Abstract Background Cluster randomized trials (CRTs) are becoming an increasingly important design. However, authors of CRTs do not always adhere to requirements to explicitly identify the design as cluster randomized in titles and abstracts, making retrieval from bibliographic databases difficult. Machine learning algorithms may improve their identification and retrieval. Therefore, we aimed to develop machine learning algorithms that accurately determine whether a bibliographic citation is a CRT report. Methods We trained, internally validated, and externally...

Additional file 2. Additional details for the external dataset.

Additional file 4: Description of the gamma and c parameters. Fig. S2. This figure shows the decision boundaries and support vectors for different settings of the regularization parameter (C) and Kernel coefficient (gamma). We used the mglearn package to create this figure [27].

Abstract The modification of physical activity (PA) on the metabolic status in relation to atrial fibrillation (AF) in obesity remains unknown. We aimed to investigate the independent and joint associations of metabolic status and PA with the risk of AF in obese population. Based on the data from UK Biobank study, we used Cox proportional hazards models for analyses. Metabolic status was categorized into metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO). PA was...

Supplementary Material 1

Additional file 9. Details and results for applying our model on a dialysis-related dataset. Table S1. Number of relevant articles retrieved with and without machine learning algorithm using the demonstration dataset (n=882 records). The research objective was to review CRTs in the hemodialysis setting to report key methodological and ethical issues.

Additional file 4: Description of the gamma and c parameters. Fig. S2. This figure shows the decision boundaries and support vectors for different settings of the regularization parameter (C) and Kernel coefficient (gamma). We used the mglearn package to create this figure [27].

In order to overcome the pandemic of COVID-19, messenger RNA (mRNA)-based vaccine has been extensively researched as a rapid and versatile strategy. Herein, we described the immunogenicity of mRNA-based vaccines for Beta and the most recent Omicron variants. The homologous mRNA-Beta and mRNA-Omicron and heterologous Ad5-nCoV plus mRNA vaccine exhibited high-level cross-reactive neutralization for Beta, original, Delta, and Omicron variants. It indicated that the COVID-19 mRNA vaccines have great potential in the clinical use against...

Additional file 2. Additional details for the external dataset.

Additional file 3: Fig. S1. A general architecture for a convolutional neural work used for text classification.

Additional file 6. Python libraries used for this project.

Additional file 6. Python libraries used for this project.

Additional file 7: Fig. S3. Probability plot for the CRTs in the first external data classified as a CRT (Figure A, 665 CRTs) and non-CRTs classified as a CRT (Figure B, 1251 non-CRTs). The x-axis depicts the stacked ensemble model's prediction of the article being classified as a CRT. The y-axis represents the proportion of all documents that had the corresponding probability.

Additional file 8. Screenshots of the front-end tool used for our machine learning algorithm.

Additional file 1: Table S1. Search strategy for EMBASE and MEDLINE. Table S2. The journals searched for dental speciality.

Abstract Background Pilot and feasibility studies (PAFS) are smaller investigations seeking to assess the feasibility of conducting a larger more definitive study. In late 2016, the CONSORT statement was extended to disseminate good practices for reporting of randomized pilot and feasibility trials. In this quality assurance review, we assessed whether PAFS in the top dental speciality journals adhere to good practices of conduct and reporting, by prioritizing assessment of feasibility and stating pre-defined progression criteria...

Abstract Background Pilot and feasibility studies (PAFS) are smaller investigations seeking to assess the feasibility of conducting a larger more definitive study. In late 2016, the CONSORT statement was extended to disseminate good practices for reporting of randomized pilot and feasibility trials. In this quality assurance review, we assessed whether PAFS in the top dental speciality journals adhere to good practices of conduct and reporting, by prioritizing assessment of feasibility and stating pre-defined progression criteria...

Additional file 1: Table S1. Search strategy for EMBASE and MEDLINE. Table S2. The journals searched for dental speciality.

Additional file 10. Examples of titles and abstracts that were classified incorrectly by our algortihms.

Additional file 1. Justification for using a CRT search filter.

Additional file 5. Continuous skip-gram architecture.

Additional file 9. Details and results for applying our model on a dialysis-related dataset. Table S1. Number of relevant articles retrieved with and without machine learning algorithm using the demonstration dataset (n=882 records). The research objective was to review CRTs in the hemodialysis setting to report key methodological and ethical issues.

Supplementary Material 2

In order to overcome the pandemic of COVID-19, messenger RNA (mRNA)-based vaccine has been extensively researched as a rapid and versatile strategy. Herein, we described the immunogenicity of mRNA-based vaccines for Beta and the most recent Omicron variants. The homologous mRNA-Beta and mRNA-Omicron and heterologous Ad5-nCoV plus mRNA vaccine exhibited high level cross-reactive neutralization for Beta, original, Delta and Omicron variants. It indicated that the COVID-19 mRNA vaccines have great potential in the clinical use...

In order to overcome the pandemic of COVID-19, messenger RNA (mRNA)-based vaccine has been extensively researched as a rapid and versatile strategy. Herein, we described the immunogenicity of mRNA-based vaccines for Beta and the most recent Omicron variants. The homologous mRNA-Beta and mRNA-Omicron and heterologous Ad5-nCoV plus mRNA vaccine exhibited high-level cross-reactive neutralization for Beta, original, Delta, and Omicron variants. It indicated that the COVID-19 mRNA vaccines have great potential in the clinical use against...