173 Works

Homogeneous horizontal and vertical seismic barriers: mathematical foundations and dimensional analysis

V.A. Bratov, A.V. Ilyashenko, S.V. Kuznetsov, T.-K. Lin & N.F. Morozov
The concept of a vertical barrier embedded in soil to protect from seismic waves of the Rayleigh type is discussed. Horizontal barriers are also analyzed. The principle idea for such a barrier is to reflect and scatter energy of an oncoming wave by the barrier, thus decreasing the amplitude of surface vibrations beyond the barrier. Numerical FE simulations of a plane model are presented and discussed.

Consuming disaster data: is IT ethical?

Sung-Yueh Perng, Monika Büscher & Luke Moffat
Most people use disaster apps infrequently, primarily only in situations of turmoil, when they are physically or emotionally vulnerable. Personal data may be necessary to help them, data protections may be waived. In some circumstances, free movement and liberties may be curtailed for public protection, as was seen in the current COVID pandemic. Consuming and producing disaster data can deepen problems arising at the confluence of surveillance and disaster capitalism, where data has become a...

Additional file 4 of A comprehensive update on CIDO: the community-based coronavirus infectious disease ontology

Yongqun He, Hong Yu, Anthony Huffman, Asiyah Yu Lin, Darren A. Natale, John Beverley, Ling Zheng, Yehoshua Perl, Zhigang Wang, Yingtong Liu, Edison Ong, Yang Wang, Philip Huang, Long Tran, Jinyang Du, Zalan Shah, Easheta Shah, Roshan Desai, Hsin-hui Huang, Yujia Tian, Eric Merrell, William D. Duncan, Sivaram Arabandi, Lynn M. Schriml, Jie Zheng … & Barry Smith
Additional file 4: Supplemental Table 3. Protein Ontology representation of SARS-CoV-2 proteins. Comparative information in RefSeq and UniProtKB is also provided.

Additional file 2 of Chemotherapy dose per kilogram lean body mass increased dose-limiting toxicity event in male head and neck cancer with taxane and platinum-based induction therapy

Chuan-Jen Hung, Bor-Hwang Kang, Keng-Ming Chang, Ying-Ying Kang, Chun-Hao Yin & Ching-Chih Lee
Additional file 2: Supplementary Figure 1. Example of skeletal muscle measurements at the third cervical vertebral (C3) level on axial neck CT (A) and MRI (B) images. The paravertebral muscles are shown in green. The left sternocleidomastoid muscle is delineated in red, and the right sternocleidomastoid muscle in yellow.

Multimodality treatment for brain arteriovenous malformation in Mainland China: design, rationale, and baseline patient characteristics of a nationwide multicenter prospective registry

Yu Chen, Heze Han, Li Ma, Ruinan Li, Zhipeng Li, Debin Yan, Haibin Zhang, Kexin Yuan, Ke Wang, Yang Zhao, Yukun Zhang, Weitao Jin, Runting Li, Fa Lin, Xiangyu Meng, Qiang Hao, Hao Wang, Xun Ye, Shuai Kang, Hengwei Jin, Youxiang Li, Dezhi Gao, Shibin Sun, Ali Liu, Shuo Wang … & Yuanli Zhao
Abstract Background Brain arteriovenous malformation (AVM) is an important cause of hemorrhagic stroke in young adults, which can lead to severe neurological impairment. The registry of Multimodality treatment for brain ArTeriovenous malformation in mainland CHina (MATCH) is a national prospective registry to identify the natural history of AVMs in Asian population; to investigate traditional and emerging hemorrhagic predictors; and to explore the superiority of the multidisciplinary assessment in improving the long-term outcomes. Methods Consecutive AVM...

Additional file 1 of Identification of a novel interaction site between the large hepatitis delta antigen and clathrin that regulates the assembly of genotype III hepatitis delta virus

Wei-Chung Chiou, Hsu-Feng Lu, Jui-Chieh Chen, Yu-Heng Lai, Ming-Fu Chang, Yuan-Li Huang, Ni Tien & Cheng Huang
Additional file 1. Fig. S1. Binding of HDV-I, HDV-II, and HDV-III HDAg-L to CHC.

Identification of a novel interaction site between the large hepatitis delta antigen and clathrin that regulates the assembly of genotype III hepatitis delta virus

Wei-Chung Chiou, Hsu-Feng Lu, Jui-Chieh Chen, Yu-Heng Lai, Ming-Fu Chang, Yuan-Li Huang, Ni Tien & Cheng Huang
Abstract Background Hepatitis delta virus (HDV), a satellite virus of hepatitis B virus (HBV), is a small, defective RNA virus strongly associated with the most severe form of hepatitis and progressive chronic liver disease and cirrhosis. Chronic hepatitis D, resulting from HBV/HDV coinfection, is considered to be the most severe form of viral hepatitis and affects 12–20 million people worldwide. Involved in the endocytosis and exocytosis of cellular and viral proteins, clathrin contributes to the...

Identification of a necroptosis-related prognostic gene signature associated with tumor immune microenvironment in cervical carcinoma and experimental verification

Kai Sun, Cheng Huang, Jing-zhang Li & Zhan-xiong Luo
Abstract Cervical carcinoma (CC) has been associated with high morbidity, poor prognosis, and high intratumor heterogeneity. Necroptosis is the significant cellular signal pathway in tumors which may overcome tumor cells’ apoptosis resistance. To investigate the relationship between CC and necroptosis, we established a prognostic model based on necroptosis-related genes for predicting the overall survival (OS) of CC patients. The gene expression data and clinical information of cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) patients...

Additional file 2 of Identification of a necroptosis-related prognostic gene signature associated with tumor immune microenvironment in cervical carcinoma and experimental verification

Kai Sun, Cheng Huang, Jing-zhang Li & Zhan-xiong Luo
Additional file 2: Table S2. 159 NRGs from KEGG in CESC. Abbreviations: CESC, Cervical squamous cell carcinoma and endocervical adenocarcinoma.

Additional file 2 of Identification of a necroptosis-related prognostic gene signature associated with tumor immune microenvironment in cervical carcinoma and experimental verification

Kai Sun, Cheng Huang, Jing-zhang Li & Zhan-xiong Luo
Additional file 2: Table S2. 159 NRGs from KEGG in CESC. Abbreviations: CESC, Cervical squamous cell carcinoma and endocervical adenocarcinoma.

Additional file 1 of Identification of a necroptosis-related prognostic gene signature associated with tumor immune microenvironment in cervical carcinoma and experimental verification

Kai Sun, Cheng Huang, Jing-zhang Li & Zhan-xiong Luo
Additional file 1: Table S1. Clinical characteristics of patients with CC. Abbreviations: CC, Cervical carcinoma.

Role of air pollutants in dengue fever incidence: evidence from two southern cities in Taiwan

Hao-Chun Lu, Fang-Yu Lin, Yao-Huei Huang, Yu-Tung Kao & El-Wui Loh
Air pollution may be involved in spreading dengue fever (DF) besides rainfalls and warmer temperatures. While particulate matter (PM), especially those with diameter of 10 μm (PM10) or 2.5 μm or less (PM25), and NO2 increase the risk of coronavirus 2 infection, their roles in triggering DF remain unclear. We explored if air pollution factors predict DF incidence in addition to the classic climate factors. Public databases and DF records of two southern cities in...

Extracellular vesicles derived from endometrial epithelial cells deliver exogenous miR-92b-3p to affect the function of embryonic trophoblast cells via targeting TSC1 and DKK3

Renwu Hua, Qiaorui Liu, Weisi Lian, Ting ting Kang, Dengying Gao, Cheng Huang, Yueying Wang & Minggang Lei
Abstract Background Extracellular vesicles (EVs) could mediate embryo-maternal communication to affect embryo implantation by delivering biology information, including microRNA (miRNA), protein, lipid. Our previous research shows that miR-92b-3p was differentially expressed in EVs of uterine flushing fluids during the embryo implantation period. However, the role of miR-92b-3p from EVs in embryo implantation remains elusive. Materials and methods EVs were isolated from porcine endometrial epithelial cells (EECs) by ultracentrifugation. MiR-92b-3p mimics and EVs were used to...

Comparative accuracy of biomarkers for the prediction of hospital-acquired acute kidney injury: a systematic review and meta-analysis

Heng-Chih Pan, Shao-Yu Yang, Terry Ting-Yu Chiou, Chih-Chung Shiao, Che-Hsiung Wu, Chun-Te Huang, Tsai-Jung Wang, Jui-Yi Chen, Hung-Wei Liao, Sheng-Yin Chen, Tao-Min Huang, Ya-Fei Yang, Hugo You-Hsien Lin, Ming-Jen Chan, Chiao-Yin Sun, Yih-Ting Chen, Yung-Chang Chen & Vin-Cent Wu
Abstract Background Several biomarkers have been proposed to predict the occurrence of acute kidney injury (AKI); however, their efficacy varies between different trials. The aim of this study was to compare the predictive performance of different candidate biomarkers for AKI. Methods In this systematic review, we searched PubMed, Medline, Embase, and the Cochrane Library for papers published up to August 15, 2022. We selected all studies of adults (> 18 years) that reported the predictive...

Additional file 2 of Densest subgraph-based methods for protein-protein interaction hot spot prediction

Ruiming Li, Jung-Yu Lee, Jinn-Moon Yang & Tatsuya Akutsu
Additional file 2. Recalls of all the methods on all the complexes.

Densest subgraph-based methods for protein-protein interaction hot spot prediction

Ruiming Li, Jung-Yu Lee, Jinn-Moon Yang & Tatsuya Akutsu
Abstract Background Hot spots play an important role in protein binding analysis. The residue interaction network is a key point in hot spot prediction, and several graph theory-based methods have been proposed to detect hot spots. Although the existing methods can yield some interesting residues by network analysis, low recall has limited their abilities in finding more potential hot spots. Result In this study, we develop three graph theory-based methods to predict hot spots from...

Densest subgraph-based methods for protein-protein interaction hot spot prediction

Ruiming Li, Jung-Yu Lee, Jinn-Moon Yang & Tatsuya Akutsu
Abstract Background Hot spots play an important role in protein binding analysis. The residue interaction network is a key point in hot spot prediction, and several graph theory-based methods have been proposed to detect hot spots. Although the existing methods can yield some interesting residues by network analysis, low recall has limited their abilities in finding more potential hot spots. Result In this study, we develop three graph theory-based methods to predict hot spots from...

sj-pdf-1-smm-10.1177_09622802221130580 - Supplemental material for Complete effect decomposition for an arbitrary number of multiple ordered mediators with time-varying confounders: A method for generalized causal multi-mediation analysis

An-Shun Tai & Sheng-Hsuan Lin
Supplemental material, sj-pdf-1-smm-10.1177_09622802221130580 for Complete effect decomposition for an arbitrary number of multiple ordered mediators with time-varying confounders: A method for generalized causal multi-mediation analysis by An-Shun Tai and Sheng-Hsuan Lin in Statistical Methods in Medical Research

Additional file 1 of Identification of cell states using super-enhancer RNA

Yueh-Hua Tu, Hsueh-Fen Juan & Hsuan-Cheng Huang
Additional file 1: Figure S1. Definition of super-enhancer RNA. Figure S2. Heat map of the cell type correlation matrix. Figure S3. NMF decomposition of the time-coursed macrophages response to the LPS experiment.

β-arrestin-2 alleviates rheumatoid arthritis injury by suppressing NLRP3 inflammasome activation and NF- κB pathway in macrophages

Feng Cao, Cheng Huang, Jiwei Cheng & Zhaochun He
Rheumatoid arthritis (RA) is a chronic inflammatory joint disorder that inflicts damage to the joints of the hands and wrist. The aim of this study was to investigate the protective effect of β-Arrestin-2 (βArr2) on RA in vivo and in vitro. The βArr2 adenovirus (βArr2-Ad) or the control (Con-Ad) was injected into the ankle joint cavity of collagen-induced arthritis (CIA) mice. According to the results, an improvement was shown in the symptoms and pathological injury...

β-arrestin-2 alleviates rheumatoid arthritis injury by suppressing NLRP3 inflammasome activation and NF- κB pathway in macrophages

Feng Cao, Cheng Huang, Jiwei Cheng & Zhaochun He
Rheumatoid arthritis (RA) is a chronic inflammatory joint disorder that inflicts damage to the joints of the hands and wrist. The aim of this study was to investigate the protective effect of β-Arrestin-2 (βArr2) on RA in vivo and in vitro. The βArr2 adenovirus (βArr2-Ad) or the control (Con-Ad) was injected into the ankle joint cavity of collagen-induced arthritis (CIA) mice. According to the results, an improvement was shown in the symptoms and pathological injury...

Anti-Helicobacter pylori activity of potential probiotic Lactiplantibacillus pentosus SLC13

Tran Thi Dieu Thuy, Pei-Yun Kuo, Sha-Ma Lin & Cheng-Yen Kao
Abstract Background Here, we aimed to evaluate and compare the anti-Helicobacter pylori activity of potential probiotic Lactiplantibacillus pentosus SLC13 to Lactobacillus gasseri BCRC 14619 T and Lacticaseibacillus rhamnosus LGG. Phenotypic assays including growth curve, cell adhesion, and cellular cytotoxicity were performed to characterize SLC13. Anti-H. pylori activity of lactobacilli was determined by the disk diffusion method and co-culture assay. Exopolysaccharide (EPS) was extracted from lactobacilli to test its immune modulation activity, and IL-8 expression in...

Genome-wide analyses identify novel risk loci for cluster headache in Han Chinese residing in Taiwan

Shih-Pin Chen, Chia-Lin Hsu, Yen-Feng Wang, Fu-Chi Yang, Ting-Huei Chen, Jia-Hsin Huang, Li-Ling Hope Pan, Jong-Ling Fuh, Hsueh-Chen Chang, Yi-Lun Lee, Hung-Ching Chang, Ko-Han Lee, Yu-Chuan Chang, Cathy Shen-Jang Fann & Shuu-Jiun Wang
Abstract Background Cluster headache is a highly debilitating neurological disorder with considerable inter-ethnic differences. Genome-wide association studies (GWAS) recently identified replicable genomic loci for cluster headache in Europeans, but the genetic underpinnings for cluster headache in Asians remain unclear. The objective of this study is to investigate the genetic architecture and susceptibility loci of cluster headache in Han Chinese resided in Taiwan. Methods We conducted a two-stage genome-wide association study in a Taiwanese cohort enrolled...

Additional file 6 of Genome-wide analyses identify novel risk loci for cluster headache in Han Chinese residing in Taiwan

Shih-Pin Chen, Chia-Lin Hsu, Yen-Feng Wang, Fu-Chi Yang, Ting-Huei Chen, Jia-Hsin Huang, Li-Ling Hope Pan, Jong-Ling Fuh, Hsueh-Chen Chang, Yi-Lun Lee, Hung-Ching Chang, Ko-Han Lee, Yu-Chuan Chang, Cathy Shen-Jang Fann & Shuu-Jiun Wang
Additional file 6: Supplemental Table 2. Meta-analysis of previous studies and the current study for previously reported cluster-associated loci.

Additional file 8 of Genome-wide analyses identify novel risk loci for cluster headache in Han Chinese residing in Taiwan

Shih-Pin Chen, Chia-Lin Hsu, Yen-Feng Wang, Fu-Chi Yang, Ting-Huei Chen, Jia-Hsin Huang, Li-Ling Hope Pan, Jong-Ling Fuh, Hsueh-Chen Chang, Yi-Lun Lee, Hung-Ching Chang, Ko-Han Lee, Yu-Chuan Chang, Cathy Shen-Jang Fann & Shuu-Jiun Wang
Additional file 8: Supplemental Table 3. GIGSEA Biological Pathway Enrichment in brain tissues. The significant level of empirical P-value was 0.05 and the BayesFactor was 100. Top significantly associated pathways in these tissues that may be relevant to cluster headache were listed in the table. UsedGenes indicates number of gene used in the enrichment estimation of the GIGSEA model.

Registration Year

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Affiliations

  • National Yang Ming Chiao Tung University
    170
  • Zhejiang University
    50
  • University of Alabama at Birmingham
    42
  • Fudan University
    42
  • First Affiliated Hospital of Chongqing Medical University
    42
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    38
  • Taipei Veterans General Hospital
    38
  • Nanjing Medical University
    38
  • Xiangya Hospital Central South University
    38
  • Tongji University
    34