49 Works

Nanoarchitectured Graphene Organic Framework for Drug Delivery and Chemo-photothermal Synergistic Therapy

Chengfeng Xu, Shuting Yao, Peng Jiang, Cui Wang, Jinhua Hu, Junmin Wan, Zhiwen Hu & Bing Wang
The combination of phototherapy and chemotherapy has received extensive attention in the field of cancer therapy. Hence, graphene organic framework (GOF) with a large d-spacing was prepared by solvothermal method, and a novel nanocomposite based on bovine serum albumin (BSA) and the anticancer drug doxorubicin (DOX) was developed, which effectively achieved a photothermal-chemotherapy synergistic treatment. When the feeding ratio was 1:1.6, the DOX loading capacity was 18.51%, and the GOF-BSA/DOX nanocomposite possessed unobvious pH response...

Additional file 1 of Nitidine chloride induces caspase 3/GSDME-dependent pyroptosis by inhibting PI3K/Akt pathway in lung cancer

Fei Yu, Weidan Tan, Zhiquan Chen, Xiaoju Shen, Xiaoxiang Mo, Xiaocheng Mo, Jingchuan He, Zhihua Deng, Jie Wang, Zhuo Luo & Jie Yang
Additional file 1: Table S1 The overlapped targets between NC and lung cancer. Fig. S1 A–C GSDMC, GSDMD and GSDME protein expression were analyzed by Western blotting. D WB analyses of GSDMC, GSDMD and GSDME in lung cancer cell lines and BEAS-2B cell line. Protein levels are expressed as mean ± SD (n=3). Fig. S2 H1688 or A549 cells were transfected with siRNA targeting caspase 3 (siRNA-cas3-1/2/3) or control siRNA for 24 h. Fig. S3...

Additional file 1 of Assessing the causal association between human blood metabolites and the risk of epilepsy

Jiahao Cai, Xiaoyu Li, Shangbin Wu, Yang Tian, Yani Zhang, Zixin Wei, Zixiang Jin, Xiaojing Li, Xiong Chen & Wen-Xiong Chen
Additional file 1: Figure S1. Forest plots for the Mendelian randomization (MR) leave-one-out analysis of the significant inverse variance weighted (IVW) estimates. Within each panel, the black points represent the causal estimate of the association between a specific metabolite and epilepsy after discarding each SNP in turn. Red points represent the pooled IVW estimates. Horizontal lines denote 95% confidence intervals.

Observation on the effectiveness and safety of sodium bicarbonate Ringer’s solution in the early resuscitation of traumatic hemorrhagic shock: a clinical single-center prospective randomized controlled trial

Jizhe Zhang, Dong Han, Kun Zhang, Weiqiang Guan, Li Li & Zhengtao Gu
Abstract Background Traumatic hemorrhagic shock (THS) is the main cause of death in trauma patients with high mortality. Rapid control of the source of bleeding and early resuscitation are crucial to clinical treatment. Guidelines recommend isotonic crystal resuscitation when blood products are not immediately available. However, the selection of isotonic crystals has been controversial. Sodium bicarbonate Ringer solutions (BRS), containing sodium bicarbonate, electrolyte levels, and osmotic pressures closer to plasma, are ideal. Therefore, in this...

Additional file 2 of Morphological changes of TMJ disc in surgically treated ADDwoR patients: a retrospective study

Ruiyu Wang, Ruiye Bi, Yao Liu, Pinyin Cao, Bassam Abotaleb & Songsong Zhu
Additional file 2. Raw data of TMJ discs following disc repositioning surgery.

Additional file 3 of Morphological changes of TMJ disc in surgically treated ADDwoR patients: a retrospective study

Ruiyu Wang, Ruiye Bi, Yao Liu, Pinyin Cao, Bassam Abotaleb & Songsong Zhu
Additional file 3. Stl files of TMJ discs in all patients.

Anatomic and optical parameters of three species of penguin (Aves: Sphenisciformes: Spheniscidae)

Peter W. Hadden, Misha Vorobyev, Stephanie B. Cassidy, Akilesh Gokul, Samantha K. Simkin, Henry Tran, Charles N.J. McGhee & Jie Zhang
This collection contains raw data obtained from in vivo and post mortem examination of the eyes of little penguins (Eudyptula minor) from Auckland, New Zealand, as well as captive king (Aptenodytes patagonicus) and gentoo penguins (Pygoscelis papua) descended from animals living on South Georgia. Included are A & B ultrasound recordings, corneal topography, photographs taken during keratoscopy, anterior segment optical coherence tomography scans and recordings made of the pupil of king, little and gentoo penguins.

Additional file 2 of Assessing the causal association between human blood metabolites and the risk of epilepsy

Jiahao Cai, Xiaoyu Li, Shangbin Wu, Yang Tian, Yani Zhang, Zixin Wei, Zixiang Jin, Xiaojing Li, Xiong Chen & Wen-Xiong Chen
Additional file 2: Table S1. List of the identification (ID) for each of the 486 blood metabolites. Table S2. Harmonization data_482 blood metabolites and overall documented epilepsy from the ILAE consortium. Table S3. Results for the Mendelian randomization estimates and sensitivity analysis in epilepsy-subgroup (focal and generalized epilepsy) analysis. Table S4. Leave one out analysis for the causal association between blood metabolites and epilepsy subtypes.

Morphological changes of TMJ disc in surgically treated ADDwoR patients: a retrospective study

Ruiyu Wang, Ruiye Bi, Yao Liu, Pinyin Cao, Bassam Abotaleb & Songsong Zhu
Abstract Background This study aimed to quantify the morphological changes of temporomandibular joint (TMJ) discs after disc repositioning surgery using the three-dimensional (3D) modeling. Methods Thirty patients who diagnosed with unilateral ADDwoR were included to compare the morphological differences between ADDWoR discs and normal discs, and fifteen patients who experienced unilateral or bilateral disc repositioning surgery were included to analyze the morphological changes before and after disc repositioning surgery. Disc 3D reconstruction and analyses were...

Correlation analysis between the static and the changed neutrophil-to-lymphocyte ratio and in-hospital mortality in critical patients with acute heart failure

Tao Liu, Bing Wang, Shengjue Xiao, Lifang Sun, Zhijian Zhu, Shasha Wang, Baoyin Li, Jianhui Yao, Conggang Huang, Wei Ge, Lei Qian, Zhigang Lu & Yesheng Pan
Association between neutrophil-to-lymphocyte ratio (NLR) on admission and poor prognosis in patients with acute heart failure (AHF) has been well established. However, the relationship between dynamic changes in NLR and in-hospital mortality in AHF patients has not been studied. Our purpose was to determine if an early change in NLR within the first week after AHF patients was admitted to intensive care unit (ICU) was associated with in-hospital mortality. Data from the medical information mart...

Effects of experimental warming on vegetative and reproductive characters of P. viviparaum in the Qinghai-Tibet Plateau

Chan Zhang, Xianting Li, Yumeng An, Zhonghua Zhang, Fei Ren & Huakun Zhou
This dataset contains data from a simulated warming experiment described in the paper: “Zhang, C., Li, XT., and An, YM. Effects of experimental warming on vegetative and reproductive growth of Polygonum viviparaum in the Qinghai-Tibet Plateau. Nordic Journal of Botany. DOI: 10.1111/njb.03157”. The experiment investigated Polygonum viviparaum, a perennial herb distributed widely in arctic and alpine regions, under two different levels of experimental warming treatments to examine effects of warming on its vegetative and reproductive...

Anatomic and optical parameters of three species of penguin (Aves: Sphenisciformes: Spheniscidae)

Peter W. Hadden, Misha Vorobyev, Stephanie B. Cassidy, Akilesh Gokul, Samantha K. Simkin, Henry Tran, Charles N.J. McGhee & Jie Zhang
This collection contains raw data obtained from in vivo and post mortem examination of the eyes of little penguins (Eudyptula minor) from Auckland, New Zealand, as well as captive king (Aptenodytes patagonicus) and gentoo penguins (Pygoscelis papua) descended from animals living on South Georgia. Included are A & B ultrasound recordings, corneal topography, photographs taken during keratoscopy, anterior segment optical coherence tomography scans and recordings made of the pupil of king, little and gentoo penguins.

Observation on the effectiveness and safety of sodium bicarbonate Ringer’s solution in the early resuscitation of traumatic hemorrhagic shock: a clinical single-center prospective randomized controlled trial

Jizhe Zhang, Dong Han, Kun Zhang, Weiqiang Guan, Li Li & Zhengtao Gu
Abstract Background Traumatic hemorrhagic shock (THS) is the main cause of death in trauma patients with high mortality. Rapid control of the source of bleeding and early resuscitation are crucial to clinical treatment. Guidelines recommend isotonic crystal resuscitation when blood products are not immediately available. However, the selection of isotonic crystals has been controversial. Sodium bicarbonate Ringer solutions (BRS), containing sodium bicarbonate, electrolyte levels, and osmotic pressures closer to plasma, are ideal. Therefore, in this...

Nitidine chloride induces caspase 3/GSDME-dependent pyroptosis by inhibting PI3K/Akt pathway in lung cancer

Fei Yu, Weidan Tan, Zhiquan Chen, Xiaoju Shen, Xiaoxiang Mo, Xiaocheng Mo, Jingchuan He, Zhihua Deng, Jie Wang, Zhuo Luo & Jie Yang
Abstract Background As the increasing mortality and incidence of lung cancer (LC), there is an urgent need to discover novel treatment agent. In this study, we aimed to investigate the anti-LC effects of nitidine chloride (NC), a small molecular compound extracted from Chinese herbal medicine, while detailing its underlying mechanisms. Methods Cell viability was detected by MTT assays and five cell death inhibitors, including ferrostatin-1 (Fer-1), Z-VAD-FMK, necrostatin-1 (Nec-1), disulfiram (DSF) and IM-54 were used...

Nitidine chloride induces caspase 3/GSDME-dependent pyroptosis by inhibting PI3K/Akt pathway in lung cancer

Fei Yu, Weidan Tan, Zhiquan Chen, Xiaoju Shen, Xiaoxiang Mo, Xiaocheng Mo, Jingchuan He, Zhihua Deng, Jie Wang, Zhuo Luo & Jie Yang
Abstract Background As the increasing mortality and incidence of lung cancer (LC), there is an urgent need to discover novel treatment agent. In this study, we aimed to investigate the anti-LC effects of nitidine chloride (NC), a small molecular compound extracted from Chinese herbal medicine, while detailing its underlying mechanisms. Methods Cell viability was detected by MTT assays and five cell death inhibitors, including ferrostatin-1 (Fer-1), Z-VAD-FMK, necrostatin-1 (Nec-1), disulfiram (DSF) and IM-54 were used...

Additional file 2 of Assessing the causal association between human blood metabolites and the risk of epilepsy

Jiahao Cai, Xiaoyu Li, Shangbin Wu, Yang Tian, Yani Zhang, Zixin Wei, Zixiang Jin, Xiaojing Li, Xiong Chen & Wen-Xiong Chen
Additional file 2: Table S1. List of the identification (ID) for each of the 486 blood metabolites. Table S2. Harmonization data_482 blood metabolites and overall documented epilepsy from the ILAE consortium. Table S3. Results for the Mendelian randomization estimates and sensitivity analysis in epilepsy-subgroup (focal and generalized epilepsy) analysis. Table S4. Leave one out analysis for the causal association between blood metabolites and epilepsy subtypes.

Additional file 2 of Morphological changes of TMJ disc in surgically treated ADDwoR patients: a retrospective study

Ruiyu Wang, Ruiye Bi, Yao Liu, Pinyin Cao, Bassam Abotaleb & Songsong Zhu
Additional file 2. Raw data of TMJ discs following disc repositioning surgery.

Additional file 1 of Morphological changes of TMJ disc in surgically treated ADDwoR patients: a retrospective study

Ruiyu Wang, Ruiye Bi, Yao Liu, Pinyin Cao, Bassam Abotaleb & Songsong Zhu
Additional file 1. Raw data of TMJ discs of ADDwoR patients.

Additional file 3 of Morphological changes of TMJ disc in surgically treated ADDwoR patients: a retrospective study

Ruiyu Wang, Ruiye Bi, Yao Liu, Pinyin Cao, Bassam Abotaleb & Songsong Zhu
Additional file 3. Stl files of TMJ discs in all patients.

Morphological changes of TMJ disc in surgically treated ADDwoR patients: a retrospective study

Ruiyu Wang, Ruiye Bi, Yao Liu, Pinyin Cao, Bassam Abotaleb & Songsong Zhu
Abstract Background This study aimed to quantify the morphological changes of temporomandibular joint (TMJ) discs after disc repositioning surgery using the three-dimensional (3D) modeling. Methods Thirty patients who diagnosed with unilateral ADDwoR were included to compare the morphological differences between ADDWoR discs and normal discs, and fifteen patients who experienced unilateral or bilateral disc repositioning surgery were included to analyze the morphological changes before and after disc repositioning surgery. Disc 3D reconstruction and analyses were...

Constructing new acid-activated anticancer peptide by attaching a desirable anionic binding partner peptide

Yun Zhang, Linlin Chang, Hexin Bao, Xiaoyan Wu, Hui Liu, Sanhu Gou, Jingying Zhang & Jingman Ni
Improving the cell selectivity of anticancer peptides (ACPs) is a major hurdle in their clinical utilisation. In this study, a new acid-activated ACP was designed by conjugating a cationic ACP LK to its anionic binding partner peptide (LEH) via a disulphide linker to trigger antitumor activity at acidic pH while masking its killing activity at normal pH. Three anionic binding peptides containing different numbers of glutamic acid (Glu) and histidine were engineered to obtain an...

High ultrafiltration rate induced intradialytic hypotension is a predictor for cardiac remodeling: a 5-year cohort study

Jinbo Yu, Xiaohong Chen, Yang Li, Yaqiong Wang, Zhonghua Liu, Bo Shen, Jie Teng, Jianzhou Zou & Xiaoqiang Ding
Intradialytic-hypotension (IDH) is a common complication of hemodialysis. High ultrafiltration rate (UFR) might lead to IDH. However, the relationships between UFR, IDH, and cardiac remodeling among hemodialysis patients in the long-term have not been deeply explored. This retrospective cohort study collected clinical and echocardiographic data. Patients were enrolled from 1 January 2014 to 31 March 2014 and were followed-up for 5-year. Those who suffered from more than four hypotensive events during three months (10% of...

Data from: Analysis of transposable elements in the genome of Asparagus officinalis from high coverage sequence data

Shu-Fen Li, Wu-Jun Gao, Xin-Peng Zhao, Tian-Yu Dong, Chuan-Liang Deng & Long-Dou Lu
Asparagus officinalis is an economically and nutritionally important vegetable crop that is widely cultivated and is used as a model dioecious species to study plant sex determination and sex chromosome evolution. To improve our understanding of its genome composition, especially with respect to transposable elements (TEs), which make up the majority of the genome, we performed Illumina HiSeq2000 sequencing of both male and female asparagus genomes followed by bioinformatics analysis. We generated 17 Gb of...

Data from: First-principles calculations of structural, electronic, magnetic and elastic properties of Mo2FeB2 under high pressure

Wang Bin, Ma Benyuan, Song Wei, Fu Zhe, Lu Zhansheng, Zhansheng Lu, Benyuan Ma, Zhe Fu, Wei Song & Bin Wang
The structural and electronic density of states, magnetic, and elastic properties of Mo2FeB2 under high pressure have been investigated with first principles calculations. Furthermore, the thermal dynamic properties of Mo2FeB2 were also studied with the quasiharmonic Debye model. The volume of Mo2FeB2 decreases with the increasing pressure. Using the analysis of the density of the states, atom population and Mulliken overlap population, it is observed that as the pressure increases, the B-B bonds are strengthened,...

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Affiliations

  • Henan Normal University
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  • Chinese Academy of Sciences
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  • Sichuan University
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  • Huazhong University of Science and Technology
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  • Chinese PLA General Hospital
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  • Nanjing Medical University
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  • West China Hospital of Sichuan University
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  • Shanghai University of Traditional Chinese Medicine
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