berckel, Ronald Boellaard, Adriaan A Lammertsma, Sandeep SV Golla in Journal of Cerebral Blood Flow & Metabolism

Supplemental material, sj-doc-1-dhj-10.1177_20552076221129084 for Effectiveness of a stepped-care programme of internet-based psychological interventions for healthcare workers with psychological distress: Study protocol for the RESPOND healthcare workers randomised controlled trial by Roberto Mediavilla, Kerry R McGreevy, Mireia Felez-Nobrega, Anna Monistrol-Mula, María-Fe Bravo-Ortiz, Carmen Bayón, Beatriz Rodríguez-Vega, Pablo Nicaise, Audrey Delaire, Marit Sijbrandij, Anke B. Witteveen, Marianna Purgato, Corrado Barbui, Federico Tedeschi, Maria Melchior, Judith van der Waerden, David McDaid, A-La Park, Raffael Kalisch, Papoula Petri-Romão, James...

Supplemental material, sj-doc-1-dhj-10.1177_20552076221129084 for Effectiveness of a stepped-care programme of internet-based psychological interventions for healthcare workers with psychological distress: Study protocol for the RESPOND healthcare workers randomised controlled trial by Roberto Mediavilla, Kerry R McGreevy, Mireia Felez-Nobrega, Anna Monistrol-Mula, María-Fe Bravo-Ortiz, Carmen Bayón, Beatriz Rodríguez-Vega, Pablo Nicaise, Audrey Delaire, Marit Sijbrandij, Anke B. Witteveen, Marianna Purgato, Corrado Barbui, Federico Tedeschi, Maria Melchior, Judith van der Waerden, David McDaid, A-La Park, Raffael Kalisch, Papoula Petri-Romão, James...

Objective: To study weekly use of smartwatches, fitness watches and physical activity apps among adults with and without impaired speech-in-noise (SIN) recognition, to identify subgroups of users. Design: Cross-sectional study. Study sample: Adults (aged 28–80 years) with impaired (n = 384) and normal SIN recognition (n = 341) as measured with a web-based digits-in-noise test, from the Netherlands Longitudinal Study on Hearing. Multiple logistic regression analyses were used to study differences and to build an...

Additional file 1. Model Consent Form.

Abstract Background Managers are considered to be main stakeholders in the return to work (RTW) of cancer survivors. However, the perspectives of cancer survivors and managers differ on what managerial actions should be taken during the RTW of cancer survivors. This difference might put effective collaboration and successful RTW at risk. Therefore, this study aims to reach consensus among managers and cancer survivors on the managerial actions to be taken during the four different RTW...

Additional file 2. SPIRIT Checklist for Trials.

Additional file 2. SPIRIT Checklist for Trials.

Background: Longitudinal studies examining mental health trajectories in refugees and asylum seekers are scarce. Objectives: To investigate trajectories of psychological symptoms and wellbeing in refugees and asylum seekers, and identify factors associated with these trajectories. Method: 912 asylum seekers and refugees from the control arm of three trials in Europe (n = 229), Turkey (n = 320), and Uganda (n = 363) were included. We described trajectories of psychological symptoms and wellbeing, and used trauma...

Additional file 1: Table S1. Comparison of demographic and clinical characteristics of RECoVERED study participants who did and did not complete at least 1 HRQL questionnaire.

Abstract Background Currently, there is limited evidence about the long-term impact on physical, social and emotional functioning, i.e. health-related quality of life (HRQL) after mild or moderate COVID-19 not requiring hospitalization. We compared HRQL among persons with initial mild, moderate or severe/critical COVID-19 at 1 and 12 months following illness onset with Dutch population norms and investigated the impact of restrictive public health control measures on HRQL. Methods RECoVERED, a prospective cohort study in Amsterdam,...

Abstract Background Excellent performance characteristics of the Vision Quadra PET/CT, e.g. a substantial increase in sensitivity, allow for precise measurements of image-derived input functions (IDIF) and tissue time activity curves. Previously we have proposed a method for a reduced 30 min (as opposed to 60 min) whole body 18F-FDG Patlak PET imaging procedure using a previously published population-averaged input function (PIF) scaled to IDIF values at 30–60 min post-injection (p.i.). The aim of the present...

Supplemental material, sj-docx-1-pcr-10.1177_26323524221137601 for Researching two Compassionate Cities: study protocol for a mixed-methods process and outcome evaluation by Bert Quintiens, Tinne Smets, Kenneth Chambaere, Lieve Van Den Block, Luc Deliens and Joachim Cohen in Palliative Care and Social Practice

Supplemental material, sj-docx-1-pcr-10.1177_26323524221137601 for Researching two Compassionate Cities: study protocol for a mixed-methods process and outcome evaluation by Bert Quintiens, Tinne Smets, Kenneth Chambaere, Lieve Van Den Block, Luc Deliens and Joachim Cohen in Palliative Care and Social Practice

Additional file 1. Appendix 1.

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X221141139 for Gray matter hypoperfusion is a late pathological event in the course of Alzheimer’s disease by Khazar Ahmadi, Joana B Pereira, David Berron, Jacob Vogel, Silvia Ingala, Olof T Strandberg, Shorena Janelidze, Frederik Barkhof, Josef Pfeuffer, Linda Knutsson, Danielle van Westen, Sebastian Palmqvist, Henk JMM Mutsaerts and Oskar Hansson in Journal of Cerebral Blood Flow & Metabolism

Supplemental material, sj-pdf-2-jcb-10.1177_0271678X221141139 for Gray matter hypoperfusion is a late pathological event in the course of Alzheimer’s disease by Khazar Ahmadi, Joana B Pereira, David Berron, Jacob Vogel, Silvia Ingala, Olof T Strandberg, Shorena Janelidze, Frederik Barkhof, Josef Pfeuffer, Linda Knutsson, Danielle van Westen, Sebastian Palmqvist, Henk JMM Mutsaerts and Oskar Hansson in Journal of Cerebral Blood Flow & Metabolism

Existing research indicates that pregnant women who conceived through fertility treatment might experience more stress and anxiety compared to women who conceived spontaneously. Therefore, these women might have additional antenatal care needs. A search for both quantitative and qualitative studies was performed in PubMed, PsycINFO, CINAHL and MEDLINE through May 2021, guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. 21 articles met the inclusion criteria. After methodological quality appraisal using the...

Additional file 1. English translation of the self-developed COVID-19 Questionnaire.

Abstract Background Palliative care provision for persons experiencing homelessness is often poor. A threefold consultation service intervention was expected to increase knowledge of palliative care and multidisciplinary collaboration, and improve palliative care for this population. This intervention comprised: 1) consultation of social service professionals by palliative care specialists and vice versa; 2) multidisciplinary meetings with these professionals; and 3) training and education of these professionals. We aimed to evaluate the implementation process and its barriers...