1,035 Works

Additional file 1 of Adaptation and implementation processes of a culture-centred community-based peer-education programme for older Māori

Mary Louisa Simpson, Stacey Ruru, John Oetzel, Pare Meha, Sophie Nock, Kathrine Holmes, Hariata Adams, Ngapera Akapita, Marama Clark, Kawarau Ngaia, Reuben Moses, Rangimahora Reddy & Brendan Hokowhitu
Additional file 1. Interview Questions.

Real-world data for precision public health of noncommunicable diseases: a scoping review

Oliver J. Canfell, Zack Kodiyattu, Elizabeth Eakin, Andrew Burton-Jones, Ides Wong, Caroline Macaulay & Clair Sullivan
Abstract Background Global public health action to address noncommunicable diseases (NCDs) requires new approaches. NCDs are primarily prevented and managed in the community where there is little investment in digital health systems and analytics; this has created a data chasm and relatively silent burden of disease. The nascent but rapidly emerging area of precision public health offers exciting new opportunities to transform our approach to NCD prevention. Precision public health uses routinely collected real-world data...

Additional file 1 of Real-world data for precision public health of noncommunicable diseases: a scoping review

Oliver J. Canfell, Zack Kodiyattu, Elizabeth Eakin, Andrew Burton-Jones, Ides Wong, Caroline Macaulay & Clair Sullivan
Additional file 1. Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) Checklist.

Additional file 1 of Real-world data for precision public health of noncommunicable diseases: a scoping review

Oliver J. Canfell, Zack Kodiyattu, Elizabeth Eakin, Andrew Burton-Jones, Ides Wong, Caroline Macaulay & Clair Sullivan
Additional file 1. Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) Checklist.

Additional file 1 of A randomized, controlled trial of ZYN002 cannabidiol transdermal gel in children and adolescents with fragile X syndrome (CONNECT-FX)

Elizabeth Berry-Kravis, Randi Hagerman, Dejan Budimirovic, Craig Erickson, Helen Heussler, Nicole Tartaglia, Jonathan Cohen, Flora Tassone, Thomas Dobbins, Elizabeth Merikle, Terri Sebree, Nancy Tich, Joseph M. Palumbo & Stephen O’Quinn
Additional file 1: Supplemental Table S1. Change in ABC-CFXS Social Avoidance, Irritability, and Socially Unresponsive/Lethargic Subscale Scores by CaGI-S Change Categories. Supplemental Table S2. Change in ABC-CFXS Social Avoidance, Irritability, and Socially Unresponsive/Lethargic Subscale Scores by CaGI-C Week 12 Values. Supplemental Figure S1. Empirical cumulative distribution function curves of change in the ABC-CFXS SA, Irritability, and SU/L subscale scores by change in the CaGI-S domain-specific and overall behavior scores. Supplemental Figure S2. Empirical cumulative distribution...

Additional file 1 of A randomized, controlled trial of ZYN002 cannabidiol transdermal gel in children and adolescents with fragile X syndrome (CONNECT-FX)

Elizabeth Berry-Kravis, Randi Hagerman, Dejan Budimirovic, Craig Erickson, Helen Heussler, Nicole Tartaglia, Jonathan Cohen, Flora Tassone, Thomas Dobbins, Elizabeth Merikle, Terri Sebree, Nancy Tich, Joseph M. Palumbo & Stephen O’Quinn
Additional file 1: Supplemental Table S1. Change in ABC-CFXS Social Avoidance, Irritability, and Socially Unresponsive/Lethargic Subscale Scores by CaGI-S Change Categories. Supplemental Table S2. Change in ABC-CFXS Social Avoidance, Irritability, and Socially Unresponsive/Lethargic Subscale Scores by CaGI-C Week 12 Values. Supplemental Figure S1. Empirical cumulative distribution function curves of change in the ABC-CFXS SA, Irritability, and SU/L subscale scores by change in the CaGI-S domain-specific and overall behavior scores. Supplemental Figure S2. Empirical cumulative distribution...

A randomized, controlled trial of ZYN002 cannabidiol transdermal gel in children and adolescents with fragile X syndrome (CONNECT-FX)

Elizabeth Berry-Kravis, Randi Hagerman, Dejan Budimirovic, Craig Erickson, Helen Heussler, Nicole Tartaglia, Jonathan Cohen, Flora Tassone, Thomas Dobbins, Elizabeth Merikle, Terri Sebree, Nancy Tich, Joseph M. Palumbo & Stephen O’Quinn
Abstract Background Fragile X syndrome (FXS) is associated with dysregulated endocannabinoid signaling and may therefore respond to cannabidiol therapy. Design CONNECT-FX was a double-blind, randomized phase 3 trial assessing efficacy and safety of ZYN002, transdermal cannabidiol gel, for the treatment of behavioral symptoms in children and adolescents with FXS. Methods Patients were randomized to 12 weeks of ZYN002 (250 mg or 500 mg daily [weight-based]) or placebo, as add-on to standard of care. The primary...

Additional file 3 of Neutrophil CD64 index as a superior indicator for diagnosing, monitoring bacterial infection, and evaluating antibiotic therapy: a case control study

Yanting Gao, Lihui Lin, Jinyan Zhao, Xia Peng & Li Li
Additional file 3: Table S1. The distributionof bacteria strains.

Self‐Assembly, Adaptive Response, and in , out‐ Stereoisomerism of Large Orthoformate Cryptands

Max von Delius, Henrik Löw, Elena Mena‐Osteritz, Kathleen M. Mullen & Christof Jäger
Abstract We report on triethylene glycol-based orthoformate cryptands, which adapt their bridgehead configurations in response to metal templates and intramolecular hydrogen bonding in a complex ma...

Data from: Re-visiting the phylogeography and demography of European badgers (Meles meles) based on broad sampling, multiple markers and simulations

Alain C. Frantz, Allan D. McDevitt, Lisa C. Pope, Joanna Kochan, John Davison, Chris F. Clements, Morten Elmeros, Guillem Molina-Vacas, Aritz Ruiz-Gonzalez, Alessandro Balestrieri, Koen Van Den Berge, Peter Breyne, Emmanuel Do Linh San, Erik O. Ågren, Franz Suchentrunk, Laurent Schley, Rafał Kowalczyk, Berit I. Kostka, Dusko Ćirović, Nikica Šprem, Marc Colyn, Marco Ghirardi, Venislava Racheva, Christophe Braun, Rita Oliveira … & Terry Burke
Although the phylogeography of European mammals has been extensively investigated since the 1990s, many studies were limited in terms of sampling distribution, the number of molecular markers used and the analytical techniques employed, frequently leading to incomplete postglacial recolonisation scenarios. The broad-scale genetic structure of the European badger (Meles meles) is of interest as it may result from historic restriction to glacial refugia and/or recent anthropogenic impact. However, previous studies were based mostly on samples...

Data from: Convergence and divergence during the adaptation to similar environments by an Australian groundsel

Federico Roda, Huanle Liu, Melanie Joye Wilkinson, Greg Matthew Walter, Maddie Ellen James, Diana Marcela Bernal, Maria Clara Melo, Andrew John Lowe, Loren H. Rieseberg, Peter Prentis, Daniel Ortiz-Barrientos & Gregory M. Walter
Adaptation to replicate environments is often achieved through similar phenotypic solutions. Whether selection also produces convergent genomic changes in these situations remains largely unknown. The variable groundsel, Senecio lautus, is an excellent system to investigate the genetic underpinnings of convergent evolution, since morphologically similar forms of these plants have adapted to the same environments along the coast of Australia. We compared range-wide patterns of genomic divergence in natural populations of this plant and searched for...

Data from: Randomised controlled trial of an education and support package for stroke patients and their carers

Sally Eames, Tammy Hoffmann, Linda Worrall, Stephen Read & Andrew Wong
Objective: Tailoring stroke information and providing reinforcement opportunities are two strategies proposed to enhance the effectiveness of education. This study aimed to evaluate the effects of an education package which utilised both strategies on the knowledge, health and psychosocial outcomes of stroke patients and carers. Design: Multisite, randomised trial comparing usual care with an education and support package. Setting: Two acute stroke units. Participants: Patients and their carers (N=138) were randomised (control n=67, intervention n=71)...

Data from: Stretched to the limit; can a short pelagic larval duration connect adult populations of an Indo-Pacific diadromous fish (Kuhlia rupestris)?

Pierre Feutry, Alan Vergnes, Damien Broderick, Josie Lambourdière, Philippe Keith & Jennifer R. Ovenden
Freshwater species on tropical islands face localized extinction and the loss of genetic diversity. Their habitats can be ephemeral due to variability in freshwater run-off and erosion. Even worse, anthropogenic effects on these ecosystems are intense. Most of these species are amphidromous or catadromous (i.e. their life cycle includes a marine larval phase), which buffers them against many of these effects. A long pelagic larval duration (PLD) was thought to be critical to ensure the...

Data from: Perioperative medication management: expanding the role of the preadmission clinic pharmacist in a single centre, randomised controlled trial of collaborative prescribing

Andrew R. Hale, Ian D. Coombes, Julie Stokes, David McDougall, Karen Whitfield, Elizabeth Maycock & Lisa Nissen
Objectives: Current evidence to support non-medical prescribing is predominantly qualitative, with little evaluation of accuracy, safety and appropriateness. Our aim was to evaluate a new model of service for the Australia healthcare system, of inpatient medication prescribing by a pharmacist in an elective surgery pre admission clinic (PAC) against usual care, using an endorsed performance framework. Design: Single centre, randomised controlled, two arm trial Setting: Elective surgery pre admission clinic in Brisbane based tertiary hospital...

Data from: Trait compensation and sex-specific aging of performance in male and female professional basketball players

Simon P. Lailvaux, Robbie Wilson & Michael M. Kasumovic
Phenotypic traits are often influenced by dynamic resource allocation trade-offs which, when occurring over the course of individual lifespans, may manifest as trait aging. Although aging is studied for a variety of traits that are closely tied to reproduction or reproductive effort, the aging of multiple traits related to fitness in other ways are less well understood. We took advantage of almost 30 years of data on human whole-organism performance in the National Basketball Association...

Data from: Ecological incumbency impedes stochastic community assembly in Holocene foraminifera from the Huon Peninsula, Papua New Guinea

Claire E. Reymond, Michael Bode, Willem Renema & John M. Pandolfi
Persistence in the structure of ecological communities can be predicted both by deterministic and by stochastic theory. Evaluating ecological patterns against the neutral theory of biodiversity provides an appropriate methodology for differentiating between these alternatives. We traced the history of benthic foraminiferal communities from the Huon Peninsula, Papua New Guinea. From the well-preserved uplifted reef terrace at Bonah River we reconstructed the benthic foraminiferal communities during a 2200-year period (9000–6800 yr B.P.) of reef building...

Data from: A genome-wide gene expression signature of environmental geography in leukocytes of Moroccan Amazighs

Youssef Idaghdour, John D. Storey, Sami J. Jadallah & Greg Gibson
The different environments that humans experience are likely to impact physiology and disease susceptibility. In order to estimate the magnitude of the impact of environment on transcript abundance, we examined gene expression in peripheral blood leukocyte samples from 46 desert nomadic, mountain agrarian and coastal urban Moroccan Amazigh individuals. Despite great expression heterogeneity in humans, as much as one third of the leukocyte transcriptome was found to be associated with differences among regions. Genome-wide polymorphism...

Data from: Does genetic diversity reduce sibling competition?

J. David Aguirre & Dustin J. Marshall
An enduring hypothesis for the proximal benefits of sex is that recombination increases the genetic variation among offspring and that this genetic variation increases offspring performance. A corollary of this hypothesis is that mothers that mate multiply increase genetic variation within a clutch and gain benefits due to genetic diversity alone. Many studies have demonstrated that multiple mating can increase offspring performance, but most attribute this increase to sexual selection and the role of genetic...

Data from: Echidna venom gland transcriptome provides insights into the evolution of monotreme venom

Emily S. W. Wong, Stewart Nichol, Wesley C. Warren, Katherine Belov & Stewart Nicol
Monotremes (echidna and platypus) are egg-laying mammals. One of their most unique characteristic is that males have venom/crural glands that are seasonally active. Male platypuses produce venom during the breeding season, delivered via spurs, to aid in competition against other males. Echidnas are not able to erect their spurs, but a milky secretion is produced by the gland during the breeding season. The function and molecular composition of echidna venom is as yet unknown. Hence,...

Data from: Not the time or the place: the missing spatio-temporal link in publicly available genetic data

Lisa C. Pope, Libby Liggins, Jude Keyse, Silvia B. Carvalho & Cynthia Riginos
Genetic data are being generated at unprecedented rates. Policies of many journals, institutions and funding bodies aim to ensure that these data are publicly archived so that published results are reproducible. Additionally, publicly archived data can be ‘repurposed’ to address new questions in the future. In 2011, along with other leading journals in ecology and evolution, Molecular Ecology implemented mandatory public data archiving (the Joint Data Archiving Policy). To evaluate the effect of this policy,...

Data from: Biodiversity gains from efficient use of private sponsorship for flagship species conservation

Joseph R. Bennett, Richard Maloney & Hugh P. Possingham
To address the global extinction crisis, both efficient use of existing conservation funding and new sources of funding are vital. Private sponsorship of charismatic ‘flagship’ species conservation represents an important source of new funding, but has been criticized as being inefficient. However, the ancillary benefits of privately sponsored flagship species conservation via actions benefiting other species have not been quantified, nor have the benefits of incorporating such sponsorship into objective prioritization protocols. Here, we use...

Data from: Catchment zoning for freshwater conservation: refining plans to enhance action on the ground

Virgilio Hermoso, Lorenzo Cattarino, Mark J. Kennard, Matthew Watts, Simon Linke & Mathew Watts
1. Recent advances in freshwater conservation planning allow addressing some of the specific needs of these systems. These include spatial connectivity or propagation of threats along stream networks, essential to ensure the maintenance of ecosystem processes and the biodiversity they sustain. However, these peculiarities make conservation recommendations difficult to implement as they often require considering large areas that cannot be managed under conventional conservation schemes (e.g. strict protection). 2. To facilitate the implementation of conservation...

Data from: High-throughput genotyping for species identification and diversity assessment in germplasm collections

Annaliese S. Mason, Jing Zhang, Reece Tollenaere, Paula Vasquez Teuber, Jessica Dalton-Morgan, Liyong Hu, Guijun Yan, David Edwards, Robert Redden & Jacqueline Batley
Germplasm collections provide an extremely valuable resource for breeders and researchers. However, misclassification of accessions by species often hinders the effective use of these collections. We propose that use of high-throughput genotyping tools can provide a fast, efficient and cost-effective way of confirming species in germplasm collections, as well as providing valuable genetic diversity data. We genotyped 180 Brassicaceae samples sourced from the Australian Grains Genebank across the recently released Illumina Infinium Brassica 60K SNP...

Data from: Serial founder effects and genetic differentiation during worldwide range expansion of monarch butterflies

Amanda A. Pierce, Myron P. Zalucki, Marie Bangura, Milan Udawatta, Marcus R. Kronforst, Sonia Altizer, Juan Fernández Haeger & Jacobus C. De Roode
Range expansions can result in founder effects, increasing genetic differentiation between expanding populations and reducing genetic diversity along the expansion front. However, few studies have addressed these effects in long-distance migratory species, for which high dispersal ability might counter the effects of genetic drift. Monarchs (Danaus plexippus) are best known for undertaking a long-distance annual migration in North America, but have also dispersed around the world to form populations that do not migrate or travel...

Data from: Less is more: extreme genome complexity reduction with ddRAD using Ion Torrent semiconductor technology

Lilian Pukk, Freed Ahmad, Shihab Hasan, Veljo Kisand, Riho Gross & Anti Vasemägi
Massively parallel sequencing a small proportion of the whole genome at high coverage enables answering a wide range of questions from molecular evolution and evolutionary biology to animal and plant breeding and forensics. In this study, we describe the development of restriction-site associated DNA (RAD) sequencing approach for Ion Torrent PGM platform. Our protocol results in extreme genome complexity reduction using two rare-cutting restriction enzymes and strict size selection of the library allowing sequencing of...

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