Das Internet spielt eine zentrale Rolle in der Gesundheitskommunikation und hat sich als Informationsquelle in Gesundheitsfragen fest etabliert. In der Folge rückt die Frage nach der Vertrauenswürdigkeit von Online-Gesundheitsinformationen in den Blick. Nutzer:innen stehen vor der Herausforderung, geeignete Suchstrategien zu entwickeln, die Verlässlichkeit der Quellen einzuschätzen und deren Bedeutung für ihre eigene Gesundheit zu bewerten. Ziel des vorliegenden Projekts war die Entwicklung einer Orientierungshilfe für den Umgang mit digitalen Gesundheitsinformationen. Das Projekt richtete sich an...

Additional file 1: Supplementary Figures S1-S23 and Supplementary Tables S1-S3.

Abstract Background IgA vasculitis (IgAV) is the most common form of systemic vasculitis in childhood and frequently involves the kidney. A minority of patients with IgA vasculitis nephritis (IgAVN), especially those presenting with heavy proteinuria and/or kidney failure at onset, are at risk of chronic end-stage kidney disease. For deciding upon treatment intensity, knowledge of the short-term clinical course of IgAVN is needed to improve treatment algorithms. Methods For this retrospective multicenter study, the medical...

Benthic foraminifera inhabit diverse marine environments, including areas of persistent bottom currents and contourite drift deposition. Certain highly adapted epibenthic foraminifera colonize contourite deposits as opportunistic suspension feeders. A correlation between these assemblages and high bottom current velocities has been highlighted in previous studies from the Iberian Margin (e.g. Schönfeld, 2002), suggesting their applicability as reliable proxy for reconstructing bottom currents. Our ongoing project aims to document biogeographic patterns of benthic foraminifera from extended contourite...

Researchers have long worried about a phenomenon where study participants give higher ratings on self-report scales the first time they take a survey compared to subsequent times, particularly for negative subjective experiences. Recent experimental evidence, using samples of U.S. college students, suggests that this initial elevation phenomenon is due to an upward bias in people’s initial responses. Such bias potentially undermines the validity of many research findings. However, more recent studies have found little evidence...

Additional file 2.

Abstract Background In the ongoing COVID-19 pandemic, advanced age is a risk factor for a severe clinical course of SARS-CoV-2 infection. Thus, older people may benefit in particular from booster doses with potent vaccines and research should focus on optimal vaccination schedules. In addition to each individual’s medical history, immunosenescence warrants further research in this population. This study investigates vaccine-induced immune response over 1 year. Methods/design EU-COVAT-1-AGED is a randomised controlled, adaptive, multicentre phase II...

Abstract Background In the ongoing COVID-19 pandemic, advanced age is a risk factor for a severe clinical course of SARS-CoV-2 infection. Thus, older people may benefit in particular from booster doses with potent vaccines and research should focus on optimal vaccination schedules. In addition to each individual’s medical history, immunosenescence warrants further research in this population. This study investigates vaccine-induced immune response over 1 year. Methods/design EU-COVAT-1-AGED is a randomised controlled, adaptive, multicentre phase II...

Psychotic disorders are frequently associated with decline in functioning and cognitive difficulties are observed in subjects at clinical high risk (CHR) for psychosis. In this work, we applied automatic approaches to neurocognitive and functioning measures, with the aim of investigating the link between global, social and occupational functioning, and cognition. 102 CHR subjects and 110 patients with recent onset depression (ROD) were recruited. Global assessment of functioning (GAF) related to symptoms (GAF-S) and disability (GAF-D)....

Abstract Background Multiple myeloma (MM) is the third most common hematologic malignancy with increasing importance due to improving treatment strategies and long-term outcomes in an aging population. This study aims to analyse influencing factors on health-related quality of life (HRQoL), such as treatment strategies, participation in a clinical trial and patient characteristics like anxiety, depression, gender, and age. A better understanding of the individual factors in context with HRQoL could provide a helpful instrument for...

Abstract Background Multiple myeloma (MM) is the third most common hematologic malignancy with increasing importance due to improving treatment strategies and long-term outcomes in an aging population. This study aims to analyse influencing factors on health-related quality of life (HRQoL), such as treatment strategies, participation in a clinical trial and patient characteristics like anxiety, depression, gender, and age. A better understanding of the individual factors in context with HRQoL could provide a helpful instrument for...

Abstract Purpose This scoping review aims to identify and describe knowledge gaps and research priorities in veno-arterial extracorporeal membrane oxygenation (VA-ECMO). Methods An expert panel was recruited consisting of eight international experts from different backgrounds. First, a list of priority topics was made. Second, the panel developed structured questions using population, intervention, comparison and outcomes (PICO) format. All PICOs were scored and prioritized. For every selected PICO, a structured literature search was performed. Results After...

Abstract Purpose This scoping review aims to identify and describe knowledge gaps and research priorities in veno-arterial extracorporeal membrane oxygenation (VA-ECMO). Methods An expert panel was recruited consisting of eight international experts from different backgrounds. First, a list of priority topics was made. Second, the panel developed structured questions using population, intervention, comparison and outcomes (PICO) format. All PICOs were scored and prioritized. For every selected PICO, a structured literature search was performed. Results After...

Abstract Background With the rapid progress of high-throughput sequencing technology, characterization of schizophrenia (SZ) with underlying probing of the gut microbiome can explore pathogenic mechanisms, estimate disease risk, and allow customization of therapeutic and prophylactic modalities. In this study, we compared the differences in gut microbial diversity and composition between 50 SZ subjects and 50 healthy matched subjects in Zhejiang, China via targeted next-generation sequencing (16S rRNA amplicon). Results Accordingly, the alpha diversity indices (observed...

Supplemental material, sj-docx-1-tak-10.1177_17539447221131203 for Cardiopulmonary function during exercise in heart failure with reduced ejection fraction following baroreflex activation therapy by Pia I. Nottebohm, Daniel Dumitrescu, Stefanie Hamacher, Christopher Hohmann, Navid Madershahian, Stephan Baldus, Hannes Reuter and Marcel Halbach in Therapeutic Advances in Cardiovascular Disease

Objective:Both genetic and environmental factors contribute to the development of ADHD, but associations between risk factors and ADHD symptom severity in affected children remain unclear. This systematic review and meta-analysis synthesizes evidence on the association between familial factors and symptom severity in children with ADHD (PROSPERO CRD42020076440).Method:PubMed and PsycINFO were searched for eligible studies.Results:Forty-three studies (N = 11,123 participants) were meta-analyzed. Five additional studies (N = 2,643 participants) were considered in the supplemental review. Parenting...

Supplemental material, sj-docx-1-tct-10.1177_15330338221117389 for Hepatic Arterial Infusion of Oxaliplatin, Fluorouracil, and Leucovorin Versus Sorafenib for Hepatocellular Carcinoma Refractory to Transarterial Chemoembolization: Retrospective Subgroup Analysis of 2 Prospective Trials by YeXing Huang, LiHong Zhang, MinKe He, ZhiCheng Lai, XiaoYun Bu, DongSheng Wen, QiJiong Li, Li Xu, Wei Wei, YaoJun Zhang, ZhongGuo Zhou, MinShan Chen, RongPing Guo, Ming Shi and Anna Kan in Technology in Cancer Research & Treatment

Supplemental material, sj-docx-1-tct-10.1177_15330338221117389 for Hepatic Arterial Infusion of Oxaliplatin, Fluorouracil, and Leucovorin Versus Sorafenib for Hepatocellular Carcinoma Refractory to Transarterial Chemoembolization: Retrospective Subgroup Analysis of 2 Prospective Trials by YeXing Huang, LiHong Zhang, MinKe He, ZhiCheng Lai, XiaoYun Bu, DongSheng Wen, QiJiong Li, Li Xu, Wei Wei, YaoJun Zhang, ZhongGuo Zhou, MinShan Chen, RongPing Guo, Ming Shi and Anna Kan in Technology in Cancer Research & Treatment

Additional file 3. This file encompasses the script for the analyses and the results of the article.

pp. 108-117. How is world literature shaped by publishing house politics? The present article deals with this question by examining the relationship between Octavio Paz and Siegfried Unseld in the context of the boom of Latin-American literature furthered by the Suhrkamp Verlag publishing house. Contemporary documents from the Siegfried Unseld Archive (German Literature Archives (DLA) Marbach) were evaluated for the first time and provide information about a conglomerate of aesthetic projections, political hopes and economic...

Globale Technologiekonzerne dringen immer stärker in den Gesundheitsbereich vor. Ihre Aktivitäten und Geschäftsfelder weisen eine enorme Bandbreite auf. Einige Unternehmen, vor allem in den USA und China, treten dabei selbst als Erbringer von Gesundheitsleistungen in Erscheinung. Dank ihrer Innovationskraft stellen diese „Tech-Giganten“ einerseits eine große Chance für die digitale Transformation von Gesundheitssystemen dar. Andererseits birgt die teils monopolartige Marktmacht der Digitalkonzerne erhebliche Risiken, etwa bei der Auswertung von Daten oder dem gleichberechtigten Zugang zu medizinischen...

Global tech companies are making increasing advances into the healthcare sector. Their business activities cover an enormous range. Some companies, especially in the USA and China, are becoming providers of healthcare services themselves. Due to their innovation capabilities, these "tech giants" represent a great opportunity for the digital transformation of public healthcare systems, on the one hand. On the other hand, the sometimes monopolistic market power of the digital corporations harbors considerable risks, for example...

Hydrothermal activity, triggered by endogenic processes, distributes and redistributes organic matter through diffuse flow networks and may lead to a production of organic matter via abiotic synthesis. Today, hydrothermal seepage, especially at seafloor spreading zones, induces oases for diverse microbial communities in otherwise relatively hostile environments. Furthermore, hydrothermal fluids can deliver organic molecules as building blocks and/or substrates for primeval microorganisms and thus probably played a central role in the emergence of life on Earth....

In diesem Beitrag wird der Fokus auf eine ethnografische Studie zum Umgang mit Mehrsprachigkeit im Elementarbereich gelegt. Anhand von ausgewählten Beobachtungs-protokollen wird eine Erkenntnis der Studie dargestellt, inwiefern Erwachsene als Modell Kinder darin unterstützen können, sich als mehrsprachige Subjekte zu offenbaren und ihre mehrsprachigen Kompetenzen im pädagogischen Alltag zu nutzen.