Additional file 9. Details and results for applying our model on a dialysis-related dataset. Table S1. Number of relevant articles retrieved with and without machine learning algorithm using the demonstration dataset (n=882 records). The research objective was to review CRTs in the hemodialysis setting to report key methodological and ethical issues.

Supplementary Material 2

In order to overcome the pandemic of COVID-19, messenger RNA (mRNA)-based vaccine has been extensively researched as a rapid and versatile strategy. Herein, we described the immunogenicity of mRNA-based vaccines for Beta and the most recent Omicron variants. The homologous mRNA-Beta and mRNA-Omicron and heterologous Ad5-nCoV plus mRNA vaccine exhibited high level cross-reactive neutralization for Beta, original, Delta and Omicron variants. It indicated that the COVID-19 mRNA vaccines have great potential in the clinical use...

In order to overcome the pandemic of COVID-19, messenger RNA (mRNA)-based vaccine has been extensively researched as a rapid and versatile strategy. Herein, we described the immunogenicity of mRNA-based vaccines for Beta and the most recent Omicron variants. The homologous mRNA-Beta and mRNA-Omicron and heterologous Ad5-nCoV plus mRNA vaccine exhibited high-level cross-reactive neutralization for Beta, original, Delta, and Omicron variants. It indicated that the COVID-19 mRNA vaccines have great potential in the clinical use against...

Supplemental material, sj-docx-3-psg-10.1177_22925503231161066 for Randomized Controlled Trial Comparing the Clinical Effectiveness of Collagenase Injection (Xiaflex®) and Palmar Fasciectomy in the Management of Dupuytren's Contracture by Achilles Thoma, Jessica Murphy and Lucas Gallo, Bimpe Ayeni, Lehana Thabane in Plastic Surgery

Supplementary Material 2

Abstract The modification of physical activity (PA) on the metabolic status in relation to atrial fibrillation (AF) in obesity remains unknown. We aimed to investigate the independent and joint associations of metabolic status and PA with the risk of AF in obese population. Based on the data from UK Biobank study, we used Cox proportional hazards models for analyses. Metabolic status was categorized into metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO). PA was...

Supplementary Material 1

Additional file 1. Justification for using a CRT search filter.

Additional file 5. Continuous skip-gram architecture.

Additional file 10. Examples of titles and abstracts that were classified incorrectly by our algortihms.

Additional file 3: Fig. S1. A general architecture for a convolutional neural work used for text classification.

Additional file 7: Fig. S3. Probability plot for the CRTs in the first external data classified as a CRT (Figure A, 665 CRTs) and non-CRTs classified as a CRT (Figure B, 1251 non-CRTs). The x-axis depicts the stacked ensemble model's prediction of the article being classified as a CRT. The y-axis represents the proportion of all documents that had the corresponding probability.

Additional file 8. Screenshots of the front-end tool used for our machine learning algorithm.

Abstract Background Cluster randomized trials (CRTs) are becoming an increasingly important design. However, authors of CRTs do not always adhere to requirements to explicitly identify the design as cluster randomized in titles and abstracts, making retrieval from bibliographic databases difficult. Machine learning algorithms may improve their identification and retrieval. Therefore, we aimed to develop machine learning algorithms that accurately determine whether a bibliographic citation is a CRT report. Methods We trained, internally validated, and externally...

Chronic rhinosinusitis (CRS) is a rather prevalent condition with a chronic inflammatory process, which is hard to cure. Herein, a new antibacterial drug, nitric oxide (NO), was used for the attempt on CRS therapy. To achieve this, a star copolymer (β-CD-PAMAM) consisting of the β-cyclodextrin (β-CD) core and seven PAMAM-G3 arms, which was designed as a low-cytotoxicity and high NO loading carrier, were synthesized and characterizied. The obtained β-CD-PAMAM/NONOate showed the effect in inhibiting and...

Supplemental material, sj-docx-1-psg-10.1177_22925503231161066 for Randomized Controlled Trial Comparing the Clinical Effectiveness of Collagenase Injection (Xiaflex®) and Palmar Fasciectomy in the Management of Dupuytren's Contracture by Achilles Thoma, Jessica Murphy and Lucas Gallo, Bimpe Ayeni, Lehana Thabane in Plastic Surgery

Introduction: Limited palmar fasciectomy (LPF) and collagenase injection (CI) are the most common procedures to manage symptoms of Dupuytren's Disease. This randomized controlled trial (RCT) aimed to directly compare patient outcomes 12 months following CI and LPF. Methods: Twenty-two patients with Dupuytren's Disease were randomized to either LPF or CI. The primary outcome was health state measured by the Michigan Hand Questionnaire. Secondary outcomes were health status (The Health Utility Index-3), function (The Unité Rhumatologique...

Introduction: Limited palmar fasciectomy (LPF) and collagenase injection (CI) are the most common procedures to manage symptoms of Dupuytren's Disease. This randomized controlled trial (RCT) aimed to directly compare patient outcomes 12 months following CI and LPF. Methods: Twenty-two patients with Dupuytren's Disease were randomized to either LPF or CI. The primary outcome was health state measured by the Michigan Hand Questionnaire. Secondary outcomes were health status (The Health Utility Index-3), function (The Unité Rhumatologique...

Supplemental material, sj-docx-3-psg-10.1177_22925503231161066 for Randomized Controlled Trial Comparing the Clinical Effectiveness of Collagenase Injection (Xiaflex®) and Palmar Fasciectomy in the Management of Dupuytren's Contracture by Achilles Thoma, Jessica Murphy and Lucas Gallo, Bimpe Ayeni, Lehana Thabane in Plastic Surgery