48 Works

Additional file 3 of Evidence-based expert consensus on the management of primary central nervous system lymphoma in China

Tong Chen, Yuanbo Liu, Yang Wang, Qing Chang, Jinsong Wu, Zhiliang Wang, Daoying Geng, Jin-Tai Yu, Yuan Li, Xiao-Qiu Li, Hong Chen, Dongxiao Zhuang, Jianyong Li, Bin Wang, Tao Jiang, Lanting Lyu, Yuqin Song, Xiaoguang Qiu, Wenbin Li, Song Lin, Xinghu Zhang, Dehong Lu, Junqiang Lei, Yaolong Chen & Ying Mao
Additional file 3. Supplementary data for focused clinical questions.

Additional file 4 of Evidence-based expert consensus on the management of primary central nervous system lymphoma in China

Tong Chen, Yuanbo Liu, Yang Wang, Qing Chang, Jinsong Wu, Zhiliang Wang, Daoying Geng, Jin-Tai Yu, Yuan Li, Xiao-Qiu Li, Hong Chen, Dongxiao Zhuang, Jianyong Li, Bin Wang, Tao Jiang, Lanting Lyu, Yuqin Song, Xiaoguang Qiu, Wenbin Li, Song Lin, Xinghu Zhang, Dehong Lu, Junqiang Lei, Yaolong Chen & Ying Mao
Additional file 4. Delphi results.

Augmentation and conservation biological control of Tetranychus urticae on hops in Ohio

Susan Ndiaye & Celeste Welty
The twospotted spider mite, Tetranychus urticae Koch (Acari: Tetranychidae), is a key pest on hops grown in the Midwestern USA, where hop production is a new industry, and little research has been done on the management of T. urticae. In 2016 and 2017, we conducted an experiment to determine the efficacy of augmentative biological control of T. urticae populations on the cultivar ‘Cascade’ at four hop yards. In both years, treatments compared Neoseiulus fallacis Garman...

Supporting trees and alignments for the publication: Cryptic and abundant marine viruses at the evolutionary origins of Earth’s RNA virome

James Wainaina, Ahmed Zayed, Guillermo Dominguez-Huerta, Benjamin Bolduc & Matthew Sullivan
Whereas DNA viruses are known to be abundant, diverse, and commonly key ecosystem players, RNA viruses are relatively understudied outside disease settings. Here, we analyzed ≈28 terabases of Global Ocean RNA sequences to expand Earth’s RNA virus catalogues and their taxonomy, investigate their evolutionary origins, and assess their marine biogeography from pole to pole. Using new approaches to optimize discovery and classification, we identified RNA viruses that necessitate substantive revisions of taxonomy (doubling phyla and...

Genetic characterization of potential venom resistance proteins in California ground squirrels (Otospermophilus beecheyi) using transcriptome analyses

Alexander Ochoa, Alyssa T. B. Hassinger, Matthew L. Holding & H. Lisle Gibbs
Understanding the molecular basis of adaptations in coevolving species requires identifying the genes that underlie reciprocally selected phenotypes, such as those involved in venom in snakes and resistance to venom in their prey. In this regard, California ground squirrels (CGS; Otospermophilus beecheyi) are eaten by northern Pacific rattlesnakes (Crotalus oreganus oreganus), but individual squirrels may still show substantial resistance to venom and survive bites. A recent study using proteomics identified venom interactive proteins (VIPs) in...

Molecular dynamics simulations of intrinsically disordered proteins p53TAD and Pup

Lei Yu & Rafael Brüschweiler
Intrinsically disordered proteins (IDPs) are highly dynamic systems that play an important role in cell signaling processes and their misfunction often causes human disease. Proper understanding of IDP function not only requires the realistic characterization of their three-dimensional conformational ensembles at atomic-level resolution but also of the time scales of interconversion between their conformational substates. Large sets of experimental data are often used in combination with molecular modeling to restrain or bias models to improve...

Data from: Temporal variability in snow accumulation and density at Summit Camp, Greenland ice sheet

Ian Howat
A 3-year record of weekly snow water equivalent (SWE) accumulation at Summit Camp, central Greenland ice sheet, obtained by direct sampling, is presented. While the overall SWE accumulation of 24.2 cm w.e. a−1 matches long-term ice core estimates, variability increases at shorter timescales. Half of the annual SWE accumulation occurs during a few large events, with the average accumulation rate decreasing 35% between the first and second halves of the record coinciding with exceptional anticyclonic...

Exposure to urban heavy metal contamination diminishes bumble bee colony growth

Sarah B. Scott, Frances S. Sivakoff & Mary M. Gardiner
As a result of their industrial past, legacy cites often have elevated concentrations of soil heavy metal contamination. Metal pollution can have negative and prolonged ecosystem impacts, and bees that forage in these urban ecosystems are at risk of exposure. Legacy cities are known to support species rich bee communities, which highlights the importance of determining the impact of heavy metal contamination on wild bee health. We examined how oral exposure to concentrations of four...

Data from: Simulated winter warming negatively impacts survival of Antarctica’s only endemic insect

Jack Devlin, Laura Unfried, Melise C. Lecheta, Eleanor A. McCabe, Josiah D. Gantz, Yuta Kawarasaki, Michael A. Elnitsky, Scott Hotaling, Andrew P. Michel, Peter Convey, Scott A. L. Hayward & Nicholas M. Teets
Antarctic winters are challenging for terrestrial invertebrates, and species that live there have specialized adaptations to conserve energy and protect against cold injury in the winter. However, rapidly occurring climate change in these regions will increase the unpredictability of winter conditions, and there is currently a dearth of knowledge on how the highly adapted invertebrates of Antarctica will respond to changes in winter temperatures. We evaluated the response of larvae of the Antarctic midge, Belgica...

Variation in behavior drives multiscale responses to habitat conditions in timber rattlesnakes (Crotalus horridus)

Andrew Hoffman, Annalee Tutterow, Meaghan Gade, Bryce Adams & William Peterman
Variations in both the behavior of wildlife and the scale at which the environment most influences the space use of wild animals (i.e., scale of effect) are critical, but often overlooked in habitat selection modeling. Ecologists have proposed that biological responses happening over longer time frames are influenced by environmental variables at larger spatial scales, but this has rarely been empirically tested. Here, we hypothesized that long-term patterns of behavior (i.e., lasting multiple weeks to...

Data for: Spatial structure within root systems moderates stability of Arbuscular Mycorrhizal mutualism and plant-soil feedbacks

Jacob Hopkins
The persistence of mutualisms is paradoxical, as there are fitness incentives for exploitation. This is particularly true for plant-microbe mutualisms like arbuscular mycorrhizae (AM), which are promiscuously horizontally-transmitted. Preferential allocation by hosts to the best mutualist can stabilize horizontal mutualisms, however, preferential allocation is imperfect, with its fidelity likely depending upon the spatial structure of symbionts in plant roots. In this study, we tested AM mutualisms’ dependence on two dimensions of spatial structure: the initial...

Influence of post-thaw culture duration on pregnancy outcomes in frozen blastocyst transfer cycles

Hui Ji, Shanren Cao, Hui Ding, Li Dong, Chun Zhao, Junqiang Zhang, Jing Lu, Xiuling Li & Xiufeng Ling
In this study, we aimed to evaluate whether post-thaw culture duration affected the clinical outcomes of frozen blastocyst transfer. This retrospective cohort study included 3,901 frozen-thawed blastocyst transfer cycles. The cohorts were divided into two groups based on the developmental stage (day 5 [D5] and day 6 [D6]) and culture duration after thawing (short culture, 2–6 h; long culture, 18–20 h). Women in the short culture group following D6 blastocyst transfer were further divided into...

Strategies to Mitigate Enteric Methane Emissions by Ruminants

C. Arndt, A.N. Hristov, W.J. Price, S.C. McClelland, A.M. Pelaez, A.R. Bayat, L.A. Crompton, J. Dijkstra, M.A. Eugène, D. Enahoro, E. Kebreab, M. Kreuzer, M. McGee, C. Martin, C.J. Newbold, C.K. Reynolds, A. Schwarm, K.J. Shingfield, J.B. Veneman, D.R. Yáñez-Ruiz & Z. Yu
To meet the 1.5°C target, methane (CH4) from ruminants must be reduced by 11 to 30% of the 2010 level by 2030 and by 24 to 47% by 2050. A meta-analysis identified strategies to decrease product-based [PB; CH4 per unit meat or milk (CH4I)] and absolute (ABS) enteric CH4 emissions while maintaining or increasing animal productivity (AP; weight gain and milk yield). Next the potential of different adoption rates of one PB and/or ABS strategies...

Data from: Food quality, security, and thermal refuge influence use of microsites and patches by pygmy rabbits (Brachylagus idahoensis) across landscapes and seasons

Peter Olsoy, Charlotte Milling, Jordan D. Nobler, Meghan J. Camp, Lisa A. Shipley, Janet Rachlow & Daniel Thornton

Data from: An integrative skeletal and paleogenomic analysis of stature variation suggests relatively reduced health for early European farmers

Stephanie Marciniak, Christina Bergey, Ana Maria Silva, Agata Hałuszko, Mirosław Furmanek, Barbara Veselka, Petr Velemínský, Giuseppe Vercellotti, Joachim Wahl, Gunita Zarina, Cristina Longhi, Jan Kolář, Rafael Garrido-Pena, Raúl Flores-Fernández, Ana M. Herrero-Corral, Angela Simalcsik, Werner Müller, Alison Sheridan, Žydrūnė Miliauskienė, Rimantas Jankauskas, Vyacheslav Moiseyev, Kitti Köhler, Ágnes Király, Beatriz Gamarra, Olivia Cheronet … & George H. Perry
Human culture, biology, and health were shaped dramatically by the onset of agriculture ~12,000 years before present (BP). This shift is hypothesized to have resulted in increased individual fitness and population growth as evidenced by archaeological and population genomic data alongside a decline in physiological health as inferred from skeletal remains. Here, we consider osteological and ancient DNA data from the same prehistoric individuals to study human stature variation as a proxy for health across...

Trends in functional composition of small mammal communities across millennial time scales

Marta Jarzyna & Collin VanBuren
Rich fossil deposits of the late Quaternary help us understand responses of biodiversity to global change and thus predict the future of ecosystems. Studies from the late Quaternary, however, are often limited taxonomically, geographically (often one site), and by their use of largely taxon-based metrics that do not inform about ecosystem-level consequences of biodiversity change. Here, we compare change in functional composition of small mammal communities at El Mirón Cave (Spain) and Samwell Cave (California,...

Culturally Responsive Postsecondary Readiness Practices for Black Males: Practice and Policy Recommendations for School Counselors

Erik M. Hines, Edward C. Fletcher Jr., James L. Moore III & Donna Y. Ford

Refractivity inversions from point-to-point X-Band radar propagation measurements

Douglas Pastore, Sarah Wessinger, Daniel Greenway, Mathew Stanek, Robert Burkholder, Tracy Haack, Qing Wang & Erin Hackett
Dynamic refractive environments within the marine atmospheric boundary layer (MABL) pose difficulties in the prediction of super high frequency (SHF), specifically X-band, radar wave propagation due to natural phenomena such as evaporation ducts (ED). This study utilizes a unique dataset collected during the CASPER-East field campaign, including multiple refractivity estimation methods and twelve point-to-point (PTP) electromagnetic datasets, to assess the efficacy of PTP inversion techniques for remote sensing of atmospheric refractivity within the MABL. Comparison...

GPS vertical time series of solid Earth deformation for the southern Antarctic Peninsula 2010-2020

Achraf Koulali, Pippa Whitehouse, Peter Clarke, Michiel van den Broeke, Grace Nield, Matt King, Michael Bentley, Bert Wouters & Terry Wilson
This dataset contains vertical GPS time series observed from selected sites in the southern Antarctic Peninsula. The dataset contains raw time series and time series corrected for the effect of elastic deformation - induced from the RACMO surface mass balance (SMB) model with a 5.5 km horizontal resolution (van Wessem et al. 2018). Hence there are two time series files for each of ten sites, presented as CSV files. There is a README file which...

Design, synthesis and antitumor activity of 5-trifluoromethylpyrimidine derivatives as EGFR inhibitors

Yaqing Zuo, Rongrong Li, Yan Zhang, Guochen Bao, Yi Le & Longjia Yan
A new series of 5-trifluoromethylpyrimidine derivatives were designed and synthesised as EGFR inhibitors. Three tumour cells A549, MCF-7, PC-3 and EGFR kinase were employed to evaluate their biological activities. The results were shown that most of the target compounds existed excellent antitumor activities. In particular, the IC50 values of compound 9u (E)-3-((2-((4-(3-(3-fluorophenyl)acrylamido)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)-N-methylthiophene-2-carboxamide against A549, MCF-7, PC-3 cells and EGFR kinase reached to 0.35 μM, 3.24 μM, 5.12 μM, and 0.091 μM, respectively. Additionally, further researches...

Additional file 4 of Evidence-based expert consensus on the management of primary central nervous system lymphoma in China

Tong Chen, Yuanbo Liu, Yang Wang, Qing Chang, Jinsong Wu, Zhiliang Wang, Daoying Geng, Jin-Tai Yu, Yuan Li, Xiao-Qiu Li, Hong Chen, Dongxiao Zhuang, Jianyong Li, Bin Wang, Tao Jiang, Lanting Lyu, Yuqin Song, Xiaoguang Qiu, Wenbin Li, Song Lin, Xinghu Zhang, Dehong Lu, Junqiang Lei, Yaolong Chen & Ying Mao
Additional file 4. Delphi results.

Additional file 2 of Evidence-based expert consensus on the management of primary central nervous system lymphoma in China

Tong Chen, Yuanbo Liu, Yang Wang, Qing Chang, Jinsong Wu, Zhiliang Wang, Daoying Geng, Jin-Tai Yu, Yuan Li, Xiao-Qiu Li, Hong Chen, Dongxiao Zhuang, Jianyong Li, Bin Wang, Tao Jiang, Lanting Lyu, Yuqin Song, Xiaoguang Qiu, Wenbin Li, Song Lin, Xinghu Zhang, Dehong Lu, Junqiang Lei, Yaolong Chen & Ying Mao
Additional file 2. Search strategies in each database.

Evidence-based expert consensus on the management of primary central nervous system lymphoma in China

Tong Chen, Yuanbo Liu, Yang Wang, Qing Chang, Jinsong Wu, Zhiliang Wang, Daoying Geng, Jin-Tai Yu, Yuan Li, Xiao-Qiu Li, Hong Chen, Dongxiao Zhuang, Jianyong Li, Bin Wang, Tao Jiang, Lanting Lyu, Yuqin Song, Xiaoguang Qiu, Wenbin Li, Song Lin, Xinghu Zhang, Dehong Lu, Junqiang Lei, Yaolong Chen & Ying Mao
Abstract Primary central nervous system lymphoma (PCNSL) is a type of central nervous system restricted non-Hodgkin lymphoma, whose histopathological diagnosis is majorly large B cell lymphoma. To provide specific, evidence-based recommendations for medical professionals and to promote more standardized, effective and safe treatment for patients with PCNSL, a panel of experts from the Chinese Neurosurgical Society of the Chinese Medical Association and the Society of Hematological Malignancies of the Chinese Anti-Cancer Association jointly developed an...

Registration Year

  • 2022
    48

Resource Types

  • Dataset
    29
  • Text
    12
  • Book
    2
  • Collection
    2
  • Journal Article
    1
  • Peer Review
    1
  • Software
    1

Affiliations

  • The Ohio State University
    47
  • Jilin University
    14
  • Fudan University Shanghai Cancer Center
    14
  • Chongqing Medical University
    13
  • Zhejiang University
    12
  • Peking University Cancer Hospital
    12
  • Huazhong University of Science and Technology
    12
  • Sichuan University
    12
  • Capital Medical University
    11
  • Affiliated Hospital of Xuzhou Medical College
    9