Abstract Background This French nationwide NETSARC exhaustive prospective cohort aims to explore the impact of systematic re-excision (RE) as adjuvant care on overall survival (OS), local recurrence free survival (LRFS), and local and distant control (RFS) in patients with soft tissue sarcoma (STS) with positive microscopic margins (R1) after initial resection performed outside of a reference center. Methods Eligible patients had experienced STS surgery outside a reference center from 2010 to 2017, and had R1...

Additional file 3. Spatial probability isocontour maps of age group 1, 2, 3 and 5. (a, b, c, and d) Maps depict the distribution of probabilities throughout the harrat based on the locations of visible vents in age group 1, 2, 3 and 5, respectively, without using age-weighting procedure.

Additional file 5. Spatio-temporal probability isocontour maps obtained by multiplying the values of the spatial analysis of last 300 ka eruptions by their long-term average recurrence rate, 1.1 eruptions/10 kyr. (a, b, and c) Maps show the probabilities of occurrence of at least one eruption in Harrat Khaybar for the next 1, 10, and 1000 years, respectively.

Abstract Background This French nationwide NETSARC exhaustive prospective cohort aims to explore the impact of systematic re-excision (RE) as adjuvant care on overall survival (OS), local recurrence free survival (LRFS), and local and distant control (RFS) in patients with soft tissue sarcoma (STS) with positive microscopic margins (R1) after initial resection performed outside of a reference center. Methods Eligible patients had experienced STS surgery outside a reference center from 2010 to 2017, and had R1...

Additional file 1: Supplementary material S1, S2, S3 and S4

Health professionals are at the forefront of information and acceptability regarding contraceptive methods, however only one study evaluated their knowledge of male contraception (MC) including hormonal MC (HMC) and thermal MC (TMC). Our objective was to evaluate the knowledge, professional attitudes, and training of French practitioners regarding the management of couple contraception by male contraception (MC). We designed a descriptive, cross-sectional, multicentre study in 2,396 French practitioners belonging to national or regional institutions involved in...

Additional file 2. Analytical data for each of the 15 age determinations of Harrat Khaybar rock that was used in this study.

Health professionals are at the forefront of information and acceptability regarding contraceptive methods, however only one study evaluated their knowledge of male contraception (MC) including hormonal MC (HMC) and thermal MC (TMC). Our objective was to evaluate the knowledge, professional attitudes, and training of French practitioners regarding the management of couple contraception by male contraception (MC). We designed a descriptive, cross-sectional, multicentre study in 2,396 French practitioners belonging to national or regional institutions involved in...

Additional file 3. Spatial probability isocontour maps of age group 1, 2, 3 and 5. (a, b, c, and d) Maps depict the distribution of probabilities throughout the harrat based on the locations of visible vents in age group 1, 2, 3 and 5, respectively, without using age-weighting procedure.

Abstract The 180,000 km2 of Arabian lava fields (“harrats” in Arabic) form one of the largest distributed basaltic provinces in the world. The most recent eruption in 1256 AD, on the outskirts of Medina, as well as shallow dike emplacement in 2009, ~ 200 km northeast of the city, suggest future volcanic threat to this area. Harrat Khaybar (~ 1.7 Ma to present) is one of the largest and most compositionally diverse Arabian lava fields;...

Additional file 1: Supplementary material S1, S2, S3 and S4

Additional file 2. Analytical data for each of the 15 age determinations of Harrat Khaybar rock that was used in this study.

Additional file 5. Spatio-temporal probability isocontour maps obtained by multiplying the values of the spatial analysis of last 300 ka eruptions by their long-term average recurrence rate, 1.1 eruptions/10 kyr. (a, b, and c) Maps show the probabilities of occurrence of at least one eruption in Harrat Khaybar for the next 1, 10, and 1000 years, respectively.

Additional file 1. Supplementary methods:Peptides and antibodies. Plasmids, siRNA and cell transfection. Western-blot and Immunoprecipitation assays. ELISA experiments. Immunofluorescence experiments. Flow cytometry experiments. Reverse Transcription-quantitative PCR (RT-qPCR). Cell migration assays. Cell Proliferation assays. Transwell invasion assays. Crispr/Cas9 deletion of genes. Experiments on animals and imaging. Immunohistochemistry. Patient cohort. Statistical analysis. Supplementary figures and tables: Supplementary Table 1: Absence of significant impact of age, KPS and steroid dose on progression-free survival or overall survival. Supplementary Table...

Abstract Rationale Glioblastoma multiforme (GBM) is a primary brain tumor with poor prognosis. The U.S. food and drug administration approved the use of the anti-VEGF antibody bevacizumab in recurrent GBM. However, resistance to this treatment is frequent and fails to enhance the overall survival of patients. In this study, we aimed to identify novel mechanism(s) responsible for bevacizumab-resistance in CD146-positive glioblastoma. Methods The study was performed using sera from GBM patients and human GBM cell...

Abstract Rationale Glioblastoma multiforme (GBM) is a primary brain tumor with poor prognosis. The U.S. food and drug administration approved the use of the anti-VEGF antibody bevacizumab in recurrent GBM. However, resistance to this treatment is frequent and fails to enhance the overall survival of patients. In this study, we aimed to identify novel mechanism(s) responsible for bevacizumab-resistance in CD146-positive glioblastoma. Methods The study was performed using sera from GBM patients and human GBM cell...

Additional file 1. Supplementary methods:Peptides and antibodies. Plasmids, siRNA and cell transfection. Western-blot and Immunoprecipitation assays. ELISA experiments. Immunofluorescence experiments. Flow cytometry experiments. Reverse Transcription-quantitative PCR (RT-qPCR). Cell migration assays. Cell Proliferation assays. Transwell invasion assays. Crispr/Cas9 deletion of genes. Experiments on animals and imaging. Immunohistochemistry. Patient cohort. Statistical analysis. Supplementary figures and tables: Supplementary Table 1: Absence of significant impact of age, KPS and steroid dose on progression-free survival or overall survival. Supplementary Table...

Additional file 1. Excel file containing separate sheets for each dataset analyzed in this study. It includes spatial and temporal datasets for Harrat Khaybar such as vent and fissure locations, bandwidth matrices, age data, recurrence rates, and spatio-temporal cumulative probabilities.

Additional file 1. Excel file containing separate sheets for each dataset analyzed in this study. It includes spatial and temporal datasets for Harrat Khaybar such as vent and fissure locations, bandwidth matrices, age data, recurrence rates, and spatio-temporal cumulative probabilities.

Additional file 4. Reduced-to-pole aeromagnetic maps of Harrat Khaybar. It shows the inconsistency between the visible volcanic vent locations and magnetic anomalies. a) Raw aeromagnetic data. b) Aeromagnetic data clipped to the extent of Harrat Khaybar lavas. c) Stratigraphic unit boundaries of Harrat Khaybar plotted over the aeromagnetic data, corresponding to the boundaries in Fig. 2a. d) Surface vent locations plotted over the aeromagnetic data. The scale in a) represents magnetic intensity.

Additional file 4. Reduced-to-pole aeromagnetic maps of Harrat Khaybar. It shows the inconsistency between the visible volcanic vent locations and magnetic anomalies. a) Raw aeromagnetic data. b) Aeromagnetic data clipped to the extent of Harrat Khaybar lavas. c) Stratigraphic unit boundaries of Harrat Khaybar plotted over the aeromagnetic data, corresponding to the boundaries in Fig. 2a. d) Surface vent locations plotted over the aeromagnetic data. The scale in a) represents magnetic intensity.

Abstract The 180,000 km2 of Arabian lava fields (“harrats” in Arabic) form one of the largest distributed basaltic provinces in the world. The most recent eruption in 1256 AD, on the outskirts of Medina, as well as shallow dike emplacement in 2009, ~ 200 km northeast of the city, suggest future volcanic threat to this area. Harrat Khaybar (~ 1.7 Ma to present) is one of the largest and most compositionally diverse Arabian lava fields;...