3 Works

Data from: Simulation of the nodal flow of mutant embryos with small number of cilia: comparison of mechanosensing and vesicle transport hypotheses

Toshihiro Omori, Katja Winter, Kyosuke Shinohara, Hiroshi Hamada & Takuji Ishikawa
Left-right (L-R) asymmetry in the body plan is determined by nodal flow in vertebrate embryos. Shinohara et al. used Dpcd and Rfx3 mutant mouse embryos and showed that only a few cilia were sufficient to achieve L-R asymmetry. However, the mechanism underlying the breaking of symmetry by such weak ciliary flow is unclear. The flow-mediated signals related to L-R asymmetry have not been clarified; there are two models for L-R symmetry breaking: vesicle transport and...

Functional convergence of gliP and aspf1 in Aspergillus fumigatus pathogenicity

Hong Liu, Wenjie Xu, Norma V. Solis, Carol Woolford, Aaron P. Mitchell & Scott G. Filler
Gliotoxin contributes to the virulence of the fungus Aspergillus fumigatus in non-neutropenic mice that are immunosuppressed with corticosteroids. To investigate how the absence of gliotoxin affects both the fungus and the host, we used a nanoString nCounter to analyze their transcriptional responses during pulmonary infection of a non-neutropenic host with a gliotoxin-deficient ΔgliP mutant. We found that the ΔgliP mutation led to increased expression of aspf1, which specifies a secreted ribotoxin. Prior studies have shown...

Functional convergence of gliP and aspf1 in Aspergillus fumigatus pathogenicity

Hong Liu, Wenjie Xu, Norma V. Solis, Carol Woolford, Aaron P. Mitchell & Scott G. Filler
Gliotoxin contributes to the virulence of the fungus Aspergillus fumigatus in non-neutropenic mice that are immunosuppressed with corticosteroids. To investigate how the absence of gliotoxin affects both the fungus and the host, we used a nanoString nCounter to analyze their transcriptional responses during pulmonary infection of a non-neutropenic host with a gliotoxin-deficient ΔgliP mutant. We found that the ΔgliP mutation led to increased expression of aspf1, which specifies a secreted ribotoxin. Prior studies have shown...

Registration Year

  • 2018
    3

Resource Types

  • Dataset
    3

Affiliations

  • Tokyo University of Agriculture and Technology
    3
  • Affiliated Hospital of Nantong University
    2
  • Temple University
    2
  • Huazhong University of Science and Technology
    2
  • Beihang University
    2
  • Ministry of Education of the People's Republic of China
    2
  • Shandong University
    2
  • Huazhong Agricultural University
    2
  • First Affiliated Hospital of Guangdong Pharmaceutical University
    2
  • Florida International University
    2