10 Works
Incorporating evolutionary and threat processes into crop wild relatives conservation
Wolke Tobón-Niedfeldt, Alicia Mastretta-Yanes, Tania Urquiza-Haas, Bárbara Goettsch, Ángela P. Cuervo-Robayo, Esmeralda Urquiza-Haas, M. Andrea Orjuela-R, Francisca Acevedo-Gasman, Oswaldo Oliveros-Galindo, Caroline Burgeff, Diana M. Rivera-Rodríguez, José De Jesús Sánchez González, Jesús Alarcón-Guerrero, Araceli Aguilar-Meléndez, Flavio Aragón Cuevas, Valeria Alavez, Gabriel Alejandre-Iturbide, Carlos-H. Avendaño-Arrazate, César Azurdia Pérez, Alfonso Delgado-Salinas, Pablo Galán, Manuel González-Ledesma, Jesús Hernández-Ruíz, Francisco G. Lorea-Hernández, Rafael Lira Saade … & Patricia Koleff
Crop wild relatives (CWR) intra- and interspecific diversity is essential for crop breeding and food security. However, intraspecific genetic diversity, which is central given the idiosyncratic threats to species in landscapes, is usually not considered in planning frameworks. Here, we introduce an approach to develop proxies of genetic differentiation to identify conservation areas, applying systematic conservation planning tools that produce hierarchical prioritizations of the landscape. It accounts for: (i) evolutionary processes, including historical and environmental...
Cost-effectiveness of adjuvant atezolizumab versus best supportive care in the treatment of patients with resectable early-stage non-small cell lung cancer and overexpression of PD-L1
Vicente Escudero-Vilaplana, Roberto Collado-Borrell, Javier De Castro, Amelia Insa, Alex Martínez, Elena Fernández, Ivana Sullivan, Andrés Flores, Natalia Arrabal, David Carcedo & Alba Manzaneque
To assess the cost-effectiveness of adjuvant atezolizumab in the treatment of early-stage NSCLC patients (stage II-IIIA) with expression PD-L1 ≥ 50% without mutations in EGFR or ALK rearrangements in Spain. A 5-states Markov model (DFS, locorregional recurrence, 1L-metastatic recurrence, 2L-metastatic recurrence, and death states) was adapted to the Spanish setting. Demographic characteristics of the hypothetical cohort, transition probabilities from the DFS state, and safety parameters were obtained from IMpower010 study (GO29527). Transition probabilities from locorregional...
Data from: Connecting genomic patterns of local adaptation and niche suitability in teosintes
Jonas Aguirre-Liguori, Maud Tenaillon, Alejandra Vázquez-Lobo, Brandon Gaut, Juan Jaramillo-Correa, Salvador Montes-Hernandez, Valeria Souza, L. E. Eguiarte, J. P. Jaramillo-Correa & M. I. Tenaillon
The central-abundance hypothesis predicts that local adaptation is a function of the distance to the center of a species’ geographic range. To test this hypothesis, we gathered genomic diversity data from 49 populations, 646 individuals and 33,464 SNPs of two wild relatives of maize, the teosintes Zea mays ssp. parviglumis and Zea. mays. ssp. mexicana. We examined the association between the distance to their climatic and geographic centroids and the enrichment of SNPs bearing signals...
Data from: An SSR based approach incorporating a novel algorithm for identification of rare maize genotypes facilitates criteria for landrace conservation in Mexico
Corina Hayano-Kanashiro, Octavio Martìnez De La Vega, M. Humberto Reyes-Valdés, José-Luis Pons-Hernández, Fernando Hernández-Godinez, Emigdia Alfaro-Laguna, José Luis Herrera-Ayala, Ma. Cristina Vega-Sánchez, José Alfredo Carrera-Valtierra & June Simpson
Since maize was domesticated in Mexico around 9000 years ago, local farmers have selected and maintained seed stocks with particular traits and adapted to local conditions. In the present day many of these landraces are still cultivated, however increased urbanization and migration from rural areas implies a risk that this invaluable maize germplasm may be lost. In order to implement an efficient mechanism of conservation in situ, the diversity of these landrace populations must be...
Data from: The evolution of bat nucleic acid sensing Toll-like receptors
Marina Escalera-Zamudio, Lisandra M. Zepeda-Mendoza, Elizabeth Loza-Rubio, Edith Rojas-Anaya, Maria L. Méndez-Ojeda, Carlos F. Arias & Alex D. Greenwood
We characterized the nucleic acid sensing Toll-like receptors (TLR) of a New World bat species, the common vampire bat (Desmodus rotundus), and through a comparative molecular evolutionary approach searched for general adaptation patterns among the nucleic acid sensing TLRs of eight different bats species belonging to three families (Pteropodidae, Vespertilionidae and Phyllostomidae). We found that the bat TLRs are evolving slowly and mostly under purifying selection and that the divergence pattern of such receptors is...
Hydroxyacetophenone defenses in white spruce against spruce budworm
Genevieve Parent, Claudia Méndez-Espinoza, Isabelle Giguère, Melissa H. Mageroy, Martin Charest, Éric Bauce, Joerg Bohlmann & John MacKay
We review a recently discovered white spruce (Picea glauca) chemical defense against spruce budworm (Choristoneura fumiferana) involving hydroxyacetophenones. These defense metabolites detected in the foliage accumulate variably as the aglycons, piceol and pungenol, or the corresponding glucosides, picein and pungenin. We summarize current knowledge of the genomic, molecular and biochemical as well as genetic underpinnings of this defense and its effects on C. fumiferana. We present an update with new results on the ontogenic variation...
Cost-effectiveness of adjuvant atezolizumab versus best supportive care in the treatment of patients with resectable early-stage non-small cell lung cancer and overexpression of PD-L1
Vicente Escudero-Vilaplana, Roberto Collado-Borrell, Javier De Castro, Amelia Insa, Alex Martínez, Elena Fernández, Ivana Sullivan, Andrés Flores, Natalia Arrabal, David Carcedo & Alba Manzaneque
To assess the cost-effectiveness of adjuvant atezolizumab in the treatment of early-stage NSCLC patients (stage II-IIIA) with expression PD-L1 ≥ 50% without mutations in EGFR or ALK rearrangements in Spain. A 5-states Markov model (DFS, locorregional recurrence, 1L-metastatic recurrence, 2L-metastatic recurrence, and death states) was adapted to the Spanish setting. Demographic characteristics of the hypothetical cohort, transition probabilities from the DFS state, and safety parameters were obtained from IMpower010 study (GO29527). Transition probabilities from locorregional...
Data from: Genetic footprints of Iberian cattle in America 500 years after the arrival of Columbus
Amparo M. Martínez, Luis T. Gama, Javier Cañón, Catarina Ginja, Juan V. Delgado, Susana Dunner, Vincenzo Landi, Inmaculada Martín-Burriel, M. Cecilia T. Penedo, Clementina Rodellar, Jose Luis Vega-Pla, Atzel Acosta, Luz Ángela Álvarez, Esperanza Camacho, Óscar Cortés, José Ribamar Marques, Óscar Roberto Martínez, Rubén Darío Martínez, Lilia Melucci, Guillermo Martínez-Velázquez, Jose Ernesto Muñoz, Alicia Postiglioni, Jorge Quiroz, Philip Sponenberg, Odalys Uffo … & Ruben D. Martínez
BACKGROUND: American Creole cattle presumably descend from animals imported from the Iberian Peninsula during the period of colonization and settlement, through different migration routes, and may have also suffered the influence of cattle directly imported from Africa. The introduction of European cattle, which began in the 18th century, and later of Zebu from India, has threatened the survival of Creole populations, some of which have nearly disappeared or were admixed with exotic breeds. Assessment of...
Data from: Estimation of genetic parameters associated with frosty pod rot (Moniliophthora roreri) and cacao production in Mexico
José Luis Solís Bonilla, Uilson Vanderlei Lopes, Alfredo Zamarripa Colmenero, Biaani Beeu Martínez Valencia, Carlos Hugo Avendaño Arrazate & Karina Peres Gramacho
Genetic parameters were estimated for frosty pod rot resistance and yield components in cacao using a linear mixed model approach (Restricted Maximum Likelihood and Best Linear Unbiased Prediction). Two progeny trials established in the Rosario Izapa Experimental Field of the INIFAP in Chiapas, Mexico, were evaluated for frosty pod rot incidence and yield components, including the number of pods per tree, bean dry weight per tree, number of beans per pod, bean dry weight per...
The Household Context of In Situ Conservation in a Center of Crop Diversity in Oaxaca, Mexico
Daniela Soleri, Flavio Aragón Cuevas, Humberto Castro García, David Cleveland & Steven Smith
Crop diversity conservation in situ is an ecosystem service with benefits at household, community, and global scales. These include risk reduction and adaptation to changing physical and sociocultural environments—both important given the accelerating changes in climate, human migration, and the industrialization of agriculture. In situ conservation typically occurs as part of small-scale, traditionally based agriculture and can support cultural identity and values. Although decisions regarding crop diversity occur at the household level, few data detail...
Affiliations
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Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias10
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National Autonomous University of Mexico3
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Universidad Veracruzana2
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Roche (Spain)2
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Universidad Autónoma Agraria Antonio Narro1
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National Council for Protected Areas1
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National Technological Institute of Mexico1
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University of Zaragoza1
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University of Lisbon1
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National Commission for the Knowledge and Use of Biodiversity1